ATE313378T1 - Mikrofluidische vorrichtungen mit verteilungseinlässen - Google Patents

Mikrofluidische vorrichtungen mit verteilungseinlässen

Info

Publication number
ATE313378T1
ATE313378T1 AT02786351T AT02786351T ATE313378T1 AT E313378 T1 ATE313378 T1 AT E313378T1 AT 02786351 T AT02786351 T AT 02786351T AT 02786351 T AT02786351 T AT 02786351T AT E313378 T1 ATE313378 T1 AT E313378T1
Authority
AT
Austria
Prior art keywords
microfluidic devices
functional features
fluids
common
distribute
Prior art date
Application number
AT02786351T
Other languages
English (en)
Inventor
Stephen D O'connor
Christoph D Karp
Eugene Dantsker
Original Assignee
Nanostream Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanostream Inc filed Critical Nanostream Inc
Application granted granted Critical
Publication of ATE313378T1 publication Critical patent/ATE313378T1/de

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/432—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/7182—Feed mechanisms characterised by the means for feeding the components to the mixer with means for feeding the material with a fractal or tree-type distribution in a surface
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/02—Preparation of the material, in the area to be joined, prior to joining or welding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C3/00—Assembling of devices or systems from individually processed components
    • B81C3/008—Aspects related to assembling from individually processed components, not covered by groups B81C3/001 - B81C3/002
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
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    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
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    • B29C65/02—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
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    • G—PHYSICS
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    • G01N30/50—Conditioning of the sorbent material or stationary liquid
    • G01N30/56—Packing methods or coating methods
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    • G01N2030/565—Packing methods or coating methods packing slurry packing
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    • G01N30/60—Construction of the column
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T137/218—Means to regulate or vary operation of device
    • Y10T137/2191—By non-fluid energy field affecting input [e.g., transducer]
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    • Y10T137/2224—Structure of body of device
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T137/00—Fluid handling
    • Y10T137/8158—With indicator, register, recorder, alarm or inspection means
    • Y10T137/8359—Inspection means

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Organic Chemistry (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micromachines (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
AT02786351T 2001-06-07 2002-06-06 Mikrofluidische vorrichtungen mit verteilungseinlässen ATE313378T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US29689701P 2001-06-07 2001-06-07
US35768302P 2002-02-13 2002-02-13
US10/160,393 US6981522B2 (en) 2001-06-07 2002-05-30 Microfluidic devices with distributing inputs
PCT/US2002/017957 WO2003045559A2 (en) 2001-06-07 2002-06-06 Microfluidic devices with distributing inputs

Publications (1)

Publication Number Publication Date
ATE313378T1 true ATE313378T1 (de) 2006-01-15

Family

ID=27388443

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02786351T ATE313378T1 (de) 2001-06-07 2002-06-06 Mikrofluidische vorrichtungen mit verteilungseinlässen

Country Status (8)

Country Link
US (1) US6981522B2 (de)
EP (1) EP1453606B1 (de)
JP (1) JP2005510695A (de)
AT (1) ATE313378T1 (de)
AU (1) AU2002349871B2 (de)
CA (1) CA2445806A1 (de)
DE (1) DE60208235T2 (de)
WO (1) WO2003045559A2 (de)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7485454B1 (en) 2000-03-10 2009-02-03 Bioprocessors Corp. Microreactor
US7323143B2 (en) * 2000-05-25 2008-01-29 President And Fellows Of Harvard College Microfluidic systems including three-dimensionally arrayed channel networks
US20040132166A1 (en) * 2001-04-10 2004-07-08 Bioprocessors Corp. Determination and/or control of reactor environmental conditions
US20050032204A1 (en) * 2001-04-10 2005-02-10 Bioprocessors Corp. Microreactor architecture and methods
US20040058407A1 (en) * 2001-04-10 2004-03-25 Miller Scott E. Reactor systems having a light-interacting component
US20040058437A1 (en) * 2001-04-10 2004-03-25 Rodgers Seth T. Materials and reactor systems having humidity and gas control
GB2380528B (en) * 2001-10-05 2003-09-10 Minebea Co Ltd A bearing assembly and method of manufacturing a bearing assembly
US20040109793A1 (en) * 2002-02-07 2004-06-10 Mcneely Michael R Three-dimensional microfluidics incorporating passive fluid control structures
US20050106714A1 (en) * 2002-06-05 2005-05-19 Zarur Andrey J. Rotatable reactor systems and methods
EP1628748A2 (de) * 2003-06-05 2006-03-01 Bioprocessors Corporation Reaktor mit speicherkomponente
JP4073023B2 (ja) * 2003-11-07 2008-04-09 財団法人新産業創造研究機構 微小流路デバイスおよびその作製方法
WO2006025858A2 (en) * 2004-02-17 2006-03-09 Yale University Microfabricated cellular traps based on three-dimensional micro-scale flow geometries
US9863941B2 (en) * 2004-04-01 2018-01-09 Nanyang Technological University Microchip and method for detecting molecules and molecular interactions
WO2005095262A1 (en) * 2004-04-01 2005-10-13 Nanyang Technological University Microchip and method for detecting molecules and molecular interactions
US7694694B2 (en) * 2004-05-10 2010-04-13 The Aerospace Corporation Phase-change valve apparatuses
US8642353B2 (en) * 2004-05-10 2014-02-04 The Aerospace Corporation Microfluidic device for inducing separations by freezing and associated method
US7419639B2 (en) * 2004-05-12 2008-09-02 The Board Of Trustees Of The Leland Stanford Junior University Multilayer microfluidic device
EP1758674A2 (de) * 2004-06-07 2007-03-07 Bioprocessors Corporation Schuberzeugung in einem reaktor
US20070036690A1 (en) * 2004-06-07 2007-02-15 Bioprocessors Corp. Inlet channel volume in a reactor
WO2005120691A1 (en) * 2004-06-07 2005-12-22 Bioprocessors Corp. Reactor mixing
US20060019333A1 (en) * 2004-06-07 2006-01-26 Rodgers Seth T Control of reactor environmental conditions
US7650910B2 (en) * 2004-06-24 2010-01-26 The Aerospace Corporation Electro-hydraulic valve apparatuses
US7721762B2 (en) 2004-06-24 2010-05-25 The Aerospace Corporation Fast acting valve apparatuses
US7686040B2 (en) * 2004-06-24 2010-03-30 The Aerospace Corporation Electro-hydraulic devices
US20060065532A1 (en) * 2004-09-30 2006-03-30 Matthias Stiene Microfluidic analytical system with accessible electrically conductive contact pads
US7402616B2 (en) * 2004-09-30 2008-07-22 Lifescan, Inc. Fusible conductive ink for use in manufacturing microfluidic analytical systems
US20060065361A1 (en) * 2004-09-30 2006-03-30 Matthias Stiene Process for manufacturing an analysis module with accessible electrically conductive contact pads for a microfluidic analytical system
US7955504B1 (en) 2004-10-06 2011-06-07 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Microfluidic devices, particularly filtration devices comprising polymeric membranes, and method for their manufacture and use
US7578167B2 (en) * 2005-05-17 2009-08-25 Honeywell International Inc. Three-wafer channel structure for a fluid analyzer
CN101248709A (zh) * 2005-05-18 2008-08-20 哈佛大学 微流体网络中传导通路、微电路和微结构的制造
US7846489B2 (en) 2005-07-22 2010-12-07 State of Oregon acting by and though the State Board of Higher Education on behalf of Oregon State University Method and apparatus for chemical deposition
US8679587B2 (en) * 2005-11-29 2014-03-25 State of Oregon acting by and through the State Board of Higher Education action on Behalf of Oregon State University Solution deposition of inorganic materials and electronic devices made comprising the inorganic materials
US20080280331A1 (en) 2006-02-07 2008-11-13 Stokes Bio Limited Microfluidic Analysis System
US20100304446A1 (en) * 2006-02-07 2010-12-02 Stokes Bio Limited Devices, systems, and methods for amplifying nucleic acids
US7445027B2 (en) * 2006-03-14 2008-11-04 The Board Of Trustees Of The University Of Illinois Multilayer microfluidic-nanofluidic device
JP4901260B2 (ja) * 2006-03-28 2012-03-21 富士フイルム株式会社 流体混合装置及び流体混合方法
US20070244258A1 (en) * 2006-03-29 2007-10-18 Shanti Swarup Clear coating compositions with improved scratch resistance
US20080108122A1 (en) * 2006-09-01 2008-05-08 State of Oregon acting by and through the State Board of Higher Education on behalf of Oregon Microchemical nanofactories
US8403557B2 (en) * 2006-09-28 2013-03-26 University Of Washington Micromixer using integrated three-dimensional porous structure
EP2069068A2 (de) * 2006-09-28 2009-06-17 The University of Washington 3d-mikrosalige manipulierte gewebemodellsysteme
CN1996009B (zh) * 2007-01-10 2010-05-19 博奥生物有限公司 一种用于多样品分析的微流体器件和使用方法
US20080237044A1 (en) * 2007-03-28 2008-10-02 The Charles Stark Draper Laboratory, Inc. Method and apparatus for concentrating molecules
WO2008130618A1 (en) 2007-04-19 2008-10-30 The Charles Stark Draper Laboratory, Inc. Method and apparatus for separating particles, cells, molecules and particulates
US7837379B2 (en) * 2007-08-13 2010-11-23 The Charles Stark Draper Laboratory, Inc. Devices for producing a continuously flowing concentration gradient in laminar flow
JP5311801B2 (ja) * 2007-11-09 2013-10-09 キヤノン株式会社 浸透圧ポンプを用いた送液駆動機構および該送液駆動機構を有するマイクロチップ
JP2011513712A (ja) * 2008-02-21 2011-04-28 アヴァントラ バイオサイエンスィズ コーポレーション アレイ上の液体流に基づく検定
US20090211977A1 (en) * 2008-02-27 2009-08-27 Oregon State University Through-plate microchannel transfer devices
JP2009210327A (ja) * 2008-03-03 2009-09-17 Yokogawa Electric Corp 化学反応用カートリッジ、混合物生成方法及び化学反応用カートリッジの制御装置
US8707971B2 (en) * 2008-05-16 2014-04-29 Xyratex Corporation Laminated walls for uniform fluid flow
EP2193839B1 (de) * 2008-11-28 2019-03-13 Corning Incorporated Vorrichtungen zur Fluidverteilung in Mikroreaktoren
US9056299B2 (en) * 2009-03-13 2015-06-16 President And Fellows Of Harvard College Scale-up of flow-focusing microfluidic devices
US8236599B2 (en) 2009-04-09 2012-08-07 State of Oregon acting by and through the State Board of Higher Education Solution-based process for making inorganic materials
TWI425981B (zh) * 2009-04-30 2014-02-11 Corning Inc 微反應器流體分配之裝置及方法
US9599407B2 (en) 2009-07-29 2017-03-21 Tokitae Llc System and structure for heating or sterilizing a liquid stream
US9930898B2 (en) * 2009-07-29 2018-04-03 Tokitae Llc Pasteurization system and method
US8753515B2 (en) 2009-12-05 2014-06-17 Home Dialysis Plus, Ltd. Dialysis system with ultrafiltration control
US20110189048A1 (en) * 2009-12-05 2011-08-04 Curtis James R Modular dialysis system
US8580161B2 (en) 2010-05-04 2013-11-12 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Fluidic devices comprising photocontrollable units
US8501009B2 (en) 2010-06-07 2013-08-06 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Fluid purification system
CN103003702B (zh) 2010-06-30 2015-04-15 美特宝思科润株式会社 微型化学芯片、其制造方法及其使用方法
DE102010053749B4 (de) * 2010-12-08 2015-02-19 Airbus Defence and Space GmbH Vorrichtung zum Identifizieren biotischer Partikel
ES2640953T3 (es) 2011-10-07 2017-11-07 Outset Medical, Inc. Purificación de líquido de intercambio de calor para un sistema de diálisis
DE102011054659A1 (de) * 2011-10-20 2013-04-25 AeroMegt GmbH Verfahren und Vorrichtung zum Messen von Aerosolen in einem großen Volumenstrom
WO2013132338A2 (en) 2012-03-06 2013-09-12 Calpro As Competitive immunoassay for calprotectin
WO2013132347A2 (en) 2012-03-06 2013-09-12 Calpro As Improved elisa immunoassay for calprotectin
CN102886280B (zh) * 2012-08-28 2014-06-11 博奥生物有限公司 一种微流控芯片及其应用
CA2886777C (en) 2012-10-08 2021-07-13 General Electric Company Preloaded test substrates for testing lal-reactive substances, methods of use, and methods of making
CN105026932B (zh) * 2013-03-15 2017-06-13 西门子医疗保健诊断公司 微流控分配设备
US10578615B2 (en) * 2014-04-08 2020-03-03 Vanderbilt University Low resource method and device for detecting analytes
WO2015168280A1 (en) 2014-04-29 2015-11-05 Outset Medical, Inc. Dialysis system and methods
US9700891B2 (en) * 2015-11-13 2017-07-11 International Business Machines Corporation Integrated nanofluidic arrays for high capacity colloid separation
JP7071738B2 (ja) 2016-04-07 2022-05-19 株式会社メタボスクリーン サーモサイクリング検査装置
WO2018035520A1 (en) 2016-08-19 2018-02-22 Outset Medical, Inc. Peritoneal dialysis system and methods
US10702866B2 (en) * 2017-02-15 2020-07-07 International Business Machines Corporation Layered silicon and stacking of microfluidic chips
US10488375B2 (en) * 2017-06-02 2019-11-26 Venica Fluid Sciences Limited System for detecting liquid analytes
US11185830B2 (en) 2017-09-06 2021-11-30 Waters Technologies Corporation Fluid mixer
WO2019083844A1 (en) * 2017-10-23 2019-05-02 Cytochip Inc. DEVICES AND METHOD FOR MEASURING TARGET ANALYTES AND PARTICLES
JP2021512619A (ja) * 2018-02-07 2021-05-20 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア ハイスループットマイクロ流体デバイス
GB201811597D0 (en) 2018-07-16 2018-08-29 Hemogad Tech Ltd Analyser
BR112021003168A2 (pt) 2018-08-23 2021-05-11 Outset Medical, Inc. métodos para preparar um conjunto de tubos e um dialisador, para testar vazamentos, para preparar um conjunto de tubos, para melhorar a durabilidade e operação de uma ou mais bombas de deslocamento e para prover terapia de diálise, sistema de diálise, e, acessório de queima de bomba
CN109158021B (zh) * 2018-10-11 2021-04-13 上海瑞迈企业管理咨询有限公司 一种防止原料渗漏的自动输送料的化工机械
US10967375B2 (en) * 2018-10-23 2021-04-06 International Business Machines Corporation Microfluidic devices with multiple inlets and outlets
JP7449876B2 (ja) 2018-11-16 2024-03-14 イルミナ インコーポレイテッド 流体カートリッジ用積層流体回路
US12390565B2 (en) 2019-04-30 2025-08-19 Outset Medical, Inc. Dialysis systems and methods
CN114207433B (zh) 2019-08-12 2025-01-14 沃特世科技公司 用于色谱系统的混合器
DE102019215692B4 (de) * 2019-10-11 2021-06-17 Gunther Krieg Vorrichtung und Verfahren zur Identifikation von Stoffen in der Fluidzusammensetzung
US11898999B2 (en) 2020-07-07 2024-02-13 Waters Technologies Corporation Mixer for liquid chromatography
CN115812146A (zh) 2020-07-07 2023-03-17 沃特世科技公司 用于流体色谱法降噪的组合式混合器装置
EP4206118A4 (de) * 2020-08-25 2024-08-14 FUJIFILM Corporation Mikrokanalvorrichtung, verfahren zur herstellung von öltröpfchen, verfahren zur herstellung von mikrokapseln
CN116194767A (zh) 2020-09-22 2023-05-30 沃特世科技公司 连续流混合器
WO2022245566A1 (en) 2021-05-20 2022-11-24 Waters Technologies Corporation Equal dispersion split-flow mixer
WO2023196418A1 (en) * 2022-04-06 2023-10-12 AtlasXomics Inc. Microfluidic chip
CN120361967B (zh) * 2025-06-25 2025-09-05 杭州霆科生物科技有限公司 进样装置及微流控系统

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3587615A (en) 1969-10-30 1971-06-28 Bell Telephone Labor Inc Electrically responsive fluid logic device
US3680576A (en) 1970-09-02 1972-08-01 Bendix Corp Bonded metal structure having intricate passages formed therein, and a method of making said structures
JPS6466556A (en) 1987-09-08 1989-03-13 Fuji Photo Film Co Ltd Manufacture of chemical analysis slide
EP0484278B1 (de) 1990-11-01 1995-04-12 Ciba-Geigy Ag Vorrichtung zur Aufbereitung oder Vorbereitung von flüssigen Proben für eine chemische Analyse
US5744366A (en) 1992-05-01 1998-04-28 Trustees Of The University Of Pennsylvania Mesoscale devices and methods for analysis of motile cells
US5534328A (en) 1993-12-02 1996-07-09 E. I. Du Pont De Nemours And Company Integrated chemical processing apparatus and processes for the preparation thereof
AU6409794A (en) 1993-03-19 1994-10-11 E.I. Du Pont De Nemours And Company Integrated chemical processing apparatus and processes for the preparation thereof
US5727618A (en) 1993-08-23 1998-03-17 Sdl Inc Modular microchannel heat exchanger
US6129973A (en) 1994-07-29 2000-10-10 Battelle Memorial Institute Microchannel laminated mass exchanger and method of making
AU705351B2 (en) 1994-11-10 1999-05-20 Orchid Biosciences, Inc. Liquid distribution system
US5863502A (en) 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
US6033544A (en) 1996-10-11 2000-03-07 Sarnoff Corporation Liquid distribution system
US5885470A (en) 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
US6221654B1 (en) 1996-09-25 2001-04-24 California Institute Of Technology Method and apparatus for analysis and sorting of polynucleotides based on size
US6123316A (en) 1996-11-27 2000-09-26 Xerox Corporation Conduit system for a valve array
US6391622B1 (en) 1997-04-04 2002-05-21 Caliper Technologies Corp. Closed-loop biochemical analyzers
US5869004A (en) 1997-06-09 1999-02-09 Caliper Technologies Corp. Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems
US6293012B1 (en) 1997-07-21 2001-09-25 Ysi Incorporated Method of making a fluid flow module
CA2301592A1 (en) 1997-09-19 1999-04-01 David S. Soane Capillary electroflow apparatus and method
WO1999019717A1 (en) 1997-10-15 1999-04-22 Aclara Biosciences, Inc. Laminate microstructure device and method for making same
US6074725A (en) 1997-12-10 2000-06-13 Caliper Technologies Corp. Fabrication of microfluidic circuits by printing techniques
CA2312102C (en) 1997-12-24 2007-09-04 Cepheid Integrated fluid manipulation cartridge
US6167910B1 (en) 1998-01-20 2001-01-02 Caliper Technologies Corp. Multi-layer microfluidic devices
DE69917761T2 (de) 1998-03-23 2005-08-11 Amalgamated Research, Inc. Fraktale struktur zur massstabsregelung und zur verteilung von fluiden
WO1999060397A1 (en) 1998-05-18 1999-11-25 University Of Washington Liquid analysis cartridge
US6494614B1 (en) 1998-07-27 2002-12-17 Battelle Memorial Institute Laminated microchannel devices, mixing units and method of making same
US6103199A (en) 1998-09-15 2000-08-15 Aclara Biosciences, Inc. Capillary electroflow apparatus and method
US6572830B1 (en) 1998-10-09 2003-06-03 Motorola, Inc. Integrated multilayered microfludic devices and methods for making the same
EP1106244A3 (de) 1999-03-03 2001-11-21 Symyx Technologies, Inc. Mikrosysteme zur chemischen Verarbeitung und Steuerung von Prozessbedingungen in solchen Systemen
US7150994B2 (en) 1999-03-03 2006-12-19 Symyx Technologies, Inc. Parallel flow process optimization reactor
US6258263B1 (en) 1999-09-17 2001-07-10 The University Of Cincinnati Liquid chromatograph on a chip
EP1222141A1 (de) * 1999-10-04 2002-07-17 Nanostream, Inc. Aus eingeklemmten schablonen bestehende, modulare, mikrofluidische vorrichtungen
US6537506B1 (en) 2000-02-03 2003-03-25 Cellular Process Chemistry, Inc. Miniaturized reaction apparatus
US6645432B1 (en) 2000-05-25 2003-11-11 President & Fellows Of Harvard College Microfluidic systems including three-dimensionally arrayed channel networks
US7351376B1 (en) 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
US6623860B2 (en) 2000-10-10 2003-09-23 Aclara Biosciences, Inc. Multilevel flow structures
US6418968B1 (en) * 2001-04-20 2002-07-16 Nanostream, Inc. Porous microfluidic valves

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