JP2005510695A - 分配流入口を有するマイクロ流体装置 - Google Patents
分配流入口を有するマイクロ流体装置 Download PDFInfo
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Abstract
Description
ここで使用される「溝」または「チャンバ」という言葉は、広義に解釈される。従って、横または縦の寸法が直径または断面寸法を大きく超えた細長い構造に制限することを意図しない。むしろ、そのような言葉は、いかなる所望の形状または構造でも、液体がそこを通して導かれる空洞または穴を含むことを意味する。そのような流体空洞は、例えば、流体が連続的に通過する貫流小室または、代りに、所定の断続比の流体を、所定の時間比保持するチャンバを含む。「溝」と「チャンバ」は、例えば、バルブ、フィルタおよび同様のまたは均等の構成要素や物質を含む内部構造が詰込まれまたは包含することができる。
特に好ましい実施形態において、本発明によるマイクロ流体装置は、型板層または溝および/またはチャンバを画定したシートを使用して構築する。先に記したように型板層は、好ましくは、事実上平面であり、層内での十分な流体の移動を可能にする層の厚み全体に切り開かれた溝またはチャンバを有する。多様な方法を使用して、そのような型板層の溝またはチャンバを画定することができる。例えば、切り刃に対応するように変更されたコンピュータ制御プロッタを使用して、材料層に多様な形状を切り開くことができる。そのような刃を使用して、型板層から分離して取り除く部分を切り取ること、または、いかなる材料をも取り除くことなく型板層の離れた場所にスリットを形成することもできる。代案として、コンピュータ制御レーザカッタを使用して、材料層の部分を切ることができる。レーザカッタを使用して正確な大きさにした微小構造を生むことができるが、レーザを使用して型板層を切ることは、本質的にいくらかの材料を取り除くことを含む。従来のロータリカッタおよび他の高速自動位置合わせ装置(時にコンバータと呼ばれる)を含む型板層の刻印または型切り技術を含んださらなる方法の例が使用できる。上述の型板層またはシートを彫る方法は、丈夫な装置を可能にし、マイクロ流体装置の製造に使用される従来の表面微細機械加工または従来の材料堆積技術に比べ素早く安価に加工できる。
Claims (9)
- 複数の装置層(11−19,702−709)を含み、
該装置層は少なくとも3つの機能要部(32A−32N,45A−45N,710A−710N)と、
それぞれに複数の溝(38,42,46,56,58,64,66,68,724A−724N)を含む少なくとも3つの分配流入口(22,24,26,722A−722N)であって、それぞれに少なくとも3つの機能要部(32A−32N,45A−45N,710A−710N)に流体伝達する分配流入口(22,24,26,722A−722N)と、
複数の溝交差(72A−72N,740A,740N)と、
前記複数の装置層(11−19,702−709)の間に配置され、前記溝交差(72A−72N,740A,740N)において、前記少なくとも3つの分配流入口(22,24,26,722A−722N)のいかなる溝(38,42,46,56,58,64,66,68,724A−724N)の間の流体伝達をも防止する介在装置層(16,17,705−707)とを画定する多層マイクロ流体装置(10,700)。 - それぞれの分配流入口(22,24,26,722A−722N)は、前記少なくとも3つの機能要部(32A−32N,45A−45N,710A−710N)のそれぞれの機能要部(32A−32N,45A−45N,710A−710N)への流体流路(73A−73N,74A−74N,750A−750N)を画定し、
それぞれの流体流路(73A−73N,74A−74N,750A−750N)は、特有の流体の流れに対する抵抗を有し、
前記流体流路(73A−73N,74A−74N,750A−750N)の抵抗はほぼ等しい請求項1の多層マイクロ流体装置(10,700)。 - それぞれの分配流入口(22,24,26,722A−722N)は、前記少なくとも3つの機能要部(32A−32N,45A−45N,710A−710N)のそれぞれの機能要部(32A−32N,45A−45N,710A−710N)への流体流路(73A−73N,74A−74N,750A−750N)を画定し、
各流体流路(73A−73N,74A−74N,750A−750N)は、特有の流体の流れに対する抵抗を有し、
前記流体流路(73A−73N,74A−74N,750A−750N)の長さはほぼ等しい前記いずれかの請求項の多層マイクロ流体装置(10,700)。 - 前記複数の装置層(11−19,702−709)は、前記少なくとも3つの機能要部(32A−32N,45A−45N,710A−710N)の少なくとも1つの機能要部(32A−32N,45A−45N,710A−710N)にそれぞれ流体伝達する複数の流体流出口(70A−70N,717A−717N)をさらに画定する前記いずれかの請求項の多層マイクロ流体装置(10,700)。
- 前記複数の装置層(11−19,702−709)は、前記少なくとも3つの機能要部(32A−32N,45A−45N,710A−710N)の少なくとも1つの機能要部(32A−32N,45A−45N,710A−710N)にそれぞれ流体伝達する複数の独立した流体流入口(28A−28N,715A−715N)をさらに画定する前記いずれかの請求項の多層マイクロ流体装置(10,700)。
- 前記複数の装置層(11−19,702−709)の少なくとも1つの装置層(11−19,702−709)は型板層である前記いずれかの請求項の多層マイクロ流体装置(10,700)。
- 前記複数の装置層(11−19,702−709)のどの装置層(11−19,702−709)も高分子材料で製造されている前記いずれかの請求項の多層マイクロ流体装置(10,700)。
- 前記複数の装置層(11−19,702−709)のどの装置層(11−19,702−709)も自己接着性テープ材料で製造されている前記いずれかの請求項の多層マイクロ流体装置(10,700)。
- 前記少なくとも3つの機能要部(32A−32N,45A−45N,710A−710N)は、ミキサ(710A−710N)、分離溝(45A−45N)、反応チャンバ(710A−710N)および分析窓(32A−32N)を含む群から選択されたものである前記いずれかの請求項の多層マイクロ流体装置(10,700)。
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US35768302P | 2002-02-13 | 2002-02-13 | |
US10/160,393 US6981522B2 (en) | 2001-06-07 | 2002-05-30 | Microfluidic devices with distributing inputs |
PCT/US2002/017957 WO2003045559A2 (en) | 2001-06-07 | 2002-06-06 | Microfluidic devices with distributing inputs |
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EP (1) | EP1453606B1 (ja) |
JP (1) | JP2005510695A (ja) |
AT (1) | ATE313378T1 (ja) |
AU (1) | AU2002349871B2 (ja) |
CA (1) | CA2445806A1 (ja) |
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JP2009210327A (ja) * | 2008-03-03 | 2009-09-17 | Yokogawa Electric Corp | 化学反応用カートリッジ、混合物生成方法及び化学反応用カートリッジの制御装置 |
US9372133B2 (en) | 2010-06-30 | 2016-06-21 | Metaboscreen Co., Ltd. | Microchemical chip, producing method thereof and method for using the microchemical chip |
KR20180128054A (ko) | 2016-04-07 | 2018-11-30 | 가부시키가이샤 메타보스크린 | 서모 사이클링 검사 장치 및 칩 홀더 |
WO2022044505A1 (ja) * | 2020-08-25 | 2022-03-03 | 富士フイルム株式会社 | マイクロ流路デバイス、油滴の製造方法、気泡の製造方法、マイクロカプセルの製造方法、多重エマルションの製造方法、気泡を内包する液滴の製造方法及びマイクロ流路デバイスの製造方法 |
JPWO2022044505A1 (ja) * | 2020-08-25 | 2022-03-03 | ||
JP7298028B2 (ja) | 2020-08-25 | 2023-06-26 | 富士フイルム株式会社 | マイクロ流路デバイス、油滴の製造方法、気泡の製造方法、マイクロカプセルの製造方法、多重エマルションの製造方法、気泡を内包する液滴の製造方法及びマイクロ流路デバイスの製造方法 |
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US6981522B2 (en) | 2006-01-03 |
AU2002349871A1 (en) | 2003-06-10 |
AU2002349871B2 (en) | 2006-10-19 |
WO2003045559A2 (en) | 2003-06-05 |
EP1453606B1 (en) | 2005-12-21 |
US20020185183A1 (en) | 2002-12-12 |
DE60208235D1 (de) | 2006-01-26 |
WO2003045559A3 (en) | 2003-09-18 |
WO2003045559A8 (en) | 2004-09-02 |
ATE313378T1 (de) | 2006-01-15 |
CA2445806A1 (en) | 2003-06-05 |
EP1453606A2 (en) | 2004-09-08 |
DE60208235T2 (de) | 2006-08-17 |
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