ATE352322T1 - Methode zur verstärkung des ultraschallechos und zur verminderung der abschwächung von mikroverkapselten gasen - Google Patents

Methode zur verstärkung des ultraschallechos und zur verminderung der abschwächung von mikroverkapselten gasen

Info

Publication number
ATE352322T1
ATE352322T1 AT98932957T AT98932957T ATE352322T1 AT E352322 T1 ATE352322 T1 AT E352322T1 AT 98932957 T AT98932957 T AT 98932957T AT 98932957 T AT98932957 T AT 98932957T AT E352322 T1 ATE352322 T1 AT E352322T1
Authority
AT
Austria
Prior art keywords
microparticles
diameter
polymers
imaging
applications
Prior art date
Application number
AT98932957T
Other languages
English (en)
Inventor
Charles C Church
Howard Bernstein
Julie Ann Straub
Henry T Brush
Original Assignee
Acusphere Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acusphere Inc filed Critical Acusphere Inc
Application granted granted Critical
Publication of ATE352322T1 publication Critical patent/ATE352322T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/481—Diagnostic techniques involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Acoustics & Sound (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Drying Of Gases (AREA)
AT98932957T 1997-06-30 1998-06-30 Methode zur verstärkung des ultraschallechos und zur verminderung der abschwächung von mikroverkapselten gasen ATE352322T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/885,933 US6045777A (en) 1997-06-30 1997-06-30 Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases

Publications (1)

Publication Number Publication Date
ATE352322T1 true ATE352322T1 (de) 2007-02-15

Family

ID=25388026

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98932957T ATE352322T1 (de) 1997-06-30 1998-06-30 Methode zur verstärkung des ultraschallechos und zur verminderung der abschwächung von mikroverkapselten gasen

Country Status (22)

Country Link
US (1) US6045777A (de)
EP (1) EP0996470B1 (de)
JP (1) JP2002507214A (de)
KR (1) KR100637022B1 (de)
CN (1) CN1268397C (de)
AT (1) ATE352322T1 (de)
AU (1) AU740728B2 (de)
BR (1) BR9810371A (de)
CA (1) CA2294199C (de)
CY (1) CY1107593T1 (de)
DE (1) DE69836961T2 (de)
DK (1) DK0996470T3 (de)
ES (1) ES2280094T3 (de)
HK (1) HK1029273A1 (de)
IL (1) IL133595A (de)
MY (1) MY122120A (de)
NO (1) NO316614B1 (de)
NZ (1) NZ501830A (de)
PT (1) PT996470E (de)
TW (1) TW360521B (de)
WO (1) WO1999000149A1 (de)
ZA (1) ZA985705B (de)

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DE69838669T2 (de) * 1997-04-30 2008-10-30 Point Biomedical Corp., San Carlos Mikropartikel, geeignet als kontrastmittel im ultraschall und zur wirkstoffgabe in den blutkreislauf
CA2345458A1 (en) * 1998-10-12 2000-04-20 Mallinckrodt Inc. Novel ultrasound contrast agents
AU6636000A (en) 1999-08-13 2001-03-13 Point Biomedical Corporation Hollow microspheres with controlled fragility for medical use
US6645162B2 (en) 2000-12-27 2003-11-11 Insightec - Txsonics Ltd. Systems and methods for ultrasound assisted lipolysis
US6626854B2 (en) 2000-12-27 2003-09-30 Insightec - Txsonics Ltd. Systems and methods for ultrasound assisted lipolysis
AU2002315505B2 (en) 2001-06-29 2008-01-17 Medgraft Microtech, Inc. Biodegradable injectable implants and related methods of manufacture and use
US20030215394A1 (en) * 2002-05-17 2003-11-20 Short Robert E. Microparticles having a matrix interior useful for ultrasound triggered delivery of drugs into the bloodstream
US6919068B2 (en) * 2002-05-17 2005-07-19 Point Biomedical Corporation Method of preparing gas-filled polymer matrix microparticles useful for echographic imaging
US20040185108A1 (en) * 2003-03-18 2004-09-23 Short Robert E. Method of preparing gas-filled polymer matrix microparticles useful for delivering drug
CA2543296A1 (en) 2003-10-31 2005-05-12 Point Biomedical Corporation Reconstitutable microsphere compositions useful as ultrasonic contrast agents
US7699832B2 (en) * 2004-05-27 2010-04-20 Medtronic, Inc. Medical device having a surface including a biologically active agent therein, and methods
WO2005120587A1 (en) * 2004-06-04 2005-12-22 Acusphere, Inc. Ultrasound contrast agent dosage formulation
US8012457B2 (en) * 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
ES2340677T3 (es) * 2004-06-04 2010-06-08 Acusphere, Inc. Formulacion de dosificacion para agente de contraste de ultrasonidos.
EP1714642A1 (de) * 2005-04-18 2006-10-25 Bracco Research S.A. Pharmazeutische Formulierung mit gasgefüllten Mikrokapseln zur ultraschallgesteuerten Freisetzung
EP1913390B1 (de) * 2005-08-11 2012-05-30 PerkinElmer LAS, Inc. Testverfahren unter Verwendung von partikelförmigen Hohlkörpern und diese enthaltende Kits
US7955281B2 (en) * 2006-09-07 2011-06-07 Nivasonix, Llc External ultrasound lipoplasty
US8262591B2 (en) * 2006-09-07 2012-09-11 Nivasonix, Llc External ultrasound lipoplasty
US8697098B2 (en) 2011-02-25 2014-04-15 South Dakota State University Polymer conjugated protein micelles
KR101061224B1 (ko) * 2008-10-08 2011-08-31 포항공과대학교 산학협력단 Ｘ 선을 이용한 유동정보 측정용 캡슐
US9177543B2 (en) 2009-08-26 2015-11-03 Insightec Ltd. Asymmetric ultrasound phased-array transducer for dynamic beam steering to ablate tissues in MRI
EP2489034B1 (de) 2009-10-14 2016-11-30 Insightec Ltd. Mapping von ultraschallköpfen
US8331194B1 (en) * 2010-04-26 2012-12-11 The United States Of America As Represented By The Secretary Of The Navy Underwater acoustic waveguide
US9852727B2 (en) 2010-04-28 2017-12-26 Insightec, Ltd. Multi-segment ultrasound transducers
KR101952599B1 (ko) 2011-02-25 2019-05-22 사우스다코타주립대학 고분자 컨쥬게이트화된 단백질 마이셀
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
JP2011140527A (ja) * 2011-04-20 2011-07-21 Acusphere Inc 超音波造影剤の投薬処方物
US10357450B2 (en) 2012-04-06 2019-07-23 Children's Medical Center Corporation Process for forming microbubbles with high oxygen content and uses thereof
EP2968163A4 (de) * 2013-03-15 2017-01-25 Children's Medical Center Corporation Hohlpartikel zur verkapselung von biologischem gas und verfahren zur verwendung
US10577554B2 (en) 2013-03-15 2020-03-03 Children's Medical Center Corporation Gas-filled stabilized particles and methods of use
WO2015156359A1 (ja) * 2014-04-10 2015-10-15 シャープ株式会社 粘性気泡液およびその製造方法、その製造装置、その保管方法
CN107952085A (zh) * 2016-10-17 2018-04-24 北京凯莱天成医药科技有限公司 一种超声造影剂及其制备方法和用途
WO2018160752A1 (en) 2017-02-28 2018-09-07 Children's Medical Center Corporation Stimuli-responsive particles encapsulating a gas and methods of use

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US5334381A (en) * 1989-12-22 1994-08-02 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5123414A (en) * 1989-12-22 1992-06-23 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
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WO1992021382A1 (en) * 1991-06-03 1992-12-10 Holmes, Michael, John Improvements in or relating to contrast agents
DE4219723A1 (de) * 1992-06-13 1993-12-16 Schering Ag Mikropartikel, Verfahren zu deren Herstellung, sowie die Verwendung dieser in der Diagnostik
GB9221329D0 (en) * 1992-10-10 1992-11-25 Delta Biotechnology Ltd Preparation of further diagnostic agents
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US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents

Also Published As

Publication number Publication date
PT996470E (pt) 2007-03-30
CN1268397C (zh) 2006-08-09
KR100637022B1 (ko) 2006-10-20
ZA985705B (en) 1999-08-04
TW360521B (en) 1999-06-11
CN1261809A (zh) 2000-08-02
NZ501830A (en) 2003-01-31
DE69836961D1 (de) 2007-03-15
HK1029273A1 (en) 2001-03-30
EP0996470A1 (de) 2000-05-03
NO316614B1 (no) 2004-03-08
CA2294199C (en) 2009-01-20
KR20010014300A (ko) 2001-02-26
DE69836961T2 (de) 2007-10-18
US6045777A (en) 2000-04-04
IL133595A (en) 2004-06-01
AU8273198A (en) 1999-01-19
NO996512D0 (no) 1999-12-28
EP0996470B1 (de) 2007-01-24
DK0996470T3 (da) 2007-05-21
MY122120A (en) 2006-03-31
JP2002507214A (ja) 2002-03-05
CA2294199A1 (en) 1999-01-07
BR9810371A (pt) 2000-09-05
WO1999000149A1 (en) 1999-01-07
CY1107593T1 (el) 2013-03-13
AU740728B2 (en) 2001-11-15
ES2280094T3 (es) 2007-09-01
IL133595A0 (en) 2001-04-30
NO996512L (no) 2000-02-29

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