CY1107593T1 - Μεθοδος ενισχυσης της ηχογενεσης και μειωσης της εξασθενησης των μικροεγκλεισμενων αepιων - Google Patents
Μεθοδος ενισχυσης της ηχογενεσης και μειωσης της εξασθενησης των μικροεγκλεισμενων αepιωνInfo
- Publication number
- CY1107593T1 CY1107593T1 CY20071100458T CY071100458T CY1107593T1 CY 1107593 T1 CY1107593 T1 CY 1107593T1 CY 20071100458 T CY20071100458 T CY 20071100458T CY 071100458 T CY071100458 T CY 071100458T CY 1107593 T1 CY1107593 T1 CY 1107593T1
- Authority
- CY
- Cyprus
- Prior art keywords
- microparticles
- diameter
- polymers
- imaging
- applications
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000011859 microparticle Substances 0.000 abstract 3
- 238000003384 imaging method Methods 0.000 abstract 2
- 210000000865 mononuclear phagocyte system Anatomy 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 229920000954 Polyglycolide Polymers 0.000 abstract 1
- 229920001273 Polyhydroxy acid Polymers 0.000 abstract 1
- 229920001963 Synthetic biodegradable polymer Polymers 0.000 abstract 1
- 230000008081 blood perfusion Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000004005 microsphere Substances 0.000 abstract 1
- 229920005615 natural polymer Polymers 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 229920000747 poly(lactic acid) Polymers 0.000 abstract 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 229920001059 synthetic polymer Polymers 0.000 abstract 1
- 238000012285 ultrasound imaging Methods 0.000 abstract 1
- 210000003462 vein Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/48—Diagnostic techniques
- A61B8/481—Diagnostic techniques involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Medical Informatics (AREA)
- Acoustics & Sound (AREA)
- Hematology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Medicinal Preparation (AREA)
- Drying Of Gases (AREA)
- Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
Abstract
Έχει ανακαλυφθεί ότι μικροσωματίδια τα οποία σχηματίζονται από φυσικά ή συνθετικά πολυμερή με πιο παχιά τοιχώματα έχουν ενισχυμένη ηχογένεση σε σύγκριση με μικροσωματίδια που έχουν λεπτότερα τοιχώματα. Η επίδραση του πάχους του τοιχώματος έχει προσδιοριστεί πειραματικά καθώς επίσης έχει εισαχθεί σε ένα τύπο για χρήση στην πρόβλεψη των βέλτιστων συνθηκών. Στην προτιμούμενη πραγματοποίηση, τα πολυμερή είναι συνθετικά βιοφθάρσιμα πολυμερή και το πάχος του τοιχώματος είναι περίπου 100 και 660 nm, αν και πάχη τοιχώματος από περίπου 20nm έως το πολύ 500nm μπορούν να χρησιμοποιούνται. Τα μικροσωματίδια κατασκευάζονται με μια διάμετρο που είναι κατάλληλη για το στοχευόμενο ιστό που πρέπει να απεικονιστεί, για παράδειγμα, με μια διάμετρο από μεταξύ 0.5 και 8 microns για ενδοφλέβια χορήγηση, και μια διάμετρο από μεταξύ 0.5 και 5 mm για στοματική χορήγηση για απεικόνιση του γαστρεντερικού αγωγού ή άλλων αυλών. Προτιμούμενα πολυμερή είναι πολυϋδροξυ οξέα τέτοια όπως polylactide-co-giycolide οξύ, πολυλακτίδια ή πολυγλυκολίδια, πλέον προτιμούμενα συζευγμένα σε πολυαιθυλενογλυκόλες ή άλλα υλικά που παρεμποδίζουν τη λήψη από το δικτυοενδοθηλιακό σύστημα (RES). Τα μικροσφαιρίδια μπορούν να χρησιμοποιούνται σε μια ποικιλία εφαρμογών απεικόνισης υπερήχων περιλαμβανομένων των καρδιολογικών εφαρμογών, εφαρμογών μετάγγισης αίματος καθώς επίσης απεικόνιση περιφερειακών φλεβών.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/885,933 US6045777A (en) | 1997-06-30 | 1997-06-30 | Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases |
EP98932957A EP0996470B1 (en) | 1997-06-30 | 1998-06-30 | Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1107593T1 true CY1107593T1 (el) | 2013-03-13 |
Family
ID=25388026
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20071100458T CY1107593T1 (el) | 1997-06-30 | 2007-04-02 | Μεθοδος ενισχυσης της ηχογενεσης και μειωσης της εξασθενησης των μικροεγκλεισμενων αepιων |
Country Status (22)
Country | Link |
---|---|
US (1) | US6045777A (el) |
EP (1) | EP0996470B1 (el) |
JP (1) | JP2002507214A (el) |
KR (1) | KR100637022B1 (el) |
CN (1) | CN1268397C (el) |
AT (1) | ATE352322T1 (el) |
AU (1) | AU740728B2 (el) |
BR (1) | BR9810371A (el) |
CA (1) | CA2294199C (el) |
CY (1) | CY1107593T1 (el) |
DE (1) | DE69836961T2 (el) |
DK (1) | DK0996470T3 (el) |
ES (1) | ES2280094T3 (el) |
HK (1) | HK1029273A1 (el) |
IL (1) | IL133595A (el) |
MY (1) | MY122120A (el) |
NO (1) | NO316614B1 (el) |
NZ (1) | NZ501830A (el) |
PT (1) | PT996470E (el) |
TW (1) | TW360521B (el) |
WO (1) | WO1999000149A1 (el) |
ZA (1) | ZA985705B (el) |
Families Citing this family (34)
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IT239807Y1 (it) * | 1996-09-11 | 2001-03-13 | Lgl Electronics Spa | Dispositivo perfezionato di separazione delle spire di filato perapparecchi alimentatori di trama |
US6193951B1 (en) * | 1997-04-30 | 2001-02-27 | Point Biomedical Corporation | Microparticles useful as ultrasonic contrast agents |
CA2345458A1 (en) * | 1998-10-12 | 2000-04-20 | Mallinckrodt Inc. | Novel ultrasound contrast agents |
WO2001012069A1 (en) | 1999-08-13 | 2001-02-22 | Point Biomedical Corporation | Hollow microspheres with controlled fragility for medical use |
US6645162B2 (en) | 2000-12-27 | 2003-11-11 | Insightec - Txsonics Ltd. | Systems and methods for ultrasound assisted lipolysis |
US6626854B2 (en) | 2000-12-27 | 2003-09-30 | Insightec - Txsonics Ltd. | Systems and methods for ultrasound assisted lipolysis |
WO2003007782A2 (en) | 2001-06-29 | 2003-01-30 | Medgraft Microtech, Inc. | Biodegradable injectable implants and related methods of manufacture and use |
US6919068B2 (en) * | 2002-05-17 | 2005-07-19 | Point Biomedical Corporation | Method of preparing gas-filled polymer matrix microparticles useful for echographic imaging |
US20030215394A1 (en) * | 2002-05-17 | 2003-11-20 | Short Robert E. | Microparticles having a matrix interior useful for ultrasound triggered delivery of drugs into the bloodstream |
US20040185108A1 (en) * | 2003-03-18 | 2004-09-23 | Short Robert E. | Method of preparing gas-filled polymer matrix microparticles useful for delivering drug |
WO2005041897A2 (en) | 2003-10-31 | 2005-05-12 | Point Biomedical Corporation | Reconstitutable microsphere compositions useful as ultrasonic contrast agents |
DE602005012950D1 (de) * | 2004-05-27 | 2009-04-09 | Medtronic Inc | Medizinprodukt mit einem biologischen wirkstoff |
CA2569134C (en) * | 2004-06-04 | 2010-11-23 | Acusphere, Inc. | Ultrasound contrast agent dosage formulation |
PT1609483E (pt) * | 2004-06-04 | 2010-05-06 | Acusphere Inc | Formulação de dosagem de agente de contraste para ultrasonografia |
US8012457B2 (en) * | 2004-06-04 | 2011-09-06 | Acusphere, Inc. | Ultrasound contrast agent dosage formulation |
EP1714642A1 (en) * | 2005-04-18 | 2006-10-25 | Bracco Research S.A. | Pharmaceutical composition comprising gas-filled microcapsules for ultrasound mediated delivery |
CA2618715C (en) * | 2005-08-11 | 2015-05-19 | Perkinelmer Las, Inc. | Assay particles and methods of use |
US7955281B2 (en) * | 2006-09-07 | 2011-06-07 | Nivasonix, Llc | External ultrasound lipoplasty |
US8262591B2 (en) * | 2006-09-07 | 2012-09-11 | Nivasonix, Llc | External ultrasound lipoplasty |
US8697098B2 (en) | 2011-02-25 | 2014-04-15 | South Dakota State University | Polymer conjugated protein micelles |
KR101061224B1 (ko) * | 2008-10-08 | 2011-08-31 | 포항공과대학교 산학협력단 | X 선을 이용한 유동정보 측정용 캡슐 |
WO2011024074A2 (en) | 2009-08-26 | 2011-03-03 | Insightec Ltd. | Asymmetric phased-array ultrasound transducer |
US8661873B2 (en) | 2009-10-14 | 2014-03-04 | Insightec Ltd. | Mapping ultrasound transducers |
US8331194B1 (en) * | 2010-04-26 | 2012-12-11 | The United States Of America As Represented By The Secretary Of The Navy | Underwater acoustic waveguide |
US9852727B2 (en) | 2010-04-28 | 2017-12-26 | Insightec, Ltd. | Multi-segment ultrasound transducers |
KR101952599B1 (ko) | 2011-02-25 | 2019-05-22 | 사우스다코타주립대학 | 고분자 컨쥬게이트화된 단백질 마이셀 |
WO2012136813A2 (en) | 2011-04-07 | 2012-10-11 | Universitetet I Oslo | Agents for medical radar diagnosis |
JP2011140527A (ja) * | 2011-04-20 | 2011-07-21 | Acusphere Inc | 超音波造影剤の投薬処方物 |
US10357450B2 (en) | 2012-04-06 | 2019-07-23 | Children's Medical Center Corporation | Process for forming microbubbles with high oxygen content and uses thereof |
WO2014144364A1 (en) | 2013-03-15 | 2014-09-18 | Children's Medical Center Corporation | Gas-filled stabilized particles and methods of use |
EP2968163A4 (en) * | 2013-03-15 | 2017-01-25 | Children's Medical Center Corporation | Hollow particles encapsulating a biological gas and methods of use |
JP6463342B2 (ja) * | 2014-04-10 | 2019-01-30 | 国立大学法人 岡山大学 | 粘性気泡液の製造装置およびそれを用いた粘性気泡液の製造方法 |
CN107952085A (zh) * | 2016-10-17 | 2018-04-24 | 北京凯莱天成医药科技有限公司 | 一种超声造影剂及其制备方法和用途 |
US11147890B2 (en) | 2017-02-28 | 2021-10-19 | Children's Medical Center Corporation | Stimuli-responsive particles encapsulating a gas and methods of use |
Family Cites Families (16)
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US4276885A (en) * | 1979-05-04 | 1981-07-07 | Rasor Associates, Inc | Ultrasonic image enhancement |
US5334381A (en) * | 1989-12-22 | 1994-08-02 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
US5123414A (en) * | 1989-12-22 | 1992-06-23 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
US5352435A (en) * | 1989-12-22 | 1994-10-04 | Unger Evan C | Ionophore containing liposomes for ultrasound imaging |
AU636481B2 (en) * | 1990-05-18 | 1993-04-29 | Bracco International B.V. | Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography |
GB9107628D0 (en) * | 1991-04-10 | 1991-05-29 | Moonbrook Limited | Preparation of diagnostic agents |
DK0586524T3 (el) * | 1991-06-03 | 1997-05-20 | Nycomed Imaging As | |
DE4219723A1 (de) * | 1992-06-13 | 1993-12-16 | Schering Ag | Mikropartikel, Verfahren zu deren Herstellung, sowie die Verwendung dieser in der Diagnostik |
GB9221329D0 (en) * | 1992-10-10 | 1992-11-25 | Delta Biotechnology Ltd | Preparation of further diagnostic agents |
DK0693924T4 (da) * | 1993-02-22 | 2008-08-04 | Abraxis Bioscience Inc | Fremgangsmåde til (in vivo) levering af biologiske materialer og sammensætninger, der er egnede dertil |
US5565215A (en) * | 1993-07-23 | 1996-10-15 | Massachusettes Institute Of Technology | Biodegradable injectable particles for imaging |
NO940711D0 (no) * | 1994-03-01 | 1994-03-01 | Nycomed Imaging As | Preparation of gas-filled microcapsules and contrasts agents for diagnostic imaging |
US5562893A (en) * | 1994-08-02 | 1996-10-08 | Molecular Biosystems, Inc. | Gas-filled microspheres with fluorine-containing shells |
US6333021B1 (en) * | 1994-11-22 | 2001-12-25 | Bracco Research S.A. | Microcapsules, method of making and their use |
WO1997022409A1 (en) * | 1995-12-21 | 1997-06-26 | Drexel University | Hollow polymer microcapsules and method of producing |
US5611344A (en) * | 1996-03-05 | 1997-03-18 | Acusphere, Inc. | Microencapsulated fluorinated gases for use as imaging agents |
-
1997
- 1997-06-30 US US08/885,933 patent/US6045777A/en not_active Expired - Fee Related
-
1998
- 1998-06-30 PT PT98932957T patent/PT996470E/pt unknown
- 1998-06-30 CN CNB98806720XA patent/CN1268397C/zh not_active Expired - Fee Related
- 1998-06-30 KR KR1019997012433A patent/KR100637022B1/ko not_active IP Right Cessation
- 1998-06-30 JP JP50586099A patent/JP2002507214A/ja active Pending
- 1998-06-30 MY MYPI98002974A patent/MY122120A/en unknown
- 1998-06-30 NZ NZ501830A patent/NZ501830A/xx not_active Application Discontinuation
- 1998-06-30 CA CA002294199A patent/CA2294199C/en not_active Expired - Fee Related
- 1998-06-30 WO PCT/US1998/013514 patent/WO1999000149A1/en active IP Right Grant
- 1998-06-30 BR BR9810371-7A patent/BR9810371A/pt not_active Application Discontinuation
- 1998-06-30 IL IL13359598A patent/IL133595A/en not_active IP Right Cessation
- 1998-06-30 ZA ZA9805705A patent/ZA985705B/xx unknown
- 1998-06-30 DK DK98932957T patent/DK0996470T3/da active
- 1998-06-30 AT AT98932957T patent/ATE352322T1/de not_active IP Right Cessation
- 1998-06-30 AU AU82731/98A patent/AU740728B2/en not_active Ceased
- 1998-06-30 EP EP98932957A patent/EP0996470B1/en not_active Expired - Lifetime
- 1998-06-30 DE DE69836961T patent/DE69836961T2/de not_active Expired - Fee Related
- 1998-06-30 ES ES98932957T patent/ES2280094T3/es not_active Expired - Lifetime
- 1998-07-01 TW TW087110599A patent/TW360521B/zh not_active IP Right Cessation
-
1999
- 1999-12-28 NO NO996512A patent/NO316614B1/no not_active IP Right Cessation
-
2000
- 2000-11-02 HK HK00106986A patent/HK1029273A1/xx not_active IP Right Cessation
-
2007
- 2007-04-02 CY CY20071100458T patent/CY1107593T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
KR20010014300A (ko) | 2001-02-26 |
HK1029273A1 (en) | 2001-03-30 |
AU740728B2 (en) | 2001-11-15 |
PT996470E (pt) | 2007-03-30 |
NO316614B1 (no) | 2004-03-08 |
AU8273198A (en) | 1999-01-19 |
IL133595A0 (en) | 2001-04-30 |
US6045777A (en) | 2000-04-04 |
IL133595A (en) | 2004-06-01 |
NZ501830A (en) | 2003-01-31 |
WO1999000149A1 (en) | 1999-01-07 |
ZA985705B (en) | 1999-08-04 |
KR100637022B1 (ko) | 2006-10-20 |
CA2294199C (en) | 2009-01-20 |
ATE352322T1 (de) | 2007-02-15 |
CN1261809A (zh) | 2000-08-02 |
MY122120A (en) | 2006-03-31 |
CA2294199A1 (en) | 1999-01-07 |
NO996512D0 (no) | 1999-12-28 |
ES2280094T3 (es) | 2007-09-01 |
JP2002507214A (ja) | 2002-03-05 |
EP0996470A1 (en) | 2000-05-03 |
CN1268397C (zh) | 2006-08-09 |
EP0996470B1 (en) | 2007-01-24 |
DE69836961T2 (de) | 2007-10-18 |
DK0996470T3 (da) | 2007-05-21 |
BR9810371A (pt) | 2000-09-05 |
DE69836961D1 (de) | 2007-03-15 |
TW360521B (en) | 1999-06-11 |
NO996512L (no) | 2000-02-29 |
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