ZA985705B - Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases. - Google Patents

Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases.

Info

Publication number
ZA985705B
ZA985705B ZA9805705A ZA985705A ZA985705B ZA 985705 B ZA985705 B ZA 985705B ZA 9805705 A ZA9805705 A ZA 9805705A ZA 985705 A ZA985705 A ZA 985705A ZA 985705 B ZA985705 B ZA 985705B
Authority
ZA
South Africa
Prior art keywords
microparticles
diameter
polymers
imaging
applications
Prior art date
Application number
ZA9805705A
Other languages
English (en)
Inventor
Charles C Church
Howard Bernstein
Julie Ann Straub
Henry T Brush
Original Assignee
Acusphere Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acusphere Inc filed Critical Acusphere Inc
Publication of ZA985705B publication Critical patent/ZA985705B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/481—Diagnostic techniques involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Acoustics & Sound (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicinal Preparation (AREA)
  • Drying Of Gases (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
ZA9805705A 1997-06-30 1998-06-30 Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases. ZA985705B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/885,933 US6045777A (en) 1997-06-30 1997-06-30 Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases

Publications (1)

Publication Number Publication Date
ZA985705B true ZA985705B (en) 1999-08-04

Family

ID=25388026

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9805705A ZA985705B (en) 1997-06-30 1998-06-30 Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases.

Country Status (22)

Country Link
US (1) US6045777A (xx)
EP (1) EP0996470B1 (xx)
JP (1) JP2002507214A (xx)
KR (1) KR100637022B1 (xx)
CN (1) CN1268397C (xx)
AT (1) ATE352322T1 (xx)
AU (1) AU740728B2 (xx)
BR (1) BR9810371A (xx)
CA (1) CA2294199C (xx)
CY (1) CY1107593T1 (xx)
DE (1) DE69836961T2 (xx)
DK (1) DK0996470T3 (xx)
ES (1) ES2280094T3 (xx)
HK (1) HK1029273A1 (xx)
IL (1) IL133595A (xx)
MY (1) MY122120A (xx)
NO (1) NO316614B1 (xx)
NZ (1) NZ501830A (xx)
PT (1) PT996470E (xx)
TW (1) TW360521B (xx)
WO (1) WO1999000149A1 (xx)
ZA (1) ZA985705B (xx)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT239807Y1 (it) * 1996-09-11 2001-03-13 Lgl Electronics Spa Dispositivo perfezionato di separazione delle spire di filato perapparecchi alimentatori di trama
US6193951B1 (en) * 1997-04-30 2001-02-27 Point Biomedical Corporation Microparticles useful as ultrasonic contrast agents
CA2345458A1 (en) * 1998-10-12 2000-04-20 Mallinckrodt Inc. Novel ultrasound contrast agents
WO2001012069A1 (en) 1999-08-13 2001-02-22 Point Biomedical Corporation Hollow microspheres with controlled fragility for medical use
US6645162B2 (en) 2000-12-27 2003-11-11 Insightec - Txsonics Ltd. Systems and methods for ultrasound assisted lipolysis
US6626854B2 (en) 2000-12-27 2003-09-30 Insightec - Txsonics Ltd. Systems and methods for ultrasound assisted lipolysis
WO2003007782A2 (en) 2001-06-29 2003-01-30 Medgraft Microtech, Inc. Biodegradable injectable implants and related methods of manufacture and use
US6919068B2 (en) * 2002-05-17 2005-07-19 Point Biomedical Corporation Method of preparing gas-filled polymer matrix microparticles useful for echographic imaging
US20030215394A1 (en) * 2002-05-17 2003-11-20 Short Robert E. Microparticles having a matrix interior useful for ultrasound triggered delivery of drugs into the bloodstream
US20040185108A1 (en) * 2003-03-18 2004-09-23 Short Robert E. Method of preparing gas-filled polymer matrix microparticles useful for delivering drug
WO2005041897A2 (en) 2003-10-31 2005-05-12 Point Biomedical Corporation Reconstitutable microsphere compositions useful as ultrasonic contrast agents
DE602005012950D1 (de) * 2004-05-27 2009-04-09 Medtronic Inc Medizinprodukt mit einem biologischen wirkstoff
CA2569134C (en) * 2004-06-04 2010-11-23 Acusphere, Inc. Ultrasound contrast agent dosage formulation
PT1609483E (pt) * 2004-06-04 2010-05-06 Acusphere Inc Formulação de dosagem de agente de contraste para ultrasonografia
US8012457B2 (en) * 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
EP1714642A1 (en) * 2005-04-18 2006-10-25 Bracco Research S.A. Pharmaceutical composition comprising gas-filled microcapsules for ultrasound mediated delivery
CA2618715C (en) * 2005-08-11 2015-05-19 Perkinelmer Las, Inc. Assay particles and methods of use
US7955281B2 (en) * 2006-09-07 2011-06-07 Nivasonix, Llc External ultrasound lipoplasty
US8262591B2 (en) * 2006-09-07 2012-09-11 Nivasonix, Llc External ultrasound lipoplasty
US8697098B2 (en) 2011-02-25 2014-04-15 South Dakota State University Polymer conjugated protein micelles
KR101061224B1 (ko) * 2008-10-08 2011-08-31 포항공과대학교 산학협력단 Ｘ 선을 이용한 유동정보 측정용 캡슐
WO2011024074A2 (en) 2009-08-26 2011-03-03 Insightec Ltd. Asymmetric phased-array ultrasound transducer
US8661873B2 (en) 2009-10-14 2014-03-04 Insightec Ltd. Mapping ultrasound transducers
US8331194B1 (en) * 2010-04-26 2012-12-11 The United States Of America As Represented By The Secretary Of The Navy Underwater acoustic waveguide
US9852727B2 (en) 2010-04-28 2017-12-26 Insightec, Ltd. Multi-segment ultrasound transducers
KR101952599B1 (ko) 2011-02-25 2019-05-22 사우스다코타주립대학 고분자 컨쥬게이트화된 단백질 마이셀
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
JP2011140527A (ja) * 2011-04-20 2011-07-21 Acusphere Inc 超音波造影剤の投薬処方物
US10357450B2 (en) 2012-04-06 2019-07-23 Children's Medical Center Corporation Process for forming microbubbles with high oxygen content and uses thereof
WO2014144364A1 (en) 2013-03-15 2014-09-18 Children's Medical Center Corporation Gas-filled stabilized particles and methods of use
EP2968163A4 (en) * 2013-03-15 2017-01-25 Children's Medical Center Corporation Hollow particles encapsulating a biological gas and methods of use
JP6463342B2 (ja) * 2014-04-10 2019-01-30 国立大学法人 岡山大学 粘性気泡液の製造装置およびそれを用いた粘性気泡液の製造方法
CN107952085A (zh) * 2016-10-17 2018-04-24 北京凯莱天成医药科技有限公司 一种超声造影剂及其制备方法和用途
US11147890B2 (en) 2017-02-28 2021-10-19 Children's Medical Center Corporation Stimuli-responsive particles encapsulating a gas and methods of use

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
US5334381A (en) * 1989-12-22 1994-08-02 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5123414A (en) * 1989-12-22 1992-06-23 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5352435A (en) * 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
GB9107628D0 (en) * 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
DK0586524T3 (xx) * 1991-06-03 1997-05-20 Nycomed Imaging As
DE4219723A1 (de) * 1992-06-13 1993-12-16 Schering Ag Mikropartikel, Verfahren zu deren Herstellung, sowie die Verwendung dieser in der Diagnostik
GB9221329D0 (en) * 1992-10-10 1992-11-25 Delta Biotechnology Ltd Preparation of further diagnostic agents
DK0693924T4 (da) * 1993-02-22 2008-08-04 Abraxis Bioscience Inc Fremgangsmåde til (in vivo) levering af biologiske materialer og sammensætninger, der er egnede dertil
US5565215A (en) * 1993-07-23 1996-10-15 Massachusettes Institute Of Technology Biodegradable injectable particles for imaging
NO940711D0 (no) * 1994-03-01 1994-03-01 Nycomed Imaging As Preparation of gas-filled microcapsules and contrasts agents for diagnostic imaging
US5562893A (en) * 1994-08-02 1996-10-08 Molecular Biosystems, Inc. Gas-filled microspheres with fluorine-containing shells
US6333021B1 (en) * 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
WO1997022409A1 (en) * 1995-12-21 1997-06-26 Drexel University Hollow polymer microcapsules and method of producing
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents

Also Published As

Publication number Publication date
KR20010014300A (ko) 2001-02-26
HK1029273A1 (en) 2001-03-30
AU740728B2 (en) 2001-11-15
PT996470E (pt) 2007-03-30
NO316614B1 (no) 2004-03-08
AU8273198A (en) 1999-01-19
IL133595A0 (en) 2001-04-30
US6045777A (en) 2000-04-04
IL133595A (en) 2004-06-01
NZ501830A (en) 2003-01-31
WO1999000149A1 (en) 1999-01-07
KR100637022B1 (ko) 2006-10-20
CA2294199C (en) 2009-01-20
ATE352322T1 (de) 2007-02-15
CN1261809A (zh) 2000-08-02
MY122120A (en) 2006-03-31
CA2294199A1 (en) 1999-01-07
NO996512D0 (no) 1999-12-28
ES2280094T3 (es) 2007-09-01
JP2002507214A (ja) 2002-03-05
EP0996470A1 (en) 2000-05-03
CN1268397C (zh) 2006-08-09
EP0996470B1 (en) 2007-01-24
DE69836961T2 (de) 2007-10-18
DK0996470T3 (da) 2007-05-21
BR9810371A (pt) 2000-09-05
DE69836961D1 (de) 2007-03-15
TW360521B (en) 1999-06-11
CY1107593T1 (el) 2013-03-13
NO996512L (no) 2000-02-29

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