DE69836961D1 - Methode zur verstärkung des ultraschallechos und zur verminderung der abschwächung von mikroverkapselten gasen - Google Patents

Methode zur verstärkung des ultraschallechos und zur verminderung der abschwächung von mikroverkapselten gasen

Info

Publication number
DE69836961D1
DE69836961D1 DE69836961T DE69836961T DE69836961D1 DE 69836961 D1 DE69836961 D1 DE 69836961D1 DE 69836961 T DE69836961 T DE 69836961T DE 69836961 T DE69836961 T DE 69836961T DE 69836961 D1 DE69836961 D1 DE 69836961D1
Authority
DE
Germany
Prior art keywords
microparticles
diameter
polymers
imaging
applications
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69836961T
Other languages
English (en)
Other versions
DE69836961T2 (de
Inventor
C Church
Howard Bernstein
Ann Straub
T Brush
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Acusphere Inc
Original Assignee
Acusphere Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acusphere Inc filed Critical Acusphere Inc
Publication of DE69836961D1 publication Critical patent/DE69836961D1/de
Application granted granted Critical
Publication of DE69836961T2 publication Critical patent/DE69836961T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/481—Diagnostic techniques involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Acoustics & Sound (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Drying Of Gases (AREA)
DE69836961T 1997-06-30 1998-06-30 Methode zur verstärkung des ultraschallechos und zur verminderung der abschwächung von mikroverkapselten gasen Expired - Fee Related DE69836961T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/885,933 US6045777A (en) 1997-06-30 1997-06-30 Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases
US885933 1997-06-30
PCT/US1998/013514 WO1999000149A1 (en) 1997-06-30 1998-06-30 Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases

Publications (2)

Publication Number Publication Date
DE69836961D1 true DE69836961D1 (de) 2007-03-15
DE69836961T2 DE69836961T2 (de) 2007-10-18

Family

ID=25388026

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69836961T Expired - Fee Related DE69836961T2 (de) 1997-06-30 1998-06-30 Methode zur verstärkung des ultraschallechos und zur verminderung der abschwächung von mikroverkapselten gasen

Country Status (22)

Country Link
US (1) US6045777A (de)
EP (1) EP0996470B1 (de)
JP (1) JP2002507214A (de)
KR (1) KR100637022B1 (de)
CN (1) CN1268397C (de)
AT (1) ATE352322T1 (de)
AU (1) AU740728B2 (de)
BR (1) BR9810371A (de)
CA (1) CA2294199C (de)
CY (1) CY1107593T1 (de)
DE (1) DE69836961T2 (de)
DK (1) DK0996470T3 (de)
ES (1) ES2280094T3 (de)
HK (1) HK1029273A1 (de)
IL (1) IL133595A (de)
MY (1) MY122120A (de)
NO (1) NO316614B1 (de)
NZ (1) NZ501830A (de)
PT (1) PT996470E (de)
TW (1) TW360521B (de)
WO (1) WO1999000149A1 (de)
ZA (1) ZA985705B (de)

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IT239807Y1 (it) * 1996-09-11 2001-03-13 Lgl Electronics Spa Dispositivo perfezionato di separazione delle spire di filato perapparecchi alimentatori di trama
DE69838669T2 (de) * 1997-04-30 2008-10-30 Point Biomedical Corp., San Carlos Mikropartikel, geeignet als kontrastmittel im ultraschall und zur wirkstoffgabe in den blutkreislauf
CA2345458A1 (en) * 1998-10-12 2000-04-20 Mallinckrodt Inc. Novel ultrasound contrast agents
EP1202670A4 (de) 1999-08-13 2004-11-10 Point Biomedical Corp Hohle mikrokugeln mit kontrollierter zerbrechlichkeit zur medizinischen verwendung
US6645162B2 (en) 2000-12-27 2003-11-11 Insightec - Txsonics Ltd. Systems and methods for ultrasound assisted lipolysis
US6626854B2 (en) 2000-12-27 2003-09-30 Insightec - Txsonics Ltd. Systems and methods for ultrasound assisted lipolysis
EP1411861B1 (de) 2001-06-29 2012-04-04 Medgraft Microtech, Inc. Biologisch abbaubare injizierbare implantate und verwandte herstellungs- und verwendungsmethoden
US6919068B2 (en) * 2002-05-17 2005-07-19 Point Biomedical Corporation Method of preparing gas-filled polymer matrix microparticles useful for echographic imaging
US20030215394A1 (en) * 2002-05-17 2003-11-20 Short Robert E. Microparticles having a matrix interior useful for ultrasound triggered delivery of drugs into the bloodstream
US20040185108A1 (en) * 2003-03-18 2004-09-23 Short Robert E. Method of preparing gas-filled polymer matrix microparticles useful for delivering drug
JP2007509989A (ja) 2003-10-31 2007-04-19 ポイント バイオメディカル コーポレイション 超音波造影剤として有用な再構成可能なミクロスフィア組成物
WO2005118016A1 (en) * 2004-05-27 2005-12-15 Medtronic, Inc. Medical device comprising a biologically active agent
JP4808214B2 (ja) * 2004-06-04 2011-11-02 アキュスフィア， インコーポレイテッド 超音波造影剤の投薬処方物
PL1609483T3 (pl) * 2004-06-04 2010-08-31 Acusphere Inc Postacie dawkowania ultrasonograficznych środków kontrastowych
US8012457B2 (en) * 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
EP1714642A1 (de) * 2005-04-18 2006-10-25 Bracco Research S.A. Pharmazeutische Formulierung mit gasgefüllten Mikrokapseln zur ultraschallgesteuerten Freisetzung
WO2007022074A2 (en) * 2005-08-11 2007-02-22 Perkinelmer Las, Inc. Assay particles and methods of use
US7955281B2 (en) * 2006-09-07 2011-06-07 Nivasonix, Llc External ultrasound lipoplasty
US8262591B2 (en) * 2006-09-07 2012-09-11 Nivasonix, Llc External ultrasound lipoplasty
US8697098B2 (en) 2011-02-25 2014-04-15 South Dakota State University Polymer conjugated protein micelles
KR101061224B1 (ko) * 2008-10-08 2011-08-31 포항공과대학교 산학협력단 Ｘ 선을 이용한 유동정보 측정용 캡슐
US9177543B2 (en) 2009-08-26 2015-11-03 Insightec Ltd. Asymmetric ultrasound phased-array transducer for dynamic beam steering to ablate tissues in MRI
US8661873B2 (en) 2009-10-14 2014-03-04 Insightec Ltd. Mapping ultrasound transducers
US8331194B1 (en) * 2010-04-26 2012-12-11 The United States Of America As Represented By The Secretary Of The Navy Underwater acoustic waveguide
US9852727B2 (en) 2010-04-28 2017-12-26 Insightec, Ltd. Multi-segment ultrasound transducers
WO2012116272A2 (en) 2011-02-25 2012-08-30 South Dakota State University Polymer conjugated protein micelles
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
JP2011140527A (ja) * 2011-04-20 2011-07-21 Acusphere Inc 超音波造影剤の投薬処方物
WO2013151682A1 (en) 2012-04-06 2013-10-10 Children's Medical Center Corporation Process for forming microbubbles with high oxygen content and uses thereof
US10577554B2 (en) 2013-03-15 2020-03-03 Children's Medical Center Corporation Gas-filled stabilized particles and methods of use
EP2968163A4 (de) * 2013-03-15 2017-01-25 Children's Medical Center Corporation Hohlpartikel zur verkapselung von biologischem gas und verfahren zur verwendung
WO2015156359A1 (ja) * 2014-04-10 2015-10-15 シャープ株式会社 粘性気泡液およびその製造方法、その製造装置、その保管方法
CN107952085A (zh) * 2016-10-17 2018-04-24 北京凯莱天成医药科技有限公司 一种超声造影剂及其制备方法和用途
WO2018160752A1 (en) 2017-02-28 2018-09-07 Children's Medical Center Corporation Stimuli-responsive particles encapsulating a gas and methods of use

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
US5123414A (en) * 1989-12-22 1992-06-23 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5352435A (en) * 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US5334381A (en) * 1989-12-22 1994-08-02 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
GB9107628D0 (en) * 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
US5558857A (en) * 1991-06-03 1996-09-24 Nycomed Imaging As Contrast agents
DE4219723A1 (de) * 1992-06-13 1993-12-16 Schering Ag Mikropartikel, Verfahren zu deren Herstellung, sowie die Verwendung dieser in der Diagnostik
GB9221329D0 (en) * 1992-10-10 1992-11-25 Delta Biotechnology Ltd Preparation of further diagnostic agents
EP0693924B2 (de) * 1993-02-22 2008-04-09 Abraxis BioScience, Inc. Verfahren für die in-vivo-verabreichung von biologischen substanzen und hierfür verwendbare zusammensetzungen
US5565215A (en) * 1993-07-23 1996-10-15 Massachusettes Institute Of Technology Biodegradable injectable particles for imaging
NO940711D0 (no) * 1994-03-01 1994-03-01 Nycomed Imaging As Preparation of gas-filled microcapsules and contrasts agents for diagnostic imaging
US5562893A (en) * 1994-08-02 1996-10-08 Molecular Biosystems, Inc. Gas-filled microspheres with fluorine-containing shells
US6333021B1 (en) * 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
AU1354497A (en) * 1995-12-21 1997-07-14 Drexel University Hollow polymer microcapsules and method of producing
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents

Also Published As

Publication number Publication date
ZA985705B (en) 1999-08-04
AU740728B2 (en) 2001-11-15
IL133595A0 (en) 2001-04-30
CA2294199A1 (en) 1999-01-07
IL133595A (en) 2004-06-01
NO996512L (no) 2000-02-29
CA2294199C (en) 2009-01-20
EP0996470B1 (de) 2007-01-24
BR9810371A (pt) 2000-09-05
DK0996470T3 (da) 2007-05-21
NO316614B1 (no) 2004-03-08
JP2002507214A (ja) 2002-03-05
NO996512D0 (no) 1999-12-28
KR20010014300A (ko) 2001-02-26
AU8273198A (en) 1999-01-19
CN1261809A (zh) 2000-08-02
HK1029273A1 (en) 2001-03-30
PT996470E (pt) 2007-03-30
NZ501830A (en) 2003-01-31
TW360521B (en) 1999-06-11
CN1268397C (zh) 2006-08-09
US6045777A (en) 2000-04-04
KR100637022B1 (ko) 2006-10-20
ATE352322T1 (de) 2007-02-15
ES2280094T3 (es) 2007-09-01
WO1999000149A1 (en) 1999-01-07
EP0996470A1 (de) 2000-05-03
DE69836961T2 (de) 2007-10-18
MY122120A (en) 2006-03-31
CY1107593T1 (el) 2013-03-13

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee