WO1996040277A3 - Spray dried polymeric microparticles containing imaging agents - Google Patents
Spray dried polymeric microparticles containing imaging agents Download PDFInfo
- Publication number
- WO1996040277A3 WO1996040277A3 PCT/US1996/008378 US9608378W WO9640277A3 WO 1996040277 A3 WO1996040277 A3 WO 1996040277A3 US 9608378 W US9608378 W US 9608378W WO 9640277 A3 WO9640277 A3 WO 9640277A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- microparticles
- imaging
- polymer
- spray dried
- microspheres
- Prior art date
Links
- 239000011859 microparticle Substances 0.000 title abstract 7
- 239000012216 imaging agent Substances 0.000 title abstract 4
- 239000007921 spray Substances 0.000 title abstract 2
- 229920000642 polymer Polymers 0.000 abstract 6
- 238000000034 method Methods 0.000 abstract 3
- 238000002059 diagnostic imaging Methods 0.000 abstract 2
- 238000003384 imaging method Methods 0.000 abstract 2
- 239000003446 ligand Substances 0.000 abstract 2
- 239000004005 microsphere Substances 0.000 abstract 2
- 239000000227 bioadhesive Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 238000002594 fluoroscopy Methods 0.000 abstract 1
- 238000010348 incorporation Methods 0.000 abstract 1
- 238000002595 magnetic resonance imaging Methods 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 230000002685 pulmonary effect Effects 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 238000001694 spray drying Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 229920001059 synthetic polymer Polymers 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
- 238000003325 tomography Methods 0.000 abstract 1
- 238000012285 ultrasound imaging Methods 0.000 abstract 1
- 210000003462 vein Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
Landscapes
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Methods are provided for the synthesis of synthetic polymeric delivery systems consisting of microparticles which contain a diagnostic imaging agent using spray drying of dilute synthetic polymer solutions, typically between 0.2 and 20 w/v% polymer. In a preferred embodiment, the imaging agent is a gas, the polymer is biodegradable, the polymer solution is saturated with gas and formed into an emulsion, then spray dried. Microparticles produced by this method typically have an average diameter of between about one to seven microns, and therefore freely pass through the pulmonary capillaries. Additional, or alternative, imaging agents can be incorporated within the microparticles. Larger microparticles can also be manufactured for administration to mucosal membranes or oral administration. Adhesion of these microparticles can be enhanced through the selection of bioadhesive polymers. Targeting can also be achieved by selection of the polymer or incorporation within or coupling to the polymer of ligands which specifically bind to particular tissue types or cell surface molecules. Additionally, ligands may be attached to the microspheres which affect the charge, lipophilicity or hydrophilicity of the particle. The polymeric microparticles are useful in a variety of diagnostic imaging procedures including ultrasound imaging, magnetic resonance imaging, fluoroscopy, X-ray, and computerized tomography. The microspheres may be used in a variety of imaging applications including cardiology applications, as well as for organ and peripheral vein imaging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU63780/96A AU6378096A (en) | 1995-06-07 | 1996-06-03 | Spray dried polymeric microparticles containing imaging agen ts |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48777595A | 1995-06-07 | 1995-06-07 | |
| US487,775 | 1995-06-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1996040277A2 WO1996040277A2 (en) | 1996-12-19 |
| WO1996040277A3 true WO1996040277A3 (en) | 1997-05-01 |
Family
ID=23937074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1996/008378 WO1996040277A2 (en) | 1995-06-07 | 1996-06-03 | Spray dried polymeric microparticles containing imaging agents |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU6378096A (en) |
| WO (1) | WO1996040277A2 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9421166B2 (en) | 2001-12-19 | 2016-08-23 | Novartis Ag | Pulmonary delivery of aminoglycoside |
| US9439862B2 (en) | 2000-05-10 | 2016-09-13 | Novartis Ag | Phospholipid-based powders for drug delivery |
| US9554993B2 (en) | 1997-09-29 | 2017-01-31 | Novartis Ag | Pulmonary delivery particles comprising an active agent |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ331460A (en) * | 1996-03-05 | 1998-12-23 | Acusphere Inc | Microencapsulated fluorinated gases for use as imaging agents |
| EP0963209A2 (en) * | 1996-10-28 | 1999-12-15 | Marsden, John Christopher | Improvements in or relating to diagnostic/therapeutic agents |
| US6261537B1 (en) | 1996-10-28 | 2001-07-17 | Nycomed Imaging As | Diagnostic/therapeutic agents having microbubbles coupled to one or more vectors |
| CN1234742A (en) | 1996-10-28 | 1999-11-10 | 奈科姆成像有限公司 | Improvements in or relating to diagnostic/therapeutic agents and improvement relating to same |
| US6331289B1 (en) | 1996-10-28 | 2001-12-18 | Nycomed Imaging As | Targeted diagnostic/therapeutic agents having more than one different vectors |
| DE19813174A1 (en) * | 1998-03-25 | 1999-05-27 | Schering Ag | Gas-filled microparticles, used for administering biologically active substances |
| WO2004105802A1 (en) * | 2003-05-27 | 2004-12-09 | Philips Intellectual Property & Standards Gmbh | Tracer for medical imaging |
| GB2519738A (en) * | 2013-09-06 | 2015-05-06 | Biocompatibles Uk Ltd | Radiopaque polymers |
| CN104399091B (en) * | 2014-10-31 | 2017-06-13 | 苏州大学 | Ultrasound/magnetic resonance bimodal contrast agent, its preparation method and application |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0458079A2 (en) * | 1990-04-26 | 1991-11-27 | Hoechst Aktiengesellschaft | Ultrasonic contrast agent, its preparation and application as diagnostic or therapeutic |
| EP0458745A1 (en) * | 1990-05-18 | 1991-11-27 | BRACCO International B.V. | Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography |
| WO1992017514A1 (en) * | 1991-04-05 | 1992-10-15 | Unger Evan C | Low density microspheres and their use as contrast agents for computed tomography |
| WO1992018164A1 (en) * | 1991-04-10 | 1992-10-29 | Delta Biotechnology Limited | Preparation of diagnostic agents |
| EP0535387A1 (en) * | 1991-09-03 | 1993-04-07 | Hoechst Aktiengesellschaft | Echographique particle, preparation and application |
| WO1994008627A1 (en) * | 1992-10-10 | 1994-04-28 | Andaris Limited | Preparation of further diagnostic agents |
-
1996
- 1996-06-03 WO PCT/US1996/008378 patent/WO1996040277A2/en active Application Filing
- 1996-06-03 AU AU63780/96A patent/AU6378096A/en not_active Abandoned
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0458079A2 (en) * | 1990-04-26 | 1991-11-27 | Hoechst Aktiengesellschaft | Ultrasonic contrast agent, its preparation and application as diagnostic or therapeutic |
| EP0458745A1 (en) * | 1990-05-18 | 1991-11-27 | BRACCO International B.V. | Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography |
| WO1992017514A1 (en) * | 1991-04-05 | 1992-10-15 | Unger Evan C | Low density microspheres and their use as contrast agents for computed tomography |
| WO1992018164A1 (en) * | 1991-04-10 | 1992-10-29 | Delta Biotechnology Limited | Preparation of diagnostic agents |
| EP0535387A1 (en) * | 1991-09-03 | 1993-04-07 | Hoechst Aktiengesellschaft | Echographique particle, preparation and application |
| WO1994008627A1 (en) * | 1992-10-10 | 1994-04-28 | Andaris Limited | Preparation of further diagnostic agents |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9554993B2 (en) | 1997-09-29 | 2017-01-31 | Novartis Ag | Pulmonary delivery particles comprising an active agent |
| US9439862B2 (en) | 2000-05-10 | 2016-09-13 | Novartis Ag | Phospholipid-based powders for drug delivery |
| US9421166B2 (en) | 2001-12-19 | 2016-08-23 | Novartis Ag | Pulmonary delivery of aminoglycoside |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1996040277A2 (en) | 1996-12-19 |
| AU6378096A (en) | 1996-12-30 |
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