ATE348826T1 - Aminopiperidin chinoline und ihre azaisosteren analoga mit antibakterieller wirkung - Google Patents

Aminopiperidin chinoline und ihre azaisosteren analoga mit antibakterieller wirkung

Info

Publication number
ATE348826T1
ATE348826T1 AT01969509T AT01969509T ATE348826T1 AT E348826 T1 ATE348826 T1 AT E348826T1 AT 01969509 T AT01969509 T AT 01969509T AT 01969509 T AT01969509 T AT 01969509T AT E348826 T1 ATE348826 T1 AT E348826T1
Authority
AT
Austria
Prior art keywords
aminopiperidine
azaisosterene
chinoline
analogues
antibacterial effect
Prior art date
Application number
AT01969509T
Other languages
English (en)
Inventor
David Thomas Davies
Graham Elgin Jones
Andrew P Lightfoot
Roger Edward Markwell
Neil David Pearson
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0018351A external-priority patent/GB0018351D0/en
Priority claimed from GB0101629A external-priority patent/GB0101629D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Application granted granted Critical
Publication of ATE348826T1 publication Critical patent/ATE348826T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT01969509T 2000-07-26 2001-07-25 Aminopiperidin chinoline und ihre azaisosteren analoga mit antibakterieller wirkung ATE348826T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0018351A GB0018351D0 (en) 2000-07-26 2000-07-26 Compounds
GB0101629A GB0101629D0 (en) 2001-01-22 2001-01-22 Compounds

Publications (1)

Publication Number Publication Date
ATE348826T1 true ATE348826T1 (de) 2007-01-15

Family

ID=26244729

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01969509T ATE348826T1 (de) 2000-07-26 2001-07-25 Aminopiperidin chinoline und ihre azaisosteren analoga mit antibakterieller wirkung

Country Status (20)

Country Link
US (2) US6962917B2 (de)
EP (1) EP1305308B1 (de)
JP (2) JP2004504397A (de)
KR (1) KR20030019621A (de)
CN (1) CN1452619A (de)
AT (1) ATE348826T1 (de)
AU (2) AU8974901A (de)
BR (1) BR0112750A (de)
CA (1) CA2417192A1 (de)
CZ (1) CZ2003243A3 (de)
DE (1) DE60125373T2 (de)
ES (1) ES2278778T3 (de)
HK (1) HK1056166A1 (de)
HU (1) HUP0300721A3 (de)
IL (1) IL154107A0 (de)
MX (1) MXPA03000708A (de)
NO (1) NO20030345L (de)
NZ (1) NZ523749A (de)
PL (1) PL366335A1 (de)
WO (1) WO2002008224A1 (de)

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9917408D0 (en) * 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
US7230000B1 (en) 1999-10-27 2007-06-12 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
US7671200B2 (en) 1999-10-27 2010-03-02 Cytokinetics, Inc. Quinazolinone KSP inhibitors
US6803369B1 (en) 2000-07-25 2004-10-12 Smithkline Beecham Corporation Compounds and methods for the treatment of neoplastic disease
EP1320529B1 (de) * 2000-09-21 2006-05-24 Smithkline Beecham Plc Chinolinderivate als antibakterielle mittel
GB0031088D0 (en) * 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
GB0031086D0 (en) * 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
GB0101577D0 (en) * 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
GB0112836D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
GB0112834D0 (en) * 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
FR2827599A1 (fr) * 2001-07-20 2003-01-24 Neuro3D Composes derives de quinoleine et quinoxaline,preparation et utilisations
GB0118238D0 (en) * 2001-07-26 2001-09-19 Smithkline Beecham Plc Medicaments
WO2003064431A2 (en) * 2002-01-29 2003-08-07 Glaxo Group Limited Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them
WO2003064421A1 (en) * 2002-01-29 2003-08-07 Glaxo Group Limited Aminopiperidine derivatives
CA2489367A1 (en) * 2002-06-14 2003-12-24 Cytokinetics, Inc. Compounds, compositions, and methods
AR040336A1 (es) * 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
TW200406413A (en) * 2002-06-26 2004-05-01 Glaxo Group Ltd Compounds
GB0217294D0 (en) * 2002-07-25 2002-09-04 Glaxo Group Ltd Medicaments
DE50312598D1 (de) * 2002-10-10 2010-05-20 Morphochem Ag Komb Chemie Neue verbindungen mit antibakterieller aktivität
JP4654035B2 (ja) 2002-11-05 2011-03-16 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー 抗菌剤
ATE461928T1 (de) * 2002-11-05 2010-04-15 Glaxosmithkline Llc Antibakterielle wirkstoffe
ES2312839T3 (es) * 2002-12-04 2009-03-01 Glaxo Group Limited Quinolinas y sus derivados nitrogenados y su uso como agentes antibacterianos.
AR042486A1 (es) * 2002-12-18 2005-06-22 Glaxo Group Ltd Compuesto de quinolina y naftiridina halosustituido en la posicion 3, procedimiento para preparar el compuesto, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion .
GB0230018D0 (en) * 2002-12-23 2003-01-29 Syngenta Ltd Fungicides
DE10316081A1 (de) 2003-04-08 2004-10-21 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen mit antibakterieller Aktivität
ES2279361T3 (es) 2003-04-16 2007-08-16 F. Hoffmann-La Roche Ag Derivados de (6-(fenoxi)-pirido-3,4-dipirimidin-2-il)-amina como inhibidores de p38 kinasa para el tratamiento de estados inflamatorios tal como artritis reumatoide.
JP2006523638A (ja) 2003-04-16 2006-10-19 エフ．ホフマン−ラ　ロシュ　アーゲー キナゾリン化合物
TWI328009B (en) 2003-05-21 2010-08-01 Glaxo Group Ltd Quinoline derivatives as phosphodiesterase inhibitors
US7348434B2 (en) 2003-08-08 2008-03-25 Antony Bigot 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them
FR2858619B1 (fr) * 2003-08-08 2006-12-22 Aventis Pharma Sa Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent
TW200526626A (en) * 2003-09-13 2005-08-16 Astrazeneca Ab Chemical compounds
CN1914182B (zh) 2004-02-03 2011-09-07 阿斯利康(瑞典)有限公司 喹唑啉衍生物
US7691850B2 (en) * 2004-06-15 2010-04-06 Glaxo Group Limited Antibacterial agents
FR2872164B1 (fr) * 2004-06-29 2006-11-17 Aventis Pharma Sa Derives de quinoleines-4-substituees, leur procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent
JP2008505920A (ja) * 2004-07-08 2008-02-28 グラクソ　グループ　リミテッド 抗菌剤
JP2008507543A (ja) * 2004-07-22 2008-03-13 グラクソ　グループ　リミテッド 抗細菌剤
DE602005024151D1 (de) 2004-08-02 2010-11-25 Glaxo Group Ltd Antibakterielle mittel
US20070161627A1 (en) * 2004-08-09 2007-07-12 Miller William H Antibacterial agents
TW200630337A (en) * 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
EP1846418A4 (de) 2005-01-25 2009-12-23 Glaxo Group Ltd Antibakterielle wirkstoffe
US7709472B2 (en) * 2005-01-25 2010-05-04 Glaxo Group Limited Antibacterial agents
US7511035B2 (en) * 2005-01-25 2009-03-31 Glaxo Group Limited Antibacterial agents
JP2008528598A (ja) 2005-01-25 2008-07-31 グラクソ グループ リミテッド 抗菌剤
WO2006081178A2 (en) 2005-01-25 2006-08-03 Glaxo Group Limited Antibacterial agents
CA2603322C (en) 2005-03-31 2014-12-16 Janssen Pharmaceutica N.V. Bicyclic pyrazole compounds as antibacterial agents
US20090131444A1 (en) * 2005-05-24 2009-05-21 Astrazeneca Ab Aminopiperidine Quinolines and Their Azaisosteric Analogues with Antibacterial Activity
MY150958A (en) 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
EP1981881B1 (de) 2006-01-26 2011-12-07 Actelion Pharmaceuticals Ltd. Tetrahydropyran-antibiotika
MX2008010671A (es) * 2006-02-21 2008-10-01 Amgen Inc Derivados de cinolina como inhibidores de fosfodiesterasa 10.
AU2007221049A1 (en) * 2006-02-28 2007-09-07 Amgen Inc. Cinnoline and quinazoline derivates as phosphodiesterase 10 inhibitors
EP1996574A1 (de) * 2006-03-08 2008-12-03 Amgen Inc. Chinolin- und isochinolinderivate als phosphodiesterase-10-inhibitoren
WO2007110449A1 (en) 2006-03-29 2007-10-04 Euro-Celtique S.A. Benzenesulfonamide compounds and their use
JP2009532504A (ja) 2006-04-06 2009-09-10 グラクソ グループ リミテッド 抗菌薬
US7709483B2 (en) 2006-04-06 2010-05-04 Glaxo Group Limited Pyrrolo-quinoxalinone derivatives as antibacterials
TW200812963A (en) 2006-04-13 2008-03-16 Euro Celtique Sa Benzenesulfonamide compounds and the use thereof
US8791264B2 (en) 2006-04-13 2014-07-29 Purdue Pharma L.P. Benzenesulfonamide compounds and their use as blockers of calcium channels
GB0613208D0 (en) 2006-07-03 2006-08-09 Glaxo Group Ltd Compounds
EP1992628A1 (de) 2007-05-18 2008-11-19 Glaxo Group Limited Derivate und Analoge von N-Ethylquinolonen und N-Ethylazaquinolonen
TW200819457A (en) 2006-08-30 2008-05-01 Actelion Pharmaceuticals Ltd Spiro antibiotic derivatives
WO2008124118A1 (en) * 2007-04-09 2008-10-16 Purdue Pharma L.P. Benzenesulfonyl compounds and the use therof
CL2008001003A1 (es) 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
CL2008001002A1 (es) 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
KR101567096B1 (ko) 2007-04-20 2015-11-06 글락소 그룹 리미티드 항균제로서의 트리시클릭 질소 함유 화합물
WO2009040659A2 (en) 2007-09-28 2009-04-02 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
EP2080761A1 (de) 2008-01-18 2009-07-22 Glaxo Group Limited Verbindungen
EP2276766A1 (de) 2008-04-15 2011-01-26 Actelion Pharmaceuticals Ltd. Tricyclische antibiotika
PT2344495E (pt) 2008-10-07 2015-04-01 Actelion Pharmaceuticals Ltd Compostos antibióticos de oxazolidinona tricíclica
WO2010043714A1 (en) 2008-10-17 2010-04-22 Glaxo Group Limited Tricyclic nitrogen compounds used as antibacterials
ES2561631T3 (es) 2009-01-15 2016-02-29 Glaxo Group Limited Compuestos de naftiridin-2(1H)-ona útiles como agentes antibacterianos
EP2332939A1 (de) 2009-11-26 2011-06-15 Æterna Zentaris GmbH Neuartige Naphthyridinderivate und ihre Verwendung als Kinasehemmer
EP2681200A4 (de) * 2011-03-03 2015-05-27 Zalicus Pharmaceuticals Ltd Benzimidazolhemmer des natriumkanals
TW201326180A (zh) 2011-11-30 2013-07-01 Actelion Pharmaceuticals Ltd ３，７－二取代八氫－２Ｈ－吡啶并［４，３－ｅ］［１，３］□嗪－２－酮抗生素
AR089929A1 (es) 2012-02-10 2014-10-01 Actelion Pharmaceuticals Ltd Proceso para manufacturar un derivado de naftiridina
AR090844A1 (es) 2012-04-27 2014-12-10 Actelion Pharmaceuticals Ltd Proceso para elaborar derivados de naftiridina
US20140148671A1 (en) * 2012-07-05 2014-05-29 Empire Technology Development Llc Compositions and methods for detecting anastomosis leakage
US9643979B2 (en) * 2012-10-10 2017-05-09 Vitas Pharma Research Private Limited Inhibitors of DNA gyrase for the treatment of bacterial infections
EP3139743B1 (de) 2014-05-08 2018-03-14 Bayer CropScience Aktiengesellschaft Pyrazolopyridinsulfonamid als nematizide
JP6580074B2 (ja) 2014-05-23 2019-09-25 アクティブ バイオテック エイビー Ｓ１００阻害薬として有用な新規化合物
EA031589B1 (ru) 2014-08-22 2019-01-31 Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед Трициклические азотсодержащие соединения для лечения инфекции, вызываемой neisseria gonorrhoeae
UY36851A (es) 2015-08-16 2017-03-31 Glaxosmithkline Ip Dev Ltd Compuestos para uso en aplicaciones antibacterianas
JP7100962B2 (ja) * 2017-05-17 2022-07-14 東京応化工業株式会社 硬化性組成物、硬化物、硬化膜、表示パネル、及び硬化物の製造方法
KR20210089656A (ko) 2018-10-05 2021-07-16 버텍스 파마슈티칼스 인코포레이티드 알파-1 항트립신 조절제
EP3927703B1 (de) * 2019-02-19 2023-04-05 Univerza V Ljubljani Antibakterielle substanzen auf basis monocyclischer fragmente, die mit aminopiperidin-naphthyridin-gerüst gekoppelt sind
US11884672B2 (en) 2019-05-14 2024-01-30 Vertex Pharmaceuticals Incorporated Modulators of alpha-1 antitrypsin
AU2020365108A1 (en) 2019-10-18 2022-04-21 Atengen, Inc. 3-phenylsulphonyl-quinoline derivatives as agents for treating pathogenic blood vessels disorders
EP4058425A4 (de) * 2019-11-11 2023-11-22 Southwest Research Institute Rekristallisiertes hi-6-dimethylsulfat
CN115485030A (zh) 2020-03-06 2022-12-16 拜耳公司 咪唑并三嗪通过抑制cdk12作用于癌症
EP4126819A1 (de) * 2020-04-03 2023-02-08 Vertex Pharmaceuticals Incorporated 7alpha-1-antitrypsin-modulatoren zur behandlung von alpha-1-antitrypsin-mangel (aatd) und 7- oder 8-hydroxychinolin-derivate

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1031844A (en) * 1910-11-25 1912-07-09 Waffen Und Munitions Fabriken Deutsche Method of forming ball-holders for ball-cages.
US1450884A (en) * 1920-04-22 1923-04-03 Eszto Joseph Lubricating device for saws
FR772190A (fr) 1934-04-21 1934-10-24 Perfectionnements aux pommes d'arrosage
GB1345872A (en) 1970-09-03 1974-02-06 Wyeth John & Brother Ltd Amino-and acylamino-pyridine and hydropyridine derivatives
GB1537867A (en) 1977-07-04 1979-01-04 Wyeth John & Brother Ltd Process for preparing 4-acylamino-piperidine derivatives
US4925877A (en) 1986-02-25 1990-05-15 Zaidanhojin Biseibutsu Kagaku Kenkyukai Physiologically active erbstatin analogue compounds and compositions
WO1988007035A1 (en) 1987-03-11 1988-09-22 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Hydroxystyrene derivatives
ZA899436B (en) * 1988-12-12 1990-08-29 Ciba Geigy Piperidine derivatives
MY110227A (en) * 1991-08-12 1998-03-31 Ciba Geigy Ag 1-acylpiperindine compounds.
EP0541486A1 (de) 1991-11-07 1993-05-12 Ciba-Geigy Ag Polycyclische Konjugate
PL179417B1 (en) 1993-10-01 2000-09-29 Novartis Ag Pharmacologically active derivatives of pyridine and methods of obtaining them
JPH07179407A (ja) 1993-11-12 1995-07-18 Green Cross Corp:The 新規縮合環系化合物またはその塩、およびその医薬用途
DK0790997T3 (da) 1994-11-14 2000-08-21 Warner Lambert Co 6-Aryl-pyrido[2,3-d]pyrimidiner og napthyridiner til hæmning af protein-tyrosin-kinase-fremkaldt celleproliferation
EP0823429B1 (de) 1995-04-26 2000-07-12 Kyowa Hakko Kogyo Co., Ltd. Derivate des radicicols
US5620997A (en) 1995-05-31 1997-04-15 Warner-Lambert Company Isothiazolones
GB9514265D0 (en) 1995-07-13 1995-09-13 Wellcome Found Hetrocyclic compounds
WO1997017957A1 (en) 1995-11-13 1997-05-22 Smithkline Beecham Corporation Hemoregulatory compounds
US5707990A (en) * 1996-01-30 1998-01-13 Ortho Pharmaceutical Corporation 2-substituted amino and thio alkyl benzoxazine antimicrobial agents
WO1997045119A1 (en) 1996-05-24 1997-12-04 Novartis Ag Use of substance p antagonists for treating social phobia
HRP970371A2 (en) * 1996-07-13 1998-08-31 Kathryn Jane Smith Heterocyclic compounds
CA2318842A1 (en) * 1998-01-26 1999-07-29 Julie Dorothy Warrack Quinoline derivatives as antibacterials
GB9822450D0 (en) 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
GB9822440D0 (en) 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
AU2437900A (en) 1999-01-20 2000-08-07 Smithkline Beecham Plc Piperidinylquinolines as protein tyrosine kinase inhibitors
GB9914486D0 (en) 1999-06-21 1999-08-18 Smithkline Beecham Plc Medicaments
GB9917408D0 (en) * 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
GB9917406D0 (en) * 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
US6403610B1 (en) 1999-09-17 2002-06-11 Aventis Pharma S.A. Quinolylpropylpiperidine derivatives, their preparation and the compositions which comprise them
FR2798656B1 (fr) 1999-09-17 2004-12-17 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent
GB0011838D0 (en) 2000-05-17 2000-07-05 Astrazeneca Ab Chemical compounds
PL364808A1 (en) 2000-07-21 2004-12-13 Ljudmila Petrovna Maljuk Plate for a stand-up meal
EP1320529B1 (de) 2000-09-21 2006-05-24 Smithkline Beecham Plc Chinolinderivate als antibakterielle mittel
FR2816618B1 (fr) 2000-11-15 2002-12-27 Aventis Pharma Sa Derives heterocyclylalcoyl piperidine, leur preparation et les compositions qui les contiennent
US6603005B2 (en) 2000-11-15 2003-08-05 Aventis Pharma S.A. Heterocyclylalkylpiperidine derivatives, their preparation and compositions containing them
GB0031086D0 (en) 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
GB0031088D0 (en) 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
GB0101577D0 (en) 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
US6602884B2 (en) 2001-03-13 2003-08-05 Aventis Pharma S.A. Quinolylpropylpiperidine derivatives, their preparation, and compositions containing them
FR2822154B1 (fr) 2001-03-13 2005-10-21 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent
GB0112836D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments

Also Published As

Publication number Publication date
HUP0300721A3 (en) 2006-02-28
NO20030345D0 (no) 2003-01-23
AU2001289749B2 (en) 2004-06-17
MXPA03000708A (es) 2003-06-04
CN1452619A (zh) 2003-10-29
EP1305308B1 (de) 2006-12-20
JP2010001306A (ja) 2010-01-07
BR0112750A (pt) 2003-09-09
DE60125373D1 (de) 2007-02-01
KR20030019621A (ko) 2003-03-06
CA2417192A1 (en) 2002-01-31
US20040038998A1 (en) 2004-02-26
EP1305308A1 (de) 2003-05-02
NZ523749A (en) 2005-03-24
AU8974901A (en) 2002-02-05
DE60125373T2 (de) 2007-10-18
ES2278778T3 (es) 2007-08-16
US7534793B2 (en) 2009-05-19
US20060014749A1 (en) 2006-01-19
JP2004504397A (ja) 2004-02-12
IL154107A0 (en) 2003-07-31
WO2002008224A1 (en) 2002-01-31
US6962917B2 (en) 2005-11-08
CZ2003243A3 (cs) 2003-09-17
NO20030345L (no) 2003-03-10
HK1056166A1 (zh) 2004-02-06
PL366335A1 (en) 2005-01-24
AU2001289749B9 (en) 2004-08-19
HUP0300721A2 (hu) 2005-08-29

Similar Documents

Publication Publication Date Title
ATE348826T1 (de) Aminopiperidin chinoline und ihre azaisosteren analoga mit antibakterieller wirkung
DE60307860D1 (de) Aminocyclohexenchinoline und ihre azaisosterischen analoga mit antibakterieller wirkung
DE60022523D1 (de) Aminopiperidinderivate als antibakterielles arzneimittel
DE60119939D1 (de) Chinolinderivate als antibakterielle mittel
ATE344799T1 (de) Piperidinderivate als antibakterielle mittel
DE69925150D1 (de) Naphthyridine und ihre azaisosteren analoga als antibakterielle mittel
ATE255104T1 (de) Quinolin-derivate und deren verwendung als antibakterielle wirkstoffe
PE20001112A1 (es) Derivados de quinolina como agentes antibacterianos
GB0031088D0 (en) Medicaments
DE60221969D1 (de) Durch piperidine-enthaltende gruppen substituierte chinoline und deren stickstoff-enthaltende derivate und ihre verwendung als antibakterielle wirkstoffe
ATE342901T1 (de) Bicyclische, stickstoffhaltige heterocyclische derivate zur verwendung als antibakterielle mittel
GB0031086D0 (en) Medicaments
ATE479683T1 (de) Antibakterielle mittel
CY1112560T1 (el) Πνευμονικη μεταφορα των αμινογλυκοσιδων
ATE218581T1 (de) Cyclosporinderivat, dessen herstellung und pharmazeutische zusammensetzung
ATE461928T1 (de) Antibakterielle wirkstoffe
AR034343A1 (es) Combinaciones farmaceuticas
EP1567520A4 (de) Chinoline und stickstoffhaltige derivatedavon und deren verwendung als antibakterielle mittel
DK1052991T3 (da) Topisk anvendelse af loperamid til behandling af mikrobielle infektioner
ECSP993176A (es) Nuevos compuestos y composiciones antibacterianas
AU2002246544A1 (en) Antimicrobial quinolone derivatives and use of the same to treat bacterial infections

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties