ATE337795T1 - Mikrokapseln, verfahren zur herstellung und ihre anwendung - Google Patents

Mikrokapseln, verfahren zur herstellung und ihre anwendung

Info

Publication number
ATE337795T1
ATE337795T1 AT95936064T AT95936064T ATE337795T1 AT E337795 T1 ATE337795 T1 AT E337795T1 AT 95936064 T AT95936064 T AT 95936064T AT 95936064 T AT95936064 T AT 95936064T AT E337795 T1 ATE337795 T1 AT E337795T1
Authority
AT
Austria
Prior art keywords
microcapsules
optionally
biodegradable
spherical
mixtures
Prior art date
Application number
AT95936064T
Other languages
English (en)
Inventor
Michel Schneider
Philippe Bussat
Original Assignee
Bracco Research Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Research Sa filed Critical Bracco Research Sa
Application granted granted Critical
Publication of ATE337795T1 publication Critical patent/ATE337795T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5015Organic compounds, e.g. fats, sugars

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT95936064T 1994-11-22 1995-11-21 Mikrokapseln, verfahren zur herstellung und ihre anwendung ATE337795T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP94810660 1994-11-22

Publications (1)

Publication Number Publication Date
ATE337795T1 true ATE337795T1 (de) 2006-09-15

Family

ID=8218339

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95936064T ATE337795T1 (de) 1994-11-22 1995-11-21 Mikrokapseln, verfahren zur herstellung und ihre anwendung

Country Status (20)

Country Link
US (2) US6333021B1 (de)
EP (1) EP0755270B1 (de)
JP (1) JP4202414B2 (de)
KR (1) KR100416163B1 (de)
CN (1) CN1066964C (de)
AT (1) ATE337795T1 (de)
AU (1) AU709240B2 (de)
CA (1) CA2178602C (de)
CZ (1) CZ291178B6 (de)
DE (1) DE69535203T2 (de)
ES (1) ES2271947T3 (de)
FI (1) FI120081B (de)
HU (1) HU226896B1 (de)
IL (1) IL116081A (de)
MX (1) MX9602697A (de)
NO (1) NO315692B1 (de)
PL (1) PL182989B1 (de)
RU (1) RU2139046C1 (de)
WO (1) WO1996015815A1 (de)
ZA (1) ZA959941B (de)

Families Citing this family (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5820850A (en) * 1995-06-07 1998-10-13 Molecular Biosystems, Inc. Gas-filled amino acid block co-polymer microspheres useful as ultrasound contrast agents
US6582392B1 (en) 1998-05-01 2003-06-24 Ekos Corporation Ultrasound assembly for use with a catheter
US6045777A (en) * 1997-06-30 2000-04-04 Acusphere, Inc. Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases
UA73715C2 (en) * 1997-09-30 2005-09-15 Lilly Co Eli Pharmaceutically acceptable formulation of olanzapine pamoate and its use for treatment
US6423345B2 (en) 1998-04-30 2002-07-23 Acusphere, Inc. Matrices formed of polymer and hydrophobic compounds for use in drug delivery
MXPA01011343A (es) * 1999-05-07 2002-06-04 Pharmasol Gmbh Particulas de lipidos a base de mezclas de lipidos liquidos y solidos asi como procedimiento para su produccion.
US6310014B1 (en) * 1999-10-05 2001-10-30 Phyzz Inc. Personal and household care compositions
US7109167B2 (en) 2000-06-02 2006-09-19 Bracco International B.V. Compounds for targeting endothelial cells, compositions containing the same and methods for their use
EP1387637B1 (de) 2001-04-06 2007-10-31 Bracco Research S.A. Vorrichtung zur Messung lokaler physikalischer Parameter in einem flüssigkeitsgefüllten Hohlraum
AU2002322024B2 (en) * 2001-05-31 2008-05-08 Pacira Pharmaceuticals, Inc. Encapsulation of nanosuspensions in liposomes and microspheres
WO2002098952A1 (en) * 2001-06-01 2002-12-12 Yamanouchi Europe B.V. Lipid-polymer-conjugates compositions
CN1278675C (zh) 2001-07-10 2006-10-11 佳能株式会社 含聚羟基烷醇酸酯的粒状体及其制备方法
JP4850390B2 (ja) * 2001-10-19 2012-01-11 アイデックス ラボラトリーズ インコーポレイテッド 薬理学的に活性な化合物の制御送達のための注射用組成物
US6946137B2 (en) 2001-10-19 2005-09-20 Idexx Laboratories, Inc. Methods for the controlled delivery of pharmacologically active compounds
US6808715B2 (en) * 2001-11-09 2004-10-26 Or-Le-Or Ltd. Wrinkle cream
ATE507816T1 (de) * 2001-11-14 2011-05-15 Durect Corp Injizierbare depotzusammensetzungen und deren verwendung
CA2467239A1 (en) * 2001-11-14 2003-05-22 Alza Corporation Catheter injectable depot compositions and uses thereof
US20070196415A1 (en) * 2002-11-14 2007-08-23 Guohua Chen Depot compositions with multiple drug release rate controls and uses thereof
US7220239B2 (en) 2001-12-03 2007-05-22 Ekos Corporation Catheter with multiple ultrasound radiating members
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US20050100963A1 (en) 2002-03-01 2005-05-12 Dyax Corporation KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
EP1572724A4 (de) 2002-03-01 2007-03-14 Dyax Corp Kdr und vegf/kdr bindungspeptide und ihre verwendung bei der diagnose und therapie
DE60321325D1 (de) * 2002-03-20 2008-07-10 Innovativebio Biz Kowloon Mikrokapseln mit kontrollierter durchlässigkeit die ein nukleinsäureamplifizierungsreaktionsgemisch enthalten und deren benutzung als reaktionsgefäss für parallele reaktionen
US8226629B1 (en) 2002-04-01 2012-07-24 Ekos Corporation Ultrasonic catheter power control
US7607436B2 (en) * 2002-05-06 2009-10-27 The Research Foundation Of State University Of New York Methods, devices and formulations for targeted endobronchial therapy
US7334580B2 (en) * 2002-05-07 2008-02-26 Smaldone Gerald C Methods, devices and formulations for targeted endobronchial therapy
EP2647400A1 (de) 2002-05-07 2013-10-09 The State University of New York at Stony Brook Vorrichtungen für die gezielte Endobronchial-Therapie
US6919068B2 (en) * 2002-05-17 2005-07-19 Point Biomedical Corporation Method of preparing gas-filled polymer matrix microparticles useful for echographic imaging
US20030215394A1 (en) * 2002-05-17 2003-11-20 Short Robert E. Microparticles having a matrix interior useful for ultrasound triggered delivery of drugs into the bloodstream
US20030225448A1 (en) 2002-05-28 2003-12-04 Scimed Life Systems, Inc. Polar radiopaque marker for stent
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
GB2399084B (en) * 2002-07-30 2007-01-31 Univ Liverpool Porous beads and method of production thereof
MXPA05001244A (es) * 2002-07-31 2005-06-08 Alza Corp Composiciones de deposito de polimero multimodal inyectable y usos de las mismas.
ES2319400T3 (es) * 2002-07-31 2009-05-07 Durect Corporation Composiciones deposito inyectables y empleo de las mismas.
CN100381463C (zh) * 2002-09-18 2008-04-16 中国人民解放军免疫学研究所 用于生产治疗用乙型肝炎疫苗或药物的免疫原及其制备方法和用途
CA2512454C (en) * 2003-02-04 2012-10-30 Bracco Research Sa Ultrasound contrast agents and process for the preparation thereof
US20070128117A1 (en) * 2003-02-04 2007-06-07 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
CA2517939C (en) 2003-03-03 2015-11-24 Dyax Corp. Peptides that specifically bind hgf receptor (cmet) and uses thereof
US20040185108A1 (en) * 2003-03-18 2004-09-23 Short Robert E. Method of preparing gas-filled polymer matrix microparticles useful for delivering drug
ITFI20030077A1 (it) * 2003-03-26 2004-09-27 Actis Active Sensors S R L Metodo per l'indagine ecografica tramite mezzi di contrasto
US7439268B2 (en) * 2003-07-18 2008-10-21 Idexx Laboratories Compositions containing prodrugs of florfenicol and methods of use
US20050049210A1 (en) * 2003-08-27 2005-03-03 Idexx Laboratories, Inc. Methods for the controlled delivery of pharmacologically active compounds
WO2005041897A2 (en) 2003-10-31 2005-05-12 Point Biomedical Corporation Reconstitutable microsphere compositions useful as ultrasonic contrast agents
CA2545362C (en) * 2003-12-22 2013-02-12 Bracco Research Sa Assembly of gas-filled microvesicle with active component for contrast imaging
CA2547024C (en) * 2003-12-22 2013-12-17 Bracco Research Sa Gas-filled microvesicle assembly for contrast imaging
GB0401950D0 (en) * 2004-01-28 2004-03-03 Unilever Plc Porous bodies and method of production thereof
US7341569B2 (en) 2004-01-30 2008-03-11 Ekos Corporation Treatment of vascular occlusions using ultrasonic energy and microbubbles
US7431849B1 (en) * 2004-03-05 2008-10-07 Specialty Earth Sciences Llc Encapsulated reactant and process
US10335757B2 (en) * 2004-03-05 2019-07-02 Specialty Earth Sciences Process for making environmental reactant(s)
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
GB2417080B (en) 2004-08-13 2008-05-21 Stichting Tech Wetenschapp Intravascular ultrasound techniques
EP1784228B1 (de) 2004-08-18 2016-10-05 Bracco Suisse SA Gasgefüllte mikrovesikelzusammensetzung für kontrastbilddarstellungen
US7282487B2 (en) * 2004-10-28 2007-10-16 Idexx Laboratories Method for treating bacterial infections in horses or pigs with tilmicosin
US20060142234A1 (en) * 2004-12-23 2006-06-29 Guohua Chen Injectable non-aqueous suspension
ATE511512T1 (de) 2005-01-05 2011-06-15 Lilly Co Eli Olanzapinpamoat-dihydrat
EP1714642A1 (de) * 2005-04-18 2006-10-25 Bracco Research S.A. Pharmazeutische Formulierung mit gasgefüllten Mikrokapseln zur ultraschallgesteuerten Freisetzung
JP4680012B2 (ja) * 2005-09-05 2011-05-11 株式会社松風 半球状中空マイクロカプセル
EP1797919A1 (de) * 2005-12-16 2007-06-20 Bracco Research S.A. Vorrichtung zum Übertragen von Flüssigkeiten für Behälter zur Abgabe von Medikamenten
US20070265560A1 (en) 2006-04-24 2007-11-15 Ekos Corporation Ultrasound Therapy System
JP5154554B2 (ja) * 2006-08-01 2013-02-27 ボストン サイエンティフィック サイムド,インコーポレイテッド 非線形イメージングのためのパルスインバージョンシーケンス
WO2008051889A1 (en) * 2006-10-24 2008-05-02 The Johns Hopkins University Rapid release mini-tablets provide analgesia in laboratory animals
JP2008120780A (ja) * 2006-11-13 2008-05-29 Kazutoyo Kawasaki 胃部検診用造影剤
US20080305175A1 (en) * 2006-11-30 2008-12-11 Agency For Science, Technology And Research Micro-Container
US8293214B2 (en) * 2006-12-19 2012-10-23 Bracco Suisse S.A. Targeting and therapeutic compounds and gas-filled microvesicles comprising said compounds
US10182833B2 (en) 2007-01-08 2019-01-22 Ekos Corporation Power parameters for ultrasonic catheter
JP2008199905A (ja) * 2007-02-16 2008-09-04 Snow Brand Milk Prod Co Ltd 乳酸菌生残性向上剤
FR2917291B1 (fr) * 2007-06-14 2009-09-18 Cooperative Bretonne D Insemin Microcapsules contenant des spermatozoides de mammiferes, dose d'insemination les contenant et un porcede pour leur obtention
WO2009002881A1 (en) 2007-06-22 2008-12-31 Ekos Corporation Method and apparatus for treatment of intracranial hemorrhages
EP2476703A1 (de) 2011-01-14 2012-07-18 Bracco Imaging S.p.A Mit einem Bakterium kreuzreagierende menschliche Antikörper und ein Autoantigen aus atherosklerotischen Plaques
US7550625B2 (en) * 2007-10-19 2009-06-23 Idexx Laboratories Esters of florfenicol
EP2090322A1 (de) 2008-02-18 2009-08-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Verwendung von FSH-Rezeptorliganden zur Diagnose und Behandlung von Krebs
GB0811856D0 (en) * 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
JP5681626B2 (ja) * 2008-07-14 2015-03-11 ポリーペイド リミテッドPolypid Ltd. 徐放性薬剤キャリア組成物
EP2147684A1 (de) 2008-07-22 2010-01-27 Bracco Imaging S.p.A Selektiv gegen Metallproteasen wirkende Diagnosemittel
CA2748995C (en) * 2008-10-07 2018-01-16 Bracco Suisse Sa Targeting construct comprising anti-polymer antibody and liposomes or microvesicles binding to the same
US20110045095A1 (en) * 2008-10-08 2011-02-24 The Regents Of The University Of California Polymer-phospholipid shelled microbubbles
US8394070B2 (en) 2008-12-16 2013-03-12 Bracco Suisse S.A. Device for bolus administration of contrast agent
WO2011007353A1 (en) 2009-07-14 2011-01-20 Polypid Ltd. Sustained-release drug carrier composition
RU2481100C2 (ru) * 2009-10-16 2013-05-10 Лайфкеа Инновейшнз Пвт. Лтд. Новая лекарственная форма для лечения грибковой инфекции
EP2525778B1 (de) 2010-01-19 2018-08-01 Polypid Ltd. Nucleinsäurematrixzusammensetzungen mit verzögerter freisetzung
US8888736B2 (en) 2010-04-30 2014-11-18 H R D Corporation High shear application in medical therapy
JP2013527845A (ja) * 2010-04-30 2013-07-04 エイチ アール ディー コーポレーション ドラッグデリバリーにおける高せん断の利用
RU2567168C2 (ru) * 2010-06-07 2015-11-10 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Суспензии микрокапсул, содержащие высокие уровни сельскохозяйственно-активных ингредиентов
HUE052894T2 (hu) 2010-08-09 2021-05-28 Bracco Suisse Sa Célbajuttató konstrukció gázzal töltött mikrovezikulákhoz
EP2654788B1 (de) 2010-12-24 2018-03-14 Bracco Suisse SA Gasgefüllte mikrovesikel zur verwendung als impfstoff
EP2474327A1 (de) 2011-01-07 2012-07-11 RWTH Aachen Mikrodosierung von Ultraschallkontrastmitteln
WO2012095516A1 (en) 2011-01-14 2012-07-19 Bracco Imaging Spa Human antibodies cross-reacting with a bacterial and a self antigen from atherosclerotic plaques
EP2545908A1 (de) 2011-07-11 2013-01-16 RWTH Aachen Medium für Mikrobläschen oder Mikropartikel und seine Herstellung
WO2013151682A1 (en) 2012-04-06 2013-10-10 Children's Medical Center Corporation Process for forming microbubbles with high oxygen content and uses thereof
RU2502510C1 (ru) * 2012-04-24 2013-12-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования Курская государственная сельскохозяйственная академия имени профессора И.И. Иванова Министерства сельского хозяйства Российской Федерации Способ получения микрокапсул лекарственных препаратов группы цефалоспоринов в конжаковой камеди в четыреххлористом углероде
RU2525158C2 (ru) * 2012-05-18 2014-08-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования Курская государственная сельскохозяйственная академия имени профессора И.И. Иванова Министерства сельского хозяйства Российской Федерации Способ получения микрокапсул лекарственных препаратов группы цефалоспоринов в конжаковой камеди в толуоле
RU2514056C2 (ru) * 2012-08-21 2014-04-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования Курская государственная сельскохозяйственная академия имени профессора И.И. Иванова Министерства сельского хозяйства Российской Федерации Способ инкапсуляции фенбендазола
WO2014143808A1 (en) * 2013-03-15 2014-09-18 Children's Medical Center Corporation Hollow particles encapsulating a biological gas and methods of use
EP2968825A4 (de) 2013-03-15 2016-09-07 Childrens Medical Center Gasgefüllte stabilisierte teilchen und verfahren zur verwendung
WO2014140197A1 (en) 2013-03-15 2014-09-18 Westfaelische Wilhelms-Universitaet Muenster Detection of acute renal allograft rejection
CN103349948B (zh) * 2013-06-21 2015-05-27 江南大学 一种植物甾烷醇微胶囊化方法
BR112015032732B1 (pt) 2013-07-03 2022-05-17 Bracco Suisse S.A. Sistema para tratamento ultrassônico de acidente vascular cerebral
JP6564369B2 (ja) 2013-12-09 2019-08-21 デュレクト コーポレイション 薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法
RU2557950C2 (ru) * 2013-12-17 2015-07-27 Александр Александрович Кролевец Способ получения микрокапсул антиоксидантов
RU2564890C1 (ru) * 2014-05-20 2015-10-10 Александр Александрович Кролевец Способ получения нанокапсул антибиотиков в конжаковой камеди
RU2577298C1 (ru) * 2014-10-01 2016-03-10 Общество с ограниченной ответственностью "МедКонтрастСинтез" (ООО "МедКонтрастСинтез") Гепатотропное магнитно-резонансное средство
RU2596485C1 (ru) * 2015-02-24 2016-09-10 Александр Александрович Кролевец Способ получения нанокапсул креатина в геллановой камеди
RU2591800C1 (ru) * 2015-04-08 2016-07-20 Александр Александрович Кролевец Способ получения нанокапсул экстракта зеленого чая
RU2591802C1 (ru) * 2015-04-27 2016-07-20 Александр Александрович Кролевец Способ получения нанокапсул экстракта зеленого чая
RU2599843C1 (ru) * 2015-05-19 2016-10-20 Александр Александрович Кролевец Способ получения нанокапсул экстракта зеленого чая в пектине
CN107708581B (zh) 2015-06-10 2021-11-19 Ekos公司 超声波导管
CA3007514C (en) 2015-12-09 2024-03-19 Koninklijke Philips N.V. Interleaved beam pattern for sonothrombolysis and other vascular acoustic resonator mediated therapies
WO2017137477A1 (en) 2016-02-09 2017-08-17 Bracco Suisse Sa A recombinant chimeric protein for selectins targeting
US10647045B1 (en) 2016-11-03 2020-05-12 Specialty Earth Sciences, Llc Shaped or sized encapsulated reactant and method of making
US11147890B2 (en) 2017-02-28 2021-10-19 Children's Medical Center Corporation Stimuli-responsive particles encapsulating a gas and methods of use
BR112022013784A2 (pt) 2020-01-13 2022-10-11 Durect Corp Sistemas de distribuição de fármacos de liberação prolongada com impurezas reduzidas e métodos relacionados
WO2023137224A2 (en) * 2022-01-17 2023-07-20 Isp Investments Llc Biodegradable microcapsules with improved storage stability, process for preparing the same and method of use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5542935A (en) * 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
AU636481B2 (en) 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US5215680A (en) 1990-07-10 1993-06-01 Cavitation-Control Technology, Inc. Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles
NZ244147A (en) * 1991-09-03 1994-09-27 Hoechst Ag Echogenic particles which comprise a gas and at least one shaping substance, and their use as diagnostic agents
DE4232755A1 (de) * 1992-09-26 1994-03-31 Schering Ag Mikropartikelpräparationen aus biologisch abbaubaren Mischpolymeren
EP0625069B1 (de) * 1992-10-26 1998-12-30 Schwarz Pharma Ag Verfahren zur herstellung von mikrokapseln
US5498421A (en) * 1993-02-22 1996-03-12 Vivorx Pharmaceuticals, Inc. Composition useful for in vivo delivery of biologics and methods employing same

Also Published As

Publication number Publication date
FI120081B (fi) 2009-06-30
EP0755270B1 (de) 2006-08-30
US6333021B1 (en) 2001-12-25
FI962917A (fi) 1996-07-19
HU9601996D0 (en) 1996-09-30
PL182989B1 (pl) 2002-05-31
DE69535203T2 (de) 2007-07-19
HU226896B1 (en) 2010-01-28
CZ214096A3 (en) 1996-10-16
JP4202414B2 (ja) 2008-12-24
AU709240B2 (en) 1999-08-26
HUT74912A (en) 1997-03-28
JPH09511762A (ja) 1997-11-25
CN1066964C (zh) 2001-06-13
NO962843D0 (no) 1996-07-05
AU3814495A (en) 1996-06-17
DE69535203D1 (de) 2006-10-12
CA2178602A1 (en) 1996-05-30
FI962917A0 (fi) 1996-07-19
PL315585A1 (en) 1996-11-12
CZ291178B6 (cs) 2003-01-15
US6403057B1 (en) 2002-06-11
CN1139386A (zh) 1997-01-01
MX9602697A (es) 1998-06-28
KR100416163B1 (ko) 2004-03-19
ZA959941B (en) 1996-06-10
IL116081A0 (en) 1996-01-31
ES2271947T3 (es) 2007-04-16
WO1996015815A1 (en) 1996-05-30
RU2139046C1 (ru) 1999-10-10
EP0755270A1 (de) 1997-01-29
NO962843L (no) 1996-07-05
CA2178602C (en) 2004-03-30
IL116081A (en) 2003-04-10
NO315692B1 (no) 2003-10-13

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