ATE313630T1 - Verfahren und zusammensetzungen zur synthese von langkettigen, mehrfach ungesättigten fettsäuren - Google Patents

Verfahren und zusammensetzungen zur synthese von langkettigen, mehrfach ungesättigten fettsäuren

Info

Publication number
ATE313630T1
ATE313630T1 AT98915430T AT98915430T ATE313630T1 AT E313630 T1 ATE313630 T1 AT E313630T1 AT 98915430 T AT98915430 T AT 98915430T AT 98915430 T AT98915430 T AT 98915430T AT E313630 T1 ATE313630 T1 AT E313630T1
Authority
AT
Austria
Prior art keywords
acid
desaturase
fatty acids
desaturated
recombinant host
Prior art date
Application number
AT98915430T
Other languages
English (en)
Inventor
Deborah Knutzon
Pradip Mukerji
Yung-Sheng Huang
Jennifer Thurmond
Sunita Chaudhary
Amanda Eun-Yeong Leonard
Original Assignee
Calgene Llc
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25267468&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE313630(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Calgene Llc, Abbott Lab filed Critical Calgene Llc
Application granted granted Critical
Publication of ATE313630T1 publication Critical patent/ATE313630T1/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083—Miscellaneous (1.14.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
    • A23D9/00—Other edible oils or fats, e.g. shortenings or cooking oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/158—Fatty acids; Fats; Products containing oils or fats
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6431—Linoleic acids [18:2[n-6]]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Pediatric Medicine (AREA)
  • Cell Biology (AREA)
  • Animal Husbandry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Fats And Perfumes (AREA)
AT98915430T 1997-04-11 1998-04-10 Verfahren und zusammensetzungen zur synthese von langkettigen, mehrfach ungesättigten fettsäuren ATE313630T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/834,655 US5968809A (en) 1997-04-11 1997-04-11 Methods and compositions for synthesis of long chain poly-unsaturated fatty acids
PCT/US1998/007126 WO1998046763A1 (en) 1997-04-11 1998-04-10 Methods and compositions for synthesis of long chain polyunsaturated fatty acids

Publications (1)

Publication Number Publication Date
ATE313630T1 true ATE313630T1 (de) 2006-01-15

Family

ID=25267468

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98915430T ATE313630T1 (de) 1997-04-11 1998-04-10 Verfahren und zusammensetzungen zur synthese von langkettigen, mehrfach ungesättigten fettsäuren

Country Status (23)

Country Link
US (5) US5968809A (de)
EP (1) EP0975766B1 (de)
JP (1) JP4355368B2 (de)
KR (1) KR20010006257A (de)
CN (1) CN1252099A (de)
AT (1) ATE313630T1 (de)
AU (1) AU726807B2 (de)
BG (1) BG103797A (de)
BR (1) BR9808507A (de)
CA (1) CA2285968A1 (de)
DE (1) DE69832874T2 (de)
DK (1) DK0975766T3 (de)
ES (1) ES2258816T3 (de)
HU (1) HUP0001236A1 (de)
IL (1) IL132150A0 (de)
MX (1) MX212281B (de)
NO (1) NO994925L (de)
NZ (1) NZ337457A (de)
PL (1) PL336143A1 (de)
PT (1) PT975766E (de)
SK (1) SK139899A3 (de)
TR (1) TR199902465T2 (de)
WO (1) WO1998046763A1 (de)

Families Citing this family (133)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6483008B1 (en) * 1990-08-15 2002-11-19 Calgene Llc Methods for producing plants with elevated oleic acid content
US7745694B1 (en) 1997-04-11 2010-06-29 Monsanto Technology Llc Methods and compositions for synthesis of long chain polyunsaturated fatty acids in plants
US6432684B1 (en) * 1997-04-11 2002-08-13 Abbott Laboratories Human desaturase gene and uses thereof
US5968809A (en) 1997-04-11 1999-10-19 Abbot Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids
GB9724783D0 (en) * 1997-11-24 1998-01-21 Inst Arable Crops Research Novel polypeptides
CA2329159A1 (en) * 1998-05-29 1999-12-02 Bruce Kelder Compositions and methods for the synthesis of fatty acids, their derivatives and downstream products
US6459018B1 (en) * 1998-06-12 2002-10-01 Monsanto Technology Llc Polyunsaturated fatty acids in plants
EP1035207A1 (de) * 1999-03-09 2000-09-13 MultiGene Biotech GmbH cDNA Moleküle der Mitglieder der Genfamilie, die für menschliche Fettsäuredesaturasen kodieren, und deren Verwendung in Diagnostik und Therapie
US20080206841A1 (en) * 1999-04-06 2008-08-28 Lalgudi Raghunath V Nucleic acid sequences from Chlorella vulgaris and uses thereof
CN1369012A (zh) * 1999-06-07 2002-09-11 巴斯夫植物科学股份有限公司 角齿藓△6－乙炔酶和△6－脱饱和酶
DE10030976A1 (de) 2000-06-30 2002-01-10 Basf Ag DELTA6-Desaturasegene exprimierende Pflanzen und PUFAS enthaltende Öle aus diesen Pflanzen und ein Verfahren zur Herstellung ungesättigter Fettsäuren
WO2001004636A1 (en) * 1999-07-12 2001-01-18 Ohio University Mammalian cells expressing desaturases and elongases
EP1254238B1 (de) 2000-02-09 2009-09-16 Basf Se Neues elongasegen und verfahren zur herstellung mehrfach ungesättigter fettsäuren
DE60141760D1 (de) 2000-09-28 2010-05-20 Bioriginal Food & Science Corp Fad4, fad5, fad5-2, and fad6, mitglieder der fettsäuredesaturasefamilie und ihre verwendungen
DE60227498D1 (de) * 2001-03-23 2008-08-21 Advanced Bionutrition Corp Abgabe von mitteln zur krankheitskontrolle in aquakultur unter verwendung von bioaktive proteine enthaltender hefe
TWI377253B (en) * 2001-04-16 2012-11-21 Martek Biosciences Corp Product and process for transformation of thraustochytriales microorganisms
WO2002092540A1 (en) * 2001-05-14 2002-11-21 Martek Biosciences Corporation Production and use of a polar lipid-rich fraction containing omega-3 and/or omega-6 highly unsatruated fatty acids from microbes, genetically modified plant seeds and marine organisms
EP1392278A4 (de) * 2001-05-14 2005-05-04 Martek Biosciences Corp Herstellung und verwendung einer polaren lipidreichen fraktion mit stearidonsäure und gamma-linolensäure aus pflanzensamen und mikroben
US7211656B2 (en) * 2002-01-30 2007-05-01 Abbott Laboratories Desaturase genes, enzymes encoded thereby, and uses thereof
US7179647B2 (en) 2002-01-30 2007-02-20 Basf Plant Science Gmbh Elongase gene and method for producing polyunsaturated fatty acids
GB2385852A (en) 2002-02-27 2003-09-03 Rothamsted Ex Station Delta 6-desaturases from Primulaceae
DE10219203A1 (de) 2002-04-29 2003-11-13 Basf Plant Science Gmbh Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in Pflanzen
CA2486559C (en) * 2002-05-22 2015-07-21 Monsanto Technology Llc Fatty acid desaturases from fungi
DE10232621A1 (de) * 2002-07-14 2004-02-12 Stiftung Alfred-Wegener-Institut Für Polar- Und Meeresforschung Für ein Enzym Delta-12-Desaturase kodierende Nukleinsäuresequenz, zugehöriges Polypeptid und Verwendung von beiden
FR2844142B1 (fr) 2002-09-11 2007-08-17 Bayer Cropscience Sa Plantes transformees a biosynthese de prenylquinones amelioree
US7244874B2 (en) * 2002-09-17 2007-07-17 The Regents Of The University Of California Stearoyl CoA desaturase transgenic non-human animals
US8841344B2 (en) * 2002-10-03 2014-09-23 Hill's Pet Nutrition, Inc. Method of using omega-3 fatty acids
US20040209953A1 (en) * 2002-12-06 2004-10-21 Wai Lee Theresa Siu-Ling Glyceride compositions and methods of making and using same
FR2848570B1 (fr) 2002-12-12 2005-04-01 Bayer Cropscience Sa Cassette d'expression codant pour une 5-enol pyruvylshikimate-3-phosphate synthase (epsps) et plantes tolerantes aux herbicides la contenant
GB0229578D0 (en) * 2002-12-19 2003-01-22 Univ Bristol Novel method for the production of polyunsaturated fatty acids
MXPA05005777A (es) 2002-12-19 2006-03-08 Univ Bristol Metodo novedoso para produccion de acidos grasos poliinsaturados.
MXPA05008216A (es) * 2003-01-31 2005-10-05 Procter & Gamble Medios para mejorar la apariencia del tejido queratinoso mamifero.
US20050123500A1 (en) * 2003-01-31 2005-06-09 The Procter & Gamble Company Means for improving the appearance of mammalian hair and nails
US20040172682A1 (en) * 2003-02-12 2004-09-02 Kinney Anthony J. Production of very long chain polyunsaturated fatty acids in oilseed plants
US8084074B2 (en) * 2003-02-12 2011-12-27 E. I. Du Pont De Nemours And Company Production of very long chain polyunsaturated fatty acids in oil seed plants
ATE517984T1 (de) 2003-02-27 2011-08-15 Basf Plant Science Gmbh Verfahren zur herstellung mehrfach ungesättigter fettsäuren
AU2004225838B2 (en) 2003-03-31 2009-11-05 University Of Bristol Novel plant acyltransferases specific for long-chained, multiply unsaturated fatty acids
BRPI0409209A (pt) 2003-04-08 2006-03-28 Basf Plant Science Gmbh seqüência de ácido nucleico isolado, construto de gene, vetor, organismo não-humano transgênico, processo para produzir ácidos graxos poliinsaturados, óleo, lipìdeos ou ácidos graxos ou uma fração dos mesmos, composição de óleo, de lipìdeo ou de ácido graxo, e, uso de óleo, de lipìdeos ou de ácidos graxos ou de composição de óleo, de lipìdeo ou de ácido graxo
US7125672B2 (en) * 2003-05-07 2006-10-24 E. I. Du Pont De Nemours And Company Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts
US7238482B2 (en) 2003-05-07 2007-07-03 E. I. Du Pont De Nemours And Company Production of polyunsaturated fatty acids in oleaginous yeasts
US7214491B2 (en) * 2003-05-07 2007-05-08 E. I. Du Pont De Nemours And Company Δ-12 desaturase gene suitable for altering levels of polyunsaturated fatty acids in oleaginous yeasts
GB0311081D0 (en) * 2003-05-14 2003-06-18 Btg Internat Limted Treatment of neurodegenerative conditions
US11952581B2 (en) 2003-08-01 2024-04-09 Basf Plant Science Gmbh Process for the production of polyunsaturated fatty acids in transgenic organisms
EP2166090B1 (de) 2003-08-01 2015-07-01 BASF Plant Science GmbH Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in transgenen Organismen
ES2304094B2 (es) 2003-08-18 2010-10-14 Btg International Limited Tratamiento de dolencias neurodegenerativas.
PT1656449E (pt) * 2003-08-21 2009-07-27 Monsanto Technology Llc Dessaturases dos ácidos gordos a partir de prímulas
US7504259B2 (en) * 2003-11-12 2009-03-17 E. I. Du Pont De Nemours And Company Δ12 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous yeast
WO2005047480A2 (en) * 2003-11-12 2005-05-26 E.I. Dupont De Nemours And Company Delta-15 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous plants and yeast
DK1710306T3 (da) * 2003-12-17 2011-09-05 Suntory Holdings Ltd Arachidonsyreholdig plante og udnyttelse deraf
CA2558726C (en) 2004-02-27 2017-11-07 Basf Plant Science Gmbh Method for producing unsaturated .omega.-3-fatty acids in transgenic organisms
JP4567047B2 (ja) 2004-02-27 2010-10-20 ビーエーエスエフ プラント サイエンス ゲーエムベーハー トランスジェニック植物における多価不飽和脂肪酸の製造方法
AU2005235081B2 (en) * 2004-04-16 2011-06-16 Monsanto Technology Llc Expression of fatty acid desaturases in corn
CA3023314C (en) 2004-04-22 2019-12-10 Commonwealth Scientific And Industrial Research Organisation Synthesis of long-chain polyunsaturated fatty acids by recombinant cells
DK1756280T3 (en) 2004-04-22 2015-02-02 Commw Scient Ind Res Org SYNTHESIS OF CHAIN, polyunsaturated fatty acids BY RECOMBINANT CELLS
US7364883B2 (en) * 2004-05-07 2008-04-29 Yeastern Biotech Co., Ltd. Process for producing poly-unsaturated fatty acids by oleaginous yeasts
US20050266051A1 (en) * 2004-05-27 2005-12-01 The Procter & Gamble Company Pet food compositions and methods
ES2351973T3 (es) 2004-06-04 2011-02-14 Fluxome Sciences A/S Células metabólicamente modificadas por ingeniería para la producción de ácidos grasos poliinsaturados.
CA2568624C (en) 2004-06-25 2014-03-25 E. I. Du Pont De Nemours And Company Delta-8 desaturase and its use in making polyunsaturated fatty acids
US7465564B2 (en) * 2004-08-10 2008-12-16 E.I. Du Pont De Nemours And Company Production of γ-linolenic acid in oleaginous yeast
US7456270B2 (en) * 2004-09-01 2008-11-25 Abbott Laboratories Δ6-desaturase genes and uses thereof
US7588931B2 (en) 2004-11-04 2009-09-15 E. I. Du Pont De Nemours And Company High arachidonic acid producing strains of Yarrowia lipolytica
US8685679B2 (en) * 2004-11-04 2014-04-01 E I Du Pont De Nemours And Company Acyltransferase regulation to increase the percent of polyunsaturated fatty acids in total lipids and oils of oleaginous organisms
GB0425932D0 (en) * 2004-11-25 2004-12-29 Btg Int Ltd Structured phospholipids
WO2006092449A2 (en) 2005-03-02 2006-09-08 Metanomics Gmbh Process for the production of fine chemicals
GB0504362D0 (en) * 2005-03-02 2005-04-06 Btg Int Ltd Cytokine modulators
GB0504333D0 (en) * 2005-03-02 2005-04-06 Btg Int Ltd Treatment of cytokine dysregulation
US7851199B2 (en) * 2005-03-18 2010-12-14 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
DE102005013779A1 (de) 2005-03-22 2006-09-28 Basf Plant Science Gmbh Verfahren zur Herstellung von mehrfach ungesättigten C20- und C22-Fettsäuren mit mindestens vier Doppelbindungen in transgenen Pflanzen
EP1714564A1 (de) * 2005-04-21 2006-10-25 N.V. Nutricia Verfahren zur Behandlung oder Vorbehandlung von Lungeninsuffiziens
AU2006249983B2 (en) 2005-05-23 2011-03-17 Arcadia Biosciences, Inc. Safflower with elevated gamma-linolenic acid
DE102005038036A1 (de) 2005-08-09 2007-02-15 Basf Plant Science Gmbh Verfahren zur Herstellung von Arachidonsäure und/oder Eicosapentaensäure in transgenen Nutzpflanzen
GB2431158A (en) 2005-10-13 2007-04-18 Rothamsted Res Ltd Process for the production of arachidonic and/or eicosapentaenoic acid
DE102005052551A1 (de) 2005-11-02 2007-05-16 Rothamsted Res Harpenden Verfahren zur Herstellung von y-Linolensäure und/oder Stearidonsäure in transgenen Brassicaceae und Linaceae
KR20080071190A (ko) 2005-11-23 2008-08-01 이 아이 듀폰 디 네모아 앤드 캄파니 델타-９ 일롱가제, 및 다중불포화 지방산 생성에 있어서의이들의 용도
GB0603160D0 (en) 2006-02-16 2006-03-29 Rothamsted Res Ltd Nucleic acid
AR059376A1 (es) 2006-02-21 2008-03-26 Basf Plant Science Gmbh Procedimiento para la produccion de acidos grasos poliinsaturados
WO2007103160A2 (en) * 2006-03-03 2007-09-13 Monsanto Technology Llc Stearidonic acid for improving cardiovascular health
US8629195B2 (en) 2006-04-08 2014-01-14 Bayer Materialscience Ag Production of polyurethane foams
US7943823B2 (en) 2006-04-28 2011-05-17 E.I. Du Pont De Nemours And Company Delta-8 desaturase and its use in making polyunsaturated fatty acids
US7678560B2 (en) * 2006-05-17 2010-03-16 E.I. Du Pont De Nemours And Company Δ 5 desaturase and its use in making polyunsaturated fatty acids
US7695950B2 (en) * 2006-05-17 2010-04-13 E. I. Du Pont De Nemours And Company Δ5 desaturase and its use in making polyunsaturated fatty acids
US20090203780A1 (en) * 2006-06-27 2009-08-13 Luisa Gambelli Use of a Polyunsaturated Fatty Acid Compound
BRPI0714390B1 (pt) * 2006-07-19 2018-05-15 Monsanto Technology Llc Polinucleotídeo, construção de dna, célula hospedeira fúngica ou bacteriana, processo para produção de alimento ou de produto alimentício e composição para alimento ou produto alimentício
EP2061879A2 (de) 2006-08-24 2009-05-27 BASF Plant Science GmbH Isolierung und charakterisierung einer neuen pythium-omega-3-desaturase mit spezifität gegen alle omega-6-fettsäuren mit einer kettenlänge von mehr als 18 kohlenstoffatomen
AU2007291937B2 (en) 2006-08-29 2014-05-15 Commonwealth Scientific And Industrial Research Organisation Synthesis of fatty acids
EP2078092A2 (de) 2006-09-28 2009-07-15 Microbia, Inc. Herstellung von carotenoiden in öliger hefe und pilzen
WO2008040787A2 (de) 2006-10-06 2008-04-10 Basf Plant Science Gmbh Verfahren zur herstellung mehrfach ungesättigter fettsäuren in transgenen organismen
BRPI0716306A2 (pt) * 2006-10-23 2015-06-16 Du Pont "polinucleotídeo isolado, constructo de dna recombinante célula, yarrowia sp transformada, método para transformar uma célula, método para produzir uma planta transformada, método para produzir leveduras, sementes trangênicas, método para produzir ácidos graxos poli-insaturados de cadeia longa em ima célula, óleo ou subprodutos, método para produzir pelo menos um ácido graxo poli-insaturada em uma célula vegetal oleaginosa, plantas oleaginosas, sementes trangênicas, alimentos ou alimentações e plantas da progênie"
US8389808B2 (en) 2007-02-12 2013-03-05 E.I. Du Pont De Nemours And Company Production of arachidonic acid in oilseed plants
CN101765658B (zh) * 2007-04-03 2013-11-20 纳幕尔杜邦公司 复合酶及其在制备多不饱和脂肪酸中的用途
US8188338B2 (en) 2007-04-10 2012-05-29 E. I. Du Pont De Nemours And Company Delta-8 desaturases and their use in making polyunsaturated fatty acids
US7794701B2 (en) 2007-04-16 2010-09-14 E.I. Du Pont De Nemours And Company Δ-9 elongases and their use in making polyunsaturated fatty acids
US8957280B2 (en) 2007-05-03 2015-02-17 E. I. Du Pont De Nemours And Company Delta-5 desaturases and their use in making polyunsaturated fatty acids
CN101939434B (zh) 2007-05-24 2015-03-25 纳幕尔杜邦公司 用于在大豆中提高种子贮藏油脂的生成和改变脂肪酸谱的来自解脂耶氏酵母的dgat基因
AU2008281760B2 (en) 2007-07-31 2014-07-17 Basf Plant Science Gmbh Elongases and methods for producing polyunsaturated fatty acids in transgenic organisms
WO2009046231A1 (en) 2007-10-03 2009-04-09 E. I. Du Pont De Nemours And Company Optimized strains of yarrowia lipolytica for high eicosapentaenoic acid production
WO2009077478A2 (en) 2007-12-14 2009-06-25 Basf Plant Science Gmbh Promoters from brassica napus for seed specific gene expression
CA2723072C (en) 2008-04-30 2017-01-10 Rothamsted Research Ltd. Desaturase and method for the production of polyunsaturated fatty acids in transgenic organisms
PL2288710T3 (pl) 2008-05-23 2014-11-28 Du Pont Geny DGAT z organizmów oleistych dla zwiększonej produkcji lipidów magazynowanych w nasionach i zmienionych profili kwasów tłuszczowych w roślinach oleistych
WO2010000708A2 (en) 2008-07-01 2010-01-07 Basf Plant Science Gmbh Promoters from brassica napus for seed specific gene expression
CN102171345B (zh) * 2008-08-01 2013-09-25 纳幕尔杜邦公司 Δ6去饱和酶及其在制备多不饱和脂肪酸中的用途
WO2010023202A2 (en) 2008-08-26 2010-03-04 Basf Plant Science Gmbh Nucleic acids encoding desaturases and modified plant oil
CA3015426C (en) 2008-11-18 2020-01-14 Commonwealth Scientific And Industrial Research Organisation Recombinant cells comprising exogenous .delta.5 and .delta.6 desaturases, .delta.5 and .delta.6 elongases, and .delta.4 desaturases
ES2653727T3 (es) 2008-12-12 2018-02-08 Basf Plant Science Gmbh Desaturasas y proceso para la producción de ácidos grasos poliinsaturados en organismos transgénicos
US8060617B2 (en) * 2008-12-19 2011-11-15 Cisco Technology, Inc. Reserving network resources during scheduling of meeting event
AR074941A1 (es) 2009-01-07 2011-02-23 Bayer Cropscience Sa Plantas transplastomicas exentas de marcador de seleccion
WO2010114989A1 (en) 2009-04-01 2010-10-07 E. I. Du Pont De Nemours And Company Use of a seed specific promoter to drive odp1 expression in cruciferous oilseed plants to increase oil content while maintaining normal germination
EP2821492A3 (de) 2009-05-13 2015-04-08 BASF Plant Science Company GmbH Acyltransferasen und Verwendungen davon zur Fettsäureherstellung
EP2561050A1 (de) 2010-04-22 2013-02-27 E.I. Du Pont De Nemours And Company Verfahren zur gewinnung von mehrfach ungesättigten säurehaltigen zusammensetzungen aus mikrobieller biomasse
US9388437B2 (en) 2010-06-25 2016-07-12 Basf Plant Science Company Gmbh Acyltransferases and uses thereof in fatty acid production
AU2011293189B2 (en) 2010-08-26 2017-02-16 E. I. Du Pont De Nemours And Company Mutant HPGG motif and HDASH motif delta-5 desaturases and their use in making polyunsaturated fatty acids
CA2821319A1 (en) 2010-12-29 2012-07-05 Abbott Laboratories Nutritional products including monoglycerides and fatty acids
WO2012120375A1 (en) 2011-03-07 2012-09-13 Ocean Nutrition Canada Limited Engineering thraustochytrid microorganisms
US20120247066A1 (en) 2011-04-01 2012-10-04 Ice House America, Llc Ice bagging apparatus and methods
AU2012258820A1 (en) 2011-05-26 2013-10-10 E. I. Du Pont De Nemours And Company Expression of caleosin in recombinant oleaginous microorganisms to increase oil content therein
WO2013082265A1 (en) * 2011-11-29 2013-06-06 Dignity Sciences Limited Compositions comprising 20-carbon fatty acids and methods of making and using same
CA2860220C (en) 2011-12-22 2021-07-13 E. I. Du Pont De Nemours And Company Use of the soybean or medicago truncatula sucrose synthase promoter to increase plant seed oil content
EP2836599B1 (de) 2012-04-12 2019-11-06 Rothamsted Research Limited Herstellung von langkettigen mehrfach ungesättigten omega-3-fettsäuren
NZ631702A (en) 2012-06-15 2017-01-27 Grains Res & Dev Corp Production of long chain polyunsaturated fatty acids in plant cells
GB201217524D0 (en) 2012-10-01 2012-11-14 Rothamsted Res Ltd Recombinant organisms
DK2970926T3 (en) 2013-03-13 2018-04-16 Dsm Nutritional Products Ag GENMANIPULATION OF MICROorganisms
SG10201803827UA (en) * 2013-12-04 2018-06-28 Nippon Suisan Kaisha Ltd Microbial oil, production method for microbial oil, concentrated microbial oil, and production method for concentrated microbial oil
EP3082405A4 (de) 2013-12-18 2017-12-13 Commonwealth Scientific and Industrial Research Organisation Lipid mit langkettigen mehrfach ungesättigten fettsäuren
PH12016502586B1 (en) 2014-06-27 2023-07-19 Commw Scient Ind Res Org Lipid comprising docosapentaenoic acid
CN104328145B (zh) * 2014-10-20 2017-05-17 南京大学 一种用基因工程大肠杆菌生产不饱和脂肪酸的方法
CA2983893A1 (en) * 2015-04-28 2016-11-03 Bayer Cropscience Nv Brassica plants with modified seed oil composition
US11053523B2 (en) * 2016-09-07 2021-07-06 Kao Corporation Method of producing lipid
US20220304358A1 (en) * 2017-02-14 2022-09-29 L-Nutra Inc. Fasting Mimicking Diet
US11197917B2 (en) 2017-12-01 2021-12-14 ByHeart, Inc. Formulations for nutritional support in subjects in need thereof
CN109837290B (zh) * 2019-04-03 2020-12-22 西南大学 ShFAD2基因家族和ShFAD3基因家族在创制高产ALA的转基因植物中的应用
CN110106019A (zh) * 2019-05-20 2019-08-09 无限极（中国）有限公司 一种利用裂壶藻生产复合型多不饱和脂肪酸油脂的方法
US20250066420A1 (en) * 2021-09-27 2025-02-27 Kansas State University Research Foundation Pd-l1 inhibitory peptide for cancer immunotherapy
CN114807091A (zh) * 2022-04-14 2022-07-29 云南师范大学 一种耐热性提高的疏棉状嗜热丝孢菌脂肪酶及应用

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3649295A (en) * 1970-06-01 1972-03-14 American Home Prod Humanized fat compositions and infant formulas thereof
US4058594A (en) * 1974-04-25 1977-11-15 John Williams Immuno-suppressive agents
US4873191A (en) 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
ATE24266T1 (de) * 1982-04-16 1987-01-15 Nestle Sa Lipidhaltige zusammensetzung fuer die orale, enterale oder parenterale ernaehrung.
US4670285A (en) * 1982-08-06 1987-06-02 The University Of Toronto Innovations Foundation Infant formula
GB8317248D0 (en) * 1983-06-24 1983-07-27 Wyeth John & Brother Ltd Fat compositions
US4526902A (en) * 1983-10-24 1985-07-02 Century Laboratories, Inc. Combined fatty acid composition for treatment or prophylaxis of thrombo-embolic conditions
GB8407195D0 (en) 1984-03-20 1984-04-26 Cadbury Schweppes Plc Microbial desaturase enzyme inhibitors
US4792523A (en) 1984-08-31 1988-12-20 Cetus Corporation 3'Expression enhancing fragments and method
NL8403433A (nl) * 1984-11-09 1986-06-02 Holland Melkunie Voedingssuppletiepreparaat op basis van melkbestanddelen.
GB8507058D0 (en) 1985-03-19 1985-04-24 Efamol Ltd Pharmaceutical & dietary compositions
GB2178752B (en) 1985-07-12 1989-10-11 Unilever Plc Substitute milk fat
GB8524275D0 (en) 1985-10-02 1985-11-06 Efamol Ltd Pharmaceutical & dietary compositions
GB8524276D0 (en) 1985-10-02 1985-11-06 Efamol Ltd Pharmaceutical & dietary compositions
US5322775A (en) 1986-06-30 1994-06-21 Pharmaceutical Proteins Ltd. Peptide production
US4920098A (en) * 1986-09-17 1990-04-24 Baxter International Inc. Nutritional support or therapy for individuals at risk or under treatment for atherosclerotic vascular, cardiovascular, and/or thrombotic diseases
US4921877A (en) * 1986-10-27 1990-05-01 Abbott Laboratories Liquid nutritional formula for glucose intolerance
EP0832981A1 (de) 1987-02-17 1998-04-01 Pharming B.V. DNA-Sequenzen die Proteine zwecks effizienter Abscheidung zur Milchdrüse leiten
US5252333A (en) * 1987-04-27 1993-10-12 Scotia Holdings Plc Lithium salt-containing pharmaceutical compositions
DE3719097C1 (de) 1987-06-06 1988-06-09 Fratzer Uwe Arzneimittel,enthaltend Eicosapentaensaeure und Docosahexaensaeure als ungesaettigte Fettsaeuren sowie Vitamin E
US4843095A (en) * 1987-08-07 1989-06-27 Century Laboratories, Inc. Free fatty acids for treatment or propyhlaxis of rheumatoid arthritis arthritis
US5011770A (en) 1987-09-04 1991-04-30 Molecular Devices, Inc. DNA detection method
CA1338683C (en) 1988-09-13 1996-10-29 Efamol Holdings Plc Fatty acid therapy and compositions
US5162215A (en) 1988-09-22 1992-11-10 Amgen Inc. Method of gene transfer into chickens and other avian species
US5057419A (en) 1988-09-22 1991-10-15 Rutgers University Genetically engineered plasmid and organisms for the production of specialized oils
US5196198A (en) 1989-06-02 1993-03-23 Abbott Laboratories Parenteral nutrition product
US5426040A (en) 1989-08-17 1995-06-20 Northeastern University Methods for producing improved strains of seaweed by fusion of spore-protoplasts, and resultant seaweeds and phycocolloids
US5407957A (en) * 1990-02-13 1995-04-18 Martek Corporation Production of docosahexaenoic acid by dinoflagellates
EP0472722B1 (de) 1990-03-16 2003-05-21 Calgene LLC Dnas, die für pflanzliche desaturasen kodieren und deren anwendungen
US5512482A (en) * 1990-04-26 1996-04-30 Calgene, Inc. Plant thioesterases
DK0537178T4 (da) * 1990-05-25 2007-07-16 Du Pont Nukleotidsekvens af sojabönne-stearoyl-ACP-desaturase-gen
US5658767A (en) 1991-01-24 1997-08-19 Martek Corporation Arachidonic acid and methods for the production and use thereof
SG49307A1 (en) * 1991-01-24 1998-05-18 Martek Corp Microbial oil mixtures and use thereof
JP3698369B2 (ja) 1991-08-13 2005-09-21 ウィスコンシン ミルク マーケティング ボード αラクトアルブミンを符号化するＤＮＡ配列及び使用方法
JPH0591886A (ja) * 1991-09-30 1993-04-16 Suntory Ltd ８，１１−エイコサジエン酸及びこれを含有する脂質の製造方法
US6683232B1 (en) 1991-10-10 2004-01-27 Rhone-Poulenc Agrochimie Production of γ linolenic acid by a Δ6-desaturase
US5614393A (en) * 1991-10-10 1997-03-25 Rhone-Poulenc Agrochimie Production of γ-linolenic acid by a Δ6-desaturase
US6355861B1 (en) 1991-10-10 2002-03-12 Rhone-Poulenc Agrochimie Production of gamma linolenic acid by a Δ6-desaturase
PH31293A (en) * 1991-10-10 1998-07-06 Rhone Poulenc Agrochimie Production of y-linolenic acid by a delta6-desaturage.
AU675923B2 (en) 1991-12-04 1997-02-27 E.I. Du Pont De Nemours And Company Fatty acid desaturase genes from plants
CA2084348A1 (en) 1991-12-31 1993-07-01 David F. Hildebrand Fatty acid alteration by a d9 desaturase in transgenic plant tissue
ES2201054T3 (es) * 1992-03-13 2004-03-16 Agrigenetics, Inc. Modificacion de aceites vegetales usando desaturasa.
WO1994005782A1 (en) 1992-09-10 1994-03-17 Trustees Of Tufts College In vivo production of transgenic organ by introducing the transgene via lumen
CA2149223C (en) * 1992-11-17 2007-04-24 Jonathan Edward Lightner Genes for microsomal delta-12 fatty acid desaturases and related enzymes from plants
AU683027B2 (en) * 1993-01-27 1997-10-30 Scotia Holdings Plc Triglycerides
CA2150133A1 (en) * 1993-02-05 1994-08-18 Vincent Jean-Marie Armel Arondel Altered linolenic and linoleic acid content in plants
US5639645A (en) 1993-09-22 1997-06-17 Mitsubishi Corporation Recombinant Δ9 desaturase and a gene encoding the same
DE69433941T2 (de) 1993-12-28 2005-07-28 Kirin Beer K.K. Gen für die fettsäure-desaturase, besagtes gen enthaltender vektor, eine pflanze, in die besagtes gen eingebracht ist, und ein verfahren zur schaffung besagter pflanze
US5639940A (en) 1994-03-03 1997-06-17 Pharmaceutical Proteins Ltd. Production of fibrinogen in transgenic animals
WO1995024488A1 (en) 1994-03-09 1995-09-14 Abbott Laboratories Transgenic animals producing oligosaccharides and glycoconjugates
AU694181B2 (en) 1994-03-09 1998-07-16 Abbott Laboratories Humanized milk
EP0779359B1 (de) 1994-08-24 2002-02-13 Meiji Milk Products Company Limited Verfahren zur kultivierung von vogelzellen
US6310194B1 (en) * 1994-09-26 2001-10-30 Carnegie Institution Of Washington Plant fatty acid hydroxylases
US5545553A (en) * 1994-09-26 1996-08-13 The Rockefeller University Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them
FR2726003B1 (fr) 1994-10-21 2002-10-18 Agronomique Inst Nat Rech Milieu de culture de cellules embryonnaires totipotentes aviaires, procede de culture de ces cellules, et cellules embryonnaires totipotentes aviaires
US5654402A (en) 1994-10-26 1997-08-05 Michigan State University Methods and compositions relating to plant Δ6 palmitoyl-acyl carrier protein desaturase
GB9508023D0 (en) 1995-04-20 1995-06-07 Scotia Holdings Plc Fatty acid derivatives
US6048557A (en) * 1996-03-26 2000-04-11 Dsm N.V. PUFA coated solid carrier particles for foodstuff
US6255505B1 (en) * 1996-03-28 2001-07-03 Gist-Brocades, B.V. Microbial polyunsaturated fatty acid containing oil from pasteurised biomass
SK139999A3 (en) 1997-04-11 2000-05-16 Calgene Llc A nucleic acids construct, isolated nucleotide sequence, recombinant plant cell, method of biosynthesis of polyunsaturated long chain fatty acids, pharmaceutical, food and cosmetic preparation and use thereof
US5972664A (en) 1997-04-11 1999-10-26 Abbott Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids
US6051754A (en) 1997-04-11 2000-04-18 Abbott Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants
US5968809A (en) 1997-04-11 1999-10-19 Abbot Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids
US6075183A (en) 1997-04-11 2000-06-13 Abbott Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants
US6459018B1 (en) * 1998-06-12 2002-10-01 Monsanto Technology Llc Polyunsaturated fatty acids in plants

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