ATE307609T1 - Präventiva/mittel zur glaukombehandlung - Google Patents
Präventiva/mittel zur glaukombehandlungInfo
- Publication number
- ATE307609T1 ATE307609T1 AT99937073T AT99937073T ATE307609T1 AT E307609 T1 ATE307609 T1 AT E307609T1 AT 99937073 T AT99937073 T AT 99937073T AT 99937073 T AT99937073 T AT 99937073T AT E307609 T1 ATE307609 T1 AT E307609T1
- Authority
- AT
- Austria
- Prior art keywords
- glaucoma
- treatment
- prophylaxis
- agent
- compound
- Prior art date
Links
- 208000010412 Glaucoma Diseases 0.000 title abstract 5
- 238000011282 treatment Methods 0.000 title abstract 5
- 238000011321 prophylaxis Methods 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 102000000568 rho-Associated Kinases Human genes 0.000 abstract 2
- 108010041788 rho-Associated Kinases Proteins 0.000 abstract 2
- 210000001742 aqueous humor Anatomy 0.000 abstract 1
- 230000017531 blood circulation Effects 0.000 abstract 1
- 230000004410 intraocular pressure Effects 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP24776298 | 1998-08-17 | ||
JP12296099 | 1999-04-28 | ||
PCT/JP1999/004403 WO2000009162A1 (fr) | 1998-08-17 | 1999-08-13 | Medicaments preventifs/curatifs pour le glaucome |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE307609T1 true ATE307609T1 (de) | 2005-11-15 |
Family
ID=26459997
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04014078T ATE529102T1 (de) | 1998-08-17 | 1999-08-13 | Verbindung zur vorbeugung und behandlung von glaukoma |
AT04014077T ATE527993T1 (de) | 1998-08-17 | 1999-08-13 | Verbindung zur vorbeugung und behandlung von augen-asthenopie und pseudomyopie |
AT99937073T ATE307609T1 (de) | 1998-08-17 | 1999-08-13 | Präventiva/mittel zur glaukombehandlung |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04014078T ATE529102T1 (de) | 1998-08-17 | 1999-08-13 | Verbindung zur vorbeugung und behandlung von glaukoma |
AT04014077T ATE527993T1 (de) | 1998-08-17 | 1999-08-13 | Verbindung zur vorbeugung und behandlung von augen-asthenopie und pseudomyopie |
Country Status (12)
Country | Link |
---|---|
US (2) | US6673812B1 (de) |
EP (3) | EP1459742B9 (de) |
JP (2) | JP3720264B2 (de) |
KR (1) | KR100616466B1 (de) |
CN (2) | CN1293878C (de) |
AT (3) | ATE529102T1 (de) |
AU (1) | AU5198199A (de) |
CA (2) | CA2635412C (de) |
DE (1) | DE69927936T2 (de) |
ES (3) | ES2372572T3 (de) |
HK (3) | HK1030883A1 (de) |
WO (1) | WO2000009162A1 (de) |
Families Citing this family (81)
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JP4260370B2 (ja) * | 1998-08-10 | 2009-04-30 | 旭化成ファーマ株式会社 | 塩酸ファスジルの経口徐放性製剤 |
WO2000057914A1 (fr) * | 1999-03-25 | 2000-10-05 | Santen Pharmaceutical Co., Ltd. | Agents permettant d'abaisser la tension oculaire |
DE60036540T2 (de) * | 1999-03-25 | 2008-07-03 | Mitsubishi Tanabe Pharma Corp. | Rho-kinase-inhibitoren für die vorbeugung oder behandlung von interstitieller pneumonie und pulmonaler fibrose |
US9603741B2 (en) | 2000-05-19 | 2017-03-28 | Michael S. Berlin | Delivery system and method of use for the eye |
BR0114020A (pt) | 2000-09-20 | 2003-07-22 | Merck Patent Gmbh | 4-amino-quinazolinas |
CN101310771B (zh) * | 2001-04-11 | 2012-08-08 | 千寿制药株式会社 | 视觉功能障碍改善剂 |
JP2003010158A (ja) * | 2001-04-26 | 2003-01-14 | Biochemical & Pharmacological Laboratories Inc | 眼精疲労モデル、その作製方法、そのモデルを用いた評価方法およびその評価法を用いて選択された薬剤 |
US7829566B2 (en) | 2001-09-17 | 2010-11-09 | Werner Mederski | 4-amino-quinazolines |
CA2472619A1 (en) | 2002-01-10 | 2003-07-24 | Bayer Corporation | Fused pyrimidine derivates as rho-kinase inhibitors |
US6924290B2 (en) | 2002-01-23 | 2005-08-02 | Bayer Pharmaceuticals Corporation | Rho-kinase inhibitors |
WO2003062227A1 (en) | 2002-01-23 | 2003-07-31 | Bayer Pharmaceuticals Corporation | Rho-kinase inhibitors |
US7645878B2 (en) | 2002-03-22 | 2010-01-12 | Bayer Healthcare Llc | Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof |
GB0206860D0 (en) | 2002-03-22 | 2002-05-01 | Glaxo Group Ltd | Compounds |
AU2003257588A1 (en) * | 2002-08-29 | 2004-03-19 | Santen Pharmaceutical Co., Ltd. | REMEDY FOR GLAUCOMA COMPRISING Rho KINASE INHIBITOR AND PROSTAGLANDINS |
AU2003269413A1 (en) * | 2002-11-01 | 2004-05-25 | Pharmacia & Upjohn Company Llc | Nicotinic acetylcholine agonists in the treatment of glaucoma and retinal neuropathy |
WO2004045644A1 (ja) * | 2002-11-18 | 2004-06-03 | Santen Pharmaceutical Co., Ltd. | Rhoキナーゼ阻害剤とβ遮断薬からなる緑内障治療剤 |
CN100390173C (zh) * | 2003-06-06 | 2008-05-28 | 旭化成制药株式会社 | 3环系化合物 |
US7160894B2 (en) * | 2003-06-06 | 2007-01-09 | Asahi Kasei Pharma Corporation | Tricyclic compound |
EP1679308B1 (de) | 2003-10-15 | 2013-07-24 | Ube Industries, Ltd. | Neues indazolderivat |
US8415364B2 (en) | 2003-11-26 | 2013-04-09 | Duke University | Method of preventing or treating glaucoma |
WO2005079829A2 (en) * | 2004-02-18 | 2005-09-01 | Wisconsin Alumni Research Foundation | Method for treating glaucoma |
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JP3066561B2 (ja) * | 1993-10-07 | 2000-07-17 | 武田薬品工業株式会社 | 近視予防・治療剤 |
JPH07133225A (ja) | 1993-11-09 | 1995-05-23 | Santen Pharmaceut Co Ltd | 毛様体筋緊張緩和剤 |
EP1195372A1 (de) * | 1994-04-18 | 2002-04-10 | Mitsubishi Pharma Corporation | N-Heterozyklisch substitutierte Benzamid Deriviate mit antihypertensiver Wirkung |
JPH08198876A (ja) * | 1995-01-30 | 1996-08-06 | Yoshitomi Pharmaceut Ind Ltd | トランス−N−(1H−ピラゾロ〔3,4−b〕ピリジン−4−イル)−4−グアニジノメチルシクロヘキサンカルボキサミド・1メタンスルホン酸塩・1水和物 |
US5888173A (en) | 1995-08-10 | 1999-03-30 | Singhal; Tara Chand | Health saver computer break |
JP3421217B2 (ja) * | 1995-11-20 | 2003-06-30 | 麒麟麦酒株式会社 | Rho標的タンパク質Rhoキナーゼ |
US5906819A (en) | 1995-11-20 | 1999-05-25 | Kirin Beer Kabushiki Kaisha | Rho target protein Rho-kinase |
JPH09143099A (ja) | 1995-11-27 | 1997-06-03 | Santen Pharmaceut Co Ltd | 毛様体筋緊張緩和剤 |
AU720326B2 (en) | 1995-12-21 | 2000-05-25 | Alcon Laboratories, Inc. | Use of certain isoquinolinesulfonyl compounds for the treatment of glaucoma and ocular ischemia |
US5798380A (en) * | 1996-02-21 | 1998-08-25 | Wisconsin Alumni Research Foundation | Cytoskeletal active agents for glaucoma therapy |
JPH10203982A (ja) * | 1996-07-05 | 1998-08-04 | Takeda Chem Ind Ltd | 視機能障害の予防・治療剤 |
CA2263425C (en) * | 1996-08-12 | 2008-09-30 | Yoshitomi Pharmaceutical Industries Ltd. | Pharmaceutical agent containing rho kinase inhibitor |
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1999
- 1999-08-13 AU AU51981/99A patent/AU5198199A/en not_active Abandoned
- 1999-08-13 AT AT04014078T patent/ATE529102T1/de not_active IP Right Cessation
- 1999-08-13 KR KR1020007004051A patent/KR100616466B1/ko not_active IP Right Cessation
- 1999-08-13 DE DE69927936T patent/DE69927936T2/de not_active Expired - Lifetime
- 1999-08-13 ES ES04014078T patent/ES2372572T3/es not_active Expired - Lifetime
- 1999-08-13 CN CNB2003101142105A patent/CN1293878C/zh not_active Expired - Fee Related
- 1999-08-13 EP EP04014077A patent/EP1459742B9/de not_active Expired - Lifetime
- 1999-08-13 CA CA2635412A patent/CA2635412C/en not_active Expired - Fee Related
- 1999-08-13 ES ES04014077T patent/ES2374518T3/es not_active Expired - Lifetime
- 1999-08-13 WO PCT/JP1999/004403 patent/WO2000009162A1/ja active IP Right Grant
- 1999-08-13 AT AT04014077T patent/ATE527993T1/de not_active IP Right Cessation
- 1999-08-13 CN CNB998018732A patent/CN1195547C/zh not_active Expired - Fee Related
- 1999-08-13 EP EP99937073A patent/EP1034793B1/de not_active Expired - Lifetime
- 1999-08-13 EP EP04014078A patent/EP1459743B9/de not_active Expired - Lifetime
- 1999-08-13 JP JP2000564663A patent/JP3720264B2/ja not_active Expired - Fee Related
- 1999-08-13 AT AT99937073T patent/ATE307609T1/de not_active IP Right Cessation
- 1999-08-13 CA CA002307285A patent/CA2307285C/en not_active Expired - Fee Related
- 1999-08-13 ES ES99937073T patent/ES2247822T3/es not_active Expired - Lifetime
- 1999-08-13 US US09/529,354 patent/US6673812B1/en not_active Expired - Lifetime
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2001
- 2001-03-12 HK HK01101779A patent/HK1030883A1/xx not_active IP Right Cessation
- 2001-03-12 HK HK05102430.9A patent/HK1069120A1/xx not_active IP Right Cessation
- 2001-03-12 HK HK05102431.8A patent/HK1069121A1/xx not_active IP Right Cessation
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2002
- 2002-11-19 US US10/298,674 patent/US6649625B2/en not_active Expired - Fee Related
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2004
- 2004-07-06 JP JP2004199836A patent/JP4490748B2/ja not_active Expired - Fee Related
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