WO2008078762A1 - ウレア構造を有する新規n-(2-アミノフェニル)ベンズアミド誘導体 - Google Patents
ウレア構造を有する新規n-(2-アミノフェニル)ベンズアミド誘導体 Download PDFInfo
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- WO2008078762A1 WO2008078762A1 PCT/JP2007/074912 JP2007074912W WO2008078762A1 WO 2008078762 A1 WO2008078762 A1 WO 2008078762A1 JP 2007074912 W JP2007074912 W JP 2007074912W WO 2008078762 A1 WO2008078762 A1 WO 2008078762A1
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- group
- aminophenyl
- novel
- urea structure
- benzamide derivative
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- C07—ORGANIC CHEMISTRY
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
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- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
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- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
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- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
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- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
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- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
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- C07D277/38—Nitrogen atoms
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- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
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- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
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- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
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- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
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- Chemical & Material Sciences (AREA)
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- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Quinoline Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Furan Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL07860141T PL2107052T3 (pl) | 2006-12-26 | 2007-12-26 | Nowa pochodna N-(2-aminofenylo)benzamidu posiadająca strukturę mocznikową |
AT07860141T ATE528285T1 (de) | 2006-12-26 | 2007-12-26 | Neue n-(2-aminophenyl)benzamidderivate mit harnstoffstruktur |
CA002674548A CA2674548A1 (en) | 2006-12-26 | 2007-12-26 | Novel n-(2-aminophenyl) benzamide derivative having urea structure |
ES07860141T ES2375522T3 (es) | 2006-12-26 | 2007-12-26 | Nuevo derivado de n-(2-aminofenil)benzamida con estructura urea. |
US12/448,259 US8076332B2 (en) | 2006-12-26 | 2007-12-26 | N- (2-aminophenyl) benzamide derivative having urea structure |
EP07860141A EP2107052B1 (en) | 2006-12-26 | 2007-12-26 | Novel n-(2-aminophenyl)benzamide derivative having an urea structure |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006-350263 | 2006-12-26 | ||
JP2006350263 | 2006-12-26 |
Publications (1)
Publication Number | Publication Date |
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WO2008078762A1 true WO2008078762A1 (ja) | 2008-07-03 |
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Application Number | Title | Priority Date | Filing Date |
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PCT/JP2007/074912 WO2008078762A1 (ja) | 2006-12-26 | 2007-12-26 | ウレア構造を有する新規n-(2-アミノフェニル)ベンズアミド誘導体 |
Country Status (10)
Country | Link |
---|---|
US (1) | US8076332B2 (ja) |
EP (1) | EP2107052B1 (ja) |
JP (1) | JP2008179624A (ja) |
KR (1) | KR20090096624A (ja) |
CN (1) | CN101568520A (ja) |
AT (1) | ATE528285T1 (ja) |
CA (1) | CA2674548A1 (ja) |
ES (1) | ES2375522T3 (ja) |
PL (1) | PL2107052T3 (ja) |
WO (1) | WO2008078762A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009142321A1 (ja) * | 2008-05-23 | 2009-11-26 | 参天製薬株式会社 | ウレア構造を有する新規チオフェンジアミン誘導体 |
JP2019065037A (ja) * | 2011-02-28 | 2019-04-25 | バイオマリン ファーマシューティカル インク | ヒストン脱アセチル化酵素阻害剤 |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9265734B2 (en) | 2008-09-03 | 2016-02-23 | Biomarin Pharmaceutical Inc. | Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors |
US9452980B2 (en) * | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
CA2791680A1 (en) * | 2010-03-01 | 2011-09-09 | Myrexis, Inc. | Compounds and therapeutic uses thereof |
US8912184B1 (en) | 2010-03-01 | 2014-12-16 | Alzheimer's Institute Of America, Inc. | Therapeutic and diagnostic methods |
US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
US9796674B2 (en) * | 2013-03-14 | 2017-10-24 | The Board Of Trustees Of The Leland Stanford Junior University | Benzyl urea derivatives for activating TGF-beta signaling |
AU2014228344C1 (en) | 2013-03-15 | 2019-02-07 | Biomarin Pharmaceutical Inc. | HDAC inhibitors |
SG10201913878YA (en) | 2016-03-17 | 2020-03-30 | Hoffmann La Roche | 5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of taar |
US20220265669A1 (en) * | 2019-02-25 | 2022-08-25 | Albert Einstein College Of Medicine | Compounds useful for inhibiting raf dimers |
CN113717079B (zh) * | 2021-09-30 | 2023-03-31 | 内蒙古康普药业有限公司 | 一种甲氧氯普胺双胺新杂质的制备方法 |
Citations (6)
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WO1990005723A1 (en) | 1988-11-24 | 1990-05-31 | Yoshitomi Pharmaceutical Industries, Ltd. | Trans-4-amino(alkyl)-1-pyridylcarbamoyl-cyclohexane compounds and their medicinal use |
WO1997030701A2 (en) | 1996-02-21 | 1997-08-28 | Wisconsin Alumni Research Foundation | Pharmaceutical compositions for the treatment of glaucoma |
JPH10152462A (ja) | 1996-09-30 | 1998-06-09 | Mitsui Chem Inc | 分化誘導剤 |
JP2000044513A (ja) * | 1998-05-25 | 2000-02-15 | Santen Pharmaceut Co Ltd | 新規ビニルベンゼン誘導体 |
WO2000009162A1 (fr) | 1998-08-17 | 2000-02-24 | Senju Pharmaceutical Co., Ltd. | Medicaments preventifs/curatifs pour le glaucome |
JP2000273070A (ja) * | 1999-01-18 | 2000-10-03 | Santen Pharmaceut Co Ltd | 新規1,2−ジフェニル−2−プロペン−1−オン誘導体 |
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US6174905B1 (en) | 1996-09-30 | 2001-01-16 | Mitsui Chemicals, Inc. | Cell differentiation inducer |
DE69931051D1 (de) | 1998-05-25 | 2006-06-01 | Santen Pharmaceutical Co Ltd | Neue vinylbenzolderivate |
WO2000041993A1 (fr) * | 1999-01-18 | 2000-07-20 | Santen Pharmaceutical Co., Ltd. | Nouveaux derives 1,2-diphenyl-e-propen-1-one |
WO2008117862A1 (ja) * | 2007-03-28 | 2008-10-02 | Santen Pharmaceutical Co., Ltd. | ウレア構造を有する新規ピリジンカルボン酸(2-アミノフェニル)アミド誘導体 |
-
2007
- 2007-12-26 EP EP07860141A patent/EP2107052B1/en not_active Not-in-force
- 2007-12-26 PL PL07860141T patent/PL2107052T3/pl unknown
- 2007-12-26 WO PCT/JP2007/074912 patent/WO2008078762A1/ja active Application Filing
- 2007-12-26 KR KR1020097014182A patent/KR20090096624A/ko not_active Application Discontinuation
- 2007-12-26 AT AT07860141T patent/ATE528285T1/de not_active IP Right Cessation
- 2007-12-26 CN CNA2007800480539A patent/CN101568520A/zh active Pending
- 2007-12-26 US US12/448,259 patent/US8076332B2/en not_active Expired - Fee Related
- 2007-12-26 JP JP2007333744A patent/JP2008179624A/ja not_active Ceased
- 2007-12-26 ES ES07860141T patent/ES2375522T3/es active Active
- 2007-12-26 CA CA002674548A patent/CA2674548A1/en not_active Abandoned
Patent Citations (6)
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WO1990005723A1 (en) | 1988-11-24 | 1990-05-31 | Yoshitomi Pharmaceutical Industries, Ltd. | Trans-4-amino(alkyl)-1-pyridylcarbamoyl-cyclohexane compounds and their medicinal use |
WO1997030701A2 (en) | 1996-02-21 | 1997-08-28 | Wisconsin Alumni Research Foundation | Pharmaceutical compositions for the treatment of glaucoma |
JPH10152462A (ja) | 1996-09-30 | 1998-06-09 | Mitsui Chem Inc | 分化誘導剤 |
JP2000044513A (ja) * | 1998-05-25 | 2000-02-15 | Santen Pharmaceut Co Ltd | 新規ビニルベンゼン誘導体 |
WO2000009162A1 (fr) | 1998-08-17 | 2000-02-24 | Senju Pharmaceutical Co., Ltd. | Medicaments preventifs/curatifs pour le glaucome |
JP2000273070A (ja) * | 1999-01-18 | 2000-10-03 | Santen Pharmaceut Co Ltd | 新規1,2−ジフェニル−2−プロペン−1−オン誘導体 |
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Title |
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INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 42, 2001, pages 137 - 144 |
OPHTHALMOLOGY & VISUAL SCIENCE, vol. 43, 2002, pages 151 - 161 |
THE JOURNAL OF CLINICAL INVESTIGATION, vol. 103, 1999, pages 1141 - 1150 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009142321A1 (ja) * | 2008-05-23 | 2009-11-26 | 参天製薬株式会社 | ウレア構造を有する新規チオフェンジアミン誘導体 |
JP2019065037A (ja) * | 2011-02-28 | 2019-04-25 | バイオマリン ファーマシューティカル インク | ヒストン脱アセチル化酵素阻害剤 |
Also Published As
Publication number | Publication date |
---|---|
CN101568520A (zh) | 2009-10-28 |
PL2107052T3 (pl) | 2012-05-31 |
ATE528285T1 (de) | 2011-10-15 |
CA2674548A1 (en) | 2008-07-03 |
EP2107052A4 (en) | 2009-12-23 |
JP2008179624A (ja) | 2008-08-07 |
ES2375522T3 (es) | 2012-03-01 |
EP2107052B1 (en) | 2011-10-12 |
KR20090096624A (ko) | 2009-09-11 |
US8076332B2 (en) | 2011-12-13 |
US20090306077A1 (en) | 2009-12-10 |
EP2107052A1 (en) | 2009-10-07 |
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