ATE529102T1 - Verbindung zur vorbeugung und behandlung von glaukoma - Google Patents
Verbindung zur vorbeugung und behandlung von glaukomaInfo
- Publication number
- ATE529102T1 ATE529102T1 AT04014078T AT04014078T ATE529102T1 AT E529102 T1 ATE529102 T1 AT E529102T1 AT 04014078 T AT04014078 T AT 04014078T AT 04014078 T AT04014078 T AT 04014078T AT E529102 T1 ATE529102 T1 AT E529102T1
- Authority
- AT
- Austria
- Prior art keywords
- compound
- glaucoma
- prophylaxis
- treatment
- agent
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP24776298 | 1998-08-17 | ||
JP12296099 | 1999-04-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE529102T1 true ATE529102T1 (de) | 2011-11-15 |
Family
ID=26459997
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04014077T ATE527993T1 (de) | 1998-08-17 | 1999-08-13 | Verbindung zur vorbeugung und behandlung von augen-asthenopie und pseudomyopie |
AT99937073T ATE307609T1 (de) | 1998-08-17 | 1999-08-13 | Präventiva/mittel zur glaukombehandlung |
AT04014078T ATE529102T1 (de) | 1998-08-17 | 1999-08-13 | Verbindung zur vorbeugung und behandlung von glaukoma |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04014077T ATE527993T1 (de) | 1998-08-17 | 1999-08-13 | Verbindung zur vorbeugung und behandlung von augen-asthenopie und pseudomyopie |
AT99937073T ATE307609T1 (de) | 1998-08-17 | 1999-08-13 | Präventiva/mittel zur glaukombehandlung |
Country Status (12)
Country | Link |
---|---|
US (2) | US6673812B1 (de) |
EP (3) | EP1459743B9 (de) |
JP (2) | JP3720264B2 (de) |
KR (1) | KR100616466B1 (de) |
CN (2) | CN1293878C (de) |
AT (3) | ATE527993T1 (de) |
AU (1) | AU5198199A (de) |
CA (2) | CA2635412C (de) |
DE (1) | DE69927936T2 (de) |
ES (3) | ES2374518T3 (de) |
HK (3) | HK1069121A1 (de) |
WO (1) | WO2000009162A1 (de) |
Families Citing this family (81)
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KR100396171B1 (ko) * | 1998-08-10 | 2003-08-27 | 아사히 가세이 가부시키가이샤 | 염산 파수딜의 경구 서방성 제제 |
EP1163910B1 (de) * | 1999-03-25 | 2007-09-26 | Mitsubishi Pharma Corporation | Rho-kinase-inhibitoren für die vorbeugung oder behandlung von interstitieller pneumonie und pulmonaler fibrose |
AU3328600A (en) * | 1999-03-25 | 2000-10-16 | Santen Pharmaceutical Co. Ltd. | Ocular tension-lowering agents |
US9603741B2 (en) | 2000-05-19 | 2017-03-28 | Michael S. Berlin | Delivery system and method of use for the eye |
AU2001293817A1 (en) | 2000-09-20 | 2002-04-02 | Merck Patent Gmbh | 4-amino-quinazolines |
EP1378247B1 (de) * | 2001-04-11 | 2016-08-24 | Senju Pharmaceutical Co., Ltd. | Wirkstoffe zur behandlung von sehfunktionsstörungen |
JP2003010158A (ja) * | 2001-04-26 | 2003-01-14 | Biochemical & Pharmacological Laboratories Inc | 眼精疲労モデル、その作製方法、そのモデルを用いた評価方法およびその評価法を用いて選択された薬剤 |
US7829566B2 (en) | 2001-09-17 | 2010-11-09 | Werner Mederski | 4-amino-quinazolines |
DE60320933D1 (de) | 2002-01-10 | 2008-06-26 | Bayer Healthcare Ag | Rho-kinase inhibitoren |
MXPA04007191A (es) | 2002-01-23 | 2005-03-31 | Bayer Pharmaceuticals Corp | Derivados de pirimidina como inhibidores de rho-quinasa. |
MXPA04007196A (es) | 2002-01-23 | 2005-06-08 | Bayer Pharmaceuticals Corp | Inhibidores de rho-quinasa. |
US7645878B2 (en) | 2002-03-22 | 2010-01-12 | Bayer Healthcare Llc | Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof |
GB0206860D0 (en) | 2002-03-22 | 2002-05-01 | Glaxo Group Ltd | Compounds |
ATE546143T1 (de) * | 2002-08-29 | 2012-03-15 | Santen Pharmaceutical Co Ltd | Mittel zur behandlung von glaukom mit einem rho- kinase-hemmer und prostaglandinen |
AU2003269413A1 (en) * | 2002-11-01 | 2004-05-25 | Pharmacia & Upjohn Company Llc | Nicotinic acetylcholine agonists in the treatment of glaucoma and retinal neuropathy |
ES2444841T3 (es) * | 2002-11-18 | 2014-02-27 | Santen Pharmaceutical Co., Ltd. | Remedio para el glaucoma que comprende inhibidor de Rho cinasa y beta-bloqueante |
US7160894B2 (en) * | 2003-06-06 | 2007-01-09 | Asahi Kasei Pharma Corporation | Tricyclic compound |
CN100390173C (zh) * | 2003-06-06 | 2008-05-28 | 旭化成制药株式会社 | 3环系化合物 |
TWI344961B (en) | 2003-10-15 | 2011-07-11 | Ube Industries | Novel indazole derivative |
US8415364B2 (en) | 2003-11-26 | 2013-04-09 | Duke University | Method of preventing or treating glaucoma |
WO2005079829A2 (en) * | 2004-02-18 | 2005-09-01 | Wisconsin Alumni Research Foundation | Method for treating glaucoma |
WO2005102345A1 (en) * | 2004-03-30 | 2005-11-03 | Alcon, Inc. | Use of rho kinase inhibitors in the treatment of hearing loss, tinnitus and improving body balance |
FR2868310A1 (fr) * | 2004-04-02 | 2005-10-07 | Oreal | Utilisation cosmetique d'au moins un inhibiteur de la production et/ou de l'activation des rhoa kinases comme agent destine a detendre les traits et/ou decontracter la peau |
ES2553953T3 (es) * | 2004-06-03 | 2015-12-15 | Senju Pharmaceutical Co., Ltd. | Fármaco para la recuperación de la percepción corneal que contiene un compuesto amida |
TWI367098B (en) | 2004-12-23 | 2012-07-01 | Kowa Co | Treating agent for glaucoma |
ZA200704959B (en) * | 2004-12-27 | 2009-04-29 | Alcon Inc | Aminopyrazine analogs for treating glaucoma and other rho kinase-mediated diseases |
US20090029970A1 (en) * | 2005-02-16 | 2009-01-29 | Astellas Pharma Inc. | Pain remedy containing rock inhibitor |
WO2006137368A1 (ja) * | 2005-06-21 | 2006-12-28 | Kowa Co., Ltd. | 緑内障の予防又は治療剤 |
PL1905452T3 (pl) * | 2005-07-12 | 2013-11-29 | Kowa Co | Środek do zapobiegania lub leczenia jaskry |
KR20080040027A (ko) | 2005-09-02 | 2008-05-07 | 아스테라스 세이야쿠 가부시키가이샤 | Rock 억제제로서 아미드 유도체 |
US7867999B1 (en) | 2005-12-22 | 2011-01-11 | Alcon Research, Ltd. | Hydroxyamino- and amino-substituted pyridine analogs for treating rho kinase-mediated diseases and conditions |
EP1962853A1 (de) * | 2005-12-22 | 2008-09-03 | Alcon Research, Ltd. | (indazol-5-yl)-pyrazine und (1,3-dihydro-indol-2-on)-pyrazine zur behandlung rho-kinase-vermittelter erkrankungen und leiden |
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US20090247552A1 (en) * | 2006-07-31 | 2009-10-01 | Shirou Sawa | Aqueous liquid preparation containing amide compound |
US20100022517A1 (en) * | 2006-12-18 | 2010-01-28 | Richards Lori A | Ophthalmic formulation of rho kinase inhibitor compound |
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US10842669B2 (en) | 2008-11-13 | 2020-11-24 | Gholam A. Peyman | Ophthalmic drug delivery method |
US10272035B2 (en) * | 2008-11-13 | 2019-04-30 | Gholam A. Peyman | Ophthalmic drug delivery method |
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WO2010135731A1 (en) * | 2009-05-22 | 2010-11-25 | Kaufman Herbert E | Preparations and methods for ameliorating or reducing presbyopia |
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EP3626245B1 (de) | 2013-04-24 | 2021-05-05 | Kyushu University, National University Corporation | Therapeutikum für erkrankungen des augenhintergrunds |
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US9844556B2 (en) | 2015-03-25 | 2017-12-19 | Megumi Honjo | Preventive/therapeutic method and preventive/therapeutic agent for complications after cataract surgery |
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US20180296474A1 (en) | 2015-10-13 | 2018-10-18 | INSERM (Institut National de la Santé et de la Recherche Médicale | Methods and pharmaceutical compositions for the treatment of retinal capillary non-perfusion |
EP4088719A1 (de) | 2015-10-13 | 2022-11-16 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Verfahren und pharmazeutische zusammensetzungen zur behandlung von kapillarer nichtperfusion der netzhaut |
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US5798380A (en) * | 1996-02-21 | 1998-08-25 | Wisconsin Alumni Research Foundation | Cytoskeletal active agents for glaucoma therapy |
JPH10203982A (ja) * | 1996-07-05 | 1998-08-04 | Takeda Chem Ind Ltd | 視機能障害の予防・治療剤 |
US6218410B1 (en) * | 1996-08-12 | 2001-04-17 | Yoshitomi Pharmaceutical Industries, Ltd. | Medicines comprising Rho kinase inhibitor |
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1999
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