ATE305970T1 - Verfahren zur affinitätstrennung und ligande zur pertinenten verwendung - Google Patents
Verfahren zur affinitätstrennung und ligande zur pertinenten verwendungInfo
- Publication number
- ATE305970T1 ATE305970T1 AT99950942T AT99950942T ATE305970T1 AT E305970 T1 ATE305970 T1 AT E305970T1 AT 99950942 T AT99950942 T AT 99950942T AT 99950942 T AT99950942 T AT 99950942T AT E305970 T1 ATE305970 T1 AT E305970T1
- Authority
- AT
- Austria
- Prior art keywords
- protein
- affinity separation
- ligands
- asn
- residues
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 238000000926 separation method Methods 0.000 title abstract 2
- 235000018102 proteins Nutrition 0.000 abstract 6
- 102000004169 proteins and genes Human genes 0.000 abstract 6
- 108090000623 proteins and genes Proteins 0.000 abstract 6
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 abstract 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 1
- 229960001230 asparagine Drugs 0.000 abstract 1
- 235000009582 asparagine Nutrition 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9823071.7A GB9823071D0 (en) | 1998-10-21 | 1998-10-21 | A method |
| PCT/GB1999/003484 WO2000023580A1 (en) | 1998-10-21 | 1999-10-21 | A method of affinity separation and ligands for use therein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE305970T1 true ATE305970T1 (de) | 2005-10-15 |
Family
ID=10841043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99950942T ATE305970T1 (de) | 1998-10-21 | 1999-10-21 | Verfahren zur affinitätstrennung und ligande zur pertinenten verwendung |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6831161B1 (enExample) |
| EP (2) | EP1123389B1 (enExample) |
| JP (1) | JP4801258B2 (enExample) |
| AT (1) | ATE305970T1 (enExample) |
| AU (1) | AU773368B2 (enExample) |
| CA (2) | CA2633345C (enExample) |
| DE (1) | DE69927598T2 (enExample) |
| DK (1) | DK1123389T3 (enExample) |
| GB (1) | GB9823071D0 (enExample) |
| NO (1) | NO323994B1 (enExample) |
| WO (1) | WO2000023580A1 (enExample) |
| ZA (1) | ZA200103252B (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7709209B2 (en) | 2002-03-25 | 2010-05-04 | Ge Healthcare Bio-Sciences Ab | Protein ligands |
| SE0200943D0 (sv) | 2002-03-25 | 2002-03-25 | Amersham Biosciences Ab | Mutant protein |
| GB0214007D0 (en) * | 2002-06-18 | 2002-07-31 | Common Services Agency | Removal of prion infectivity |
| CA2529001A1 (en) * | 2003-06-10 | 2004-12-16 | Catchmabs B.V. | Binding peptides: methods for their generation and use |
| SE0301936D0 (sv) * | 2003-06-30 | 2003-06-30 | Affibody Ab | New polypeptide |
| JP4871126B2 (ja) * | 2003-07-04 | 2012-02-08 | アフィボディ・アーベー | Ｈｅｒ２に対する結合親和性を有するポリペプチド |
| DE05733048T1 (de) | 2004-04-06 | 2007-05-10 | Affibody Ab | Serumalbuminbindende peptidkonjugate zur arzneimittelherstellung |
| CN101522278B (zh) | 2006-09-29 | 2016-08-10 | 通用电气健康护理生物科学股份公司 | 用于抗体分离的包含来自金黄色葡萄球菌a蛋白的结构域c的层析配体 |
| CA2694139C (en) * | 2007-07-31 | 2018-06-05 | Affibody Ab | Albumin binding polypeptide compositions |
| GB2452301A (en) * | 2007-08-30 | 2009-03-04 | Ge Healthcare Bio Sciences Ab | Sterilization Method |
| US8592555B2 (en) * | 2008-08-11 | 2013-11-26 | Emd Millipore Corporation | Immunoglobulin-binding proteins with improved specificity |
| EP2339339A4 (en) * | 2008-09-25 | 2016-10-12 | Jsr Corp | CHARGE FOR AFFINITY CHROMATOGRAPHY |
| JP5229888B2 (ja) * | 2008-09-30 | 2013-07-03 | 独立行政法人産業技術総合研究所 | 弱酸性域での易解離性を向上したプロテインａ変異型タンパク質及び抗体捕捉剤 |
| SG195555A1 (en) * | 2008-12-24 | 2013-12-30 | Emd Millipore Corp | Caustic stable chromatography ligands |
| JPWO2010110288A1 (ja) | 2009-03-24 | 2012-09-27 | 株式会社カネカ | 免疫グロブリンに親和性を有するタンパク質および免疫グロブリン結合性アフィニティーリガンド |
| WO2011118699A1 (ja) | 2010-03-24 | 2011-09-29 | 株式会社カネカ | 免疫グロブリンに特異的に結合するタンパク質および免疫グロブリン結合性アフィニティーリガンド |
| CN103403020A (zh) * | 2010-12-21 | 2013-11-20 | Jsr株式会社 | 蛋白a的新型耐碱变体及其在亲和色谱中的用途 |
| CN103270044B (zh) | 2010-12-21 | 2016-03-09 | Jsr株式会社 | 亲和色谱用载体和分离免疫球蛋白的方法 |
| EP2690106A4 (en) | 2011-03-24 | 2015-04-22 | Kaneka Corp | LOW-MOLECULAR COMPOUND OF LOW MOLECULAR WEIGHT FOR BONDING PROTEIN-CONTAINING SUBSTANCES |
| AU2012233980B2 (en) | 2011-03-25 | 2016-10-13 | Kaneka Corporation | Novel immunoglobulin-binding polypeptide |
| SG10201604554WA (en) | 2011-06-08 | 2016-07-28 | Emd Millipore Corp | Chromatography matrices including novel staphylococcus aureus protein a based ligands |
| WO2014076179A1 (en) | 2012-11-14 | 2014-05-22 | Affibody Ab | New polypeptide |
| WO2014076177A1 (en) * | 2012-11-14 | 2014-05-22 | Affibody Ab | New polypeptide |
| US9255262B2 (en) * | 2013-03-06 | 2016-02-09 | Vision Global Holdings Ltd. | Albumin-binding arginine deminase and the use thereof |
| USRE48805E1 (en) | 2013-03-06 | 2021-11-02 | Vision Global Holdings Ltd. | Method for cancer targeting treatment and detection of arginine using albumin-binding arginine deiminase fusion protein |
| CN114560906A (zh) | 2013-09-04 | 2022-05-31 | Emd密理博公司 | 清洗基于a蛋白的亲和色谱柱的方法 |
| US10221211B2 (en) | 2013-09-27 | 2019-03-05 | Kaneka Corporation | Process for producing porous cellulose beads using alkali aqueous solution |
| WO2015088677A1 (en) | 2013-12-12 | 2015-06-18 | Emd Millipore Corporation | Protein separations using an acrylamide containing filter |
| JP6369807B2 (ja) * | 2014-10-21 | 2018-08-08 | 株式会社プロテイン・エクスプレス | プロテインｌ変異体 |
| JPWO2016121701A1 (ja) | 2015-01-26 | 2017-11-09 | 株式会社カネカ | 免疫グロブリンκ鎖可変領域含有タンパク質精製用アフィニティー分離マトリックス |
| EP3252158A4 (en) | 2015-01-26 | 2018-07-18 | Kaneka Corporation | Mutant immunoglobulin kappa chain variable region-binding peptide |
| JP6705806B2 (ja) | 2015-03-26 | 2020-06-03 | Jsr株式会社 | イムノグロブリン結合タンパク質およびそれを用いたアフィニティー担体 |
| EP3283508B1 (en) | 2015-04-17 | 2021-03-17 | Alpine Immune Sciences, Inc. | Immunomodulatory proteins with tunable affinities |
| WO2017069158A1 (ja) | 2015-10-22 | 2017-04-27 | プロテノバ株式会社 | イムノグロブリン結合ポリペプチド |
| WO2017191748A1 (ja) * | 2016-05-02 | 2017-11-09 | 株式会社カネカ | 改変型免疫グロブリンκ鎖可変領域結合性ペプチド |
| WO2017195638A1 (ja) | 2016-05-09 | 2017-11-16 | 株式会社カネカ | 抗体またはκ鎖可変領域含有抗体断片の精製方法 |
| EP3592759A1 (en) | 2017-03-07 | 2020-01-15 | JMVA Biotech AB | Modified adsorptive surfaces |
| EP3689894A4 (en) | 2017-09-25 | 2021-12-22 | JSR Corporation | IMMUNOGLOBULIN-BINDING PROTEIN AND AFFINITY CARRIERS THEREFORE |
| IL323061A (en) | 2018-04-11 | 2025-10-01 | Inhibrx Biosciences Inc | Multispecific polypeptide constructs with forced CD3 binding and related methods and uses |
| EP3842536A4 (en) | 2018-08-24 | 2023-01-18 | JSR Corporation | IMMUNOGLOBULIN BINDING PROTEIN AND AFFINITY SUPPORT USING THE SAME |
| US20240026344A1 (en) | 2020-10-13 | 2024-01-25 | Avitide LLC | Affinity ligand libraries of three-helix bundle proteins and uses thereof |
| EP4269590A4 (en) | 2020-12-22 | 2025-01-01 | Protenova Co., Ltd. | IMMUNOGLOBULIN-BINDING POLYPEPTIDE |
| KR20240000462A (ko) | 2021-02-19 | 2024-01-02 | 아비타이드 엘엘씨 | Aav2 친화성 제제 |
| GB2609185A (en) | 2021-05-24 | 2023-02-01 | Astrea Uk Services Ltd | Scaffold for isolation of a biomolecule |
| EP4541814A1 (en) * | 2023-10-20 | 2025-04-23 | Cytiva BioProcess R&D AB | Stabilized polypeptides |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE462046C (sv) * | 1982-08-23 | 1998-04-27 | Pharmacia Biotech Ab | Hybrid-DNA-vektor innehållande DNA-sekvens från Staphylococcus aureus, förfarande för dess framställning och bakterie innehållande densamma |
| US5401832A (en) * | 1984-12-24 | 1995-03-28 | Merck & Co., Inc. | Brain derived and recombinant acidic fibroblast growth factor |
| US5089473A (en) * | 1988-08-29 | 1992-02-18 | Monsanto Company | Somatotropin variants and their use |
| DE69230061T2 (de) * | 1991-07-25 | 2000-01-05 | Oriental Yeast Co. Ltd., Tokio/Tokyo | Künstliches immunoglobulin-bindendes protein |
| JP2584697B2 (ja) * | 1991-08-23 | 1997-02-26 | オリエンタル酵母工業株式会社 | ＩｇＧ精製用組換え型プロテインＡ |
| EP0565978B1 (de) * | 1992-04-16 | 1997-06-18 | MERCK PATENT GmbH | Aktivierte Trägermaterialien, ihre Herstellung und Verwendung |
| SE9400088D0 (sv) * | 1994-01-14 | 1994-01-14 | Kabi Pharmacia Ab | Bacterial receptor structures |
| US5736499A (en) * | 1995-06-06 | 1998-04-07 | Genencor International, Inc. | Mutant A-amylase |
| SE9503925D0 (sv) * | 1995-11-07 | 1995-11-07 | Pharmacia Biotech Ab | Separationsmedium för IgG |
| JP2002508656A (ja) * | 1997-03-12 | 2002-03-19 | スミスクライン・ビーチャム・コーポレイション | 抗−アルファベータ３ヒト化モノクローナル抗体 |
-
1998
- 1998-10-21 GB GBGB9823071.7A patent/GB9823071D0/en not_active Ceased
-
1999
- 1999-10-21 CA CA2633345A patent/CA2633345C/en not_active Expired - Lifetime
- 1999-10-21 DE DE69927598T patent/DE69927598T2/de not_active Expired - Lifetime
- 1999-10-21 JP JP2000577291A patent/JP4801258B2/ja not_active Expired - Lifetime
- 1999-10-21 DK DK99950942T patent/DK1123389T3/da active
- 1999-10-21 WO PCT/GB1999/003484 patent/WO2000023580A1/en not_active Ceased
- 1999-10-21 EP EP99950942A patent/EP1123389B1/en not_active Expired - Lifetime
- 1999-10-21 EP EP05077192A patent/EP1672068A1/en not_active Ceased
- 1999-10-21 US US09/830,080 patent/US6831161B1/en not_active Expired - Lifetime
- 1999-10-21 AU AU63532/99A patent/AU773368B2/en not_active Expired
- 1999-10-21 AT AT99950942T patent/ATE305970T1/de not_active IP Right Cessation
- 1999-10-21 CA CA002347960A patent/CA2347960C/en not_active Expired - Lifetime
-
2001
- 2001-04-20 NO NO20011969A patent/NO323994B1/no not_active IP Right Cessation
- 2001-04-20 ZA ZA200103252A patent/ZA200103252B/en unknown
-
2004
- 2004-12-01 US US11/000,747 patent/US20050100970A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2347960C (en) | 2008-08-05 |
| NO20011969D0 (no) | 2001-04-20 |
| DK1123389T3 (da) | 2006-01-16 |
| US6831161B1 (en) | 2004-12-14 |
| NO20011969L (no) | 2001-06-19 |
| NO323994B1 (no) | 2007-07-30 |
| CA2633345A1 (en) | 2000-04-27 |
| EP1672068A1 (en) | 2006-06-21 |
| AU773368B2 (en) | 2004-05-20 |
| ZA200103252B (en) | 2002-07-22 |
| CA2633345C (en) | 2013-02-26 |
| JP2002527107A (ja) | 2002-08-27 |
| EP1123389B1 (en) | 2005-10-05 |
| DE69927598D1 (de) | 2006-02-16 |
| WO2000023580A1 (en) | 2000-04-27 |
| GB9823071D0 (en) | 1998-12-16 |
| AU6353299A (en) | 2000-05-08 |
| CA2347960A1 (en) | 2000-04-27 |
| EP1123389A1 (en) | 2001-08-16 |
| JP4801258B2 (ja) | 2011-10-26 |
| US20050100970A1 (en) | 2005-05-12 |
| DE69927598T2 (de) | 2006-07-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |