ATE305970T1 - Verfahren zur affinitätstrennung und ligande zur pertinenten verwendung - Google Patents

Verfahren zur affinitätstrennung und ligande zur pertinenten verwendung

Info

Publication number
ATE305970T1
ATE305970T1 AT99950942T AT99950942T ATE305970T1 AT E305970 T1 ATE305970 T1 AT E305970T1 AT 99950942 T AT99950942 T AT 99950942T AT 99950942 T AT99950942 T AT 99950942T AT E305970 T1 ATE305970 T1 AT E305970T1
Authority
AT
Austria
Prior art keywords
protein
affinity separation
ligands
asn
residues
Prior art date
Application number
AT99950942T
Other languages
English (en)
Inventor
Mathias Uhlen
Sophia Hober
Original Assignee
Affibody Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affibody Ab filed Critical Affibody Ab
Application granted granted Critical
Publication of ATE305970T1 publication Critical patent/ATE305970T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT99950942T 1998-10-21 1999-10-21 Verfahren zur affinitätstrennung und ligande zur pertinenten verwendung ATE305970T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9823071.7A GB9823071D0 (en) 1998-10-21 1998-10-21 A method
PCT/GB1999/003484 WO2000023580A1 (en) 1998-10-21 1999-10-21 A method of affinity separation and ligands for use therein

Publications (1)

Publication Number Publication Date
ATE305970T1 true ATE305970T1 (de) 2005-10-15

Family

ID=10841043

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99950942T ATE305970T1 (de) 1998-10-21 1999-10-21 Verfahren zur affinitätstrennung und ligande zur pertinenten verwendung

Country Status (12)

Country Link
US (2) US6831161B1 (de)
EP (2) EP1672068A1 (de)
JP (1) JP4801258B2 (de)
AT (1) ATE305970T1 (de)
AU (1) AU773368B2 (de)
CA (2) CA2347960C (de)
DE (1) DE69927598T2 (de)
DK (1) DK1123389T3 (de)
GB (1) GB9823071D0 (de)
NO (1) NO323994B1 (de)
WO (1) WO2000023580A1 (de)
ZA (1) ZA200103252B (de)

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SE0200943D0 (sv) 2002-03-25 2002-03-25 Amersham Biosciences Ab Mutant protein
US7709209B2 (en) 2002-03-25 2010-05-04 Ge Healthcare Bio-Sciences Ab Protein ligands
GB0214007D0 (en) * 2002-06-18 2002-07-31 Common Services Agency Removal of prion infectivity
CA2529001A1 (en) * 2003-06-10 2004-12-16 Catchmabs B.V. Binding peptides: methods for their generation and use
SE0301936D0 (sv) * 2003-06-30 2003-06-30 Affibody Ab New polypeptide
EP1641818B1 (de) * 2003-07-04 2008-12-03 Affibody AB Polypeptide mit bindungsaffinität für her2
US8642743B2 (en) 2004-04-06 2014-02-04 Affibody Ab Method for reducing the immune response to a biologically active protein
US8329860B2 (en) 2006-09-29 2012-12-11 Ge Healthcare Bio-Sciences Ab Chromatography ligand comprising domain C from Staphylococcus aureus protein A for antibody isolation
JP5718638B2 (ja) * 2007-07-31 2015-05-13 アフィボディ・アーベー 新規な組成物、方法および使用
GB2452301A (en) 2007-08-30 2009-03-04 Ge Healthcare Bio Sciences Ab Sterilization Method
US8592555B2 (en) * 2008-08-11 2013-11-26 Emd Millipore Corporation Immunoglobulin-binding proteins with improved specificity
JP5626526B2 (ja) * 2008-09-25 2014-11-19 Jsr株式会社 アフィニティークロマトグラフィー用充填剤
JP5229888B2 (ja) * 2008-09-30 2013-07-03 独立行政法人産業技術総合研究所 弱酸性域での易解離性を向上したプロテインａ変異型タンパク質及び抗体捕捉剤
SG162687A1 (en) 2008-12-24 2010-07-29 Millipore Corp Caustic stable chromatography ligands
US9403883B2 (en) 2009-03-24 2016-08-02 Kaneka Corporation Protein having affinity for immunoglobulin, and immunoglobulin-binding affinity ligand
WO2011118699A1 (ja) 2010-03-24 2011-09-29 株式会社カネカ 免疫グロブリンに特異的に結合するタンパク質および免疫グロブリン結合性アフィニティーリガンド
CN103403020A (zh) * 2010-12-21 2013-11-20 Jsr株式会社 蛋白a的新型耐碱变体及其在亲和色谱中的用途
JP5298242B2 (ja) 2010-12-21 2013-09-25 Ｊｓｒ株式会社 アフィニティークロマトグラフィー用担体およびイムノグロブリンを単離する方法
WO2012128353A1 (ja) * 2011-03-24 2012-09-27 株式会社カネカ タンパク性物質結合性低分子化合物
EP2690108B1 (de) 2011-03-25 2018-07-25 Kaneka Corporation Neuartiges immunoglobulinbindendes polypeptid
SG10201604559TA (en) 2011-06-08 2016-07-28 Emd Millipore Corp Chromatography matrices including novel staphylococcus aureus protein a based ligands
WO2014076177A1 (en) * 2012-11-14 2014-05-22 Affibody Ab New polypeptide
WO2014076179A1 (en) 2012-11-14 2014-05-22 Affibody Ab New polypeptide
US9255262B2 (en) * 2013-03-06 2016-02-09 Vision Global Holdings Ltd. Albumin-binding arginine deminase and the use thereof
USRE48805E1 (en) 2013-03-06 2021-11-02 Vision Global Holdings Ltd. Method for cancer targeting treatment and detection of arginine using albumin-binding arginine deiminase fusion protein
DK3041857T3 (da) 2013-09-04 2019-07-22 Emd Millipore Corp Protein a-kromatografi
WO2015046473A1 (ja) 2013-09-27 2015-04-02 株式会社カネカ アルカリ水溶液を用いた多孔質セルロースビーズの製造方法、リガンド固定化用担体および吸着体
KR101891522B1 (ko) 2013-12-12 2018-08-24 이엠디 밀리포어 코포레이션 아크릴아미드 함유 필터를 사용한 단백질 분리
JP6369807B2 (ja) * 2014-10-21 2018-08-08 株式会社プロテイン・エクスプレス プロテインｌ変異体
WO2016121703A1 (ja) 2015-01-26 2016-08-04 株式会社カネカ 変異型免疫グロブリンκ鎖可変領域結合性ペプチド
JPWO2016121701A1 (ja) 2015-01-26 2017-11-09 株式会社カネカ 免疫グロブリンκ鎖可変領域含有タンパク質精製用アフィニティー分離マトリックス
JP6705806B2 (ja) 2015-03-26 2020-06-03 Jsr株式会社 イムノグロブリン結合タンパク質およびそれを用いたアフィニティー担体
JP2018512856A (ja) 2015-04-17 2018-05-24 アルパイン イミューン サイエンシズ インコーポレイテッド 調整可能な親和性を有する免疫調節タンパク質
EP3375873A4 (de) 2015-10-22 2019-05-22 Protenova Co., Ltd. Immunoglobulinbindendes polypeptid
WO2017191748A1 (ja) * 2016-05-02 2017-11-09 株式会社カネカ 改変型免疫グロブリンκ鎖可変領域結合性ペプチド
WO2017195638A1 (ja) 2016-05-09 2017-11-16 株式会社カネカ 抗体またはκ鎖可変領域含有抗体断片の精製方法
WO2018162501A1 (en) 2017-03-07 2018-09-13 Jmva Biotech Ab Modified adsorptive surfaces
CN111148753B (zh) 2017-09-25 2024-02-23 Jsr株式会社 免疫球蛋白结合蛋白质和使用其的亲和载体
EP3842536A4 (de) 2018-08-24 2023-01-18 JSR Corporation Immunglobulin-bindendes protein und affinitätsträger damit
EP4229068A1 (de) 2020-10-13 2023-08-23 Avitide LLC Affinitätsligandbibliotheken von drei helixbündelproteinen und verwendungen davon
EP4269590A1 (de) 2020-12-22 2023-11-01 Protenova Co., Ltd. Immunglobulinbindendes polypeptid
US20240137538A1 (en) 2021-02-19 2024-04-25 Avitide LLC Aav2 affinity agents
GB2609185A (en) 2021-05-24 2023-02-01 Astrea Uk Services Ltd Scaffold for isolation of a biomolecule

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SE8204810L (sv) * 1982-08-23 1984-02-24 Pharmacia Fine Chemicals Ab Hybrid-dna-molekyl, transformerad mikroorganism och sett att framstella protein a
US5401832A (en) * 1984-12-24 1995-03-28 Merck & Co., Inc. Brain derived and recombinant acidic fibroblast growth factor
US5089473A (en) * 1988-08-29 1992-02-18 Monsanto Company Somatotropin variants and their use
WO1993002107A1 (en) * 1991-07-25 1993-02-04 Oriental Yeast Co., Ltd. Immunoglobulin-combining artificial protein
JP2584697B2 (ja) * 1991-08-23 1997-02-26 オリエンタル酵母工業株式会社 ＩｇＧ精製用組換え型プロテインＡ
ATE154526T1 (de) * 1992-04-16 1997-07-15 Merck Patent Gmbh Aktivierte trägermaterialien, ihre herstellung und verwendung
SE9400088D0 (sv) 1994-01-14 1994-01-14 Kabi Pharmacia Ab Bacterial receptor structures
US5736499A (en) * 1995-06-06 1998-04-07 Genencor International, Inc. Mutant A-amylase
SE9503925D0 (sv) * 1995-11-07 1995-11-07 Pharmacia Biotech Ab Separationsmedium för IgG
ES2234099T3 (es) * 1997-03-12 2005-06-16 Smithkline Beecham Corporation Anticuerpos monoclanales humanizados anti-alfa beta 3.

Also Published As

Publication number Publication date
CA2633345C (en) 2013-02-26
US20050100970A1 (en) 2005-05-12
DE69927598D1 (de) 2006-02-16
DK1123389T3 (da) 2006-01-16
GB9823071D0 (en) 1998-12-16
AU6353299A (en) 2000-05-08
CA2347960A1 (en) 2000-04-27
EP1123389A1 (de) 2001-08-16
NO323994B1 (no) 2007-07-30
JP2002527107A (ja) 2002-08-27
EP1672068A1 (de) 2006-06-21
ZA200103252B (en) 2002-07-22
NO20011969L (no) 2001-06-19
US6831161B1 (en) 2004-12-14
CA2347960C (en) 2008-08-05
CA2633345A1 (en) 2000-04-27
NO20011969D0 (no) 2001-04-20
JP4801258B2 (ja) 2011-10-26
EP1123389B1 (de) 2005-10-05
DE69927598T2 (de) 2006-07-13
WO2000023580A1 (en) 2000-04-27
AU773368B2 (en) 2004-05-20

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