ATE289994T1 - Chinolin-derivate - Google Patents

Chinolin-derivate

Info

Publication number
ATE289994T1
ATE289994T1 AT96941023T AT96941023T ATE289994T1 AT E289994 T1 ATE289994 T1 AT E289994T1 AT 96941023 T AT96941023 T AT 96941023T AT 96941023 T AT96941023 T AT 96941023T AT E289994 T1 ATE289994 T1 AT E289994T1
Authority
AT
Austria
Prior art keywords
quinoline derivatives
quinoline
derivatives
Prior art date
Application number
AT96941023T
Other languages
German (de)
English (en)
Inventor
Giuseppe Arnaldo Mari Giardina
Mario Grugni
Luca Francesco Raveglia
Carlo Farino
Original Assignee
Glaxosmithkline Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT95MI002461 external-priority patent/IT1276170B1/it
Priority claimed from IT96MI001689 external-priority patent/IT1307331B1/it
Application filed by Glaxosmithkline Spa filed Critical Glaxosmithkline Spa
Application granted granted Critical
Publication of ATE289994T1 publication Critical patent/ATE289994T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT96941023T 1995-11-24 1996-11-22 Chinolin-derivate ATE289994T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT95MI002461 IT1276170B1 (it) 1995-11-24 1995-11-24 Derivati chinolinici
IT96MI001689 IT1307331B1 (it) 1996-08-02 1996-08-02 Derivati chinolinici
PCT/EP1996/005203 WO1997021680A1 (en) 1995-11-24 1996-11-22 Quinoline derivatives

Publications (1)

Publication Number Publication Date
ATE289994T1 true ATE289994T1 (de) 2005-03-15

Family

ID=26331326

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96941023T ATE289994T1 (de) 1995-11-24 1996-11-22 Chinolin-derivate

Country Status (26)

Country Link
US (1) US6277862B1 (enExample)
EP (1) EP0876347B1 (enExample)
JP (1) JP2000501104A (enExample)
KR (1) KR19990071597A (enExample)
CN (1) CN1207730A (enExample)
AP (1) AP9801237A0 (enExample)
AR (1) AR004972A1 (enExample)
AT (1) ATE289994T1 (enExample)
BG (1) BG102558A (enExample)
BR (1) BR9611820A (enExample)
CA (1) CA2238298A1 (enExample)
CZ (1) CZ157998A3 (enExample)
DE (1) DE69634416T2 (enExample)
EA (1) EA002124B1 (enExample)
ES (1) ES2236757T3 (enExample)
IL (1) IL124522A0 (enExample)
MX (1) MX9804107A (enExample)
NO (1) NO311212B1 (enExample)
NZ (1) NZ323387A (enExample)
OA (1) OA11010A (enExample)
PL (1) PL326967A1 (enExample)
SK (1) SK66798A3 (enExample)
TR (1) TR199800924T2 (enExample)
TW (1) TW353066B (enExample)
UY (1) UY24733A1 (enExample)
WO (1) WO1997021680A1 (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2119155C (en) * 1991-10-18 1999-06-15 Dennis Paul Phillion Fungicides for the control of take-all disease of plants
SE9703407D0 (sv) * 1997-09-19 1997-09-19 Astra Ab New use
SE9802073D0 (sv) 1998-06-11 1998-06-11 Astra Ab New use
GB9825554D0 (en) 1998-11-20 1999-01-13 Smithkline Beecham Spa Novel Compounds
US7037922B1 (en) 2000-03-10 2006-05-02 Neurogen Corporation Aryl fused 2,4-disubstituted pyridines: NK3 receptor ligands
ATE247652T1 (de) 1999-03-29 2003-09-15 Neurogen Corp 4-substituierte chinolinderivate als nk-3 und/oder gaba(a) rezeptor liganden
AU4802500A (en) * 1999-04-26 2000-11-10 Neurogen Corporation 2-aminoquinolinecarboxamides: neurokinin receptor ligands
WO2002083663A1 (en) * 2001-04-11 2002-10-24 Glaxosmithkline S.P.A. Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists
WO2002089802A2 (en) * 2001-05-08 2002-11-14 Schering Corporation Use of neurokinin receptor antagonists to treat androgen-dependent diseases
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
BRPI0407071B8 (pt) 2003-01-28 2021-05-25 Ironwood Pharmaceuticals Inc peptídeo purificado, seu método de produção e composição farmacêutica para o tratamento de distúrbios gastrointestinais
GB0303086D0 (en) * 2003-02-11 2003-03-19 Merck Sharp & Dohme New compounds
GB0419192D0 (en) 2004-08-27 2004-09-29 Merck Sharp & Dohme Therapeutic agents
SG155229A1 (en) * 2004-11-09 2009-09-30 Smithkline Beecham Corp Glycogen phosphorylase inhibitor compounds and pharmaceutical compositions thereof
GB0425077D0 (en) * 2004-11-12 2004-12-15 Smithkline Beecham Corp Novel compounds
GB0515580D0 (en) 2005-07-29 2005-09-07 Merck Sharp & Dohme Therapeutic compounds
CN101282961A (zh) * 2005-08-11 2008-10-08 阿斯利康(瑞典)有限公司 作为nk3受体调节剂的烷基吡啶基喹啉
AR057130A1 (es) 2005-09-21 2007-11-14 Astrazeneca Ab Quinolinas de alquilsulfoxido y una composicion farmaceutica
TW200804288A (en) 2005-12-12 2008-01-16 Astrazeneca Ab Alkylsulphonamide quinolines
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
DK2170930T3 (da) 2007-06-04 2012-11-05 Synergy Pharmaceuticals Inc Agonister af guanylatcyclase, anvendelige til behandlingen af gastrointestinale sygdomme, inflammation, cancer og andre sygdomme
JP2010540553A (ja) * 2007-09-28 2010-12-24 グラクソスミスクライン エルエルシー グリコーゲンホスホリラーゼ阻害剤化合物及びその医薬組成物
JP2010540552A (ja) * 2007-09-28 2010-12-24 グラクソスミスクライン エルエルシー グリコーゲンホスホリラーゼ阻害剤化合物及びその医薬組成物
EP2328910B1 (en) 2008-06-04 2014-08-06 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
ES2657938T3 (es) 2008-12-31 2018-03-07 Ardelyx, Inc. Compuestos y métodos para inhibir el antipuerto mediado por NHE en el tratamiento de trastornos asociados a la retención de líquidos o a la sobrecarga de sales y trastornos del tracto gastrointestinal
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EP2887964B1 (en) 2012-08-21 2019-07-03 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
US10376481B2 (en) 2012-08-21 2019-08-13 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
WO2014169094A2 (en) 2013-04-12 2014-10-16 Ardelyx, Inc Nhe3-binding compounds and methods for inhibiting phosphate transport
WO2014170648A1 (en) 2013-04-19 2014-10-23 Astrazeneca Ab A nk3 receptor antagonist compound (nk3ra) for use in a method for the treatment of polycystic ovary syndrome (pcos)
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
WO2017072629A1 (en) 2015-10-29 2017-05-04 Cadila Healthcare Limited Pharmaceutical combination of nk3 receptor antagonist and biguanides
KR20240090875A (ko) 2017-01-09 2024-06-21 알데릭스, 인코포레이티드 위장관 장애를 치료하는 데 유용한 화합물
WO2018129557A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Inhibitors of nhe-mediated antiport

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2538388B1 (fr) * 1982-12-24 1985-06-21 Pharmuka Lab Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments
JPS6399057A (ja) * 1986-06-27 1988-04-30 Nippon Shinyaku Co Ltd グリシン誘導体
PL186665B1 (pl) * 1994-05-27 2004-02-27 Smithkline Beecham Spa Pochodne chinoliny jako antagoniści receptorów NKtachykininy, sposób ich wytwarzania, kompozycja farmaceutyczna zawierająca pochodne chinoliny oraz ich zastosowanie
IT1270615B (it) * 1994-07-14 1997-05-07 Smithkline Beecham Farma Uso di derivati di chinolina

Also Published As

Publication number Publication date
EA002124B1 (ru) 2001-12-24
PL326967A1 (en) 1998-11-09
DE69634416T2 (de) 2005-12-29
UY24733A1 (es) 2001-08-27
EA199800477A1 (ru) 1998-12-24
KR19990071597A (ko) 1999-09-27
CA2238298A1 (en) 1997-06-19
IL124522A0 (en) 1998-12-06
NO982331D0 (no) 1998-05-22
DE69634416D1 (de) 2005-04-07
NO311212B1 (no) 2001-10-29
WO1997021680A1 (en) 1997-06-19
OA11010A (en) 2003-03-06
ES2236757T3 (es) 2005-07-16
US6277862B1 (en) 2001-08-21
CN1207730A (zh) 1999-02-10
JP2000501104A (ja) 2000-02-02
EP0876347A1 (en) 1998-11-11
AP9801237A0 (en) 1998-06-30
MX9804107A (es) 1998-09-30
BG102558A (bg) 1999-03-31
BR9611820A (pt) 1999-07-13
NZ323387A (en) 2000-02-28
SK66798A3 (en) 1999-01-11
AR004972A1 (es) 1999-04-07
EP0876347B1 (en) 2005-03-02
TR199800924T2 (xx) 1998-08-21
CZ157998A3 (cs) 1998-12-16
NO982331L (no) 1998-07-22
TW353066B (en) 1999-02-21

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Legal Events

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