ATE288424T1 - Diaminothiazole und ihre verwendung zur inhibierung von proteinkinasen - Google Patents

Diaminothiazole und ihre verwendung zur inhibierung von proteinkinasen

Info

Publication number
ATE288424T1
ATE288424T1 AT00942660T AT00942660T ATE288424T1 AT E288424 T1 ATE288424 T1 AT E288424T1 AT 00942660 T AT00942660 T AT 00942660T AT 00942660 T AT00942660 T AT 00942660T AT E288424 T1 ATE288424 T1 AT E288424T1
Authority
AT
Austria
Prior art keywords
diaminothiazoles
protein kinases
inhibiting protein
inhibiting
kinases
Prior art date
Application number
AT00942660T
Other languages
German (de)
English (en)
Inventor
Shao Song Chu
Larry Andrew Alegria
Steven Lee Bender
Suzanne Pritchett Benedict
Allen J Borchardt
Robert Steven Kania
Mitchell David Nambu
Anna Maria Tempczyk-Russell
Sepehr Sarshar
Dilip Bhumralkar
Peng Zhengwei
Yi Michelle Yang
Original Assignee
Agouron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharma filed Critical Agouron Pharma
Application granted granted Critical
Publication of ATE288424T1 publication Critical patent/ATE288424T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT00942660T 1999-06-04 2000-06-02 Diaminothiazole und ihre verwendung zur inhibierung von proteinkinasen ATE288424T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13781099P 1999-06-04 1999-06-04
PCT/US2000/015188 WO2000075120A1 (en) 1999-06-04 2000-06-02 Diaminothiazoles and their use for inhibiting protein kinases

Publications (1)

Publication Number Publication Date
ATE288424T1 true ATE288424T1 (de) 2005-02-15

Family

ID=22479135

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00942660T ATE288424T1 (de) 1999-06-04 2000-06-02 Diaminothiazole und ihre verwendung zur inhibierung von proteinkinasen

Country Status (34)

Country Link
US (1) US6620828B2 (enExample)
EP (1) EP1181283B1 (enExample)
JP (1) JP2003501420A (enExample)
KR (1) KR20020015333A (enExample)
CN (1) CN1359380A (enExample)
AP (1) AP2001002341A0 (enExample)
AT (1) ATE288424T1 (enExample)
AU (1) AU778071B2 (enExample)
BG (1) BG106276A (enExample)
BR (1) BR0011585A (enExample)
CA (1) CA2371158A1 (enExample)
CZ (1) CZ20014213A3 (enExample)
DE (1) DE60017894T2 (enExample)
EA (1) EA200101268A1 (enExample)
EE (1) EE200100659A (enExample)
ES (1) ES2234628T3 (enExample)
HR (1) HRP20020008A2 (enExample)
HU (1) HUP0202897A3 (enExample)
IL (1) IL146094A0 (enExample)
IS (1) IS6183A (enExample)
MA (1) MA25530A1 (enExample)
MX (1) MXPA01012483A (enExample)
NO (1) NO20015045L (enExample)
NZ (1) NZ514881A (enExample)
OA (1) OA11959A (enExample)
PE (1) PE20010211A1 (enExample)
PL (1) PL352714A1 (enExample)
SK (1) SK17302001A3 (enExample)
SV (1) SV2002000096A (enExample)
UA (1) UA71971C2 (enExample)
UY (1) UY26190A1 (enExample)
WO (1) WO2000075120A1 (enExample)
YU (1) YU85601A (enExample)
ZA (1) ZA200108291B (enExample)

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MXPA01012483A (es) 2002-07-30
JP2003501420A (ja) 2003-01-14
CA2371158A1 (en) 2000-12-14
PL352714A1 (en) 2003-09-08
NO20015045L (no) 2002-02-04
EA200101268A1 (ru) 2002-06-27
HUP0202897A2 (hu) 2002-12-28
HUP0202897A3 (en) 2004-12-28
EE200100659A (et) 2003-02-17
EP1181283A1 (en) 2002-02-27
IS6183A (is) 2001-11-29
MA25530A1 (fr) 2002-10-01
IL146094A0 (en) 2002-07-25
KR20020015333A (ko) 2002-02-27
SK17302001A3 (sk) 2004-01-08
BR0011585A (pt) 2002-03-19
UA71971C2 (en) 2005-01-17
YU85601A (sh) 2004-09-03
WO2000075120A1 (en) 2000-12-14
DE60017894T2 (de) 2005-12-29
ES2234628T3 (es) 2005-07-01
EP1181283B1 (en) 2005-02-02
US6620828B2 (en) 2003-09-16
BG106276A (bg) 2002-10-31
UY26190A1 (es) 2000-12-29
SV2002000096A (es) 2002-06-07
NZ514881A (en) 2003-10-31
AU5725400A (en) 2000-12-28
US20020025976A1 (en) 2002-02-28
NO20015045D0 (no) 2001-10-17
DE60017894D1 (de) 2005-03-10
AP2001002341A0 (en) 2001-12-31
AU778071B2 (en) 2004-11-11
PE20010211A1 (es) 2001-03-16
ZA200108291B (en) 2002-12-24
CZ20014213A3 (cs) 2002-04-17
HRP20020008A2 (en) 2004-02-29
CN1359380A (zh) 2002-07-17
OA11959A (en) 2006-04-17

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