DE69826693D1 - Amidinoderivate und ihre verwendung als thrombininhibitoren - Google Patents

Amidinoderivate und ihre verwendung als thrombininhibitoren

Info

Publication number
DE69826693D1
DE69826693D1 DE69826693T DE69826693T DE69826693D1 DE 69826693 D1 DE69826693 D1 DE 69826693D1 DE 69826693 T DE69826693 T DE 69826693T DE 69826693 T DE69826693 T DE 69826693T DE 69826693 D1 DE69826693 D1 DE 69826693D1
Authority
DE
Germany
Prior art keywords
amidine derivatives
thrombine
inhibitors
thrombine inhibitors
amidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69826693T
Other languages
English (en)
Other versions
DE69826693T2 (de
Inventor
Olle Karlsson
Marcel Linschoten
Jan-Erik Nystroem
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9702378A external-priority patent/SE9702378D0/xx
Priority claimed from SE9801099A external-priority patent/SE9801099D0/xx
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of DE69826693D1 publication Critical patent/DE69826693D1/de
Application granted granted Critical
Publication of DE69826693T2 publication Critical patent/DE69826693T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
DE69826693T 1997-06-19 1998-06-09 Amidinoderivate und ihre verwendung als thrombininhibitoren Expired - Fee Related DE69826693T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE9702378 1997-06-19
SE9702378A SE9702378D0 (sv) 1997-06-19 1997-06-19 New compounds
SE9801099 1998-03-30
SE9801099A SE9801099D0 (sv) 1998-03-30 1998-03-30 New compounds
PCT/SE1998/001103 WO1998057932A1 (en) 1997-06-19 1998-06-09 New amidino derivatives and their use as thrombin inhibitors

Publications (2)

Publication Number Publication Date
DE69826693D1 true DE69826693D1 (de) 2004-11-04
DE69826693T2 DE69826693T2 (de) 2006-02-16

Family

ID=26663014

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69826693T Expired - Fee Related DE69826693T2 (de) 1997-06-19 1998-06-09 Amidinoderivate und ihre verwendung als thrombininhibitoren

Country Status (20)

Country Link
US (2) US6265397B1 (de)
EP (1) EP1012140B1 (de)
JP (2) JP3919236B2 (de)
KR (1) KR100540413B1 (de)
CN (1) CN1205187C (de)
AR (1) AR013084A1 (de)
AT (1) ATE277902T1 (de)
AU (1) AU737645C (de)
BR (1) BR9810177A (de)
CA (1) CA2294059C (de)
DE (1) DE69826693T2 (de)
EE (1) EE9900600A (de)
IL (1) IL133490A0 (de)
IS (1) IS5302A (de)
NO (1) NO315156B1 (de)
NZ (1) NZ501635A (de)
PL (1) PL337645A1 (de)
SK (1) SK167099A3 (de)
TR (1) TR199903134T2 (de)
WO (1) WO1998057932A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR013084A1 (es) * 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
SE9704543D0 (sv) 1997-12-05 1997-12-05 Astra Ab New compounds
SE9804313D0 (sv) * 1998-12-14 1998-12-14 Astra Ab New compounds
EP1150996B1 (de) 1999-01-13 2007-11-21 AstraZeneca AB Neue amidinbenzylamin-derivate und ihre verwendung als thrombin-inhibitoren
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
EP1059302A1 (de) * 1999-06-08 2000-12-13 Aventis Pharma Deutschland GmbH Faktor VIIa Inhibitore
SE0000382D0 (sv) 2000-02-07 2000-02-07 Astrazeneca Ab New process
US6403818B1 (en) 2000-02-28 2002-06-11 Eisai Co., Ltd. Process for producing α-hydroxy-carbonyl compound
SE0001803D0 (sv) 2000-05-16 2000-05-16 Astrazeneca Ab New compounds i
US6433186B1 (en) 2000-08-16 2002-08-13 Astrazeneca Ab Amidino derivatives and their use as thormbin inhibitors
US7129233B2 (en) * 2000-12-01 2006-10-31 Astrazeneca Ab Mandelic acid derivatives and their use as thrombin inhibitors
AR035216A1 (es) * 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
WO2002088298A1 (en) 2001-04-27 2002-11-07 The Procter & Gamble Company Compounds, compositions, and methods for controlling biofilms
AR034517A1 (es) * 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
SE0201661D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab New salts
SE0201659D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
US7723349B2 (en) 2003-04-24 2010-05-25 Incyte Corporation Aza spiro alkane derivatives as inhibitors of metalloproteases
US7781424B2 (en) * 2003-05-27 2010-08-24 Astrazeneca Ab Modified release pharmaceutical formulation
DE602004008959T2 (de) * 2003-11-07 2008-06-19 F. Hoffmann-La Roche Ag Benzoäbüä1,4üdioxepinderivate
US7524354B2 (en) * 2005-07-07 2009-04-28 Research Foundation Of State University Of New York Controlled synthesis of highly monodispersed gold nanoparticles
UA95788C2 (en) 2005-12-15 2011-09-12 Ф. Хоффманн-Ля Рош Аг Fused pyrrole derivatives
TW200827336A (en) * 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
US20090061000A1 (en) * 2007-08-31 2009-03-05 Astrazeneca Ab Pharmaceutical formulation use 030
DE102008007440A1 (de) * 2008-02-01 2009-08-13 Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co.Kg Aminosäurederivate als Arzneistoffe
JP2011525487A (ja) * 2008-06-23 2011-09-22 アストラゼネカ アクチボラグ トロンビン阻害剤としての使用のための新規複素環式カルボキサミド
CN104327029A (zh) * 2014-09-21 2015-02-04 湖南华腾制药有限公司 一种含氧杂环化合物的制备方法

Family Cites Families (44)

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Publication number Priority date Publication date Assignee Title
HU178398B (en) 1979-06-12 1982-04-28 Gyogyszerkutato Intezet Process for producing new agmatine derivatives of activity against haemagglutination
HU192646B (en) 1984-12-21 1987-06-29 Gyogyszerkutato Intezet Process for preparing new n-alkyl-peptide aldehydes
CA1341029C (en) 1985-02-04 2000-06-20 Michael Kolb Peptidase inhibitors
US5187157A (en) 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
EP0362002B1 (de) 1988-09-01 1995-07-26 Merrell Dow Pharmaceuticals Inc. HIV Protease-Hemmer
ZA897515B (en) 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
TW201303B (de) 1990-07-05 1993-03-01 Hoffmann La Roche
CA2075154A1 (en) 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
SE9102462D0 (sv) 1991-08-28 1991-08-28 Astra Ab New isosteric peptides
ZA928581B (en) 1991-11-12 1994-05-06 Lilly Co Eli Antithrombotic agents
SE9103612D0 (sv) 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
JPH08501057A (ja) * 1992-03-04 1996-02-06 ヂョヂセルクタトー インテーゼット カーエフテー 新規な抗凝結因子ペプチド誘導体及びそれを含有する製薬学的組成物及びその製造方法
TW223629B (de) 1992-03-06 1994-05-11 Hoffmann La Roche
AU675981B2 (en) 1992-12-02 1997-02-27 Bristol-Myers Squibb Company Guanidinyl-substituted heterocyclic thrombin inhibitors
US5583146A (en) 1992-12-02 1996-12-10 Bristol-Myers Squibb Company Heterocyclic thrombin inhibitors
JPH06340619A (ja) 1993-05-03 1994-12-13 Bristol Myers Squibb Co グアニジニルまたはアミジニル置換メチルアミノ複素環トロンビン抑制剤
US5783563A (en) 1993-06-03 1998-07-21 Astra Aktiebolag Method for treatment or prophylaxis of venous thrombosis
SE9301916D0 (sv) 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
EP0648780A1 (de) 1993-08-26 1995-04-19 Bristol-Myers Squibb Company Heterozyklische Thrombinhemmer
TW394760B (en) 1993-09-07 2000-06-21 Hoffmann La Roche Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same
AU1025795A (en) 1994-01-27 1995-08-03 Mitsubishi Chemical Corporation Prolineamide derivatives
US5705487A (en) 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5707966A (en) 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
US5726159A (en) 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
IL112795A (en) 1994-03-04 2001-01-28 Astrazeneca Ab Derivatives of peptides as antithrombotic drugs, their preparation, and pharmaceutical preparations containing them
US5561146A (en) 1994-06-10 1996-10-01 Bristol-Myers Squibb Company Modified guanidino and amidino thrombin inhibitors
DE4421052A1 (de) 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
US5510369A (en) 1994-07-22 1996-04-23 Merck & Co., Inc. Pyrrolidine thrombin inhibitors
DE4443390A1 (de) 1994-12-06 1996-06-13 Basf Ag Neue dipeptidische p-Amidinobenzylamide mit N-terminalen Sulfonyl- bzw. Aminosulfonylresten
CN1173872A (zh) 1995-02-10 1998-02-18 巴斯福股份公司 凝血酶抑制剂
NZ302649A (en) 1995-02-17 2000-01-28 Basf Ag Dipeptide amidine derivatives, preparation and pharmaceutical compositions thereof
US5710130A (en) 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
US5914319A (en) 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
EP0820453A4 (de) 1995-04-04 2001-08-29 Merck & Co Inc Thrombin-inhibitoren
US5629324A (en) 1995-04-10 1997-05-13 Merck & Co., Inc. Thrombin inhibitors
SA96170106A (ar) 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
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AU1990197A (en) 1996-03-12 1997-10-01 Bristol-Myers Squibb Company Carbamyl guanidine and amidine prodrugs
JPH1095898A (ja) 1996-09-25 1998-04-14 Sumitomo Bakelite Co Ltd 難燃性樹脂組成物およびこれを用いた積層板
SE9602263D0 (sv) 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
DE19632772A1 (de) 1996-08-14 1998-02-19 Basf Ag Neue Benzamidine
DE19632773A1 (de) 1996-08-14 1998-02-19 Basf Ag Neue Thrombininhibitoren
AR013084A1 (es) * 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados

Also Published As

Publication number Publication date
JP2006321807A (ja) 2006-11-30
AR013084A1 (es) 2000-12-13
IS5302A (is) 1999-12-15
US6576657B2 (en) 2003-06-10
EP1012140B1 (de) 2004-09-29
IL133490A0 (en) 2001-04-30
CA2294059C (en) 2008-12-09
CN1205187C (zh) 2005-06-08
EE9900600A (et) 2000-08-15
JP2002503256A (ja) 2002-01-29
US20020022612A1 (en) 2002-02-21
AU737645B2 (en) 2001-08-23
BR9810177A (pt) 2000-08-08
NO315156B1 (no) 2003-07-21
WO1998057932A1 (en) 1998-12-23
KR20010013982A (ko) 2001-02-26
AU7946198A (en) 1999-01-04
SK167099A3 (en) 2000-06-12
US6265397B1 (en) 2001-07-24
TR199903134T2 (xx) 2000-07-21
EP1012140A1 (de) 2000-06-28
DE69826693T2 (de) 2006-02-16
NO996313L (no) 2000-02-21
AU737645C (en) 2002-03-21
KR100540413B1 (ko) 2006-01-12
PL337645A1 (en) 2000-08-28
CA2294059A1 (en) 1998-12-23
NZ501635A (en) 2001-09-28
NO996313D0 (no) 1999-12-17
CN1266427A (zh) 2000-09-13
ATE277902T1 (de) 2004-10-15
JP3919236B2 (ja) 2007-05-23

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee