ATE277023T1 - Indanderivate und ihre verwendung als zelladhäsionsinihibitoren - Google Patents

Indanderivate und ihre verwendung als zelladhäsionsinihibitoren

Info

Publication number
ATE277023T1
ATE277023T1 AT01907923T AT01907923T ATE277023T1 AT E277023 T1 ATE277023 T1 AT E277023T1 AT 01907923 T AT01907923 T AT 01907923T AT 01907923 T AT01907923 T AT 01907923T AT E277023 T1 ATE277023 T1 AT E277023T1
Authority
AT
Austria
Prior art keywords
indanderivates
cell adhesion
adhesion inhibitors
inhibitors
cell
Prior art date
Application number
AT01907923T
Other languages
English (en)
Inventor
Garry Fenton
Clive Mccarthy
Robert Edward Mackenzie
Andrew David Morley
Original Assignee
Aventis Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Ltd filed Critical Aventis Pharma Ltd
Application granted granted Critical
Publication of ATE277023T1 publication Critical patent/ATE277023T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
AT01907923T 2000-02-28 2001-02-28 Indanderivate und ihre verwendung als zelladhäsionsinihibitoren ATE277023T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0004686.2A GB0004686D0 (en) 2000-02-28 2000-02-28 Chemical compounds
PCT/GB2001/000844 WO2001064659A2 (en) 2000-02-28 2001-02-28 Indane derivatives and their use as cell adhesion inhibitors

Publications (1)

Publication Number Publication Date
ATE277023T1 true ATE277023T1 (de) 2004-10-15

Family

ID=9886551

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01907923T ATE277023T1 (de) 2000-02-28 2001-02-28 Indanderivate und ihre verwendung als zelladhäsionsinihibitoren

Country Status (13)

Country Link
US (1) US6762199B2 (de)
EP (1) EP1259495B1 (de)
JP (1) JP5021133B2 (de)
AR (1) AR027578A1 (de)
AT (1) ATE277023T1 (de)
AU (1) AU3579001A (de)
CA (1) CA2401441C (de)
DE (1) DE60105771T2 (de)
ES (1) ES2227137T3 (de)
GB (1) GB0004686D0 (de)
IL (1) IL150724A0 (de)
MX (1) MXPA02008375A (de)
WO (1) WO2001064659A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2430978C (en) 2000-12-28 2012-05-15 Daiichi Pharmaceutical Co., Ltd. Vla-4 inhibitors
GB0123765D0 (en) * 2001-10-03 2001-11-21 Bayer Ag Para-amino benzoic acids
US8005919B2 (en) 2002-11-18 2011-08-23 Aol Inc. Host-based intelligent results related to a character stream
AU2003287671A1 (en) 2002-11-18 2004-06-15 America Online, Inc. People lists
TWI340134B (en) 2003-07-24 2011-04-11 Daiichi Seiyaku Co Cyclohexanecarboxylic acids
JP2006056830A (ja) * 2004-08-20 2006-03-02 Dai Ichi Seiyaku Co Ltd ２−アリールアミノベンゾオキサゾール誘導体
WO2012074980A2 (en) * 2010-12-01 2012-06-07 Dara Biosciences, Inc. Methods of treating or preventing autoimmune disorders and liver disorders using indane acetic acid derivatives
JP2023525047A (ja) 2020-05-06 2023-06-14 エイジャックス セラピューティクス， インコーポレイテッド Ｊａｋ２阻害薬としての６－ヘテロアリールオキシベンゾイミダゾール及びアザベンゾイミダゾール
WO2023086319A1 (en) 2021-11-09 2023-05-19 Ajax Therapeutics, Inc. 6-he tero aryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors

Family Cites Families (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2041594A5 (de) * 1969-04-30 1971-01-29 Expanscience
US4331692A (en) * 1971-07-23 1982-05-25 Ulla Drevici Cocoa fruits and products
GB1541463A (en) * 1975-10-11 1979-02-28 Lion Dentifrice Co Ltd Process for prparing a multiple emulsion having a dispersing form of water-phase/oil-phase/water-phase
US4151304A (en) * 1976-11-05 1979-04-24 Lever Brothers Company Method and composition for moisturizing the skin
FR2380775A1 (fr) * 1977-02-22 1978-09-15 Sederma Sarl Composition " apres-epilation " favorisant un ralentissement progressif de la repousse des poils
US4190671A (en) * 1977-03-17 1980-02-26 Biorex Laboratories Limited Chalcone derivatives
US4279930A (en) * 1978-10-10 1981-07-21 The Upjohn Company Process for treating inflammation
DE3040246C2 (de) * 1979-10-29 1985-01-10 Osaka Chemical Laboratory Co., Ltd., Osaka Sojasaponine A↓1↓ und A↓2↓ und ihre Verwendung
JPS56135416A (en) * 1980-03-27 1981-10-22 Mitsubishi Chem Ind Ltd Pharmaceutical preparation for skin
US4278570A (en) * 1980-08-20 1981-07-14 Eli Lilly And Company Cosmetic cleanser formulation
US4272544A (en) * 1980-08-20 1981-06-09 Eli Lilly And Company Skin cell renewal regime
DE3109420A1 (de) * 1981-03-12 1982-09-23 Kastell, Wolfgang, 2000 Hamburg Mittel zum anhalten des haarausfalls und zum foerdern des haarwuchses
FR2509988B1 (fr) * 1981-07-23 1986-05-30 Oreal Melange d'huiles vegetales a base d'huile de jojoba comme agent de stabilisation a l'oxydation et compositions cosmetiques le contenant
DE3129867A1 (de) * 1981-07-29 1983-02-17 Henkel Kgaa "ungesaettigte arylketone als antiseborrhoische zusaetze fuer kosmetische mittel"
US4382960A (en) * 1981-08-03 1983-05-10 Eli Lilly And Company Cosmetic cleanser formulation
US4368187A (en) * 1981-08-03 1983-01-11 Eli Lilly And Company Sensitive-skin care regime
US4578267A (en) * 1981-09-15 1986-03-25 Morton Thiokol, Inc. Skin conditioning polymer containing alkoxylated nitrogen salts of sulfonic acid
US4462981A (en) * 1982-12-10 1984-07-31 Creative Products Resource, Associates Ltd. Cosmetic applicator useful for skin moisturizing and deodorizing
US5192332A (en) * 1983-10-14 1993-03-09 L'oreal Cosmetic temporary coloring compositions containing protein derivatives
JPS60109544A (ja) * 1983-11-17 1985-06-15 Kao Corp 新規カルコン誘導体及びこれを含有する紫外線吸収剤
FR2580478B1 (fr) * 1985-04-17 1989-05-12 Christian Chapoton Dispositif de traitement capillaire liberant une substance active et procede de fabrication
US4760096A (en) * 1985-09-27 1988-07-26 Schering Corporation Moisturizing skin preparation
US4847267A (en) * 1986-03-17 1989-07-11 Charles Of The Ritz Group Ltd. Skin treatment composition and method
IT1203515B (it) * 1987-02-26 1989-02-15 Indena Spa Complessi di saponine con fosfolipidi e composizioni farmaceutiche e cosmetiche che li contengono
US4824662A (en) * 1987-06-15 1989-04-25 Vi-Jon Laboratories, Inc. Nail polish remover
IT1222012B (it) * 1987-07-10 1990-08-31 Indena Spa Composizioni farmaceutiche e cosmetiche contenenti complessi di flavonolignani con fosfolipidi
IT1223290B (it) * 1987-07-27 1990-09-19 Indena Spa Acidi poliinsaturi ad azione vasocinetica e relative formulazioni farmaceutiche e cosmetiche
LU86997A1 (fr) * 1987-09-21 1989-04-06 Oreal Composition cosmetique filtrante photostable contenant de la bixine associee a un filtre uv liposoluble et son utilisation pour la protection de l'epiderme humain contre les radiations ultraviolettes
EP0317667B1 (de) * 1987-11-24 1993-02-17 Agfa-Gevaert N.V. Magnetische Trägerteilchen
CH676470A5 (de) * 1988-02-03 1991-01-31 Nestle Sa
DE3814839A1 (de) * 1988-05-02 1989-11-16 Henkel Kgaa Haarbehandlungsmittel mit natuerlichen inhaltsstoffen
US4906457A (en) * 1988-09-06 1990-03-06 Washington State University Research Foundation, Inc. Compositions and methods for reducing the risk of sunlight and ultraviolet induced skin cancer
US4851214A (en) * 1988-09-07 1989-07-25 Ici Americas Inc. Deodorants containing N-soya-N-ethyl morpholinium ethosulfate
US4943462A (en) * 1989-01-17 1990-07-24 Semex Medical, Inc. Nail treatment device
US5116605A (en) * 1989-03-09 1992-05-26 Alt John P Composition and skin treatment method therewith for mitigating acne and male-pattern baldness
US5194252A (en) * 1989-07-27 1993-03-16 Vijon Laboratories, Inc. Moisture retaining aftershave
US5032400A (en) * 1989-11-02 1991-07-16 Erie Laboratories Shark liver oil and garlic oil topical analgesic
US5622690A (en) * 1990-04-05 1997-04-22 Nurture, Inc. Seed-derived proteinaceous compositions for reduction of sunburn cell formation
FR2663633B1 (fr) * 1990-06-22 1994-06-17 Adir Nouvelles chalcones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5231090A (en) * 1990-07-30 1993-07-27 University Of Miami Treatment for hypercholesterolemia
US5407675A (en) * 1990-08-10 1995-04-18 Etemad-Moghadam; Parviz Method and composition for use on the scalp and eyebrow region of a subject
CA2049728A1 (en) * 1990-08-24 1992-02-25 Kenji Kitamura Washing composition capable of preventing and ameliorating skin irritation
US5217717A (en) * 1990-09-06 1993-06-08 Central Soya Company, Inc. Method of making soybean Bowman-Birk inhibitor concentrate and use of same as a human cancer preventative and therapy
DE69107056D1 (de) * 1990-11-14 1995-03-09 Oreal Amphiphile, nichtionische derivate des glycerins sowie die entsprechenden zwischenprodukte, verfahren zu ihrer herstellung und diese enthaltende zusammensetzungen.
US5110603A (en) * 1991-01-31 1992-05-05 Kao Corporation Bathing preparation for colloidal material
US5188823A (en) * 1991-02-07 1993-02-23 Stepan Company Antiperspirant formulations
US5498420A (en) * 1991-04-12 1996-03-12 Merz & Co. Gmbh & Co. Stable small particle liposome preparations, their production and use in topical cosmetic, and pharmaceutical compositions
US5229104A (en) * 1991-04-29 1993-07-20 Richardson-Vicks Inc. Artificial tanning compositions containing positively charged paucilamellar vesicles
EP0514576A1 (de) * 1991-05-24 1992-11-25 Societe Des Produits Nestle S.A. Öllösliche Antioxydationsmischung
US5310734A (en) * 1991-07-05 1994-05-10 Rhone-Poulenc Rorer Phospholipid composition
EP0532465B1 (de) * 1991-09-13 2002-07-10 Pentapharm A.G. Proteinfraktion zur kosmetischen und dermatologischen Pflege der Haut
EP0958810B1 (de) * 1991-11-25 2003-05-02 Richardson-Vicks Inc. VERWENDUNG VON SALICYLSÄURE ZUR KONTROLLE von Hautfalten und/oder HAUTATROPHIE
CA2122923C (en) * 1991-11-25 1999-01-19 Roy L. Blank Compositions for regulating skin wrinkles and/or skin atrophy
FR2687314A1 (fr) * 1992-02-18 1993-08-20 Oreal Dispersion de vesicules lipidiques, composition cosmetique et/ou pharmaceutique la contenant et procede de preparation de ladite dispersion.
US5766628A (en) * 1992-02-24 1998-06-16 Merz + Co. Gmbh & Co. Bath and shower composition having vesicle-forming properties and method for the production and use thereof
US5393519A (en) * 1992-03-27 1995-02-28 Helene Curtis, Inc. Shampoo compositions
DE4226173A1 (de) * 1992-08-07 1994-02-10 Solvay Fluor & Derivate Badezusatzpräparat
FR2694934B1 (fr) * 1992-08-24 1994-11-10 Oreal Composition pour le traitement de l'acné contenant un dérivé d'acide salicylique et dérivés d'acide salicylique.
US6048520A (en) * 1992-09-24 2000-04-11 Helene Curtis, Inc. Clear leave-on hair treatment composition and method
US5753612A (en) * 1992-10-27 1998-05-19 Yissum Research Development Co. Of The Hebrew University Of Jerusalem Pharmaceutical composition and method for inhibiting hair growth by administration of activin or activin agonists
CA2119064A1 (en) * 1993-03-17 1994-09-18 Richard A. Berg Dermal-epidermal in vitro test system
US5276058A (en) * 1993-06-09 1994-01-04 Nippon Hypox Laboratories Incorporated 3,4-dihydroxychalcone derivatives
FR2710264B1 (fr) * 1993-09-21 1995-12-08 Rocher Yves Biolog Vegetale Utilisation pour le traitement des peaux mixtes d'une quantité efficace de substances actives.
DE4343431C1 (de) * 1993-12-18 1995-05-04 Henkel Kgaa Kosmetische und/oder pharamzeutische Zubereitungen
FR2714596B1 (fr) * 1993-12-30 1996-02-09 Oreal Composition cosmétique pour le traitement simultané des couches superficielles et profondes de la peau, son utilisation.
US6013255A (en) * 1994-04-18 2000-01-11 Gist-Brocades B.V. Stable water-in-oil emulsions
GB9414045D0 (en) * 1994-07-12 1994-08-31 Berwind Pharma Service Moisture barrier film coating composition, method, and coated form
DE4444238A1 (de) * 1994-12-13 1996-06-20 Beiersdorf Ag Kosmetische oder dermatologische Wirkstoffkombinationen aus Zimtsäurederivaten und Flavonglycosiden
US5523308A (en) * 1995-06-07 1996-06-04 Costanzo; Michael J. Peptidyl heterocycles useful in the treatment of thrombin related disorders
US5639785A (en) * 1995-06-07 1997-06-17 Global Pharma, Ltd. Methods for the treatment of baldness and gray hair using isoflavonoid derivatives
US6013250A (en) * 1995-06-28 2000-01-11 L'oreal S. A. Composition for treating hair against chemical and photo damage
US6063398A (en) * 1995-09-20 2000-05-16 L'oreal Cosmetic or dermopharmaceutical patch containing, in an anhydrous polymeric matrix, at least one active compound which is, in particular, unstable in oxidizing mediums, and at least one water-absorbing agent
US5885593A (en) * 1995-09-28 1999-03-23 The Andrew Jergens Company Skin care composition including cyclodextrin materials and method for treating skin therewith
US6019962A (en) * 1995-11-07 2000-02-01 The Procter & Gamble Co. Compositions and methods for improving cosmetic products
US5880314A (en) * 1995-11-24 1999-03-09 Mitsui Chemicals, Inc. Hydrochalcone derivatives, cosmetic compositions containing said derivatives and methods of producing the same
US5643587A (en) * 1996-02-15 1997-07-01 Avon Products, Inc. Composition and method for under-eye skin lightening
FR2747568B1 (fr) * 1996-04-17 1999-09-17 Oreal Utilisation d'au moins un inhibiteur de lipoxygenase et d'au moins un inhibiteur de cyclo-oxygenase pour modifier la pousse des poils et/ou des cheveux
IL119535A (en) * 1996-10-31 2001-01-11 Chajuss Daniel Soy molasses and modified soy molasses for topical application
FR2757767B1 (fr) * 1996-12-27 1999-02-05 Oreal Composition topique contenant au moins une proteine d'origine vegetale et/ou une proteine d'origine animale et une poly(acide 2-acrylamido 2-methylpropane sulfonique) reticule
US5863546A (en) * 1997-03-02 1999-01-26 Swinehart; James M Cosmetic composition
US5885600A (en) * 1997-04-01 1999-03-23 Burlington Bio-Medical & Scientific Corp. Natural insect repellent formula and method of making same
US5885596A (en) * 1997-07-23 1999-03-23 Bristol-Myers Squibb Company Methods and compositions for fine lines and/or wrinkles
US6017893A (en) * 1997-08-29 2000-01-25 Natures Sunshine Products, Inc. Use of isoflavones to prevent hair loss and preserve the integrity of existing hair
US5928658A (en) * 1997-12-05 1999-07-27 U.S. Cosmetics Oil-free wax-free solid cosmetic composition
FR2772613B1 (fr) * 1997-12-19 2003-05-09 Oreal Utilisation du phloroglucinol dans une composition cosmetique
US6030931A (en) * 1998-02-03 2000-02-29 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Foaming cleansing skin product
US5928889A (en) * 1998-02-13 1999-07-27 S.C. Johnson & Son, Inc. Protocol for simulated natural biofilm formation
EP1063966A1 (de) * 1998-03-16 2001-01-03 The Procter & Gamble Company Zusammensetzung für die regelung des hautaussehens
CO5090829A1 (es) * 1998-07-21 2001-10-30 Novartis Ag Compuestos organicos de la formula i, utiles como inhibido res de la proteina de transferencia de triglicerido microso mal y de la secrecion de la apolipoproteina b.
GB9916374D0 (en) * 1998-07-23 1999-09-15 Zeneca Ltd Chemical compounds
AU5052199A (en) * 1998-07-23 2000-02-14 Astrazeneca Ab Chemical compounds
EP1153017B1 (de) * 1999-02-16 2006-05-03 Aventis Pharma Limited Bicyclische verbindungen und ihre verwendung als integrinrezeptorliganden
CA2372840C (en) * 1999-05-05 2008-07-22 Aventis Pharma Limited Substituted bicyclic compounds

Also Published As

Publication number Publication date
JP2003525281A (ja) 2003-08-26
IL150724A0 (en) 2003-02-12
CA2401441C (en) 2011-11-15
AR027578A1 (es) 2003-04-02
EP1259495B1 (de) 2004-09-22
CA2401441A1 (en) 2001-09-07
WO2001064659A2 (en) 2001-09-07
MXPA02008375A (es) 2002-12-13
JP5021133B2 (ja) 2012-09-05
US6762199B2 (en) 2004-07-13
DE60105771T2 (de) 2006-02-16
US20030199564A1 (en) 2003-10-23
AU3579001A (en) 2001-09-12
ES2227137T3 (es) 2005-04-01
WO2001064659A3 (en) 2001-12-27
EP1259495A2 (de) 2002-11-27
GB0004686D0 (en) 2000-04-19
DE60105771D1 (de) 2004-10-28

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