ATE270266T1 - Quadratsäurederivate als integrin-antagonisten - Google Patents

Quadratsäurederivate als integrin-antagonisten

Info

Publication number
ATE270266T1
ATE270266T1 AT00987574T AT00987574T ATE270266T1 AT E270266 T1 ATE270266 T1 AT E270266T1 AT 00987574 T AT00987574 T AT 00987574T AT 00987574 T AT00987574 T AT 00987574T AT E270266 T1 ATE270266 T1 AT E270266T1
Authority
AT
Austria
Prior art keywords
group
optionally substituted
acid derivatives
hydrogen atom
aromatic
Prior art date
Application number
AT00987574T
Other languages
English (en)
Inventor
Barry John Langham
Rikki Peter Alexander
John Clifford Head
Janeen Marsha Linsley
John Robert Porter
Sarah Catherine Archibald
Graham John Warrellow
Original Assignee
Celltech R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9930558.3A external-priority patent/GB9930558D0/en
Priority claimed from GB0002872A external-priority patent/GB0002872D0/en
Priority claimed from GB0028838A external-priority patent/GB0028838D0/en
Application filed by Celltech R&D Ltd filed Critical Celltech R&D Ltd
Application granted granted Critical
Publication of ATE270266T1 publication Critical patent/ATE270266T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Photoreceptors In Electrophotography (AREA)
AT00987574T 1999-12-23 2000-12-22 Quadratsäurederivate als integrin-antagonisten ATE270266T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9930558.3A GB9930558D0 (en) 1999-12-23 1999-12-23 Chemical compounds
GB0002872A GB0002872D0 (en) 2000-02-08 2000-02-08 Chemical compounds
GB0028838A GB0028838D0 (en) 2000-11-27 2000-11-27 Chemical compounds
PCT/GB2000/004995 WO2001047867A1 (en) 1999-12-23 2000-12-22 Squaric acid derivatives as integrin antagonists

Publications (1)

Publication Number Publication Date
ATE270266T1 true ATE270266T1 (de) 2004-07-15

Family

ID=27255523

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00987574T ATE270266T1 (de) 1999-12-23 2000-12-22 Quadratsäurederivate als integrin-antagonisten

Country Status (7)

Country Link
US (1) US6455539B2 (de)
EP (1) EP1244611B1 (de)
AT (1) ATE270266T1 (de)
AU (1) AU2382201A (de)
DE (1) DE60011940T2 (de)
ES (1) ES2223639T3 (de)
WO (1) WO2001047867A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6939855B2 (en) * 1997-07-31 2005-09-06 Elan Pharmaceuticals, Inc. Anti-inflammatory compositions and method
AU2001267753A1 (en) * 2000-07-07 2002-01-21 Celltech R And D Limited Squaric acid derivatives containing a bicyclic heteroaromatic ring as integrin antagonists
DE60336986D1 (de) 2002-03-05 2011-06-16 Sumitomo Chemical Co Verfahren zur herstellung von biarylverbindungen
DE102004043363A1 (de) * 2004-09-08 2006-03-09 Bayer Materialscience Ag Abspalterfrei-härtende blockierte Polyisocyanate für Dual Cure Systeme
US8450348B2 (en) 2007-02-21 2013-05-28 Forma Tm, Llc Derivatives of squaric acid with anti-proliferative activity
WO2008125210A1 (en) * 2007-04-12 2008-10-23 Ucb Pharma, S.A. Quinoline and naphthalene derivatives, processes for their preparation and their use in treatment of inflammatory diseases
MX2010014310A (es) 2008-06-24 2011-02-15 Topotarget As Derivados de acido escuarico como inhibidores de la nicotinamida.
LT2852602T (lt) * 2012-05-21 2020-10-26 Agilent Technologies, Inc. Oligonukleotidų konjugavimo būdas
US8901144B2 (en) 2013-02-07 2014-12-02 Scifluor Life Sciences, Llc Fluorinated 3-(2-oxo-3-(3-arylpropyl)imidazolidin-1-yl)-3-arylpropanoic acid derivatives
ES2763556T3 (es) * 2013-02-07 2020-05-29 Scifluor Life Sciences Inc Antagonistas fluorados de integrina
EP3925959A1 (de) * 2015-02-19 2021-12-22 OcuTerra Therapeutics, Inc. Fluorierte derivate von 3-(2-oxo-3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl)imidazolidin-1-yl)propansäure und verwendungen davon
WO2018200571A1 (en) 2017-04-25 2018-11-01 Arbutus Biopharma Corporation Substituted 2,3-dihydro-1h-indene analogs and methods using same

Family Cites Families (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1437781A (en) 1972-04-04 1976-06-03 Beecham Group Ltd Pyridine derivatives having hypoglycaemic activity
JPS609718B2 (ja) 1977-08-25 1985-03-12 塩野義製薬株式会社 チアジアゾリルチオセフアロスポリン類縁抗生物質
JPS5683483A (en) 1979-12-13 1981-07-08 Santen Pharmaceut Co Ltd Thiazolidine compound
JPS5690045A (en) 1979-12-25 1981-07-21 Tokuyama Soda Co Ltd Alpha*alpha**di substituted amino phenylenediacetic acid
JPS56139455A (en) 1980-04-02 1981-10-30 Santen Pharmaceut Co Ltd Sulfur-containing acylaminoacid
US4470973A (en) 1982-07-19 1984-09-11 E. R. Squibb & Sons, Inc. Substituted peptide compounds
FR2540871B1 (fr) 1983-02-16 1986-01-10 Lipha Amino-2 phenyl-5 benzodiazepines-1,3; procede de preparation et medicaments les contenant
GB8332704D0 (en) 1983-12-07 1984-01-11 Pfizer Ltd Growth promotants for animals
IT1176983B (it) 1984-10-16 1987-08-26 Zambon Spa Dipeptidi ad attivita' farmacologica
CN1030415A (zh) 1987-02-20 1989-01-18 山之内制药株式会社 饱和的杂环碳酰胺衍生物和它的制备方法
JPH0784424B2 (ja) 1987-04-15 1995-09-13 味の素株式会社 チロシン誘導体及びその用途
US5510346A (en) 1987-12-07 1996-04-23 Hoechst Marion Roussel, Inc. 4-heteroaryl-1,3-benzodiazepines and 2-substituted-gamma-(heteroaryl)benzeneethanamines
IT1223565B (it) 1987-12-21 1990-09-19 Zambon Spa Derivati dell'acido tiazolidin 4 carbossilico ad attivita' farmaceutica
US5256812A (en) 1989-01-31 1993-10-26 Hoffmann-La Roche Inc. Carboxamides and sulfonamides
US5164372A (en) 1989-04-28 1992-11-17 Fujisawa Pharmaceutical Company, Ltd. Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same
JPH07121917B2 (ja) 1989-07-31 1995-12-25 四国化成工業株式会社 ４（５）―チオカルバモイル―イミダゾール化合物及びその合成方法
US5260277A (en) 1990-09-10 1993-11-09 Tanabe Seiyaku Co., Ltd. Guanidinyl and related cell adhesion modulation compounds
IT1244548B (it) 1991-02-06 1994-07-15 Poli Ind Chimica Spa Derivati della 5-oxo-l-prolina e loro applicazioni farmaceutiche
WO1993000095A2 (en) 1991-06-28 1993-01-07 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
US5296486A (en) 1991-09-24 1994-03-22 Boehringer Ingelheim Pharmaceuticals, Inc. Leukotriene biosynthesis inhibitors
US5250679A (en) 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
DE69222433D1 (de) 1991-11-22 1997-10-30 Yeda Res & Dev Nicht-peptidische surrogate der arg-gly-asp sequenz und entsprechende pharmazeutische zusammensetzungen
US5227490A (en) 1992-02-21 1993-07-13 Merck & Co., Inc. Fibrinogen receptor antagonists
AU686115B2 (en) 1992-11-02 1998-02-05 Fujisawa Pharmaceutical Co., Ltd. Imidazo (I,2-a) pyridine derivatives as bradykinin antagonists, pharmaceuticals and processes for their preparation
FR2700167B1 (fr) 1993-01-07 1995-02-03 Rhone Poulenc Rorer Sa Dérivés de pyrrolidine et thiazolidine, leur préparation et les médicaments les contenant.
FR2700168B1 (fr) 1993-01-07 1995-02-03 Rhone Poulenc Rorer Sa Dérivés de thiazolidine, leur préparation et les médicaments les contenant.
GB9311661D0 (en) 1993-06-05 1993-07-21 Smithkline Beecham Plc Novel compounds
AU678503B2 (en) 1993-09-24 1997-05-29 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds and their use as squalene synthetase inhibitors
WO1995013811A1 (de) 1993-11-17 1995-05-26 Byk Nederland Bv Verwendung substituierter thiazolidinderivate zur behandlung von erhöhtem augeninnendruck
WO1995015973A1 (en) 1993-12-06 1995-06-15 Cytel Corporation Cs-1 peptidomimetics, compositions and methods of using the same
JP2973271B2 (ja) 1994-01-18 1999-11-08 参天製薬株式会社 エンドペプチダーゼ２４．１５阻害剤
FR2721608B1 (fr) 1994-06-22 1996-07-19 Rhone Poulenc Rorer Sa Dérivés de thiazolidine, leur préparation et les médicaments les contenant.
CA2193508A1 (en) 1994-07-11 1996-01-25 Eugene D. Thorsett Inhibitors of leukocyte adhesion
TW403748B (en) 1994-11-02 2000-09-01 Takeda Chemical Industries Ltd An oxazolidinedione derivative, its production and a pharmaceutical composition for lowering blood sugar and lipid in blood comprising the same
DK0710657T3 (da) 1994-11-02 1999-05-25 Merck Patent Gmbh Adhæsionsreceptor-antagonister
US6306840B1 (en) 1995-01-23 2001-10-23 Biogen, Inc. Cell adhesion inhibitors
WO1996026190A1 (en) 1995-02-22 1996-08-29 Smithkline Beecham Corporation Integrin receptor antagonists
US6248713B1 (en) 1995-07-11 2001-06-19 Biogen, Inc. Cell adhesion inhibitors
GB9515073D0 (en) 1995-07-22 1995-09-20 Blair Neil Securement device and method
RO118289B1 (ro) 1995-08-30 2003-04-30 Gd Searle & Co Chicago Derivati de fenilcarboniluree si compozitie farmaceutica
US5714488A (en) 1995-10-03 1998-02-03 Abbott Laboratories Bis-heteroarylylmethoxyphenyl ketone derivatives as inhibitors of leukotriene biosynthesis
AU1345697A (en) 1995-12-22 1997-07-17 Du Pont Merck Pharmaceutical Company, The Novel integrin receptor antagonists
TR199801254T2 (xx) 1995-12-29 1998-10-21 Smithkline Beecham Corporation Vitronektin resept�r� antagonistleri.
GB9604242D0 (en) 1996-02-28 1996-05-01 Glaxo Wellcome Inc Chemical compounds
JP2000506538A (ja) 1996-03-29 2000-05-30 ジー．ディー．サール アンド カンパニー メタ―置換フェニレン誘導体
PT891325E (pt) 1996-03-29 2002-07-31 Searle & Co Derivados do acido fenilpropanoico para-substituido como antagonistas de integrina
AU2420897A (en) 1996-03-29 1997-10-22 G.D. Searle & Co. Meta-substituted phenylene sulphonamide derivatives
JP2000507575A (ja) 1996-03-29 2000-06-20 ジー．ディー．サール アンド カンパニー シクロプロピルアルカノイック酸誘導体
DE19620041A1 (de) 1996-05-17 1998-01-29 Merck Patent Gmbh Adhäsionsrezeptor-Antagonisten
WO1997047618A1 (en) 1996-06-10 1997-12-18 Merck & Co., Inc. Substituted imidazoles having cytokine inhibitory activity
KR20000022190A (ko) 1996-06-28 2000-04-25 플레믹 크리스티안 인테그린 저해제로서의 페닐알라닌 유도체
DE19654483A1 (de) 1996-06-28 1998-01-02 Merck Patent Gmbh Phenylalanin-Derivate
NZ333904A (en) 1996-07-25 2000-06-23 Biogen Inc VLA-4 and IIb/IIIa cell adhesion inhibitors
ATE236626T1 (de) 1996-10-30 2003-04-15 Merck & Co Inc Integrin antagonist
DE19647380A1 (de) 1996-11-15 1998-05-20 Hoechst Ag 5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten
DE19647381A1 (de) 1996-11-15 1998-05-20 Hoechst Ag Neue Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten
JP2001506632A (ja) 1996-12-09 2001-05-22 イーライ リリー アンド カンパニー インテグリン拮抗物質
EP1007026A4 (de) 1997-01-17 2002-08-07 Merck & Co Inc Integrin-antagonisten
US6034136A (en) 1997-03-20 2000-03-07 Novartis Ag Certain cyclic thio substituted acylaminoacid amide derivatives
AU728435B2 (en) 1997-05-29 2001-01-11 Merck & Co., Inc. Sulfonamides as cell adhesion inhibitors
WO1998053817A1 (en) 1997-05-29 1998-12-03 Merck & Co., Inc. Biarylalkanoic acids as cell adhesion inhibitors
EP1001764A4 (de) 1997-05-29 2005-08-24 Merck & Co Inc Heterozyklische amide als zelladhäsionshemmern
WO1998054207A1 (en) 1997-05-30 1998-12-03 Celltech Therapeutics Limited Anti-inflammatory tyrosine derivatives
AU8163398A (en) 1997-06-23 1999-01-04 Pharmacia & Upjohn Company Inhibitors of alpha4beta1mediated cell adhesion
KR20010022405A (ko) 1997-07-31 2001-03-15 진 엠. 듀발 Ｖｌａ-4에 의해 매개된 백혈구 유착을 억제하는설포닐화된 디펩타이드 화합물
ZA986834B (en) 1997-07-31 2000-05-02 Athena Neurosciences Inc Compounds which inhibit leukocyte adhesion mediated by VLA-4.
AR016133A1 (es) 1997-07-31 2001-06-20 Wyeth Corp Compuesto de carbamiloxi que inhiben la adhesion de leucocitos mediada por vla-4, compuestos que son prodrogas de dichos compuestos, composicionfarmaceutica, metodo para fijar vla-4 a una muestra biologica, metodo para el tratamiento de una condicion inflamatoria
BR9812114A (pt) 1997-07-31 2000-07-18 Elan Pharm Inc Compostos do tipo fenilalanina substituìda que inibem a adesão de leucócito mediada por vla-4
HUP0002495A3 (en) 1997-07-31 2001-01-29 American Home Prod Dipeptide and related compounds which inhibit leukocyte adhesion mediated by vla-4, pharmaceutical compositions comprising thereof and their use
DE69834642T2 (de) 1997-07-31 2007-05-03 Elan Pharmaceuticals, Inc., South San Francisco Verbindungen mit einer 4-amino-phenylalaningruppe, die die vla-4 vermittelte adhäsion von leukozyten inhibieren
WO1999006433A1 (en) 1997-07-31 1999-02-11 Elan Pharmaceuticals, Inc. Compounds which inhibit leukocyte adhesion mediated by vla-4
CN1265675A (zh) 1997-07-31 2000-09-06 伊兰药品公司 抑制由vla－4介导的白细胞粘着的苄基化合物
NZ502813A (en) 1997-08-22 2002-10-25 F N-aroylphenylalanine derivatives as inhibitors of the interaction between a4 containing integrins and VCAM-1
DE69821950T2 (de) 1997-08-22 2004-12-16 F. Hoffmann-La Roche Ag N-aroylphenylalaninderivate
AU1361499A (en) 1997-10-21 1999-05-10 Merck & Co., Inc. Azapeptide acids as cell adhesion inhibitors
WO1999026922A1 (en) 1997-11-21 1999-06-03 Merck & Co., Inc. Substituted pyrrole derivatives as cell adhesion inhibitors
DE69824037T2 (de) 1997-11-24 2005-06-02 Merck & Co., Inc. Beta-alanin-derivate als zell-adhäsions-inhibitoren
CA2309204A1 (en) 1997-11-26 1999-06-03 Dupont Pharmaceuticals Company 1,3,4-thiadiazoles and 1,3,4-oxadiazoles as .alpha.v.beta.3 antagonists
WO1999030709A1 (en) 1997-12-17 1999-06-24 Merck & Co., Inc. Integrin receptor antagonists
ES2243016T3 (es) 1997-12-17 2005-11-16 MERCK & CO., INC. Antagonistas de receptores de integrinas.
DE69829996T2 (de) 1997-12-17 2006-02-23 Merck & Co., Inc. (A New Jersey Corp.) Integrin-rezeptor-antagonisten
EP0933367A1 (de) 1997-12-19 1999-08-04 Hoechst Marion Roussel Deutschland GmbH Acylguanidin Derivate als Inhibitoren von Knochenaufsauge und als Vitronectin Rezeptor Antagonisten
US6197794B1 (en) 1998-01-08 2001-03-06 Celltech Therapeutics Limited Phenylalanine derivatives
MY153569A (en) 1998-01-20 2015-02-27 Mitsubishi Tanabe Pharma Corp Inhibitors of ?4 mediated cell adhesion
US6329372B1 (en) 1998-01-27 2001-12-11 Celltech Therapeutics Limited Phenylalanine derivatives
DE69919334T2 (de) 1998-02-26 2005-08-04 Celltech Therapeutics Ltd., Slough Phenylalaninderivate als inhibitoren von alpha4 integrinen
ZA994406B (en) 1998-03-04 2000-02-11 Searle & Co Meta-azacyclic amino benzoic acid and derivatives thereof.
US6521626B1 (en) 1998-03-24 2003-02-18 Celltech R&D Limited Thiocarboxamide derivatives
AU765294B2 (en) 1998-04-10 2003-09-11 G.D. Searle & Co. Heterocyclic glycyl beta-alanine derivatives as vitronectin antagonists
AU3561099A (en) 1998-04-14 1999-11-01 American Home Products Corporation Acylresorcinol derivatives as selective vitronectin receptor inhibitors
CA2328234C (en) 1998-04-16 2009-03-17 Texas Biotechnology Corporation Compounds that inhibit the binding of integrins to their receptors
DE19821483A1 (de) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
GB9811159D0 (en) 1998-05-22 1998-07-22 Celltech Therapeutics Ltd Chemical compounds
AU8059598A (en) 1998-06-11 1999-12-30 Merck & Co., Inc. Heterocyclic amide compounds as cell adhesion inhibitors
TW591026B (en) 1998-06-23 2004-06-11 Upjohn Co Inhibitors of alpha4beta1 mediated cell adhesion

Also Published As

Publication number Publication date
ES2223639T3 (es) 2005-03-01
DE60011940T2 (de) 2005-07-21
US20010020017A1 (en) 2001-09-06
AU2382201A (en) 2001-07-09
WO2001047867A1 (en) 2001-07-05
EP1244611A1 (de) 2002-10-02
EP1244611B1 (de) 2004-06-30
DE60011940D1 (de) 2004-08-05
US6455539B2 (en) 2002-09-24

Similar Documents

Publication Publication Date Title
ATE273273T1 (de) Phenylalaninderivate als inhibitoren von alpha4 integrinen
ATE270266T1 (de) Quadratsäurederivate als integrin-antagonisten
ATE275559T1 (de) Aromatische amin-derivate verwendbar als pharmazeutische mittel
DE60140456D1 (de) Aza heterocyclische derivate und ihre therapeutische verwendung
EA200400550A1 (ru) Бициклические производные оксопиридина и оксопиримидина
DE60130910D1 (de) Enamin-derivate als zell-adhäsionsmoleküle
HUP9901590A2 (hu) Szubsztituált aza- és diaza-cikloheptán- és -ciklooktán-származékok, alkalmazásuk, a vegyületeket tartalmazó gyógyászati készítmények
ATE283270T1 (de) Condensierte pyridazine derivate,deren herstellung und verwendung
EA200100710A1 (ru) 4-(аминометил)пиперидинбензамиды для лечения желудочно-кишечных расстройств
DE69216509D1 (de) Kondensierte Pyrimidinderivate, ihre Herstellung und ihre Verwendung als Antitumormittel
EP0309422A3 (de) Amidinotricyclische Derivate
HUP0303160A2 (hu) Fenilalanin enamidszármazékok és ezeket tartalmazó gyógyszerkészítmények
TR199801218T2 (xx) Takikinin antagonistleri olarak N-asil-2-ikameli-4-(Benzimidazolil-ya da imidazopiridinil-ikameli art�klar)-piperidinler.
HUP9701080A2 (hu) Virusellenes hatású vegyületet és hidroximsavszármazékot tartalmazó gyógyszerkészítmény
CA2134077A1 (en) 4-imidomethyl-1-[2'phenyl-2'oxoethyl-]piperidines as serotonin 5ht2-antagonists, their preparation and use in therapy
CA2262997A1 (en) Pharmaceutical products for curing and preventing illnesses connected with the malfunction of vascular endothelial cells
RU2001126120A (ru) Амидные соединения для усиления холинергической активности
EA200100825A1 (ru) Новые 1-арил-4-тиотриазины
ZA200704584B (en) New 3-Phenylpropionic acid derivatives for the treatment of diabetes
MXPA02011352A (es) Nuevos derivados de benzofurano.
DE69907683D1 (de) Zimtsäure-derivate als zelladhäsions-moleküle
DE69402703T2 (de) 3-(INDOL-3-YL) PROPENSäURDERIVATE, DIE ALS NMDA- ANTAGONISTEN NÜTZLICH SIND
ATE229953T1 (de) Naphtho-imidazo(1,2-a)pyridin derivate, deren herstellung und deren verwendung in der behandlung von störungen des zentralnervensystems
ATE398131T1 (de) Kondensierte camptothecine als antitumormittel
IL115085A0 (en) Bicyclic carboxamide derivatives their preparation and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties