ATE283270T1 - Condensierte pyridazine derivate,deren herstellung und verwendung - Google Patents

Condensierte pyridazine derivate,deren herstellung und verwendung

Info

Publication number
ATE283270T1
ATE283270T1 AT98917645T AT98917645T ATE283270T1 AT E283270 T1 ATE283270 T1 AT E283270T1 AT 98917645 T AT98917645 T AT 98917645T AT 98917645 T AT98917645 T AT 98917645T AT E283270 T1 ATE283270 T1 AT E283270T1
Authority
AT
Austria
Prior art keywords
substituted
group
atom
hydrogen atom
independently
Prior art date
Application number
AT98917645T
Other languages
English (en)
Inventor
Yasuhiko Kawano
Hideaki Nagaya
Michiyo Gyoten
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ATE283270T1 publication Critical patent/ATE283270T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT98917645T 1997-04-25 1998-04-23 Condensierte pyridazine derivate,deren herstellung und verwendung ATE283270T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP10991497 1997-04-25
JP4668898 1998-02-27
PCT/JP1998/001869 WO1998049167A1 (en) 1997-04-25 1998-04-23 Condensed pyridazine derivatives, their production and use

Publications (1)

Publication Number Publication Date
ATE283270T1 true ATE283270T1 (de) 2004-12-15

Family

ID=26386797

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98917645T ATE283270T1 (de) 1997-04-25 1998-04-23 Condensierte pyridazine derivate,deren herstellung und verwendung

Country Status (9)

Country Link
US (1) US6248740B1 (de)
EP (1) EP0979231B1 (de)
KR (1) KR100389192B1 (de)
CN (1) CN1248259A (de)
AT (1) ATE283270T1 (de)
AU (1) AU7079998A (de)
CA (1) CA2285264A1 (de)
DE (1) DE69827786T2 (de)
WO (1) WO1998049167A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1026160A4 (de) 1997-09-16 2003-01-22 Takeda Chemical Industries Ltd Verbindungen mit stickstoffhaltigen, kondensierten ringen, verfahren zu ihrer herstellung und medikamente
AU6003099A (en) 1998-10-06 2000-04-26 Takeda Chemical Industries Ltd. Fused pyridazine compounds, process for the preparation of the same and uses thereof
CA2348022A1 (en) 1998-10-21 2000-04-27 Takeda Chemical Industries, Ltd. Condensed pyridazine derivatives, their production and use
EP1243271A1 (de) * 1999-11-11 2002-09-25 Takeda Chemical Industries, Ltd. Nasentropfen die kondensierte pyridazinderivate enthalten
FR2815031A1 (fr) * 2000-10-11 2002-04-12 Gilles Fillion Compositions et methodes pour la regulation du systeme nerveux
US20040254189A1 (en) * 2001-08-23 2004-12-16 Hideaki Nagaya Jnk inhibitors
US20040137052A1 (en) * 2001-12-25 2004-07-15 Yoshihiro Uchiyama Acid-containing preparations
US7235556B2 (en) 2003-04-16 2007-06-26 Alcon, Inc. Methods of treating dry eye disorders
JP2006525299A (ja) * 2003-05-01 2006-11-09 ヴァーナリス リサーチ リミテッド アゼチジンカルボキサミド誘導体及びｃｂ１レセプター媒介障害の治療におけるその使用
DE102005042742A1 (de) * 2005-09-02 2007-03-08 Schering Ag Substituierte Imidazo[1,2b]pyridazine als Kinase-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
US7750000B2 (en) 2005-09-02 2010-07-06 Bayer Schering Pharma Ag Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments
EP1845098A1 (de) * 2006-03-29 2007-10-17 Ferrer Internacional, S.A. Imidazo[1,2-b]pyridazinen, deren Herstellungverfahren und ihre Verwendung als GABA Rezeptor Liganden
PL2350075T3 (pl) 2008-09-22 2014-07-31 Array Biopharma Inc Podstawione związki imidazo[1,2b]pirydazynowe jako inhibitory kinaz Trk
BRPI0919873B8 (pt) 2008-10-22 2021-05-25 Array Biopharma Inc compostos de pirazol[1,5-a]pirimidina substituídos como inibidores da trk quinase, seus processos de preparação e composições farmacêuticas
AR077468A1 (es) 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
LT3205654T (lt) 2010-05-20 2019-05-27 Array Biopharma, Inc. Makrocikliniai junginiai kaip trk kinazės slopikliai
EP3074001A1 (de) * 2013-11-27 2016-10-05 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Piperidin- und piperazinderivate und deren verwendung bei der behandlung von vireninfektionen und krebs
CN105503877A (zh) 2014-09-24 2016-04-20 和记黄埔医药（上海）有限公司 咪唑并哒嗪类化合物及其用途
PL3699181T3 (pl) 2014-11-16 2023-05-22 Array Biopharma, Inc. Postać krystaliczna wodorosiarczanu (s)-n-(5-((r)-2-(2,5-difluorofenylo) - pirolidyn-1-ylo)-pirazolo[1,5-a]pirimidyn-3-ylo)-3-hydroksypirolidyno-1-karboksyamidu
EP3368039A1 (de) 2015-10-26 2018-09-05 The Regents of The University of Colorado, A Body Corporate Punktmutationen bei trk-inhibitor-resistentem krebs und zugehörige verfahren
GEP20227339B (en) 2016-04-04 2022-01-25 Loxo Oncology Inc Liquid formulations of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)- pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydro-xypyrrolidine-1-carboxamide
US10045991B2 (en) 2016-04-04 2018-08-14 Loxo Oncology, Inc. Methods of treating pediatric cancers
CA3024603A1 (en) 2016-05-18 2017-11-23 Charles Todd Eary Process for the preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide and salts thereof
JOP20190092A1 (ar) 2016-10-26 2019-04-25 Array Biopharma Inc عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
JOP20190213A1 (ar) 2017-03-16 2019-09-16 Array Biopharma Inc مركبات حلقية ضخمة كمثبطات لكيناز ros1
US10513515B2 (en) 2017-08-25 2019-12-24 Biotheryx, Inc. Ether compounds and uses thereof
US11236103B2 (en) 2018-07-27 2022-02-01 Biotheryx, Inc. Bifunctional compounds
WO2021222150A2 (en) 2020-04-28 2021-11-04 Anwita Biosciences, Inc. Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3878217A (en) * 1972-01-28 1975-04-15 Richardson Merrell Inc Alpha-aryl-4-substituted piperidinoalkanol derivatives
PH27291A (en) 1989-01-31 1993-05-04 Takeda Chemical Industries Ltd Imidazolpyrimidazines their production and use
EP0440119A1 (de) 1990-01-31 1991-08-07 Takeda Chemical Industries, Ltd. Imidazopyridazinverbindungen, ihre Herstellung und Verwendung
DE69106902T2 (de) 1990-03-01 1995-07-06 Takeda Chemical Industries Ltd Imidazopyridazine, ihre Herstellung und Verwendung.
TW211013B (de) 1991-12-27 1993-08-11 Takeda Pharm Industry Co Ltd
DE69322673T2 (de) 1992-03-18 1999-05-06 Takeda Chemical Industries, Ltd., Osaka Imidazopyridazine als Antiasthmatika
LT3200B (en) * 1992-03-18 1995-03-27 Takeda Chemical Industries Ltd Triazolopyridazine methodfor production thereof and use
CA2120997A1 (en) 1993-04-12 1994-10-13 Akio Miyake Triazolopyridazine derivatives, their production and use
JPH0717971A (ja) 1993-07-02 1995-01-20 Takeda Chem Ind Ltd イミダゾール誘導体、その製造法及び用途
TW304878B (de) 1993-09-21 1997-05-11 Takeda Pharm Industry Co Ltd
AU695377B2 (en) 1994-09-16 1998-08-13 Takeda Chemical Industries Ltd. Triazolopyridazines process and intermediates for their preparation and their use as medicaments
AU4496896A (en) 1995-01-30 1996-08-21 Takeda Chemical Industries Ltd. Cephem compounds, their production and use

Also Published As

Publication number Publication date
CN1248259A (zh) 2000-03-22
DE69827786T2 (de) 2005-11-24
KR20000049156A (ko) 2000-07-25
EP0979231B1 (de) 2004-11-24
EP0979231A1 (de) 2000-02-16
CA2285264A1 (en) 1998-11-05
WO1998049167A1 (en) 1998-11-05
DE69827786D1 (de) 2004-12-30
AU7079998A (en) 1998-11-24
US6248740B1 (en) 2001-06-19
KR100389192B1 (ko) 2003-06-27

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