ATE252580T1 - Azaindolizinon-derivate und agenzien zur verbesserung der kognitiver fähigkeiten,die dieselben als aktive inhaltstoffe enthalten - Google Patents
Azaindolizinon-derivate und agenzien zur verbesserung der kognitiver fähigkeiten,die dieselben als aktive inhaltstoffe enthaltenInfo
- Publication number
- ATE252580T1 ATE252580T1 AT00948260T AT00948260T ATE252580T1 AT E252580 T1 ATE252580 T1 AT E252580T1 AT 00948260 T AT00948260 T AT 00948260T AT 00948260 T AT00948260 T AT 00948260T AT E252580 T1 ATE252580 T1 AT E252580T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- agents
- same
- active ingredients
- phenyl
- Prior art date
Links
- 239000004480 active ingredient Substances 0.000 title 1
- 230000001149 cognitive effect Effects 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- -1 C1-C6alkoxy Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- PQNFLJBBNBOBRQ-UHFFFAOYSA-N indane Chemical compound C1=CC=C2CCCC2=C1 PQNFLJBBNBOBRQ-UHFFFAOYSA-N 0.000 abstract 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 2
- 229920002554 vinyl polymer Polymers 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Chemical group C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21700299 | 1999-07-30 | ||
| PCT/JP2000/005034 WO2001009131A1 (en) | 1999-07-30 | 2000-07-28 | Azaindolizinone derivatives and cerebral function improvers containing the same as the active ingredient |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE252580T1 true ATE252580T1 (de) | 2003-11-15 |
Family
ID=16697291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00948260T ATE252580T1 (de) | 1999-07-30 | 2000-07-28 | Azaindolizinon-derivate und agenzien zur verbesserung der kognitiver fähigkeiten,die dieselben als aktive inhaltstoffe enthalten |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6635652B1 (de) |
| EP (1) | EP1219621B1 (de) |
| JP (1) | JP4530597B2 (de) |
| KR (1) | KR100738136B1 (de) |
| CN (1) | CN1179962C (de) |
| AT (1) | ATE252580T1 (de) |
| AU (1) | AU766122B2 (de) |
| CA (1) | CA2387719C (de) |
| DE (1) | DE60006145T2 (de) |
| DK (1) | DK1219621T3 (de) |
| ES (1) | ES2209927T3 (de) |
| WO (1) | WO2001009131A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100338074C (zh) * | 2001-01-30 | 2007-09-19 | 全药工业株式会社 | 杂环化合物和以其为有效成分的脑机能改善剂 |
| US7348432B2 (en) * | 2004-10-27 | 2008-03-25 | Janssen Phamaceutica N.V. | Pyridine imidazoles and aza-indoles as progesterone receptor modulators |
| JP5160764B2 (ja) * | 2006-10-13 | 2013-03-13 | 全薬工業株式会社 | 特定の構造の複素環化合物を含む抗鬱剤、脳保護剤、アミロイドβ沈着抑制剤または老化抑制剤 |
| US20080268067A1 (en) * | 2007-03-09 | 2008-10-30 | Llinas Rodolfo R | Methods and Compositions for Treating Thalamocortical Dysrhythmia |
| US20090221554A1 (en) * | 2008-02-28 | 2009-09-03 | Zenyaku Kogyo Kabushiki Kaisha | Method of treating cognitive impairment |
| WO2010077852A2 (en) * | 2008-12-15 | 2010-07-08 | The Regents Of The University Of California | Method of inducing cleavage of amyloid precursor protein to form a novel fragment |
| US20100256173A1 (en) * | 2009-04-02 | 2010-10-07 | Eckard Weber | Method of Treating Cognitive Impairment |
| JP2012524097A (ja) * | 2009-04-14 | 2012-10-11 | キム， ニコラス グリーン， | プロａｄａｍ１０セクレターゼ及び／又はベータセクレターゼレベルの減少方法 |
| US20100298348A1 (en) * | 2009-05-11 | 2010-11-25 | Kim Nicholas Green | Method of Decreasing Ubiquitylated Protein Levels |
| MX2023013537A (es) * | 2021-05-19 | 2024-02-06 | Amyriad Pharma Inc | Metodo de tratamiento de la enfermedad de alzheimer. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4514415A (en) | 1981-10-28 | 1985-04-30 | Ciba Geigy Corporation | Benzofuran-2(3H)-ones used as anti-inflammatory agents |
| FR2525602A1 (fr) | 1982-04-21 | 1983-10-28 | Synthelabo | Imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique |
| US4760083A (en) * | 1986-04-10 | 1988-07-26 | E. I. Dupont De Nemours & Company | 3,3-disubstituted indolines |
| JP2585086B2 (ja) * | 1988-12-28 | 1997-02-26 | 大鵬薬品工業株式会社 | ジアザビシクロアルカン誘導体 |
| US5464843A (en) * | 1992-06-23 | 1995-11-07 | G.D. Searle & Co. | Imidazo[1,2-a]pyridinyldiacid compounds for cognitive enhancement and for treatment of cognitive disorders and neutrotoxic injury |
-
2000
- 2000-07-28 WO PCT/JP2000/005034 patent/WO2001009131A1/ja not_active Ceased
- 2000-07-28 AT AT00948260T patent/ATE252580T1/de not_active IP Right Cessation
- 2000-07-28 JP JP2001514334A patent/JP4530597B2/ja not_active Expired - Fee Related
- 2000-07-28 DK DK00948260T patent/DK1219621T3/da active
- 2000-07-28 AU AU61803/00A patent/AU766122B2/en not_active Ceased
- 2000-07-28 CA CA2387719A patent/CA2387719C/en not_active Expired - Lifetime
- 2000-07-28 ES ES00948260T patent/ES2209927T3/es not_active Expired - Lifetime
- 2000-07-28 DE DE60006145T patent/DE60006145T2/de not_active Expired - Lifetime
- 2000-07-28 US US10/030,159 patent/US6635652B1/en not_active Expired - Lifetime
- 2000-07-28 KR KR1020027001338A patent/KR100738136B1/ko not_active Expired - Fee Related
- 2000-07-28 EP EP00948260A patent/EP1219621B1/de not_active Expired - Lifetime
- 2000-07-28 CN CNB008137390A patent/CN1179962C/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU6180300A (en) | 2001-02-19 |
| EP1219621A4 (de) | 2003-01-02 |
| WO2001009131A1 (en) | 2001-02-08 |
| CN1179962C (zh) | 2004-12-15 |
| JP4530597B2 (ja) | 2010-08-25 |
| CA2387719C (en) | 2010-04-27 |
| US6635652B1 (en) | 2003-10-21 |
| AU766122B2 (en) | 2003-10-09 |
| CA2387719A1 (en) | 2001-02-08 |
| EP1219621A1 (de) | 2002-07-03 |
| KR100738136B1 (ko) | 2007-07-10 |
| KR20020016931A (ko) | 2002-03-06 |
| DE60006145T2 (de) | 2004-06-09 |
| ES2209927T3 (es) | 2004-07-01 |
| EP1219621B1 (de) | 2003-10-22 |
| DE60006145D1 (de) | 2003-11-27 |
| CN1377351A (zh) | 2002-10-30 |
| DK1219621T3 (da) | 2004-02-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |