ATE252580T1 - Azaindolizinon-derivate und agenzien zur verbesserung der kognitiver fähigkeiten,die dieselben als aktive inhaltstoffe enthalten - Google Patents

Azaindolizinon-derivate und agenzien zur verbesserung der kognitiver fähigkeiten,die dieselben als aktive inhaltstoffe enthalten

Info

Publication number
ATE252580T1
ATE252580T1 AT00948260T AT00948260T ATE252580T1 AT E252580 T1 ATE252580 T1 AT E252580T1 AT 00948260 T AT00948260 T AT 00948260T AT 00948260 T AT00948260 T AT 00948260T AT E252580 T1 ATE252580 T1 AT E252580T1
Authority
AT
Austria
Prior art keywords
alkyl
agents
same
active ingredients
phenyl
Prior art date
Application number
AT00948260T
Other languages
English (en)
Inventor
Seiichiro Kenkyusho Kawashima
Nerima-Ku
Toshiyuki Matsuno
Naoki Fukuda
Kenichi Saitoh
Yoshimasa Yamaguchi
Masaya Higashi
Original Assignee
Zenyaku Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zenyaku Kogyo Kk filed Critical Zenyaku Kogyo Kk
Application granted granted Critical
Publication of ATE252580T1 publication Critical patent/ATE252580T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT00948260T 1999-07-30 2000-07-28 Azaindolizinon-derivate und agenzien zur verbesserung der kognitiver fähigkeiten,die dieselben als aktive inhaltstoffe enthalten ATE252580T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP21700299 1999-07-30
PCT/JP2000/005034 WO2001009131A1 (fr) 1999-07-30 2000-07-28 Derives d'azaindolizinone et ameliorants de la fonction cerebrale contenant lesdits derives en tant que principes actifs

Publications (1)

Publication Number Publication Date
ATE252580T1 true ATE252580T1 (de) 2003-11-15

Family

ID=16697291

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00948260T ATE252580T1 (de) 1999-07-30 2000-07-28 Azaindolizinon-derivate und agenzien zur verbesserung der kognitiver fähigkeiten,die dieselben als aktive inhaltstoffe enthalten

Country Status (12)

Country Link
US (1) US6635652B1 (de)
EP (1) EP1219621B1 (de)
JP (1) JP4530597B2 (de)
KR (1) KR100738136B1 (de)
CN (1) CN1179962C (de)
AT (1) ATE252580T1 (de)
AU (1) AU766122B2 (de)
CA (1) CA2387719C (de)
DE (1) DE60006145T2 (de)
DK (1) DK1219621T3 (de)
ES (1) ES2209927T3 (de)
WO (1) WO2001009131A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE301125T1 (de) * 2001-01-30 2005-08-15 Zenyaku Kogyo Kk Heterocyclische verbindungen und mittel, die die hirnfunktion verbessern und als wirkstoff diese verbindungen enthalten
WO2006049890A1 (en) * 2004-10-27 2006-05-11 Janssen Pharmaceutica N.V. Pyridine imidazoles and aza-indoles as progesterone receptor modulators
JP5160764B2 (ja) * 2006-10-13 2013-03-13 全薬工業株式会社 特定の構造の複素環化合物を含む抗鬱剤、脳保護剤、アミロイドβ沈着抑制剤または老化抑制剤
EP2131827A2 (de) * 2007-03-09 2009-12-16 New York University Verfahren und zusammensetzungen zur behandlung von thalamokortikaler dysrhythmie
US20090221554A1 (en) * 2008-02-28 2009-09-03 Zenyaku Kogyo Kabushiki Kaisha Method of treating cognitive impairment
WO2010077852A2 (en) * 2008-12-15 2010-07-08 The Regents Of The University Of California Method of inducing cleavage of amyloid precursor protein to form a novel fragment
WO2010115078A2 (en) * 2009-04-02 2010-10-07 Eckard Weber Method of treating cognitive impairment
WO2010120872A2 (en) * 2009-04-14 2010-10-21 Kim Nicholas Green Method of decreasing pro-adam10 secretase and/or beta secretase levels
US20100298348A1 (en) * 2009-05-11 2010-11-25 Kim Nicholas Green Method of Decreasing Ubiquitylated Protein Levels
WO2022246059A1 (en) * 2021-05-19 2022-11-24 Amyriad Pharma, Inc. Method of treating alzheimer's disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4514415A (en) * 1981-10-28 1985-04-30 Ciba Geigy Corporation Benzofuran-2(3H)-ones used as anti-inflammatory agents
FR2525602A1 (fr) 1982-04-21 1983-10-28 Synthelabo Imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
US4760083A (en) 1986-04-10 1988-07-26 E. I. Dupont De Nemours & Company 3,3-disubstituted indolines
JP2585086B2 (ja) * 1988-12-28 1997-02-26 大鵬薬品工業株式会社 ジアザビシクロアルカン誘導体
US5464843A (en) * 1992-06-23 1995-11-07 G.D. Searle & Co. Imidazo[1,2-a]pyridinyldiacid compounds for cognitive enhancement and for treatment of cognitive disorders and neutrotoxic injury

Also Published As

Publication number Publication date
EP1219621B1 (de) 2003-10-22
CN1377351A (zh) 2002-10-30
DE60006145D1 (de) 2003-11-27
WO2001009131A1 (fr) 2001-02-08
EP1219621A4 (de) 2003-01-02
ES2209927T3 (es) 2004-07-01
KR20020016931A (ko) 2002-03-06
EP1219621A1 (de) 2002-07-03
KR100738136B1 (ko) 2007-07-10
DK1219621T3 (da) 2004-02-02
AU766122B2 (en) 2003-10-09
CA2387719C (en) 2010-04-27
JP4530597B2 (ja) 2010-08-25
DE60006145T2 (de) 2004-06-09
US6635652B1 (en) 2003-10-21
AU6180300A (en) 2001-02-19
CA2387719A1 (en) 2001-02-08
CN1179962C (zh) 2004-12-15

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