DE60006145D1 - Azaindolizinon-derivate und agenzien zur verbesserung der kognitiver fähigkeiten,die dieselben als aktive inhaltstoffe enthalten - Google Patents

Azaindolizinon-derivate und agenzien zur verbesserung der kognitiver fähigkeiten,die dieselben als aktive inhaltstoffe enthalten

Info

Publication number
DE60006145D1
DE60006145D1 DE60006145T DE60006145T DE60006145D1 DE 60006145 D1 DE60006145 D1 DE 60006145D1 DE 60006145 T DE60006145 T DE 60006145T DE 60006145 T DE60006145 T DE 60006145T DE 60006145 D1 DE60006145 D1 DE 60006145D1
Authority
DE
Germany
Prior art keywords
alkyl
agents
improve
active ingredients
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60006145T
Other languages
English (en)
Other versions
DE60006145T2 (de
Inventor
Seiichiro Kawashima
Toshiyuki Matsuno
Naoki Fukuda
Kenichi Saitoh
Yoshimasa Yamaguchi
Masaya Higashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zenyaku Kogyo KK
Original Assignee
Zenyaku Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zenyaku Kogyo KK filed Critical Zenyaku Kogyo KK
Application granted granted Critical
Publication of DE60006145D1 publication Critical patent/DE60006145D1/de
Publication of DE60006145T2 publication Critical patent/DE60006145T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE60006145T 1999-07-30 2000-07-28 Azaindolizinon-derivate und agenzien zur verbesserung der kognitiver fähigkeiten,die dieselben als aktive inhaltstoffe enthalten Expired - Lifetime DE60006145T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP21700299 1999-07-30
JP21700299 1999-07-30
PCT/JP2000/005034 WO2001009131A1 (fr) 1999-07-30 2000-07-28 Derives d'azaindolizinone et ameliorants de la fonction cerebrale contenant lesdits derives en tant que principes actifs

Publications (2)

Publication Number Publication Date
DE60006145D1 true DE60006145D1 (de) 2003-11-27
DE60006145T2 DE60006145T2 (de) 2004-06-09

Family

ID=16697291

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60006145T Expired - Lifetime DE60006145T2 (de) 1999-07-30 2000-07-28 Azaindolizinon-derivate und agenzien zur verbesserung der kognitiver fähigkeiten,die dieselben als aktive inhaltstoffe enthalten

Country Status (12)

Country Link
US (1) US6635652B1 (de)
EP (1) EP1219621B1 (de)
JP (1) JP4530597B2 (de)
KR (1) KR100738136B1 (de)
CN (1) CN1179962C (de)
AT (1) ATE252580T1 (de)
AU (1) AU766122B2 (de)
CA (1) CA2387719C (de)
DE (1) DE60006145T2 (de)
DK (1) DK1219621T3 (de)
ES (1) ES2209927T3 (de)
WO (1) WO2001009131A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60205338T2 (de) * 2001-01-30 2006-06-01 Zenyaku Kogyo K.K. Heterocyclische verbindungen und mittel, die die hirnfunktion verbessern und als wirkstoff diese verbindungen enthalten
CA2585544A1 (en) * 2004-10-27 2006-05-11 Janssen Pharmaceutica N.V. Pyridine imidazoles and aza-indoles as progesterone receptor modulators
JP5160764B2 (ja) * 2006-10-13 2013-03-13 全薬工業株式会社 特定の構造の複素環化合物を含む抗鬱剤、脳保護剤、アミロイドβ沈着抑制剤または老化抑制剤
US20080268067A1 (en) * 2007-03-09 2008-10-30 Llinas Rodolfo R Methods and Compositions for Treating Thalamocortical Dysrhythmia
US20090221554A1 (en) * 2008-02-28 2009-09-03 Zenyaku Kogyo Kabushiki Kaisha Method of treating cognitive impairment
EP2361088A4 (de) * 2008-12-15 2012-05-30 Univ California Verfahren zur herbeiführung der spaltung von amyloidvorläuferproteinen zur formung eines neuartigen fragments
WO2010115078A2 (en) * 2009-04-02 2010-10-07 Eckard Weber Method of treating cognitive impairment
EP2419100A4 (de) * 2009-04-14 2013-07-17 Kim Nicholas Green Verfahren zur senkung der pro-adam10-sekretase- und/oder beta-sekretase-konzentration
CN102573839A (zh) * 2009-05-11 2012-07-11 加利福尼亚大学董事会 降低泛素化蛋白水平的方法
KR20240021760A (ko) * 2021-05-19 2024-02-19 아미리어드 파마 아이엔씨. 알츠하이머병의 치료 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4514415A (en) * 1981-10-28 1985-04-30 Ciba Geigy Corporation Benzofuran-2(3H)-ones used as anti-inflammatory agents
FR2525602A1 (fr) * 1982-04-21 1983-10-28 Synthelabo Imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
US4760083A (en) * 1986-04-10 1988-07-26 E. I. Dupont De Nemours & Company 3,3-disubstituted indolines
JP2585086B2 (ja) * 1988-12-28 1997-02-26 大鵬薬品工業株式会社 ジアザビシクロアルカン誘導体
US5464843A (en) * 1992-06-23 1995-11-07 G.D. Searle & Co. Imidazo[1,2-a]pyridinyldiacid compounds for cognitive enhancement and for treatment of cognitive disorders and neutrotoxic injury

Also Published As

Publication number Publication date
CN1377351A (zh) 2002-10-30
KR100738136B1 (ko) 2007-07-10
WO2001009131A1 (fr) 2001-02-08
JP4530597B2 (ja) 2010-08-25
CA2387719C (en) 2010-04-27
CA2387719A1 (en) 2001-02-08
EP1219621B1 (de) 2003-10-22
DE60006145T2 (de) 2004-06-09
DK1219621T3 (da) 2004-02-02
ATE252580T1 (de) 2003-11-15
AU6180300A (en) 2001-02-19
AU766122B2 (en) 2003-10-09
KR20020016931A (ko) 2002-03-06
CN1179962C (zh) 2004-12-15
EP1219621A4 (de) 2003-01-02
ES2209927T3 (es) 2004-07-01
US6635652B1 (en) 2003-10-21
EP1219621A1 (de) 2002-07-03

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