LT2852602T - Oligonukleotidų konjugavimo būdas - Google Patents
Oligonukleotidų konjugavimo būdasInfo
- Publication number
- LT2852602T LT2852602T LTEP13794477.3T LT13794477T LT2852602T LT 2852602 T LT2852602 T LT 2852602T LT 13794477 T LT13794477 T LT 13794477T LT 2852602 T LT2852602 T LT 2852602T
- Authority
- LT
- Lithuania
- Prior art keywords
- conjugating oligonucleotides
- conjugating
- oligonucleotides
- Prior art date
Links
- 108091034117 Oligonucleotide Proteins 0.000 title 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
- 230000001268 conjugating effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261649766P | 2012-05-21 | 2012-05-21 | |
| PCT/US2013/038703 WO2013176844A1 (en) | 2012-05-21 | 2013-04-29 | Compositions and methods for conjugating oligonucleotides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT2852602T true LT2852602T (lt) | 2020-10-26 |
Family
ID=49624240
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP13794477.3T LT2852602T (lt) | 2012-05-21 | 2013-04-29 | Oligonukleotidų konjugavimo būdas |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9512163B2 (lt) |
| EP (2) | EP2852602B1 (lt) |
| JP (2) | JP6351577B2 (lt) |
| KR (1) | KR102129148B1 (lt) |
| CN (2) | CN110156844A (lt) |
| LT (1) | LT2852602T (lt) |
| WO (1) | WO2013176844A1 (lt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10900034B2 (en) | 2014-12-03 | 2021-01-26 | Agilent Technologies, Inc. | Guide RNA with chemical modifications |
| US10059940B2 (en) * | 2015-01-27 | 2018-08-28 | Minghong Zhong | Chemically ligated RNAs for CRISPR/Cas9-lgRNA complexes as antiviral therapeutic agents |
| US9890190B2 (en) | 2015-02-24 | 2018-02-13 | Agilent Technologies, Inc. | Preparation of long synthetic oligonucleotides by squarate conjugation chemistry |
| KR102888521B1 (ko) | 2015-04-06 | 2025-11-19 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | Crispr/cas-매개 유전자 조절을 위한 화학적으로 변형된 가이드 rna |
| WO2017040511A1 (en) * | 2015-08-31 | 2017-03-09 | Agilent Technologies, Inc. | Compounds and methods for crispr/cas-based genome editing by homologous recombination |
| US10767175B2 (en) | 2016-06-08 | 2020-09-08 | Agilent Technologies, Inc. | High specificity genome editing using chemically modified guide RNAs |
| SE541640C2 (sv) | 2016-08-29 | 2019-11-19 | Bae Systems Bofors Ab | Optikmodul för siktesenhet och metod för konvertering av vapenstation |
| MX2020013384A (es) * | 2019-03-01 | 2021-04-28 | Illumina Cambridge Ltd | Compuestos de comarina sustituidos con amina exocíclica y sus usos como etiquetas fluorescentes. |
| CA3140410A1 (en) * | 2019-06-20 | 2020-12-24 | Martin Edelmann | Radiolabeled moem type oligonucleotides and process for their preparation |
| EP4087857B1 (en) * | 2020-01-06 | 2023-11-01 | Bristol-Myers Squibb Company | Immunomodulators |
| GB2613225B (en) | 2020-03-04 | 2024-01-03 | Verve Therapeutics Inc | Compositions and methods for targeted RNA delivery |
| CN116368226A (zh) | 2020-09-04 | 2023-06-30 | 维乎医疗有限公司 | 用于加帽rna的组合物和方法 |
| JP2024530647A (ja) | 2021-08-03 | 2024-08-23 | ヴァーヴ・セラピューティクス，インコーポレーテッド | 標的ｒｎａ送達のための組成物および方法 |
| WO2023039586A1 (en) | 2021-09-10 | 2023-03-16 | Agilent Technologies, Inc. | Guide rnas with chemical modification for prime editing |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4341524C2 (de) * | 1993-12-06 | 1997-01-16 | Gluesenkamp Karl Heinz Dr | Verfahren zur Immobilisierung von Biomolekülen und Affinitätsliganden an polymere Träger |
| EP0898596B1 (en) | 1996-04-19 | 2001-08-29 | Amersham Pharmacia Biotech UK Limited | Squarate dyes and their use in fluorescent sequencing method |
| EP2256133B1 (en) | 1997-01-08 | 2016-12-14 | Sigma-Aldrich Co. LLC | Bioconjugation of macromolecules |
| EP1015629A1 (en) * | 1997-01-08 | 2000-07-05 | Proligo L.L.C. | Bioconjugation of oligonucleotides |
| US6455539B2 (en) * | 1999-12-23 | 2002-09-24 | Celltech R&D Limited | Squaric acid derivates |
| GB0119665D0 (en) * | 2001-08-10 | 2001-10-03 | Isis Innovation | Conjugates |
| SE520256C2 (sv) * | 2001-10-25 | 2003-06-17 | Lundonia Biotech Ab | Biomolekylkvadratsyramonoamidkopplingsreagensintermediär |
| WO2003084982A2 (en) * | 2001-11-14 | 2003-10-16 | Luminex Corporation | Functionalized compositions for improved immobilization |
| JP2005247706A (ja) | 2004-03-01 | 2005-09-15 | Japan Science & Technology Agency | スクアリルアミド骨格を有する新規な核酸類縁体 |
| US8926945B2 (en) | 2005-10-07 | 2015-01-06 | Guerbet | Compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium |
| MX2010014310A (es) * | 2008-06-24 | 2011-02-15 | Topotarget As | Derivados de acido escuarico como inhibidores de la nicotinamida. |
| WO2010129672A1 (en) | 2009-05-05 | 2010-11-11 | Miragen Therapeutics | Lipophilic polynucleotide conjugates |
| WO2012027206A1 (en) * | 2010-08-24 | 2012-03-01 | Merck Sharp & Dohme Corp. | SINGLE-STRANDED RNAi AGENTS CONTAINING AN INTERNAL, NON-NUCLEIC ACID SPACER |
| KR20150016334A (ko) | 2012-05-21 | 2015-02-11 | 애질런트 테크놀로지스, 인크. | Dna/rna 적용 분야에서 절단가능한 연결기로서 레트로 딜스 알더 반응 생성물 |
-
2013
- 2013-04-29 EP EP13794477.3A patent/EP2852602B1/en active Active
- 2013-04-29 EP EP20155163.7A patent/EP3747891A3/en active Pending
- 2013-04-29 WO PCT/US2013/038703 patent/WO2013176844A1/en not_active Ceased
- 2013-04-29 LT LTEP13794477.3T patent/LT2852602T/lt unknown
- 2013-04-29 CN CN201910515855.0A patent/CN110156844A/zh active Pending
- 2013-04-29 CN CN201380026149.0A patent/CN104321332A/zh active Pending
- 2013-04-29 JP JP2015514032A patent/JP6351577B2/ja active Active
- 2013-04-29 KR KR1020147035692A patent/KR102129148B1/ko active Active
- 2013-04-29 US US14/402,220 patent/US9512163B2/en active Active
-
2018
- 2018-02-19 JP JP2018026974A patent/JP6515222B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR102129148B1 (ko) | 2020-07-01 |
| CN110156844A (zh) | 2019-08-23 |
| EP2852602A1 (en) | 2015-04-01 |
| EP2852602A4 (en) | 2016-02-17 |
| EP3747891A3 (en) | 2021-03-24 |
| WO2013176844A1 (en) | 2013-11-28 |
| CN104321332A (zh) | 2015-01-28 |
| US20150133631A1 (en) | 2015-05-14 |
| JP6351577B2 (ja) | 2018-07-04 |
| EP2852602B1 (en) | 2020-08-12 |
| JP2018123133A (ja) | 2018-08-09 |
| JP2015520766A (ja) | 2015-07-23 |
| KR20150013854A (ko) | 2015-02-05 |
| EP3747891A2 (en) | 2020-12-09 |
| JP6515222B2 (ja) | 2019-05-15 |
| US9512163B2 (en) | 2016-12-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA201501833B (en) | Method for obtaining 1-kestone | |
| GB201223172D0 (en) | Method | |
| LT2852602T (lt) | Oligonukleotidų konjugavimo būdas | |
| GB201207997D0 (en) | Process | |
| GB201212937D0 (en) | Method | |
| GB201212932D0 (en) | Method | |
| PL2817775T3 (pl) | Sposób pomiaru oglądalności | |
| GB201212934D0 (en) | Method | |
| GB201213636D0 (en) | Method | |
| GB201210858D0 (en) | Method | |
| GB201213360D0 (en) | Process | |
| SG11201407032WA (en) | Method | |
| GB201218570D0 (en) | Method | |
| EP2852660A4 (en) | PROCESS | |
| GB201219960D0 (en) | Process | |
| GB201202198D0 (en) | Method | |
| GB201223316D0 (en) | Method | |
| GB201211393D0 (en) | Method | |
| GB201222737D0 (en) | Method | |
| GB201217688D0 (en) | Method | |
| GB201214029D0 (en) | method | |
| GB201210147D0 (en) | Method | |
| GB201201332D0 (en) | Method | |
| GB2505662B (en) | Vehicle loadfloor apparatus | |
| GB201213858D0 (en) | Method |