EA200400550A1 - Бициклические производные оксопиридина и оксопиримидина - Google Patents

Бициклические производные оксопиридина и оксопиримидина

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Publication number
EA200400550A1
EA200400550A1 EA200400550A EA200400550A EA200400550A1 EA 200400550 A1 EA200400550 A1 EA 200400550A1 EA 200400550 A EA200400550 A EA 200400550A EA 200400550 A EA200400550 A EA 200400550A EA 200400550 A1 EA200400550 A1 EA 200400550A1
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atom
group
optionally substituted
compounds
substituted
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EA200400550A
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EA007957B1 (ru
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Джереми Мартин Дейвис
Дэниел Кристофер Брукингз
Барри Джон Лангем
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Селлтек Р Энд Д Лимитед
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Publication of EA200400550A1 publication Critical patent/EA200400550A1/ru
Publication of EA007957B1 publication Critical patent/EA007957B1/ru

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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D495/04—Ortho-condensed systems

Abstract

Описываются соединения формул (1a) и (1b), в которых пунктирная линия представляет собой необязательную связь; A представляет собой атом -N= или группу -N(R)-, -C(R)= или -C(R)(R)-; R, Rи R, каждый независимо, представляет собой атом водорода или необязательно замещенную Cалкильную группу; X представляет собой атом -O- или -S-, группу -NH- или замещенный атом N; каждый из Y независимо представляет собой атом N, или группу CH, или замещенный атом C; n равно нулю или 1; Alkпредставляет собой необязательно замещенную алифатическую или гетероалифатическую цепь; Lпредставляет собой ковалентную связь, или связующий атом, или связующую группу; Cyпредставляет собой атом водорода или необязательно замещенную циклоалифатическую, полициклоалифатическую, гетероциклоалифатическую, полигетероциклоалифатическую, ароматическую или гетероароматическую группу; Ar представляет собой необязательно замещенную ароматическую или гетероароматическую группу; и соли, сольваты, гидраты и N-оксиды указанных соединений. Соединения являются эффективными ингибиторами p-38-киназы и применяются для профилактики или лечения заболеваний или расстройств, опосредованных p-38-киназой, таких как ревматоидный артрит.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200400550A 2001-10-16 2002-10-16 Производные тиенопиримидина, содержащая их фармацевтическая композиция и их применение EA007957B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0124848.3A GB0124848D0 (en) 2001-10-16 2001-10-16 Chemical compounds
PCT/GB2002/004680 WO2003033502A1 (en) 2001-10-16 2002-10-16 Bicyclic oxopyridine and oxopyrimidine derivatives

Publications (2)

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EA200400550A1 true EA200400550A1 (ru) 2004-10-28
EA007957B1 EA007957B1 (ru) 2007-02-27

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EA200400550A EA007957B1 (ru) 2001-10-16 2002-10-16 Производные тиенопиримидина, содержащая их фармацевтическая композиция и их применение

Country Status (17)

Country Link
US (1) US7176215B2 (ru)
EP (1) EP1438313A1 (ru)
JP (1) JP2005505627A (ru)
KR (1) KR20040062565A (ru)
CN (1) CN1310921C (ru)
AU (1) AU2002336172B2 (ru)
CA (1) CA2462147A1 (ru)
EA (1) EA007957B1 (ru)
GB (1) GB0124848D0 (ru)
HU (1) HUP0401718A3 (ru)
IL (1) IL161384A0 (ru)
MX (1) MXPA04003450A (ru)
NO (1) NO20041975L (ru)
NZ (1) NZ532713A (ru)
PL (1) PL369867A1 (ru)
WO (1) WO2003033502A1 (ru)
ZA (1) ZA200402803B (ru)

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KR20040062565A (ko) 2004-07-07
IL161384A0 (en) 2004-09-27
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JP2005505627A (ja) 2005-02-24
HUP0401718A2 (hu) 2004-12-28
GB0124848D0 (en) 2001-12-05
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NO20041975L (no) 2005-07-16
US7176215B2 (en) 2007-02-13
MXPA04003450A (es) 2004-07-16
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WO2003033502A1 (en) 2003-04-24
NZ532713A (en) 2005-10-28
HUP0401718A3 (en) 2008-07-28
AU2002336172B2 (en) 2007-09-13
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