ATE23716T1 - 5,6,7-trinor-4,8-inter-m-phenylen-prostaglandin i2-derivate. - Google Patents

5,6,7-trinor-4,8-inter-m-phenylen-prostaglandin i2-derivate.

Info

Publication number
ATE23716T1
ATE23716T1 AT83100449T AT83100449T ATE23716T1 AT E23716 T1 ATE23716 T1 AT E23716T1 AT 83100449 T AT83100449 T AT 83100449T AT 83100449 T AT83100449 T AT 83100449T AT E23716 T1 ATE23716 T1 AT E23716T1
Authority
AT
Austria
Prior art keywords
carbon atoms
hydrogen
trinor
prostaglandin
phenylene
Prior art date
Application number
AT83100449T
Other languages
German (de)
English (en)
Inventor
Kiyotaka Ohno
Hiroshi Nagase
Kazuhisa Matsumoto
Shintaro Nishio
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11630492&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE23716(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Toray Industries filed Critical Toray Industries
Application granted granted Critical
Publication of ATE23716T1 publication Critical patent/ATE23716T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/09—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis
    • C07C29/12—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of esters of mineral acids
    • C07C29/124—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of esters of mineral acids of halides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/56—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by isomerisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4015—Esters of acyclic unsaturated acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT83100449T 1982-01-20 1983-01-19 5,6,7-trinor-4,8-inter-m-phenylen-prostaglandin i2-derivate. ATE23716T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP57006150A JPS58124778A (ja) 1982-01-20 1982-01-20 ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体
EP83100449A EP0084856B2 (en) 1982-01-20 1983-01-19 5,6,7-Trinor-4, 8-inter-m-phenylene prostaglandin I2 derivatives

Publications (1)

Publication Number Publication Date
ATE23716T1 true ATE23716T1 (de) 1986-12-15

Family

ID=11630492

Family Applications (1)

Application Number Title Priority Date Filing Date
AT83100449T ATE23716T1 (de) 1982-01-20 1983-01-19 5,6,7-trinor-4,8-inter-m-phenylen-prostaglandin i2-derivate.

Country Status (8)

Country Link
US (1) US4474802A (Direct)
EP (1) EP0084856B2 (Direct)
JP (1) JPS58124778A (Direct)
AT (1) ATE23716T1 (Direct)
AU (1) AU556348B2 (Direct)
CA (1) CA1226280A (Direct)
DE (1) DE3367774D1 (Direct)
ZA (1) ZA83328B (Direct)

Families Citing this family (61)

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Publication number Priority date Publication date Assignee Title
CA1275287C (en) * 1986-01-24 1990-10-16 Kiyotaka Ohno 2,5,6,7-tetranor-4,8-inter-m-phanylene pgi derivatives
US4880939A (en) * 1986-12-11 1989-11-14 Toray Industries 2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8-inter-m-phenylene PGI2 derivatives
US5202447A (en) * 1989-02-27 1993-04-13 Toray Industries, Inc. Process of producing 5,6,7-trinor-4,8-inter-m-phenylene pgi2 derivatives
NO174962C (no) * 1989-03-14 1994-08-10 Toray Industries Analogifremgangsmåte for fremstilling av terapeutisk aktive 2,5,6,7-tetranor-4,8-inter-m-fenylen PGI2-derivater
JP2608135B2 (ja) * 1989-03-31 1997-05-07 科研製薬株式会社 糖尿病性神経障害治療剤
DE4104607A1 (de) * 1991-02-12 1992-08-13 Schering Ag Prostacyclin- und carbacyclinderivate als mittel zur behandlung von fiebrigen erkrankungen
JP3230246B2 (ja) * 1991-04-11 2001-11-19 東レ株式会社 悪性腫瘍転移抑制剤
US5496850A (en) * 1991-04-11 1996-03-05 Toray Industries, Inc. Antimetastasis agent of malignant tumors
US5233059A (en) * 1991-07-25 1993-08-03 Iowa State University Research Foundation, Inc. Synthesis of benzoprostacyclins using palladium catalysis
US5169959A (en) * 1991-09-23 1992-12-08 Iowa State University Research Foundation, Inc. Free radical-catalyzed synthesis of benzoprostacyclins
US5475026A (en) * 1991-10-25 1995-12-12 Toray Industries, Inc. Agent for treating hepatic diseases
JP3102141B2 (ja) * 1992-05-29 2000-10-23 東レ株式会社 養毛育毛剤
ATE149838T1 (de) * 1992-08-07 1997-03-15 Schering Ag Verwendung von prostanderivaten zur herstellung eines arzneimittels zur behandlung der chronischen polyarthritis
DE4226615C1 (de) * 1992-08-07 1994-05-19 Schering Ag Verwendung von Prostan-Derivaten zur Behandlung von chronischer Polyarthritis
CA2123890C (en) * 1992-09-18 1998-01-20 Kiyotaka Ohno Novel sulfonic acid derivative and medicinal use thereof
JPH07126161A (ja) * 1993-10-29 1995-05-16 Toray Ind Inc 心不全治療剤
JP3541417B2 (ja) * 1994-02-24 2004-07-14 日産化学工業株式会社 フェニル置換ヒドロキシシクロペンテノン類、ペンタノン類及びフェニル置換プロスタグランジンｉ２類中間体並びにその製造法及び光学分割法
ATE220911T1 (de) * 1994-11-17 2002-08-15 Toray Industries Transdermal absorbierbare zubereitung
FI964303A0 (fi) * 1995-02-27 1996-10-25 Toray Industries Keuhkosydänvian hoitamiseen tarkoitettu aine
CZ168896A3 (en) * 1995-06-27 1997-01-15 Egyt Gyogyszervegyeszeti Gyar Oxaindene derivatives and process for preparing thereof
DE19530884C2 (de) * 1995-08-11 1997-07-31 Schering Ag Verwendung von Prostan-Derivaten sowie deren Kombination mit Antibiotika zur Behandlung von bakteriellen Meningitis
WO1997041864A1 (en) 1996-05-07 1997-11-13 Kaken Pharmaceutical Co., Ltd. Ophthalmic preparations
WO1998011899A1 (fr) * 1996-09-17 1998-03-26 Toray Industries, Inc. Agent de potentialisation de la fonction plaquettaire et procede de traitement du dysfonctionnement plaquettaire
CN1224354A (zh) * 1997-02-27 1999-07-28 东丽株式会社 肺循环改善剂
EP0925788A4 (en) * 1997-03-13 1999-12-01 Toray Industries MEDICINES FOR TREATING DIABETIC VASCULAR INJURIES
CN100502877C (zh) * 1997-03-14 2009-06-24 东丽株式会社 前列腺素i衍生物缓释制剂
US6653345B2 (en) 1997-09-16 2003-11-25 Toray Industries, Inc. C-C chemokine synthesis inhibitor
CA2316485C (en) 1997-12-26 2008-01-22 Yamanouchi Pharmaceutical Co., Ltd. Sustained-release pharmaceutical composition
JP4019481B2 (ja) 1998-01-23 2007-12-12 ソニー株式会社 情報処理装置および方法、情報処理システム、並びに提供媒体
EP1022030A1 (en) * 1998-08-12 2000-07-26 Toray Industries, Inc. Plasminogen activator inhibitor 1 production regulatory agents
WO2000009135A1 (en) * 1998-08-14 2000-02-24 Toray Industries, Inc. Peridermal cell protecting agents
US20030092760A1 (en) * 2001-03-12 2003-05-15 Toray Industries, Inc. Therapeutic agent for renal failure
HU227157B1 (en) * 2001-07-30 2010-09-28 Chinoin Gyogyszer Es Vegyeszet Production of beraprost ester by selective oxidation
JP3340732B1 (ja) * 2001-10-05 2002-11-05 日本医薬品工業株式会社 シクロペンタベンゾフラン誘導体の製造方法及びその製造原料となる新規化合物
GB0215757D0 (en) * 2002-07-08 2002-08-14 Cascade Biochem Ltd Benzoprostacyclin intermediates methods for their preparation and products derived therefrom
CA2529351C (en) 2003-05-09 2012-04-17 Toray Industries, Inc. Use of prostaglandin i for enhancing the effect of a renin-angiotensin system inhibitor on a renal disease
WO2005000316A1 (ja) * 2003-06-25 2005-01-06 Cardiovascular Institute, Ltd. 性交機能改善用外用製剤
ES2451627T3 (es) 2005-07-08 2014-03-28 Toray Industries, Inc. Agente terapéutico y método de tratamiento para mejorar uremia
JP5424291B2 (ja) * 2006-03-03 2014-02-26 独立行政法人国立循環器病研究センター 骨髄細胞の動員剤および動員方法
EP2094273B1 (en) * 2006-11-16 2013-03-06 Gemmus Pharma Inc. EP2 and EP4 agonists as agents for the treatment of influenza A viral infection
MX350011B (es) * 2008-08-13 2017-08-22 Actelion Pharmaceuticals Ltd Composiciones terapeuticas que contienen macitentan.
NZ599128A (en) 2009-10-14 2014-02-28 Gemmus Pharma Inc Combination therapy treatment for viral infections
JP5697260B2 (ja) 2009-11-13 2015-04-08 東レ株式会社 糖尿病の治療または予防薬
CN105418567B (zh) 2011-06-16 2019-09-06 琅歌生物技术股份有限公司 贝前列素的生产方法
CN103509044A (zh) * 2012-06-21 2014-01-15 上海天伟生物制药有限公司 贝前列素钠中间体及其制备方法
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CN106632372B (zh) * 2016-09-26 2019-04-02 上海北卡医药技术有限公司 一种中间体及其制备方法和用途
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CN107325122B (zh) * 2017-01-06 2020-05-01 常州博海威医药科技股份有限公司 制备贝前列腺素的新中间体及其制备方法
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Family Cites Families (3)

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Publication number Priority date Publication date Assignee Title
DE2734791A1 (de) * 1977-07-29 1979-02-15 Schering Ag Neue prostaglandin-i tief 2 -derivate und verfahren zu ihrer herstellung
JPS5931510B2 (ja) * 1979-09-03 1984-08-02 東レ株式会社 ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体
JPS57144276A (en) * 1981-03-03 1982-09-06 Toray Ind Inc 5,6,7-trinor-4,8-inter-m-phenylene pgi2 derivative

Also Published As

Publication number Publication date
CA1226280A (en) 1987-09-01
US4474802A (en) 1984-10-02
JPH0153672B2 (Direct) 1989-11-15
AU1060983A (en) 1983-07-28
ZA83328B (en) 1983-10-26
AU556348B2 (en) 1986-10-30
DE3367774D1 (de) 1987-01-08
EP0084856B1 (en) 1986-11-20
EP0084856A1 (en) 1983-08-03
JPS58124778A (ja) 1983-07-25
EP0084856B2 (en) 1994-05-04

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Legal Events

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UEP Publication of translation of european patent specification
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time