ATE235490T1 - Heteroarylamine als neue acetylcholinesterase- inhibitoren - Google Patents
Heteroarylamine als neue acetylcholinesterase- inhibitorenInfo
- Publication number
- ATE235490T1 ATE235490T1 AT92918761T AT92918761T ATE235490T1 AT E235490 T1 ATE235490 T1 AT E235490T1 AT 92918761 T AT92918761 T AT 92918761T AT 92918761 T AT92918761 T AT 92918761T AT E235490 T1 ATE235490 T1 AT E235490T1
- Authority
- AT
- Austria
- Prior art keywords
- heteroarylamines
- acetylcholinesterase inhibitors
- new
- new acetylcholinesterase
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Control Of Indicators Other Than Cathode Ray Tubes (AREA)
- Control Of El Displays (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77128391A | 1991-10-03 | 1991-10-03 | |
| PCT/US1992/007230 WO1993007140A1 (en) | 1991-10-03 | 1992-08-31 | Heteroaryl amines as novel acetyl cholinesterase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE235490T1 true ATE235490T1 (de) | 2003-04-15 |
Family
ID=25091318
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92918761T ATE235490T1 (de) | 1991-10-03 | 1992-08-31 | Heteroarylamine als neue acetylcholinesterase- inhibitoren |
Country Status (36)
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5620973A (en) * | 1993-11-30 | 1997-04-15 | Takeda Chemical Industries, Ltd. | Tetracyclic condensed heterocyclic compounds and their use |
| EP0976404A3 (en) * | 1998-07-30 | 2001-06-27 | Pfizer Products Inc. | A pharmaceutical composition for the prevention and treatment of diseases of cognitive dysfunction in a mammal |
| US6218383B1 (en) | 1998-08-07 | 2001-04-17 | Targacept, Inc. | Pharmaceutical compositions for the prevention and treatment of central nervous system disorders |
| HUP0104493A3 (en) | 1998-09-30 | 2002-12-28 | Takeda Pharmaceutical | Drugs for improving vesical excretory strength |
| SE9902268D0 (sv) * | 1999-06-16 | 1999-06-16 | Astra Ab | Pharmaceutically active compounds |
| CN1317276C (zh) * | 2000-09-29 | 2007-05-23 | 中国科学院上海药物研究所 | 一类吲哚基哌啶类化合物及其制备方法和用途 |
| BR0114552A (pt) * | 2000-10-20 | 2003-07-01 | Biovitrum Ab | N1- (benzenosulfonil) indóis 2-,3-,4-, 5- substituìdos e seu uso em terapia |
| WO2004035571A1 (en) * | 2002-10-15 | 2004-04-29 | Rigel Pharmaceuticals, Inc. | Substituted indoles and their use as hcv inhibitors |
| US20060014801A1 (en) * | 2002-11-22 | 2006-01-19 | The Johns Hopkins University | Prevention and treatment of cognitive impairment using (R)-(-)-5-methyl-1-nicotynoyl-2-pyrazoline (MNP) and analogs |
| WO2005112946A1 (en) * | 2004-05-14 | 2005-12-01 | The Johns Hopkins University | Method for improving cognitive function by co-administration of a gabab receptor antagonist and an acetylcholinesterase inhibitor |
| EP1600447A1 (en) * | 2004-05-28 | 2005-11-30 | Neuropharma S.A.U. | Butyrylcholinesterase selective inhibitors |
| HRP20090034T3 (en) | 2004-06-09 | 2009-03-31 | Glaxo Group Limited | Pyrrolopyridine derivatives |
| AU2005322611A1 (en) * | 2004-12-23 | 2006-07-06 | Voyager Pharmaceutical Corporation | Leuprolide acetate and acetylcholinesterase inhibitors or NMDA receptor antagonists for the treatment of Alzheimer's disease |
| CN1808106B (zh) * | 2005-01-21 | 2010-11-24 | 中国科学院上海药物研究所 | 一种用核磁共振筛选乙酰胆碱酯酶抑制剂的方法 |
| US8846315B2 (en) | 2008-08-12 | 2014-09-30 | Zinfandel Pharmaceuticals, Inc. | Disease risk factors and methods of use |
| ME01898B (me) * | 2008-08-12 | 2014-12-20 | Zinfandel Pharmaceuticals Inc | Metoda za identifikaciju faktora rizika od alchajmerove bolesti |
| CN101503414B (zh) * | 2009-03-04 | 2013-10-30 | 沈阳药科大学 | 噻唑并[3,2-b]-1,2,4-三嗪衍生物及其应用 |
| KR20120089701A (ko) * | 2009-10-02 | 2012-08-13 | 아벡신 에이에스 | 소염제 2-옥소티아졸 및 2-옥소옥사졸 |
| EA202092673A3 (ru) | 2010-02-09 | 2021-05-31 | Дзе Джонс Хопкинс Юниверсити | Способы и композиции для улучшения когнитивной функции |
| JP2014505055A (ja) | 2011-01-10 | 2014-02-27 | ジンファンデル ファーマシューティカルズ インコーポレイテッド | アルツハイマー病を治療するための方法及び製剤 |
| CA2891122C (en) | 2012-11-14 | 2021-07-20 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| KR102268357B1 (ko) | 2013-01-29 | 2021-06-23 | 아벡신 에이에스 | 항염증성 및 항종양성 2-옥소티아졸 및 2-옥소티오펜 화합물 |
| WO2014144801A1 (en) | 2013-03-15 | 2014-09-18 | Agenebio Inc. | Methods and compositions for improving cognitive function |
| US10806717B2 (en) | 2013-03-15 | 2020-10-20 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| CN103333163A (zh) * | 2013-07-09 | 2013-10-02 | 广州中医药大学 | 一种苯并呋喃类衍生物及其制备方法和应用 |
| GB201413695D0 (en) | 2014-08-01 | 2014-09-17 | Avexxin As | Compound |
| NZ738682A (en) | 2015-05-22 | 2022-01-28 | Agenebio Inc | Extended release pharmaceutical compositions of levetiracetam |
| GB201604318D0 (en) | 2016-03-14 | 2016-04-27 | Avexxin As | Combination therapy |
| CN107141266B (zh) * | 2017-06-28 | 2019-04-09 | 佳木斯大学附属第一医院 | 一种用于治疗阿尔茨海默病的杂环化合物及其制备方法 |
| CN115466211B (zh) * | 2022-06-09 | 2024-02-23 | 中国人民解放军空军军医大学 | 一种n-苯基喹啉-4-胺类化合物及其应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1068259B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1954-04-28 | 1959-11-05 | ||
| FR2334358A1 (fr) * | 1975-12-12 | 1977-07-08 | Sogeras | Nouveaux medicaments derives de l'indole |
| US4122265A (en) * | 1976-05-21 | 1978-10-24 | Hoffmann-La Roche Inc. | Derivatives of 3-phenylisoindole-1-carboxylic acid |
| BE889931A (fr) * | 1980-08-12 | 1982-02-11 | Glaxo Group Ltd | Derives indoliques, leur preparation et leurs applications en tant que medicaments |
| GB8615562D0 (en) * | 1986-06-25 | 1986-07-30 | Maggioni Farma | Aminoalcohols |
| KR910006138B1 (ko) * | 1986-09-30 | 1991-08-16 | 에자이 가부시끼가이샤 | 환상아민 유도체 |
| FI95572C (fi) * | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
| IT1226100B (it) * | 1988-07-07 | 1990-12-10 | Dompe Farmaceutici Spa | Derivati benzimidazolici farmacologicamente attivi. |
| FR2640266B2 (fr) * | 1988-07-12 | 1992-07-10 | Synthelabo | Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique |
| US4908372A (en) * | 1988-10-13 | 1990-03-13 | Merrell Dow Pharmaceuticals Inc. | Antihistaminic piperidinyl benzimidazoles |
| JP2969359B2 (ja) * | 1989-01-13 | 1999-11-02 | 武田薬品工業株式会社 | 環状アミン化合物 |
| US5064840A (en) * | 1989-08-03 | 1991-11-12 | Merrell Dow Pharmaceuticals | Anti-psychotic piperidylbenzimidazole compounds |
| TW197442B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1990-02-08 | 1993-01-01 | Pfizer | |
| US5116846A (en) * | 1990-03-28 | 1992-05-26 | Du Pont Merck Pharmaceutical Company | N-aralkyl piperidine derivatives as psychotropic drugs |
| TW197435B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1990-11-22 | 1993-01-01 | Takeda Pharm Industry Co Ltd | |
| NZ243065A (en) * | 1991-06-13 | 1995-07-26 | Lundbeck & Co As H | Piperidine derivatives and pharmaceutical compositions |
| PT626968E (pt) * | 1992-02-13 | 2002-03-28 | Merrell Pharma Inc | Derivados de piperidinilo tiaciclicos |
| TW226019B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1992-03-23 | 1994-07-01 | Sankyo Co |
-
1992
- 1992-08-29 TW TW081106843A patent/TW263504B/zh active
- 1992-08-31 CA CA002119647A patent/CA2119647C/en not_active Expired - Fee Related
- 1992-08-31 EP EP92918761A patent/EP0606248B1/en not_active Expired - Lifetime
- 1992-08-31 DK DK92918761T patent/DK0606248T3/da active
- 1992-08-31 RO RO94-00533A patent/RO112868B1/ro unknown
- 1992-08-31 PL PL92303096A patent/PL171669B1/pl not_active IP Right Cessation
- 1992-08-31 BR BR9206577A patent/BR9206577A/pt not_active Application Discontinuation
- 1992-08-31 DE DE69232976T patent/DE69232976T2/de not_active Expired - Fee Related
- 1992-08-31 UA UA94005424A patent/UA41290C2/uk unknown
- 1992-08-31 KR KR1019940701066A patent/KR0170458B1/ko not_active Expired - Fee Related
- 1992-08-31 US US08/211,044 patent/US5574046A/en not_active Expired - Lifetime
- 1992-08-31 RU RU9494019972A patent/RU2100357C1/ru not_active IP Right Cessation
- 1992-08-31 JP JP5506442A patent/JP2546785B2/ja not_active Expired - Fee Related
- 1992-08-31 SG SG1996006904A patent/SG52618A1/en unknown
- 1992-08-31 HU HU9400952A patent/HU225049B1/hu unknown
- 1992-08-31 AT AT92918761T patent/ATE235490T1/de not_active IP Right Cessation
- 1992-08-31 PL PL92312752A patent/PL171693B1/pl not_active IP Right Cessation
- 1992-08-31 DE DE9290112U patent/DE9290112U1/de not_active Expired - Lifetime
- 1992-08-31 CZ CZ1994785A patent/CZ290807B6/cs not_active IP Right Cessation
- 1992-08-31 ES ES92918761T patent/ES2193137T3/es not_active Expired - Lifetime
- 1992-08-31 AU AU25196/92A patent/AU667053B2/en not_active Ceased
- 1992-08-31 WO PCT/US1992/007230 patent/WO1993007140A1/en active IP Right Grant
- 1992-08-31 PL PL92312751A patent/PL171984B1/pl not_active IP Right Cessation
- 1992-09-07 AP APAP/P/1992/000421A patent/AP314A/en active
- 1992-09-15 PH PH44935A patent/PH31290A/en unknown
- 1992-09-24 IL IL10327492A patent/IL103274A/en not_active IP Right Cessation
- 1992-09-25 IS IS3919A patent/IS1745B/is unknown
- 1992-09-30 EG EG58192A patent/EG21481A/xx active
- 1992-09-30 CN CN92112079A patent/CN1035615C/zh not_active Expired - Fee Related
- 1992-10-01 PT PT100917A patent/PT100917B/pt not_active IP Right Cessation
- 1992-10-02 ZA ZA927589A patent/ZA927589B/xx unknown
- 1992-10-02 MX MX9205678A patent/MX9205678A/es unknown
- 1992-10-02 UY UY23484A patent/UY23484A1/es not_active IP Right Cessation
- 1992-10-02 MA MA22956A patent/MA22672A1/fr unknown
- 1992-10-02 NZ NZ244601A patent/NZ244601A/en not_active IP Right Cessation
-
1994
- 1994-03-18 OA OA60484A patent/OA09895A/en unknown
- 1994-03-30 NO NO941179A patent/NO308533B1/no unknown
- 1994-03-31 FI FI941518A patent/FI116939B/fi active IP Right Grant
- 1994-03-31 BG BG98689A patent/BG61727B1/bg unknown
-
1997
- 1997-10-24 US US08/957,639 patent/US6124321A/en not_active Expired - Fee Related
-
1999
- 1999-11-11 US US09/438,712 patent/US6303633B1/en not_active Expired - Fee Related
-
2001
- 2001-08-23 US US09/935,903 patent/US20020049210A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0606248 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |