ATE221086T1 - Photovernetztes hyaluronsäuregel und verfahren zu dessen herstellung - Google Patents
Photovernetztes hyaluronsäuregel und verfahren zu dessen herstellungInfo
- Publication number
- ATE221086T1 ATE221086T1 AT96938473T AT96938473T ATE221086T1 AT E221086 T1 ATE221086 T1 AT E221086T1 AT 96938473 T AT96938473 T AT 96938473T AT 96938473 T AT96938473 T AT 96938473T AT E221086 T1 ATE221086 T1 AT E221086T1
- Authority
- AT
- Austria
- Prior art keywords
- hyaluronic acid
- pct
- date
- acid gel
- photo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/042—Polysaccharides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP31982595 | 1995-11-15 | ||
PCT/JP1996/003349 WO1997018244A1 (en) | 1995-11-15 | 1996-11-14 | Photocured cross-linked-hyaluronic acid gel and method of preparation thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE221086T1 true ATE221086T1 (de) | 2002-08-15 |
Family
ID=18114635
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT96938473T ATE221086T1 (de) | 1995-11-15 | 1996-11-14 | Photovernetztes hyaluronsäuregel und verfahren zu dessen herstellung |
Country Status (15)
Country | Link |
---|---|
US (1) | US6031017A (de) |
EP (1) | EP0861270B1 (de) |
JP (1) | JP3439481B2 (de) |
KR (1) | KR100509882B1 (de) |
CN (1) | CN1098863C (de) |
AT (1) | ATE221086T1 (de) |
AU (1) | AU722250B2 (de) |
CA (1) | CA2237192C (de) |
DE (1) | DE69622575T2 (de) |
ES (1) | ES2179215T3 (de) |
HK (1) | HK1015799A1 (de) |
HU (1) | HU224697B1 (de) |
NO (1) | NO982212L (de) |
RU (1) | RU2197501C2 (de) |
WO (1) | WO1997018244A1 (de) |
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6630457B1 (en) | 1998-09-18 | 2003-10-07 | Orthogene Llc | Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same |
EP1217008B1 (de) * | 2000-12-19 | 2006-03-01 | Seikagaku Corporation | Photohärtbare Derivate von Hyaluronsäure, Verfahren zu deren Herstellung, vernetztes und photogehärtetes Derivat der Hyaluronsäure und diese enthaltendes medizinisches Material |
JP4172176B2 (ja) * | 2000-12-19 | 2008-10-29 | 生化学工業株式会社 | 光反応性ヒアルロン酸およびその製造方法ならびに光架橋ヒアルロン酸および医用材料 |
FR2819722B1 (fr) * | 2001-01-19 | 2006-11-24 | Corneal Ind | Utilisation de l'acide hyaluronique ou d'au moins l'un de ses sels dans le cadre d'un traitemnet chirurgical de la presbytie |
CA2435491C (en) | 2001-01-31 | 2010-02-02 | Seikagaku Corporation | Crosslinked polysaccharide sponge |
US6673919B2 (en) | 2001-03-30 | 2004-01-06 | Chisso Cororation | Chemically modified hyaluronic acid or salts thereof, and a process for producing thereof |
EP1249247B1 (de) | 2001-03-30 | 2007-02-28 | Chisso Corporation | Pharmazeutische Zusammensetzung zur Behandlung gynäkologischer Erkrankungen |
JP2003052819A (ja) * | 2001-08-10 | 2003-02-25 | Seikagaku Kogyo Co Ltd | 薬剤充填注射器包装物およびその滅菌または殺菌方法 |
ITPD20020064A1 (it) * | 2002-03-12 | 2003-09-12 | Fidia Advanced Biopolymers Srl | Derivati esterei dell'acido ialuronico per la preparazione di idrogelda utilizzare in campo biomedico, sanitario e chirurgico e come sistem |
KR20040009891A (ko) * | 2002-07-26 | 2004-01-31 | 주식회사 엘지생명과학 | 히알루론산의 유도체 겔 및 그 제조방법 |
EP1534764B1 (de) * | 2002-08-09 | 2014-07-16 | Carnegie Mellon University | Polymere, superweichelastomere und verfahren zur herstellung derselben |
US7465766B2 (en) | 2004-01-08 | 2008-12-16 | The Cleveland Clinic Foundation | Hydroxyphenyl cross-linked macromolecular network and applications thereof |
US8137688B2 (en) | 2003-01-10 | 2012-03-20 | The Cleveland Clinic Foundation | Hydroxyphenyl cross-linked macromolecular network and applications thereof |
US8138265B2 (en) | 2003-01-10 | 2012-03-20 | The Cleveland Clinic Foundation | Hydroxyphenyl cross-linked macromolecular network and applications thereof |
US6982298B2 (en) | 2003-01-10 | 2006-01-03 | The Cleveland Clinic Foundation | Hydroxyphenyl cross-linked macromolecular network and applications thereof |
US20040167480A1 (en) * | 2003-02-21 | 2004-08-26 | Advanced Medical Optics, Inc. | Administration of multiple viscoelastic solutions with a multi-compartment syringe |
EP1607405B1 (de) * | 2003-03-11 | 2011-05-04 | Seikagaku Corporation | Photovernetzte polysaccharidzusammensetzung und herstellungsverfahren dafür |
JP2004323454A (ja) * | 2003-04-25 | 2004-11-18 | Chisso Corp | 薬剤 |
US8071756B2 (en) | 2003-09-12 | 2011-12-06 | Seikagaku Corporation | Polysaccharide pseudo-sponge |
EP1725590A4 (de) * | 2004-03-05 | 2013-08-07 | Univ Carnegie Mellon | Verfahren zur atom transfer radical polymerization |
US8293890B2 (en) | 2004-04-30 | 2012-10-23 | Advanced Cardiovascular Systems, Inc. | Hyaluronic acid based copolymers |
US8222399B2 (en) * | 2004-09-15 | 2012-07-17 | Seikagaku Corporation | Photoreactive polysaccharide, photocrosslinked polysaccharide product and method of making same and medical materials made from the crosslinked polysaccharide |
US20060069063A1 (en) * | 2004-09-27 | 2006-03-30 | Yng-Jiin Wang | Crosslinked polygalacturonic acid used for postsurgical tissue adhesion prevention |
US20090088846A1 (en) | 2007-04-17 | 2009-04-02 | David Myung | Hydrogel arthroplasty device |
SI2664334T1 (sl) * | 2004-12-30 | 2015-06-30 | Genzyme Corporation | Reĺ˝imi za intraartikularno viskosuplemantacijo |
CA2611693A1 (en) * | 2005-06-15 | 2006-12-28 | Surmodics, Inc. | Macromer composition including light activated initiator |
WO2007004675A1 (ja) * | 2005-07-06 | 2007-01-11 | Seikagaku Corporation | 薬剤導入光架橋ヒアルロン酸誘導体ゲル |
KR20080080481A (ko) * | 2005-09-02 | 2008-09-04 | 콜바르 라이프사이언스 리미티드 | 교차-결합된 다당류 및 단백질 매트릭스 및 그의 제조 방법 |
WO2007043702A1 (en) * | 2005-10-12 | 2007-04-19 | Seikagaku Corporation | Agent for applying to mucosa and method for production thereof |
JP5043364B2 (ja) * | 2006-05-01 | 2012-10-10 | 生化学工業株式会社 | 多糖誘導体の製造方法 |
CN100389145C (zh) * | 2006-09-29 | 2008-05-21 | 北京大学 | 含天然高分子的水凝胶及其辐射制备方法 |
AU2007328871B2 (en) | 2006-12-06 | 2013-11-21 | Seikagaku Corporation | Pharmaceutical agent having long-lasting effect of treating arthritic disorders |
US20110136935A1 (en) * | 2007-08-30 | 2011-06-09 | National University Of Singapore | Bone and/or dental cement composition and uses thereof |
EP2249891B1 (de) | 2008-02-13 | 2016-05-25 | The Cleveland Clinic Foundation | Molekulare verstärkung von extrazellulärer matrix und anwendungsverfahren |
WO2009117737A2 (en) * | 2008-03-21 | 2009-09-24 | Biomimedica, Inc | Methods, devices and compositions for adhering hydrated polymer implants to bone |
US8410180B2 (en) | 2008-04-30 | 2013-04-02 | The Cleveland Clinic Foundation | Methods to treat urinary incontinence |
US20120209396A1 (en) | 2008-07-07 | 2012-08-16 | David Myung | Orthopedic implants having gradient polymer alloys |
US8883915B2 (en) | 2008-07-07 | 2014-11-11 | Biomimedica, Inc. | Hydrophobic and hydrophilic interpenetrating polymer networks derived from hydrophobic polymers and methods of preparing the same |
AU2009268687A1 (en) * | 2008-07-07 | 2010-01-14 | Biomimedica, Inc | Hydrophilic interpenetrating polymer networks derived from hydrophobic polymers |
WO2010017282A1 (en) | 2008-08-05 | 2010-02-11 | Biomimedica, Inc. | Polyurethane-grafted hydrogels |
US20110229565A1 (en) | 2008-09-17 | 2011-09-22 | Karp Jeffrey M | Drug Delivery Composition Comprising a Self-Assembled Gelator |
ITRM20080636A1 (it) * | 2008-11-28 | 2010-05-29 | Univ Palermo | Procedimento per la produzione di derivati funzionalizzati dell acido ialuronico e relativi idrogeli. |
US8962764B2 (en) | 2009-03-27 | 2015-02-24 | Carnegie Mellon University | Preparation of functional star macromolecules |
WO2010138074A1 (en) * | 2009-05-29 | 2010-12-02 | Hilborn Joens | Hyaluronic acid based delivery systems |
JO3008B1 (ar) | 2009-08-13 | 2016-09-05 | Seikagaku Kogyo Co Ltd | تركيب صيدلي لتخفيف الألم |
CN101716331B (zh) * | 2009-12-16 | 2012-03-07 | 中山大学 | 利用支链淀粉-对硝基肉桂酸接枝物原位包埋蛋白类生物大分子的方法 |
WO2011075742A1 (en) * | 2009-12-18 | 2011-06-23 | Biomimedica, Inc. | Method, device, and system for shaving and shaping of a joint |
US9017712B2 (en) * | 2010-07-12 | 2015-04-28 | Shin Poong Pharmaceutical Co., Ltd. | Filler composition for tissue reinforcement |
WO2012040623A2 (en) | 2010-09-24 | 2012-03-29 | The Brigham And Women's Hospital, Inc. | Nanostructured gels capable of controlled release of encapsulated agents |
US9644042B2 (en) | 2010-12-17 | 2017-05-09 | Carnegie Mellon University | Electrochemically mediated atom transfer radical polymerization |
ITTO20110428A1 (it) * | 2011-05-13 | 2012-11-14 | Rottapharm Spa | Esteri dell'acido ialuronico, loro preparazione ed uso in dermatologia |
CN102225220A (zh) * | 2011-06-14 | 2011-10-26 | 天津晶明新技术开发有限公司 | 眼科手术粘弹剂 |
US20140275420A1 (en) | 2011-08-22 | 2014-09-18 | Carnegie Mellon University | Atom transfer radical polymerization under biologically compatible conditions |
KR20140115294A (ko) | 2011-10-03 | 2014-09-30 | 바이오미메디카, 인코포레이티드 | 순응성 재료들을 또 다른 표면으로 앵커링하기 위한 중합체성 접착제 |
CA2856512A1 (en) | 2011-11-21 | 2013-05-30 | Biomimedica, Inc. | Systems, devices, and methods for anchoring orthopaedic implants to bone |
WO2013126745A2 (en) | 2012-02-23 | 2013-08-29 | Carnegie Mellon University | Ligands designed to provide highly active catalyst complexes |
CZ304267B6 (cs) * | 2012-11-27 | 2014-02-05 | Contipro Biotech S.R.O. | Fotoreaktivní derivát kyseliny hyaluronové, způsob jeho přípravy, 3D síťovaný derivát kyseliny hyaluronové, způsob jeho přípravy a použití |
RU2513838C1 (ru) * | 2013-02-21 | 2014-04-20 | Общество с ограниченной ответственностью "ДЖИ-Групп" | Гистоэквивалент-биопластический материал |
KR101869988B1 (ko) * | 2013-03-27 | 2018-06-21 | 주식회사 엘지화학 | 점탄성 히알루론산 가교물 제조용 조성물, 및 이를 이용하여 얻은 히알루론산 가교물 |
WO2015053282A1 (ja) * | 2013-10-08 | 2015-04-16 | キユーピー株式会社 | カルボキシメチル基含有修飾ヒアルロン酸および/またはその塩の架橋物およびその製造方法 |
EP3085768A4 (de) | 2013-12-18 | 2017-08-09 | Japan Science And Technology Agency | Struktur für tierzelle, verfahren zur trennung von tierzelle und verfahren zur anpassung der elastizität der oberfläche einer struktur für tierzelle |
EP3167914B1 (de) * | 2014-07-11 | 2021-09-29 | Menicon Co., Ltd. | Material zur sicherstellung der sichtbarkeit und vorrichtung zum entladen des materials zur sicherstellung der sichtbarkeit |
US9982070B2 (en) | 2015-01-12 | 2018-05-29 | Carnegie Mellon University | Aqueous ATRP in the presence of an activator regenerator |
US11077228B2 (en) | 2015-08-10 | 2021-08-03 | Hyalex Orthopaedics, Inc. | Interpenetrating polymer networks |
WO2017057504A1 (ja) | 2015-09-30 | 2017-04-06 | 学校法人自治医科大学 | 粘弾性組成物 |
KR20170090965A (ko) * | 2016-01-29 | 2017-08-08 | 한미약품 주식회사 | 복합 히알루론산 가교물 및 그 제조방법 |
CN115837006A (zh) | 2016-05-06 | 2023-03-24 | 布里格姆及妇女医院股份有限公司 | 用于向软骨中受控递送被囊封的药剂的二元自组装凝胶 |
US20190264008A1 (en) | 2016-10-31 | 2019-08-29 | Kewpie Corporation | Gel Composition and Method for Producing Same |
WO2018132582A1 (en) | 2017-01-12 | 2018-07-19 | Carnegie Mellon University | Surfactant assisted formation of a catalyst complex for emulsion atom transfer radical polymerization processes |
US11020410B2 (en) | 2017-02-03 | 2021-06-01 | The Brigham And Women's Hospital, Inc. | Self-assembled gels formed with anti-retroviral drugs, prodrugs thereof, and pharmaceutical uses thereof |
CN106832439A (zh) * | 2017-03-26 | 2017-06-13 | 广州市芯检康生物科技有限公司 | 一种用于全血成分保护的新型气凝胶多功能即用型复合材料及其制备方法 |
JP7211974B2 (ja) * | 2017-05-08 | 2023-01-24 | アリヴィオ セラピューティクス, インコーポレイテッド | 増大した薬剤負荷および接着のためのナノ構造化ゲルの製剤 |
CN107469140B (zh) * | 2017-08-14 | 2021-01-05 | 高鼎精细化工(昆山)有限公司 | 一种具抗菌功能的光动力学抗菌敷料、制备方法及应用 |
JP7346380B2 (ja) * | 2018-02-28 | 2023-09-19 | 持田製薬株式会社 | 新規光架橋性アルギン酸誘導体 |
US10869950B2 (en) | 2018-07-17 | 2020-12-22 | Hyalex Orthopaedics, Inc. | Ionic polymer compositions |
CN108837299B (zh) * | 2018-07-18 | 2020-08-07 | 武汉大学 | 一种智能调节血糖的微针贴片及其制备方法 |
WO2020076453A1 (en) | 2018-10-11 | 2020-04-16 | Alivio Therapeutics, Inc. | Non-injectable hydrogel formulations for smart release |
MX2021005327A (es) * | 2018-11-22 | 2021-06-23 | Univ Jichi Medical | Composicion viscoelastica para asegurar el campo visual de un endoscopio. |
BR112021010815A2 (pt) | 2018-12-21 | 2021-08-31 | Advanced Aesthetic Technologies, Inc. | Polissacarídeos reticulados e métodos relacionados |
CN110063758B (zh) * | 2019-05-27 | 2024-06-18 | 博志生物科技(深圳)有限公司 | 一种紫外线光固化凝胶微创穿刺注射方法及系统 |
IT201900019724A1 (it) * | 2019-10-24 | 2021-04-24 | Bmg Pharma S P A | “procedimento in solvente organico per la purificazione dell’acido ialuronico sale sodico” |
CN111617313B (zh) * | 2020-04-29 | 2022-09-06 | 天津医科大学眼科医院 | 一种眼用线性凝胶在作为临床孔源性视网膜脱离药物方面中的应用 |
US20240269349A1 (en) | 2021-09-09 | 2024-08-15 | Sunbio Inc. | Sol-gel conversion over time of 6-arm peg hydrogel |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5410016A (en) * | 1990-10-15 | 1995-04-25 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
AU3124793A (en) * | 1991-10-29 | 1993-06-07 | Clover Consolidated, Limited | Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release |
JP2855307B2 (ja) * | 1992-02-05 | 1999-02-10 | 生化学工業株式会社 | 光反応性グリコサミノグリカン、架橋グリコサミノグリカン及びそれらの製造方法 |
-
1996
- 1996-11-14 WO PCT/JP1996/003349 patent/WO1997018244A1/en not_active Application Discontinuation
- 1996-11-14 CN CN96199650A patent/CN1098863C/zh not_active Expired - Lifetime
- 1996-11-14 DE DE69622575T patent/DE69622575T2/de not_active Expired - Lifetime
- 1996-11-14 KR KR1019980703648A patent/KR100509882B1/ko active IP Right Grant
- 1996-11-14 RU RU98111203/04A patent/RU2197501C2/ru active
- 1996-11-14 JP JP51874597A patent/JP3439481B2/ja not_active Expired - Lifetime
- 1996-11-14 AT AT96938473T patent/ATE221086T1/de active
- 1996-11-14 AU AU75872/96A patent/AU722250B2/en not_active Expired
- 1996-11-14 ES ES96938473T patent/ES2179215T3/es not_active Expired - Lifetime
- 1996-11-14 US US09/068,227 patent/US6031017A/en not_active Expired - Lifetime
- 1996-11-14 EP EP96938473A patent/EP0861270B1/de not_active Expired - Lifetime
- 1996-11-14 HU HU0000390A patent/HU224697B1/hu active IP Right Grant
- 1996-11-14 CA CA002237192A patent/CA2237192C/en not_active Expired - Lifetime
-
1998
- 1998-05-14 NO NO982212A patent/NO982212L/no not_active Application Discontinuation
-
1999
- 1999-03-01 HK HK99100824A patent/HK1015799A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP3439481B2 (ja) | 2003-08-25 |
KR19990067621A (ko) | 1999-08-25 |
CN1098863C (zh) | 2003-01-15 |
NO982212D0 (no) | 1998-05-14 |
JPH11512778A (ja) | 1999-11-02 |
HK1015799A1 (en) | 1999-10-22 |
KR100509882B1 (ko) | 2006-01-27 |
AU7587296A (en) | 1997-06-05 |
HUP0000390A2 (hu) | 2000-05-28 |
AU722250B2 (en) | 2000-07-27 |
HU224697B1 (en) | 2006-01-30 |
NO982212L (no) | 1998-07-14 |
DE69622575T2 (de) | 2003-02-13 |
RU2197501C2 (ru) | 2003-01-27 |
US6031017A (en) | 2000-02-29 |
EP0861270A1 (de) | 1998-09-02 |
HUP0000390A3 (en) | 2000-09-28 |
DE69622575D1 (de) | 2002-08-29 |
ES2179215T3 (es) | 2003-01-16 |
CN1207744A (zh) | 1999-02-10 |
WO1997018244A1 (en) | 1997-05-22 |
CA2237192A1 (en) | 1997-05-22 |
EP0861270B1 (de) | 2002-07-24 |
CA2237192C (en) | 2006-06-20 |
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