ATE221086T1 - Photovernetztes hyaluronsäuregel und verfahren zu dessen herstellung - Google Patents

Photovernetztes hyaluronsäuregel und verfahren zu dessen herstellung

Info

Publication number
ATE221086T1
ATE221086T1 AT96938473T AT96938473T ATE221086T1 AT E221086 T1 ATE221086 T1 AT E221086T1 AT 96938473 T AT96938473 T AT 96938473T AT 96938473 T AT96938473 T AT 96938473T AT E221086 T1 ATE221086 T1 AT E221086T1
Authority
AT
Austria
Prior art keywords
hyaluronic acid
pct
date
acid gel
photo
Prior art date
Application number
AT96938473T
Other languages
English (en)
Inventor
Michinori Waki
Kenji Miyamoto
Original Assignee
Seikagaku Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seikagaku Kogyo Co Ltd filed Critical Seikagaku Kogyo Co Ltd
Application granted granted Critical
Publication of ATE221086T1 publication Critical patent/ATE221086T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Materials For Medical Uses (AREA)
AT96938473T 1995-11-15 1996-11-14 Photovernetztes hyaluronsäuregel und verfahren zu dessen herstellung ATE221086T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP31982595 1995-11-15
PCT/JP1996/003349 WO1997018244A1 (en) 1995-11-15 1996-11-14 Photocured cross-linked-hyaluronic acid gel and method of preparation thereof

Publications (1)

Publication Number Publication Date
ATE221086T1 true ATE221086T1 (de) 2002-08-15

Family

ID=18114635

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96938473T ATE221086T1 (de) 1995-11-15 1996-11-14 Photovernetztes hyaluronsäuregel und verfahren zu dessen herstellung

Country Status (15)

Country Link
US (1) US6031017A (de)
EP (1) EP0861270B1 (de)
JP (1) JP3439481B2 (de)
KR (1) KR100509882B1 (de)
CN (1) CN1098863C (de)
AT (1) ATE221086T1 (de)
AU (1) AU722250B2 (de)
CA (1) CA2237192C (de)
DE (1) DE69622575T2 (de)
ES (1) ES2179215T3 (de)
HK (1) HK1015799A1 (de)
HU (1) HU224697B1 (de)
NO (1) NO982212L (de)
RU (1) RU2197501C2 (de)
WO (1) WO1997018244A1 (de)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6630457B1 (en) 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
EP1217008B1 (de) * 2000-12-19 2006-03-01 Seikagaku Corporation Photohärtbare Derivate von Hyaluronsäure, Verfahren zu deren Herstellung, vernetztes und photogehärtetes Derivat der Hyaluronsäure und diese enthaltendes medizinisches Material
JP4172176B2 (ja) * 2000-12-19 2008-10-29 生化学工業株式会社 光反応性ヒアルロン酸およびその製造方法ならびに光架橋ヒアルロン酸および医用材料
FR2819722B1 (fr) * 2001-01-19 2006-11-24 Corneal Ind Utilisation de l'acide hyaluronique ou d'au moins l'un de ses sels dans le cadre d'un traitemnet chirurgical de la presbytie
JP4135502B2 (ja) 2001-01-31 2008-08-20 生化学工業株式会社 架橋多糖スポンジ
US6673919B2 (en) 2001-03-30 2004-01-06 Chisso Cororation Chemically modified hyaluronic acid or salts thereof, and a process for producing thereof
DE60218375D1 (de) 2001-03-30 2007-04-12 Chisso Corp Pharmazeutische Zusammensetzung zur Behandlung gynäkologischer Erkrankungen
JP2003052819A (ja) * 2001-08-10 2003-02-25 Seikagaku Kogyo Co Ltd 薬剤充填注射器包装物およびその滅菌または殺菌方法
ITPD20020064A1 (it) * 2002-03-12 2003-09-12 Fidia Advanced Biopolymers Srl Derivati esterei dell'acido ialuronico per la preparazione di idrogelda utilizzare in campo biomedico, sanitario e chirurgico e come sistem
KR20040009891A (ko) * 2002-07-26 2004-01-31 주식회사 엘지생명과학 히알루론산의 유도체 겔 및 그 제조방법
AU2003276847A1 (en) * 2002-08-09 2004-02-25 Carnegie Mellon University Polymers, supersoft elastomers and methods for preparing the same
US6982298B2 (en) 2003-01-10 2006-01-03 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US7465766B2 (en) 2004-01-08 2008-12-16 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US8138265B2 (en) 2003-01-10 2012-03-20 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US8137688B2 (en) 2003-01-10 2012-03-20 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US20040167480A1 (en) * 2003-02-21 2004-08-26 Advanced Medical Optics, Inc. Administration of multiple viscoelastic solutions with a multi-compartment syringe
US7365059B2 (en) 2003-03-11 2008-04-29 Seikagaku Corporation Photocrosslinked-polysaccharide composition and production process of the same
JP2004323454A (ja) * 2003-04-25 2004-11-18 Chisso Corp 薬剤
EP1666503B1 (de) * 2003-09-12 2010-05-05 Seikagaku Corporation Polysaccharid-pseudoschwamm
EP1725590A4 (de) * 2004-03-05 2013-08-07 Univ Carnegie Mellon Verfahren zur atom transfer radical polymerization
US8293890B2 (en) * 2004-04-30 2012-10-23 Advanced Cardiovascular Systems, Inc. Hyaluronic acid based copolymers
EP2287205A3 (de) 2004-09-15 2012-08-01 Seikagaku Corporation Photovernetzbare polysaccharide. photovernetzte Polysaccharidprodukte, deren Verfahren zur Herstellung und deren Verwendung als medizinischen Werkstoffe
US20060069063A1 (en) * 2004-09-27 2006-03-30 Yng-Jiin Wang Crosslinked polygalacturonic acid used for postsurgical tissue adhesion prevention
US20090088846A1 (en) 2007-04-17 2009-04-02 David Myung Hydrogel arthroplasty device
DK2664334T3 (en) * 2004-12-30 2015-03-23 Genzyme Corp Intra-articular viscosupplement regimens
US7968614B2 (en) * 2005-06-15 2011-06-28 Surmodics, Inc. Macromer composition including light activated initiator
WO2007004675A1 (ja) * 2005-07-06 2007-01-11 Seikagaku Corporation 薬剤導入光架橋ヒアルロン酸誘導体ゲル
EP1937701A4 (de) * 2005-09-02 2009-09-16 Colbar Lifescience Ltd Quervernetzte polysaccharid- und proteinmatrizen und verfahren zu ihrer herstellung
WO2007043702A1 (en) 2005-10-12 2007-04-19 Seikagaku Corporation Agent for applying to mucosa and method for production thereof
JP5043364B2 (ja) * 2006-05-01 2012-10-10 生化学工業株式会社 多糖誘導体の製造方法
CN100389145C (zh) * 2006-09-29 2008-05-21 北京大学 含天然高分子的水凝胶及其辐射制备方法
TWI528964B (zh) 2006-12-06 2016-04-11 生化學工業股份有限公司 治療關節失調之長效藥劑
WO2009029049A1 (en) * 2007-08-30 2009-03-05 National University Of Singapore A bone and/or dental cement composition and uses thereof
WO2009102967A2 (en) 2008-02-13 2009-08-20 The Cleveland Clinic Foundation Molecular enhancement of extracellular matrix and methods of use
EP2268331A2 (de) * 2008-03-21 2011-01-05 Biomimedica, Inc Verfahren, vorrichtungen und zusammensetzungen zur anheftung von hydrierten polymerimplantaten an knochen
EP2300042A4 (de) 2008-04-30 2012-05-02 Cleveland Clinic Foundation Zusammensetzungen und verfahren zur behandlung von harninkontinenz
KR20110044219A (ko) * 2008-07-07 2011-04-28 바이오미메디카, 인코포레이티드 소수성 중합체에서 유래된 친수성 상호 침투 중합체 네트워크
US20120209396A1 (en) 2008-07-07 2012-08-16 David Myung Orthopedic implants having gradient polymer alloys
WO2010017282A1 (en) 2008-08-05 2010-02-11 Biomimedica, Inc. Polyurethane-grafted hydrogels
US20110229565A1 (en) 2008-09-17 2011-09-22 Karp Jeffrey M Drug Delivery Composition Comprising a Self-Assembled Gelator
ITRM20080636A1 (it) * 2008-11-28 2010-05-29 Univ Palermo Procedimento per la produzione di derivati funzionalizzati dell acido ialuronico e relativi idrogeli.
WO2010111708A1 (en) 2009-03-27 2010-09-30 Carnegie Mellon University Preparation of functional star macromolecules
WO2010138074A1 (en) * 2009-05-29 2010-12-02 Hilborn Joens Hyaluronic acid based delivery systems
JO3008B1 (ar) 2009-08-13 2016-09-05 Seikagaku Kogyo Co Ltd تركيب صيدلي لتخفيف الألم
CN101716331B (zh) * 2009-12-16 2012-03-07 中山大学 利用支链淀粉-对硝基肉桂酸接枝物原位包埋蛋白类生物大分子的方法
WO2011075742A1 (en) * 2009-12-18 2011-06-23 Biomimedica, Inc. Method, device, and system for shaving and shaping of a joint
JP2013530785A (ja) * 2010-07-12 2013-08-01 シン・プーン・ファーマシューティカル・カンパニー・リミテッド 組織増大用充填組成物
AU2011293169A1 (en) 2010-08-27 2013-03-21 Biomimedica, Inc. Hydrophobic and hydrophilic interpenetrating polymer networks derived from hydrophobic polymers and methods of preparing the same
WO2012040623A2 (en) 2010-09-24 2012-03-29 The Brigham And Women's Hospital, Inc. Nanostructured gels capable of controlled release of encapsulated agents
US9644042B2 (en) 2010-12-17 2017-05-09 Carnegie Mellon University Electrochemically mediated atom transfer radical polymerization
ITTO20110428A1 (it) * 2011-05-13 2012-11-14 Rottapharm Spa Esteri dell'acido ialuronico, loro preparazione ed uso in dermatologia
CN102225220A (zh) * 2011-06-14 2011-10-26 天津晶明新技术开发有限公司 眼科手术粘弹剂
WO2013028756A1 (en) 2011-08-22 2013-02-28 Carnegie Mellon University Atom transfer radical polymerization under biologically compatible conditions
EP2763707B1 (de) 2011-10-03 2018-03-28 Hyalex Orthopaedics, Inc. Polymerer klebstoff zur verankerung von nachgiebigen materialien auf einer anderen oberfläche
WO2013078284A1 (en) 2011-11-21 2013-05-30 Biomimedica, Inc. Systems, devices, and methods for anchoring orthopaedic implants to bone
US9533297B2 (en) 2012-02-23 2017-01-03 Carnegie Mellon University Ligands designed to provide highly active catalyst complexes
CZ2012844A3 (cs) * 2012-11-27 2014-02-05 Contipro Biotech S.R.O. Fotoreaktivní derivát kyseliny hyaluronové, způsob jeho přípravy, 3D síťovaný derivát kyseliny hyaluronové, způsob jeho přípravy a použití
RU2513838C1 (ru) * 2013-02-21 2014-04-20 Общество с ограниченной ответственностью "ДЖИ-Групп" Гистоэквивалент-биопластический материал
KR101869988B1 (ko) * 2013-03-27 2018-06-21 주식회사 엘지화학 점탄성 히알루론산 가교물 제조용 조성물, 및 이를 이용하여 얻은 히알루론산 가교물
JPWO2015053282A1 (ja) * 2013-10-08 2017-03-09 キユーピー株式会社 カルボキシメチル基含有修飾ヒアルロン酸および／またはその塩の架橋物およびその製造方法
JP6226338B2 (ja) 2013-12-18 2017-11-08 国立研究開発法人科学技術振興機構 動物細胞用構造体、動物細胞の分離方法及び動物細胞用構造体表面の弾性調節方法
WO2016006693A1 (ja) * 2014-07-11 2016-01-14 株式会社メニコン 視認性確保材および視認性確保材吐出装置
US9982070B2 (en) 2015-01-12 2018-05-29 Carnegie Mellon University Aqueous ATRP in the presence of an activator regenerator
US11077228B2 (en) 2015-08-10 2021-08-03 Hyalex Orthopaedics, Inc. Interpenetrating polymer networks
BR112018005842B1 (pt) 2015-09-30 2021-07-27 Otsuka Pharmaceutical Factory, Inc. Composições viscoelásticas e método para assegurar o campo de visão de um endoscópio
KR20170090965A (ko) * 2016-01-29 2017-08-08 한미약품 주식회사 복합 히알루론산 가교물 및 그 제조방법
EP3978022A1 (de) 2016-05-06 2022-04-06 The Brigham and Women's Hospital, Inc. Binäre selbstangeordnete gele zur kontrollierten abgabe von verkapselten wirkstoffen an knorpel
WO2018079812A1 (ja) 2016-10-31 2018-05-03 キユーピー株式会社 ゲル組成物及びその製造方法
WO2018132582A1 (en) 2017-01-12 2018-07-19 Carnegie Mellon University Surfactant assisted formation of a catalyst complex for emulsion atom transfer radical polymerization processes
WO2018144991A1 (en) 2017-02-03 2018-08-09 The Brigham And Women's Hospital, Inc. Self-assembled gels formed with anti-retroviral drugs, prodrugs thereof, and pharmaceutical uses thereof
CN106832439A (zh) * 2017-03-26 2017-06-13 广州市芯检康生物科技有限公司 一种用于全血成分保护的新型气凝胶多功能即用型复合材料及其制备方法
EP3621594A1 (de) * 2017-05-08 2020-03-18 Alivio Therapeutics, Inc. Formulierung von nanostrukturierten gelen für erhöhte wirkstoffladung und adhäsion
CN107469140B (zh) * 2017-08-14 2021-01-05 高鼎精细化工(昆山)有限公司 一种具抗菌功能的光动力学抗菌敷料、制备方法及应用
CA3092253A1 (en) * 2018-02-28 2019-09-06 Mochida Pharmaceutical Co., Ltd. Novel photocrosslinkable alginic acid derivative
US10869950B2 (en) 2018-07-17 2020-12-22 Hyalex Orthopaedics, Inc. Ionic polymer compositions
CN108837299B (zh) * 2018-07-18 2020-08-07 武汉大学 一种智能调节血糖的微针贴片及其制备方法
WO2020076453A1 (en) 2018-10-11 2020-04-16 Alivio Therapeutics, Inc. Non-injectable hydrogel formulations for smart release
NZ776877A (en) * 2018-11-22 2022-07-29 Otsuka Pharma Factory Inc Endoscope visual field-securing viscoelastic composition
WO2020132532A1 (en) 2018-12-21 2020-06-25 Advanced Aesthetic Technologies, Inc. Crosslinked polysaccharides and related methods
CN110063758B (zh) * 2019-05-27 2024-06-18 博志生物科技(深圳)有限公司 一种紫外线光固化凝胶微创穿刺注射方法及系统
IT201900019724A1 (it) * 2019-10-24 2021-04-24 Bmg Pharma S P A “procedimento in solvente organico per la purificazione dell’acido ialuronico sale sodico”
CN111617313B (zh) * 2020-04-29 2022-09-06 天津医科大学眼科医院 一种眼用线性凝胶在作为临床孔源性视网膜脱离药物方面中的应用
CN117915964A (zh) 2021-09-09 2024-04-19 太阳生物公司 6臂peg水凝胶随时间推移的溶胶-凝胶转换

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5410016A (en) * 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
CA2121129A1 (en) * 1991-10-29 1993-05-13 Patrick Soon-Shiong Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release
JP2855307B2 (ja) * 1992-02-05 1999-02-10 生化学工業株式会社 光反応性グリコサミノグリカン、架橋グリコサミノグリカン及びそれらの製造方法

Also Published As

Publication number Publication date
HUP0000390A2 (hu) 2000-05-28
DE69622575D1 (de) 2002-08-29
KR100509882B1 (ko) 2006-01-27
JPH11512778A (ja) 1999-11-02
AU722250B2 (en) 2000-07-27
CN1207744A (zh) 1999-02-10
HUP0000390A3 (en) 2000-09-28
NO982212L (no) 1998-07-14
CA2237192A1 (en) 1997-05-22
EP0861270A1 (de) 1998-09-02
CN1098863C (zh) 2003-01-15
ES2179215T3 (es) 2003-01-16
DE69622575T2 (de) 2003-02-13
US6031017A (en) 2000-02-29
AU7587296A (en) 1997-06-05
WO1997018244A1 (en) 1997-05-22
HK1015799A1 (en) 1999-10-22
HU224697B1 (en) 2006-01-30
JP3439481B2 (ja) 2003-08-25
KR19990067621A (ko) 1999-08-25
RU2197501C2 (ru) 2003-01-27
EP0861270B1 (de) 2002-07-24
NO982212D0 (no) 1998-05-14
CA2237192C (en) 2006-06-20

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