DE69818058D1 - Verwendung von polyallylamin-polymeren zur herstellung eines medikamentes zur behandlung von hypercholesterolemia - Google Patents
Verwendung von polyallylamin-polymeren zur herstellung eines medikamentes zur behandlung von hypercholesterolemiaInfo
- Publication number
- DE69818058D1 DE69818058D1 DE69818058T DE69818058T DE69818058D1 DE 69818058 D1 DE69818058 D1 DE 69818058D1 DE 69818058 T DE69818058 T DE 69818058T DE 69818058 T DE69818058 T DE 69818058T DE 69818058 D1 DE69818058 D1 DE 69818058D1
- Authority
- DE
- Germany
- Prior art keywords
- medicine
- producing
- treating hypercholesterolemia
- polyallylamine polymers
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229920000642 polymer Polymers 0.000 title abstract 2
- 208000035150 Hypercholesterolemia Diseases 0.000 title 1
- 229920000083 poly(allylamine) Polymers 0.000 title 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000003833 bile salt Substances 0.000 abstract 1
- 229940093761 bile salts Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87842297A | 1997-06-18 | 1997-06-18 | |
US878422 | 1997-06-18 | ||
US92724797A | 1997-09-11 | 1997-09-11 | |
US927247 | 1997-09-11 | ||
US08/979,096 US6423754B1 (en) | 1997-06-18 | 1997-11-26 | Method for treating hypercholesterolemia with polyallylamine polymers |
US979096 | 1997-11-26 | ||
PCT/US1998/012422 WO1998057652A1 (en) | 1997-06-18 | 1998-06-15 | Polyallylamine polymers for treating hypercholesterolemia |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69818058D1 true DE69818058D1 (de) | 2003-10-16 |
DE69818058T2 DE69818058T2 (de) | 2004-07-08 |
Family
ID=27420493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69818058T Expired - Lifetime DE69818058T2 (de) | 1997-06-18 | 1998-06-15 | Verwendung von polyallylamin-polymeren zur herstellung eines medikamentes zur behandlung von hypercholesterolemia |
Country Status (16)
Country | Link |
---|---|
US (3) | US6423754B1 (de) |
EP (1) | EP0996454B1 (de) |
JP (1) | JP4420143B2 (de) |
KR (1) | KR100567751B1 (de) |
CN (1) | CN1211091C (de) |
AT (1) | ATE249228T1 (de) |
AU (1) | AU735260C (de) |
CA (1) | CA2294036C (de) |
DE (1) | DE69818058T2 (de) |
HK (1) | HK1029920A1 (de) |
IL (1) | IL133434A (de) |
MX (1) | MXPA99011826A (de) |
MY (1) | MY125874A (de) |
NZ (1) | NZ501719A (de) |
TW (1) | TW526063B (de) |
WO (1) | WO1998057652A1 (de) |
Families Citing this family (53)
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TW568788B (en) * | 1998-10-12 | 2004-01-01 | Chugai Pharmaceutical Co Ltd | Polymer combining with phosphoric acid and preparation containing the same |
EP1293211A1 (de) * | 1998-12-23 | 2003-03-19 | G.D. Searle LLC. | Kombination von Ileumgallensäuretransport-Inhibitoren und Gallensäure-Sequestriermittel für kardiovaskuläre Indikationen |
WO2000063259A1 (en) * | 1999-04-16 | 2000-10-26 | Abbott Laboratories | Process for producing cross-linked polyallylamine hydrochloride |
US6362266B1 (en) | 1999-09-03 | 2002-03-26 | The Dow Chemical Company | Process for reducing cohesiveness of polyallylamine polymer gels during drying |
US6180754B1 (en) | 1999-09-03 | 2001-01-30 | The Dow Chemical Company | Process for producing cross-linked polyallylamine polymer |
US20020054903A1 (en) * | 1999-10-19 | 2002-05-09 | Joseph Tyler | Direct compression polymer tablet core |
US6733780B1 (en) | 1999-10-19 | 2004-05-11 | Genzyme Corporation | Direct compression polymer tablet core |
EP1911462A3 (de) | 2001-01-26 | 2011-11-30 | Schering Corporation | Zusammensetzungen enthaltend einen Sterolabsorptionshemmer |
WO2002085379A1 (en) * | 2001-04-18 | 2002-10-31 | Geltex Pharmaceuticals, Inc. | Method for improving vascular access in patients with vascular shunts |
MXPA03009562A (es) * | 2001-04-18 | 2004-02-12 | Genzyme Corp | METODO PARA TRATAR EL SiNDROME X CON POLIAMINAS ALIFATICAS. |
PT1923064T (pt) | 2001-04-18 | 2017-08-23 | Genzyme Corp | Utilização de um aminopolímero para reduzir a glicose sérica |
EP1379258B1 (de) * | 2001-04-18 | 2006-06-28 | Genzyme Corporation | Salzformarme polyallylamine |
JP2005510524A (ja) * | 2001-11-16 | 2005-04-21 | アルス・セラピー・デベロツプメント・フアンデーシヨン・インコーポレーテツド | ポリアミン経路の調節による神経変性障害の治療 |
AU2003282867A1 (en) * | 2002-10-22 | 2004-05-13 | Genzyme Corporation | Amine polymers for promoting bone formation |
US7608674B2 (en) * | 2003-11-03 | 2009-10-27 | Ilypsa, Inc. | Pharmaceutical compositions comprising cross-linked small molecule amine polymers |
US7449605B2 (en) * | 2003-11-03 | 2008-11-11 | Ilypsa, Inc. | Crosslinked amine polymers |
US7459502B2 (en) | 2003-11-03 | 2008-12-02 | Ilypsa, Inc. | Pharmaceutical compositions comprising crosslinked polyamine polymers |
US7385012B2 (en) | 2003-11-03 | 2008-06-10 | Ilypsa, Inc. | Polyamine polymers |
US7767768B2 (en) * | 2003-11-03 | 2010-08-03 | Ilypsa, Inc. | Crosslinked amine polymers |
US7335795B2 (en) * | 2004-03-22 | 2008-02-26 | Ilypsa, Inc. | Crosslinked amine polymers |
WO2005051298A2 (en) | 2003-11-19 | 2005-06-09 | Metabasis Therapeutics, Inc. | Novel phosphorus-containing thyromimetics |
PL3219312T3 (pl) | 2004-03-30 | 2019-07-31 | Relypsa, Inc. | Polimery wiążące jon i ich zastosowania |
US20050244367A1 (en) * | 2004-05-03 | 2005-11-03 | Ilypsa, Inc. | Phospholipase inhibitors localized in the gastrointestinal lumen |
US20050276781A1 (en) * | 2004-06-09 | 2005-12-15 | Ross Edward A | Molecularly imprinted phosphate binders for therapeutic use |
US7985418B2 (en) | 2004-11-01 | 2011-07-26 | Genzyme Corporation | Aliphatic amine polymer salts for tableting |
US20060177415A1 (en) * | 2004-11-01 | 2006-08-10 | Burke Steven K | Once a day formulation for phosphate binders |
JP2008533272A (ja) * | 2005-03-16 | 2008-08-21 | ユーエスヴィー リミテッド | 架橋ポリアリルアミンポリマーの調製のための改良された方法 |
JP2008545711A (ja) | 2005-05-26 | 2008-12-18 | メタバシス・セラピューティクス・インコーポレイテッド | 新規ホスフィン酸含有甲状腺ホルモン様剤 |
US8986669B2 (en) | 2005-09-02 | 2015-03-24 | Genzyme Corporation | Method for removing phosphate and polymer used therefore |
AR056499A1 (es) * | 2005-09-06 | 2007-10-10 | Serapis Farmaceuticals Ltd | Compuestos |
EP3000460A1 (de) | 2005-09-15 | 2016-03-30 | Genzyme Corporation | Beutelformulierung für aminpolymere |
JP2009536246A (ja) * | 2006-05-05 | 2009-10-08 | ゲンズイメ コーポレーション | ホスフェート捕捉剤としてのアミン縮合重合体 |
WO2008011047A2 (en) * | 2006-07-18 | 2008-01-24 | Genzyme Corporation | Amine dendrimers |
JP2010504975A (ja) | 2006-09-29 | 2010-02-18 | ゲンズイメ コーポレーション | アミドデンドリマー組成物 |
EP2076286B1 (de) * | 2006-10-25 | 2016-03-09 | Wisconsin Alumni Research Foundation | Verfahren zur verminderung der absorption von phosphat mit hilfe eines anti-npt2b antikörper |
US8877198B2 (en) * | 2006-10-26 | 2014-11-04 | Wisconsin Alumni Research Foundation | Methods of reducing phosphate absorption |
BRPI0720234A2 (pt) | 2006-12-14 | 2013-12-24 | Genzyme Corp | Composição farmacêutica |
HUE046465T2 (hu) | 2006-12-22 | 2020-03-30 | Ironwood Pharmaceuticals Inc | Epesavat megkötõ anyagokat tartalmazó készítmények nyelõcsõ-rendellenességek kezelésére |
WO2008103368A1 (en) * | 2007-02-23 | 2008-08-28 | Genzyme Corporation | Amine polymer compositions |
EP2131820A1 (de) * | 2007-03-08 | 2009-12-16 | Genzyme Corporation | Sulfonpolymerzusammensetzungen |
EP2152277A1 (de) * | 2007-04-27 | 2010-02-17 | Genzyme Corporation | Amido-amin-dendrimer-zusammensetzungen |
PA8807201A1 (es) * | 2007-12-14 | 2009-07-23 | Genzyme Corp | Composiciones farmaceuticas |
US20100316589A1 (en) * | 2007-12-14 | 2010-12-16 | Hitesh Bhagat | Coated Pharmaceutical Compositions |
WO2009154747A1 (en) * | 2008-06-20 | 2009-12-23 | Genzyme Corporation | Pharmaceutical compositions |
US8404784B2 (en) * | 2008-12-03 | 2013-03-26 | Navinta Llc | Manufacturing process of making polymeric amine salts |
WO2010093601A1 (en) | 2009-02-10 | 2010-08-19 | Metabasis Therapeutics, Inc. | Novel sulfonic acid-containing thyromimetics, and methods for their use |
IT1394299B1 (it) * | 2009-05-12 | 2012-06-06 | Chimico Internaz Spa Lab | Procedimento per la preparazione di sevelamer |
JP5285000B2 (ja) * | 2010-02-23 | 2013-09-11 | 富士フイルム株式会社 | 低密度リポ蛋白コレステロールの測定方法 |
US20130156720A1 (en) | 2010-08-27 | 2013-06-20 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
US9486433B2 (en) | 2012-10-12 | 2016-11-08 | Mochida Pharmaceuticals Co. Ltd. | Compositions and methods for treating non-alcoholic steatohepatitis |
US10441560B2 (en) | 2013-03-15 | 2019-10-15 | Mochida Pharmaceutical Co., Ltd. | Compositions and methods for treating non-alcoholic steatohepatitis |
JP6442412B2 (ja) | 2013-03-15 | 2018-12-19 | 持田製薬株式会社 | 非アルコール性脂肪性肝炎治療のための組成物および方法 |
CN112047854B (zh) * | 2020-10-20 | 2021-07-02 | 中国科学院长春应用化学研究所 | 一种n-乙烯基烷基酰胺的制备方法 |
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GB798488A (en) | 1956-01-09 | 1958-07-23 | Nat Aluminate Corp | Quaternary ammonium compounds and method for the preparation thereof |
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-
1997
- 1997-11-26 US US08/979,096 patent/US6423754B1/en not_active Expired - Lifetime
-
1998
- 1998-06-15 AU AU79675/98A patent/AU735260C/en not_active Expired
- 1998-06-15 NZ NZ501719A patent/NZ501719A/en not_active IP Right Cessation
- 1998-06-15 WO PCT/US1998/012422 patent/WO1998057652A1/en active IP Right Grant
- 1998-06-15 KR KR1019997011968A patent/KR100567751B1/ko not_active IP Right Cessation
- 1998-06-15 JP JP50464599A patent/JP4420143B2/ja not_active Expired - Lifetime
- 1998-06-15 DE DE69818058T patent/DE69818058T2/de not_active Expired - Lifetime
- 1998-06-15 EP EP98930234A patent/EP0996454B1/de not_active Expired - Lifetime
- 1998-06-15 AT AT98930234T patent/ATE249228T1/de not_active IP Right Cessation
- 1998-06-15 CA CA002294036A patent/CA2294036C/en not_active Expired - Lifetime
- 1998-06-15 CN CNB988071118A patent/CN1211091C/zh not_active Expired - Lifetime
- 1998-06-15 IL IL13343498A patent/IL133434A/xx not_active IP Right Cessation
- 1998-06-15 MX MXPA99011826A patent/MXPA99011826A/es active IP Right Grant
- 1998-06-17 MY MYPI98002704A patent/MY125874A/en unknown
- 1998-07-09 TW TW087109749A patent/TW526063B/zh not_active IP Right Cessation
-
2001
- 2001-01-22 HK HK01100549A patent/HK1029920A1/xx not_active IP Right Cessation
-
2002
- 2002-05-29 US US10/158,207 patent/US20030086898A1/en not_active Abandoned
-
2006
- 2006-02-01 US US11/344,862 patent/US20060239959A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20030086898A1 (en) | 2003-05-08 |
KR20010013943A (ko) | 2001-02-26 |
CN1263468A (zh) | 2000-08-16 |
CA2294036C (en) | 2007-08-21 |
HK1029920A1 (en) | 2001-04-20 |
IL133434A (en) | 2005-09-25 |
CN1211091C (zh) | 2005-07-20 |
EP0996454A1 (de) | 2000-05-03 |
MY125874A (en) | 2006-08-30 |
DE69818058T2 (de) | 2004-07-08 |
AU7967598A (en) | 1999-01-04 |
AU735260C (en) | 2002-03-28 |
WO1998057652A1 (en) | 1998-12-23 |
MXPA99011826A (es) | 2002-07-02 |
US6423754B1 (en) | 2002-07-23 |
EP0996454B1 (de) | 2003-09-10 |
ATE249228T1 (de) | 2003-09-15 |
JP2002516613A (ja) | 2002-06-04 |
JP4420143B2 (ja) | 2010-02-24 |
IL133434A0 (en) | 2001-04-30 |
TW526063B (en) | 2003-04-01 |
KR100567751B1 (ko) | 2006-04-05 |
US20060239959A1 (en) | 2006-10-26 |
NZ501719A (en) | 2001-10-26 |
AU735260B2 (en) | 2001-07-05 |
CA2294036A1 (en) | 1998-12-23 |
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