ATE249228T1 - Verwendung von polyallylamin-polymeren zur herstellung eines medikamentes zur behandlung von hypercholesterolemia - Google Patents

Verwendung von polyallylamin-polymeren zur herstellung eines medikamentes zur behandlung von hypercholesterolemia

Info

Publication number
ATE249228T1
ATE249228T1 AT98930234T AT98930234T ATE249228T1 AT E249228 T1 ATE249228 T1 AT E249228T1 AT 98930234 T AT98930234 T AT 98930234T AT 98930234 T AT98930234 T AT 98930234T AT E249228 T1 ATE249228 T1 AT E249228T1
Authority
AT
Austria
Prior art keywords
polyallylamin
medication
polymers
producing
treating hypercholesterolemia
Prior art date
Application number
AT98930234T
Other languages
English (en)
Inventor
Stephen Randall Holmes-Farley
W Harry Mandeville Iii
Steven K Burke
Dennis I Goldberg
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Application granted granted Critical
Publication of ATE249228T1 publication Critical patent/ATE249228T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT98930234T 1997-06-18 1998-06-15 Verwendung von polyallylamin-polymeren zur herstellung eines medikamentes zur behandlung von hypercholesterolemia ATE249228T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US87842297A 1997-06-18 1997-06-18
US92724797A 1997-09-11 1997-09-11
US08/979,096 US6423754B1 (en) 1997-06-18 1997-11-26 Method for treating hypercholesterolemia with polyallylamine polymers
PCT/US1998/012422 WO1998057652A1 (en) 1997-06-18 1998-06-15 Polyallylamine polymers for treating hypercholesterolemia

Publications (1)

Publication Number Publication Date
ATE249228T1 true ATE249228T1 (de) 2003-09-15

Family

ID=27420493

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98930234T ATE249228T1 (de) 1997-06-18 1998-06-15 Verwendung von polyallylamin-polymeren zur herstellung eines medikamentes zur behandlung von hypercholesterolemia

Country Status (15)

Country Link
US (3) US6423754B1 (de)
EP (1) EP0996454B1 (de)
JP (1) JP4420143B2 (de)
KR (1) KR100567751B1 (de)
CN (1) CN1211091C (de)
AT (1) ATE249228T1 (de)
AU (1) AU735260C (de)
CA (1) CA2294036C (de)
DE (1) DE69818058T2 (de)
IL (1) IL133434A (de)
MX (1) MXPA99011826A (de)
MY (1) MY125874A (de)
NZ (1) NZ501719A (de)
TW (1) TW526063B (de)
WO (1) WO1998057652A1 (de)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW568788B (en) * 1998-10-12 2004-01-01 Chugai Pharmaceutical Co Ltd Polymer combining with phosphoric acid and preparation containing the same
EP1293211A1 (de) * 1998-12-23 2003-03-19 G.D. Searle LLC. Kombination von Ileumgallensäuretransport-Inhibitoren und Gallensäure-Sequestriermittel für kardiovaskuläre Indikationen
PT1175451E (pt) * 1999-04-16 2007-09-24 Abbott Lab ''processo para produção de cloridrato de polialilamina reticulada''
US6180754B1 (en) 1999-09-03 2001-01-30 The Dow Chemical Company Process for producing cross-linked polyallylamine polymer
US6362266B1 (en) 1999-09-03 2002-03-26 The Dow Chemical Company Process for reducing cohesiveness of polyallylamine polymer gels during drying
US6733780B1 (en) 1999-10-19 2004-05-11 Genzyme Corporation Direct compression polymer tablet core
US20020054903A1 (en) * 1999-10-19 2002-05-09 Joseph Tyler Direct compression polymer tablet core
US6982251B2 (en) 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
SI1413331T1 (sl) 2001-01-26 2008-02-29 Schering Corp Kombinacije fenofibrata peroksisomskega proliferator aktivirajocega receptorja (PPAR) z ezetimib zaviralcem absorpcije sterola za vaskularne indikacije
US7071181B2 (en) 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
JP4711600B2 (ja) 2001-01-26 2011-06-29 シェーリング コーポレイション シトステロール血症の処置のための置換アゼチジノン化合物の使用
EP1911462A3 (de) 2001-01-26 2011-11-30 Schering Corporation Zusammensetzungen enthaltend einen Sterolabsorptionshemmer
JP2004526778A (ja) * 2001-04-18 2004-09-02 ジェンザイム コーポレーション 脂肪族ポリアミンを用いるｘ症候群の処置方法
WO2002085379A1 (en) * 2001-04-18 2002-10-31 Geltex Pharmaceuticals, Inc. Method for improving vascular access in patients with vascular shunts
KR20040018357A (ko) * 2001-04-18 2004-03-03 젠자임 코포레이션 저염 형태의 폴리알릴아민
ES2304437T3 (es) 2001-04-18 2008-10-16 Genzyme Corporation Uso de colesevelam o de hidrocloruro de sevelamer para reducir la glucosa serica.
US7132415B2 (en) 2001-09-21 2006-11-07 Schering Corporation Methods and therapeutic combinations for the treatment of xanthoma using sterol absorption inhibitors
US7056906B2 (en) 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
US7053080B2 (en) 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US7273888B2 (en) * 2001-11-16 2007-09-25 Als Therapy Development Foundation, Inc. Use of difluoromethylornithine (DFMO) for the treatment of amyotrophic lateral sclerosis
AU2003282867A1 (en) * 2002-10-22 2004-05-13 Genzyme Corporation Amine polymers for promoting bone formation
CA2504878A1 (en) 2002-11-06 2004-05-27 Schering Corporation Cholesterol absorption inhibitors for the treatment of demyelination
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
CN100439361C (zh) 2003-03-07 2008-12-03 先灵公司 取代的2-吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
CN1756755A (zh) 2003-03-07 2006-04-05 先灵公司 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
JP4589919B2 (ja) 2003-03-07 2010-12-01 シェーリング コーポレイション 高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用
US7335795B2 (en) * 2004-03-22 2008-02-26 Ilypsa, Inc. Crosslinked amine polymers
US7449605B2 (en) * 2003-11-03 2008-11-11 Ilypsa, Inc. Crosslinked amine polymers
US7608674B2 (en) * 2003-11-03 2009-10-27 Ilypsa, Inc. Pharmaceutical compositions comprising cross-linked small molecule amine polymers
US7767768B2 (en) * 2003-11-03 2010-08-03 Ilypsa, Inc. Crosslinked amine polymers
US7459502B2 (en) * 2003-11-03 2008-12-02 Ilypsa, Inc. Pharmaceutical compositions comprising crosslinked polyamine polymers
US7385012B2 (en) 2003-11-03 2008-06-10 Ilypsa, Inc. Polyamine polymers
US7829552B2 (en) 2003-11-19 2010-11-09 Metabasis Therapeutics, Inc. Phosphorus-containing thyromimetics
EP2158902B1 (de) 2004-03-30 2017-12-06 Relypsa, Inc. Ionen bindende polymere und ihre verwendung
US20050244367A1 (en) * 2004-05-03 2005-11-03 Ilypsa, Inc. Phospholipase inhibitors localized in the gastrointestinal lumen
US20050276781A1 (en) * 2004-06-09 2005-12-15 Ross Edward A Molecularly imprinted phosphate binders for therapeutic use
US7985418B2 (en) 2004-11-01 2011-07-26 Genzyme Corporation Aliphatic amine polymer salts for tableting
US20060177415A1 (en) * 2004-11-01 2006-08-10 Burke Steven K Once a day formulation for phosphate binders
CA2601236A1 (en) * 2005-03-16 2006-09-21 Usv Limited An improved process for the preparation of crosslinked polyallylamine polymer
MX2007014501A (es) 2005-05-26 2008-02-07 Metabasis Therapeutics Inc Tiromimeticos novedosos que contienen acido fosfinico.
JP2009507019A (ja) 2005-09-02 2009-02-19 ジェンザイム・コーポレーション リン酸塩を除去する方法およびそれに使用される重合体
AR056499A1 (es) * 2005-09-06 2007-10-10 Serapis Farmaceuticals Ltd Compuestos
WO2007035313A2 (en) 2005-09-15 2007-03-29 Genzyme Corporation Sachet formulation for amine polymers
EP2016114A2 (de) * 2006-05-05 2009-01-21 Genzyme Corporation Aminkondensationspolymere als phosphatkomplexbildner
EP2049014A2 (de) * 2006-07-18 2009-04-22 Genzyme Corporation Amindendrimere
WO2008042222A2 (en) 2006-09-29 2008-04-10 Genzyme Corporation Amide dendrimer compositions
EP2076286B1 (de) * 2006-10-25 2016-03-09 Wisconsin Alumni Research Foundation Verfahren zur verminderung der absorption von phosphat mit hilfe eines anti-npt2b antikörper
JP5701504B2 (ja) 2006-10-26 2015-04-15 ウィスコンシン アルムニ リサーチ ファンデイション リン酸塩吸収の低減方法
EP2120972A1 (de) * 2006-12-14 2009-11-25 Genzyme Corporation Amido-amin-polymerzusammensetzungen
NZ598728A (en) 2006-12-22 2013-09-27 Ironwood Pharmaceuticals Inc Compositions comprising bile acid sequestrants for treating esophageal disorders
WO2008103368A1 (en) * 2007-02-23 2008-08-28 Genzyme Corporation Amine polymer compositions
WO2008109095A1 (en) * 2007-03-08 2008-09-12 Genzyme Corporation Sulfone polymer compositions
EP2152277A1 (de) * 2007-04-27 2010-02-17 Genzyme Corporation Amido-amin-dendrimer-zusammensetzungen
EP2217215A1 (de) * 2007-12-14 2010-08-18 Genzyme Corporation Beschichtete pharmazeutische zusammensetzungen
PA8807201A1 (es) * 2007-12-14 2009-07-23 Genzyme Corp Composiciones farmaceuticas
WO2009154747A1 (en) * 2008-06-20 2009-12-23 Genzyme Corporation Pharmaceutical compositions
US8404784B2 (en) * 2008-12-03 2013-03-26 Navinta Llc Manufacturing process of making polymeric amine salts
US20120046364A1 (en) 2009-02-10 2012-02-23 Metabasis Therapeutics, Inc. Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use
IT1394299B1 (it) * 2009-05-12 2012-06-06 Chimico Internaz Spa Lab Procedimento per la preparazione di sevelamer
JP5285000B2 (ja) * 2010-02-23 2013-09-11 富士フイルム株式会社 低密度リポ蛋白コレステロールの測定方法
WO2012027331A1 (en) 2010-08-27 2012-03-01 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
WO2014057522A1 (en) 2012-10-12 2014-04-17 Mochida Pharmaceutical Co., Ltd. Compositions and methods for treating non-alcoholic steatohepatitis
US10441560B2 (en) 2013-03-15 2019-10-15 Mochida Pharmaceutical Co., Ltd. Compositions and methods for treating non-alcoholic steatohepatitis
WO2014142364A2 (en) 2013-03-15 2014-09-18 Mochida Pharmaceutical Co., Ltd. Compositions and methods for treating non-alcoholic steatohepatitis
JP6708764B1 (ja) * 2019-01-28 2020-06-10 久保田　徹 機能水
CN112047854B (zh) * 2020-10-20 2021-07-02 中国科学院长春应用化学研究所 一种n-乙烯基烷基酰胺的制备方法

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB798488A (en) 1956-01-09 1958-07-23 Nat Aluminate Corp Quaternary ammonium compounds and method for the preparation thereof
US2874132A (en) 1956-11-02 1959-02-17 Rohm & Haas Anion-exchange resins for sugar decolorization and their preparation
BE580490A (fr) 1958-07-15 1960-01-08 Merck & Co Inc Compositions et procédés pour abaisser la teneur en cholestérol du sang
US3383281A (en) 1961-09-22 1968-05-14 Merck & Co Inc Method for binding bile acids in vivo
US3308020A (en) 1961-09-22 1967-03-07 Merck & Co Inc Compositions and method for binding bile acids in vivo including hypocholesteremics
US3288770A (en) 1962-12-14 1966-11-29 Peninsular Chem Res Inc Water soluble quaternary ammonium polymers
CH486202A (de) 1966-05-31 1970-02-28 Agripat Sa Mikrobizides Mittel
US3562266A (en) 1969-05-26 1971-02-09 Montedison Spa Quaternary ammonium halides having a 2-chloro cyclohexyl or 2-chloro alkyl substituent
BE756035A (fr) 1969-09-12 1971-03-11 Inveresk Res Int Polymeres pontes
US3803237A (en) 1969-11-03 1974-04-09 Upjohn Co Reaction products of polyethylenepolyamines and chlorohydrins or epoxy containing compounds
NL7017227A (de) 1969-12-27 1971-06-29
US3692895A (en) 1970-09-08 1972-09-19 Norman A Nelson Method of reducing hypercholesteremia in humans employing a copolymer of polyethylenepolyamine and a bifunctional substance, such as epichlorohydria
US3980770A (en) 1971-06-04 1976-09-14 Pharmacia Aktiebolag Polymerization products containing amino groups useful in serum cholesterol level control
US4217429A (en) 1973-06-11 1980-08-12 Merck & Co., Inc. Poly-[(methylimino)trimethylene]
US4205064A (en) 1973-06-11 1980-05-27 Merck & Co., Inc. Bile acid sequestering composition containing poly[{alkyl-(3-ammoniopropyl)imino}-trimethylenedihalides]
US4027009A (en) 1973-06-11 1977-05-31 Merck & Co., Inc. Compositions and methods for depressing blood serum cholesterol
CS187563B1 (en) 1974-02-08 1979-02-28 Petr Strop Method of preparation of the hydrophilic homogeneous or macroporous annexes
CS173201B1 (de) 1974-02-13 1977-02-28
US4016209A (en) 1975-04-23 1977-04-05 Merck & Co., Inc. 3-[N'-(3-Halopropyl)-N-'-methylamino]-N,N,N-trimethyl-1-propanaminium halide and acid addition salts thereof
US4071478A (en) 1976-06-07 1978-01-31 Merck & Co., Inc. Controlled partially cross-linked 3,3-ionenes
FI67483C (fi) 1977-02-17 1985-04-10 Merck & Co Inc Foerfarande foer framstaellning av ett icke adhesivt friflytande farmakologiskt godtagbart gallsyrakomplexbildande adsorbatpreparat
IT1106718B (it) 1978-12-21 1985-11-18 Alfa Farmaceutici Spa Composizioni a base di resine anioniche salificate farmacologicamente attive
US4426489A (en) 1980-02-21 1984-01-17 The Dow Chemical Company Surface active polymeric surfactants containing side chain hydrophobes
GB2090605B (en) 1980-12-12 1984-09-05 Smith & Nephew Ass Polymer of diallyl ammonium monomers pharmaceutical compositions thereof
JPS5879022A (ja) 1981-11-04 1983-05-12 Bitamin Kenkyusho:Kk 第四級窒素原子を含有する新規な金属架橋高分子化合物、その製法及び該高分子化合物を有効成分とする高脂血症治療剤
EP0098884B1 (de) 1982-01-18 1986-07-23 Mitsubishi Petrochemical Co., Ltd. Heilmittel zum absenken cholesterolspiegels
JPS6090243A (ja) 1983-10-25 1985-05-21 Nitto Boseki Co Ltd 小球状モノアリルアミン橋かけ重合体の製造方法
US4528347A (en) 1983-11-10 1985-07-09 501 Nitto Boseki, Co. Ltd Process for producing polymers of monoallylamine
EP0142962A3 (de) 1983-11-14 1986-01-15 Nitto Boseki Co., Ltd. Verfahren zur Herstellung von Polyallyaminderivaten
JPS60106803A (ja) 1983-11-14 1985-06-12 Nitto Boseki Co Ltd アリル尿素重合体の製造方法
CA1220897A (en) 1984-01-11 1987-04-21 Kiyoshi Shimizu Process for producing polymers of monoallylamine
OA08092A (fr) 1984-05-11 1987-03-31 Bristol Myers Co Novel bile sequestrant resin and uses.
US4759923A (en) 1987-06-25 1988-07-26 Hercules Incorporated Process for lowering serum cholesterol using poly(diallylmethylamine) derivatives
DE3800199A1 (de) 1988-01-07 1989-07-20 Sandoz Ag Seitenkettenhaltige vinylpolymere
GB8829088D0 (en) 1988-12-13 1989-01-25 Smith Kline French Lab Compounds
US5236701A (en) 1989-07-19 1993-08-17 Lowchol Scientific Inc. Ingestible hydrophilic polymeric amines useful for lowering blood cholesterol
GB8928278D0 (en) 1989-12-14 1990-02-21 Smith Kline French Lab Compounds
CA2040996A1 (en) 1990-05-02 1991-11-03 Robert L. Albright Composition and method for controlling cholesterol
GB9011332D0 (en) 1990-05-21 1990-07-11 Smith Kline French Lab Compounds
IE914179A1 (en) 1990-12-07 1992-06-17 Ici Plc Nitrogen derivatives
US5055197A (en) 1991-04-05 1991-10-08 Rohm And Haas Company Process for removing residual monomers and oligemers from amine-containing polymers
JP3247435B2 (ja) 1992-07-11 2002-01-15 日産アルティア株式会社 芯材添設型樹脂製車両用ルーフレールの製造方法及び車両用ルーフレール
EP0580078B1 (de) 1992-07-22 1997-10-15 Hoechst Aktiengesellschaft Hydrophile Zentren aufweisende Polyvinylamin-Derivate, Verfahren zu ihrer Herstellung sowie die Verwendung der Verbindungen als Arzneimittel, Wirkstoffträger und Nahrungsmittelhilfsstoff
DK0580079T3 (da) 1992-07-22 1997-06-30 Hoechst Ag Tværbundne, nitrogenholdige vinylcopolymerer, fremgangsmåde til deres fremstilling samt anvendelse af disse forbindelser
NZ255758A (en) 1992-08-20 1997-10-24 Du Pont Crosslinked polymeric ammonium salts useful as bile sequestrants
US5451397A (en) 1992-12-21 1995-09-19 Rohm And Haas Company Bile acid sequestrant
JPH06321786A (ja) * 1993-05-12 1994-11-22 Sekisui Chem Co Ltd 胆汁酸腸管吸収抑制剤
US5487888A (en) 1993-05-20 1996-01-30 Geltex, Inc. Iron-binding polymers for oral administration
US5607669A (en) * 1994-06-10 1997-03-04 Geltex Pharmaceuticals, Inc. Amine polymer sequestrant and method of cholesterol depletion
JPH09500368A (ja) 1993-06-02 1997-01-14 ジェルテックス ファーマシューティカルズ，インコーポレイテッド 胆汁酸塩を除去するための組成物および方法
US5624963A (en) 1993-06-02 1997-04-29 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
US5618530A (en) 1994-06-10 1997-04-08 Geltex Pharmaceuticals, Inc. Hydrophobic amine polymer sequestrant and method of cholesterol depletion
US5496545A (en) 1993-08-11 1996-03-05 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
US5414068A (en) 1994-01-24 1995-05-09 Rohm And Haas Company Crosslinked anion exchange particles and method for producing the particles
TW474813B (en) 1994-06-10 2002-02-01 Geltex Pharma Inc Alkylated composition for removing bile salts from a patient
US5792749A (en) * 1997-01-09 1998-08-11 Virginia Commonwealth University Method and composition for lowering low density lipoprotein cholesterol

Also Published As

Publication number Publication date
CN1263468A (zh) 2000-08-16
CN1211091C (zh) 2005-07-20
NZ501719A (en) 2001-10-26
DE69818058D1 (de) 2003-10-16
KR100567751B1 (ko) 2006-04-05
MY125874A (en) 2006-08-30
IL133434A (en) 2005-09-25
AU7967598A (en) 1999-01-04
IL133434A0 (en) 2001-04-30
US6423754B1 (en) 2002-07-23
US20030086898A1 (en) 2003-05-08
HK1029920A1 (en) 2001-04-20
WO1998057652A1 (en) 1998-12-23
AU735260C (en) 2002-03-28
CA2294036C (en) 2007-08-21
JP4420143B2 (ja) 2010-02-24
US20060239959A1 (en) 2006-10-26
EP0996454B1 (de) 2003-09-10
MXPA99011826A (es) 2002-07-02
CA2294036A1 (en) 1998-12-23
TW526063B (en) 2003-04-01
DE69818058T2 (de) 2004-07-08
AU735260B2 (en) 2001-07-05
JP2002516613A (ja) 2002-06-04
KR20010013943A (ko) 2001-02-26
EP0996454A1 (de) 2000-05-03

Similar Documents

Publication Publication Date Title
ATE249228T1 (de) Verwendung von polyallylamin-polymeren zur herstellung eines medikamentes zur behandlung von hypercholesterolemia
ATE196252T1 (de) Behandlung von hornincontinenz durch verwendung von (s)-oxybutynin und (s)-desethyloxybutynin
ATE201594T1 (de) Verwendung von venlafaxin oder eines aryloxy- propanaminderivates zur herstellung eines medikaments zur behandlung von inkontinenz
DE69616376D1 (de) Verwendung von Tiagabin zur Behandlung von Schlafstörungen
ATE133336T1 (de) Verwendung von rapamycin zur herstellung eines arzneimittels zur behandlung von augenentzündungen
DE69310065D1 (de) Verwendung von 2-(3,4-Dimethoxycinnamoyl)aminobenzoesäure zur Herstellung eines Arzeimittels zur Behandlung der Restenose
GR3033786T3 (en) Novel 2,3,5-trimethyl-4-hydroxy anilide derivatives, preparation thereof and therapeutical use thereof
ATE189601T1 (de) Verwendung von raloxifen und dessen analogen zur herstellung eines medikaments zur behandlung viraler erkrankungen
ATE191849T1 (de) Verwendung von (s)-(-)-alpha-ethyl-2-oxo-1- pyrrolidinacetamid zur herstellung eines medikaments zur behandlung von angst
ATE137965T1 (de) Verwendung von tomoxetine zur behandlung von funktionsstörungen der niedrigen harnwege
DE3888340D1 (de) Verwendung von 1,4-disubstituierten-Piperidinyl-Verbindungen zur Herstellung eines Arzneimittels zur Behandlung von Schlaflosigkeit.
ATE307203T1 (de) Verwendung eines anti-interleukin-9 antikörpers zur herstellung eines medikamentes zur behandlung von asthma
ATE180669T1 (de) Verwendung von pregnanderivaten zur behandlung von tumoren
ATE217191T1 (de) Verwendung von phanquinon zur behandlung von alzheimer's krankheit
DE60026883D1 (de) Methoden und zusammensetzungen zur behandlung von schmerzen
DE69822626D1 (de) Verwendung eines nitroxids oder seiner prodrugs zur prophylaktischen und therapeutischen behandlung von krebs
DE69525631D1 (de) Verwendung von prostaglandinen zur herstellung eines arzneimittels zur prävention und behandlung des sekundären katarakts
DE69623767D1 (de) Verwendung von pyrrolidinderivaten zur behandlung des alkoholismus
BR9708922A (pt) Piridil-e pirimidil-piperazinas no tratamento de doenças causadas por substâncias usadas em excesso
DE69424415D1 (de) Verwendung von efaroxan und dessen derivaten zur herstellung eines arzneimittels zur behandlung parkinsonscher krankheit
ATE263565T1 (de) Verwendung von 8,9-dehydroestron zur herstellung eines arzneimittels zur behandlung von durch freie radikale verursachte krankheiten
DE69619088D1 (de) Quinoxalin-Derivate zur Behandlung von Tinnitus
DE69529070D1 (de) Verwendung von 5,6-o-benzyliden-l-ascorbinsäure oder deren salze zur herstellung eines medikaments zur behandlung von hiv
DE69329252D1 (de) Verwendung von piperazinderivaten zur behandlung von kognitiven erkrankungen
ATE145133T1 (de) Verwendung von thiol-5-(2-diethyl-aminoethyl)- ester-verbindungen zur herstellung eines arzneimittels zur behandlung der neuromuskuläre inkontinenz

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties