DE69527802D1 - Verfahren zur herstellung von benzyl-substituierten rhodanin derivaten - Google Patents
Verfahren zur herstellung von benzyl-substituierten rhodanin derivatenInfo
- Publication number
- DE69527802D1 DE69527802D1 DE69527802T DE69527802T DE69527802D1 DE 69527802 D1 DE69527802 D1 DE 69527802D1 DE 69527802 T DE69527802 T DE 69527802T DE 69527802 T DE69527802 T DE 69527802T DE 69527802 D1 DE69527802 D1 DE 69527802D1
- Authority
- DE
- Germany
- Prior art keywords
- substituted
- derivatives
- benzyl
- rhodanin
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- KIWUVOGUEXMXSV-UHFFFAOYSA-N rhodanine Chemical class O=C1CSC(=S)N1 KIWUVOGUEXMXSV-UHFFFAOYSA-N 0.000 title abstract 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 abstract 2
- -1 benzyl-substituted mercaptopropanoic acids Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/14—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/361,281 US5563277A (en) | 1994-12-21 | 1994-12-21 | Process for preparing benzyl-substituted rhodanine derivatives |
| PCT/US1995/016372 WO1996019466A1 (en) | 1994-12-21 | 1995-12-14 | Process for preparing benzyl-substituted rhodanine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69527802D1 true DE69527802D1 (de) | 2002-09-19 |
| DE69527802T2 DE69527802T2 (de) | 2003-04-10 |
Family
ID=23421401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69527802T Expired - Fee Related DE69527802T2 (de) | 1994-12-21 | 1995-12-14 | Verfahren zur herstellung von benzyl-substituierten rhodanin derivaten |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5563277A (de) |
| EP (1) | EP0799215B1 (de) |
| JP (1) | JPH10511352A (de) |
| AT (1) | ATE222245T1 (de) |
| AU (1) | AU4520596A (de) |
| CA (1) | CA2207901A1 (de) |
| DE (1) | DE69527802T2 (de) |
| ES (1) | ES2181809T3 (de) |
| WO (1) | WO1996019466A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0761657B1 (de) * | 1995-09-07 | 2000-05-24 | Eli Lilly And Company | Verfahren zur Herstellung von benzylsubstituierten Rhodaninederivaten |
| US6005142A (en) | 1996-09-03 | 1999-12-21 | Eli Lilly And Company | Process for preparing benzyl-substituted rhodanine derivatives |
| US6063799A (en) * | 1996-09-03 | 2000-05-16 | Eli Lilly And Company | Alternate crystal form of Tazofelone |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0048159A3 (de) * | 1980-09-17 | 1982-05-12 | University Of Miami | Carboxyalkyl-Peptide und Thioäther und Äther von Peptiden als antihypertensive Mittel |
| IE62214B1 (en) * | 1988-05-25 | 1995-01-11 | Warner Lambert Co | Arylmethylenyl derivatives of thiazolidinones, imidazolidinones and oxazolidinones useful as antiallergy agents and antiinflammatory agents |
| DE69027472T2 (de) * | 1989-04-07 | 1996-12-05 | Lilly Co Eli | Arylsubstituierte Rhodaninderivate |
| US5216002A (en) * | 1989-12-21 | 1993-06-01 | Eli Lilly And Company | Method of treating inflammatory bowel disease |
| ZA9010041B (en) * | 1989-12-21 | 1992-08-26 | Lilly Co Eli | Compounds for treating inflammatory bowel disease |
| FI922867A (fi) * | 1991-06-21 | 1992-12-22 | Tanabe Seiyaku Co | Dikarbonsyraderivat och foerfarande foer framstaellning av dem |
| GB9213934D0 (en) * | 1992-06-30 | 1992-08-12 | Smithkline Beecham Corp | Chemical compounds |
| ES2121036T3 (es) * | 1992-07-14 | 1998-11-16 | Nippon Chemiphar Co | Derivados de alquilenodiamina. |
| EP0587377A3 (en) * | 1992-09-10 | 1994-09-21 | Lilly Co Eli | Thiazolidinone derivatives as hypoglycemic agents and for treating alzheimer's disease |
| JPH06234630A (ja) * | 1992-12-17 | 1994-08-23 | Tanabe Seiyaku Co Ltd | 中性メタロエンドペプチダーゼ阻害剤 |
| US5476865A (en) * | 1994-07-06 | 1995-12-19 | Eli Lilly And Company | Methods of inhibiting bone loss |
-
1994
- 1994-12-21 US US08/361,281 patent/US5563277A/en not_active Expired - Fee Related
-
1995
- 1995-12-14 WO PCT/US1995/016372 patent/WO1996019466A1/en active IP Right Grant
- 1995-12-14 EP EP95943829A patent/EP0799215B1/de not_active Expired - Lifetime
- 1995-12-14 AT AT95943829T patent/ATE222245T1/de not_active IP Right Cessation
- 1995-12-14 AU AU45205/96A patent/AU4520596A/en not_active Abandoned
- 1995-12-14 ES ES95943829T patent/ES2181809T3/es not_active Expired - Lifetime
- 1995-12-14 DE DE69527802T patent/DE69527802T2/de not_active Expired - Fee Related
- 1995-12-14 JP JP8519911A patent/JPH10511352A/ja not_active Ceased
- 1995-12-14 CA CA002207901A patent/CA2207901A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU4520596A (en) | 1996-07-10 |
| US5563277A (en) | 1996-10-08 |
| DE69527802T2 (de) | 2003-04-10 |
| JPH10511352A (ja) | 1998-11-04 |
| EP0799215A4 (de) | 1998-03-11 |
| ES2181809T3 (es) | 2003-03-01 |
| CA2207901A1 (en) | 1996-06-27 |
| EP0799215B1 (de) | 2002-08-14 |
| ATE222245T1 (de) | 2002-08-15 |
| EP0799215A1 (de) | 1997-10-08 |
| WO1996019466A1 (en) | 1996-06-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8339 | Ceased/non-payment of the annual fee |