DE69500313D1 - Neues verfahren zur herstellung von clonidin-derivaten - Google Patents

Neues verfahren zur herstellung von clonidin-derivaten

Info

Publication number
DE69500313D1
DE69500313D1 DE69500313T DE69500313T DE69500313D1 DE 69500313 D1 DE69500313 D1 DE 69500313D1 DE 69500313 T DE69500313 T DE 69500313T DE 69500313 T DE69500313 T DE 69500313T DE 69500313 D1 DE69500313 D1 DE 69500313D1
Authority
DE
Germany
Prior art keywords
pct
producing
new method
clonidine derivatives
date aug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69500313T
Other languages
English (en)
Other versions
DE69500313T2 (de
Inventor
David Pierce
William Dean
Michael Deason
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Vision LLC
Original Assignee
Alcon Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Laboratories Inc filed Critical Alcon Laboratories Inc
Publication of DE69500313D1 publication Critical patent/DE69500313D1/de
Application granted granted Critical
Publication of DE69500313T2 publication Critical patent/DE69500313T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/12—Nitrogen atoms not forming part of a nitro radical
    • C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE69500313T 1994-02-08 1995-02-07 Neues verfahren zur herstellung von clonidin-derivaten Expired - Lifetime DE69500313T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19331994A 1994-02-08 1994-02-08
PCT/US1995/001641 WO1995021818A1 (en) 1994-02-08 1995-02-07 Novel process for preparation of clonidine derivatives

Publications (2)

Publication Number Publication Date
DE69500313D1 true DE69500313D1 (de) 1997-06-26
DE69500313T2 DE69500313T2 (de) 1997-11-06

Family

ID=22713139

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69500313T Expired - Lifetime DE69500313T2 (de) 1994-02-08 1995-02-07 Neues verfahren zur herstellung von clonidin-derivaten

Country Status (17)

Country Link
US (1) US5684156A (de)
EP (1) EP0693055B1 (de)
JP (1) JP2686367B2 (de)
KR (1) KR100218978B1 (de)
CN (2) CN1046501C (de)
AT (1) ATE153330T1 (de)
AU (1) AU677513B2 (de)
CA (1) CA2158763C (de)
DE (1) DE69500313T2 (de)
DK (1) DK0693055T3 (de)
ES (1) ES2103151T3 (de)
FI (1) FI113649B (de)
GR (1) GR3024164T3 (de)
HK (1) HK1019742A1 (de)
NO (1) NO305432B1 (de)
NZ (1) NZ281460A (de)
WO (1) WO1995021818A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5612364A (en) * 1995-11-08 1997-03-18 Alcon Laboratories, Inc. Substantially pure apraclonidine
KR20030007489A (ko) 2000-03-31 2003-01-23 트러스티즈 오브 터프츠 칼리지 7- 및 9-카르바메이트, 우레아, 티오우레아,티오카르바메이트 및 헤테로아릴-아미노 치환된테트라사이클린 화합물
CN100404516C (zh) * 2004-02-13 2008-07-23 大连绿源药业有限责任公司 六氢哒嗪三羧酸酯的制备方法
BRPI0618643A2 (pt) 2005-11-09 2011-09-06 Combinatorx Inc composição compreendendo um par de fármacos, composição compreendendo um corticosteróide e um imunossupressor dependente de imunofilina não-esteróide, kits e uso
EP2765131B1 (de) 2013-02-08 2016-11-23 Arevipharma GmbH Verfahren zur Herstellung von Moxonidin
CN104557716B (zh) * 2014-12-26 2017-12-22 东华大学 一种α2‑肾上腺素能受体激动剂盐酸安普乐定及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3236857A (en) * 1961-10-09 1966-02-22 Boehringer Sohn Ingelheim 2-(phenyl-amino)-1, 3-diazacyclopentene-(2) substitution products
DE1568593A1 (de) * 1966-09-22 1970-04-02 Bayer Ag Verfahren zur Herstellung o.o-dihalogensubstituierter aromatischer Senfoele
BE795970A (fr) * 1972-02-29 1973-08-27 Pfizer Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant
US4515800A (en) * 1981-11-20 1985-05-07 Icilio Cavero Method of lowering intraocular pressure using phenylimino-imidazoles
US4517199A (en) * 1981-11-20 1985-05-14 Alcon Laboratories, Inc. Method for lowering intraocular pressure using phenylimino-imidazoles
US4444782A (en) * 1982-12-23 1984-04-24 Smithkline Beckman Corporation 2(4-tert.-Butyl-2,6-dichlorophenyl-imino)imidazolidine and use as an anti-hypertension agent
US4656291A (en) * 1985-03-15 1987-04-07 Mcneilab, Inc. Process for producing amidine sulfonic acids
EP0442878A4 (en) * 1988-04-05 1991-10-23 Abbott Laboratories Derivatives of tryptophan as cck antagonists
US5204347A (en) * 1989-10-12 1993-04-20 Allergan, Inc. Methods for using (2-imidazolin-2-ylamino) tetrahydroquinoxalines
US5112822A (en) * 1989-10-12 1992-05-12 Allergan, Inc. (2-imidazolin-2-ylamino) quinoxaline derivatives and methods for using same
US5231096A (en) * 1989-10-12 1993-07-27 Allergan, Inc. Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
US5077292A (en) * 1989-10-12 1991-12-31 Allergan, Inc. (2-imidazolin-2-ylamino) tetrahydroquinoxalines and methods for using same
US5130441A (en) * 1990-02-06 1992-07-14 Allergan, Inc. Method for producing amino-2-imidazoline derivatives

Also Published As

Publication number Publication date
CN1107056C (zh) 2003-04-30
GR3024164T3 (en) 1997-10-31
JP2686367B2 (ja) 1997-12-08
EP0693055A1 (de) 1996-01-24
DK0693055T3 (da) 1997-12-15
CA2158763A1 (en) 1995-08-17
MX9504262A (es) 1997-12-31
NO953988L (no) 1995-12-07
NO305432B1 (no) 1999-05-31
WO1995021818A1 (en) 1995-08-17
FI954749A (fi) 1995-10-05
CA2158763C (en) 2002-10-29
FI954749A0 (fi) 1995-10-05
AU1840895A (en) 1995-08-29
NO953988D0 (no) 1995-10-06
CN1123026A (zh) 1996-05-22
NZ281460A (en) 1996-10-28
ES2103151T3 (es) 1997-08-16
AU677513B2 (en) 1997-04-24
HK1019742A1 (en) 2000-02-25
KR100218978B1 (ko) 1999-09-01
DE69500313T2 (de) 1997-11-06
KR960701836A (ko) 1996-03-28
CN1046501C (zh) 1999-11-17
US5684156A (en) 1997-11-04
ATE153330T1 (de) 1997-06-15
EP0693055B1 (de) 1997-05-21
JPH08509005A (ja) 1996-09-24
CN1220261A (zh) 1999-06-23
FI113649B (fi) 2004-05-31

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