MX9504262A - Procedimiento novedoso para la preparacion de derivados de clonidina. - Google Patents

Procedimiento novedoso para la preparacion de derivados de clonidina.

Info

Publication number
MX9504262A
MX9504262A MX9504262A MX9504262A MX9504262A MX 9504262 A MX9504262 A MX 9504262A MX 9504262 A MX9504262 A MX 9504262A MX 9504262 A MX9504262 A MX 9504262A MX 9504262 A MX9504262 A MX 9504262A
Authority
MX
Mexico
Prior art keywords
novel process
preparation
clonidine derivatives
discovered
derivatives
Prior art date
Application number
MX9504262A
Other languages
English (en)
Other versions
MXPA95004262A (es
Inventor
David R Pierce
William D Dean
Michael E Deason
Original Assignee
Alcon Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Lab Inc filed Critical Alcon Lab Inc
Publication of MX9504262A publication Critical patent/MX9504262A/es
Publication of MXPA95004262A publication Critical patent/MXPA95004262A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/12—Nitrogen atoms not forming part of a nitro radical
    • C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Se ha descubierto un procedimiento novedoso para la preparacion de derivados de clonidina que es más corto, menos costoso y más seguro que los métodos anteriormente conocidos; un nuevo complejo de tiourea de la formula (I); en donde: Ar es un fenilo o naftilo sustituido o no substituido con una o más porciones seleccionadas a partir del grupo que consiste de: Cl, F, Br, I, alquilo de 1 a 4 átomos de carbono, arilo, alcoxi o arilalcoxi de 1 a 4 átomos de carbono; NO2 está en la posicion para u ortho; y n es de 1 a 4; y se ha descubierto también puede ciclizarse directamente para producir el producto heterocíclico correspondiente.
MXPA/A/1995/004262A 1994-02-08 1995-10-06 Procedimiento novedoso para la preparacion dederivados de clonidina MXPA95004262A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US19331994A 1994-02-08 1994-02-08
US193,319 1994-02-08
US193319 1994-02-08
PCT/US1995/001641 WO1995021818A1 (en) 1994-02-08 1995-02-07 Novel process for preparation of clonidine derivatives

Publications (2)

Publication Number Publication Date
MX9504262A true MX9504262A (es) 1997-12-31
MXPA95004262A MXPA95004262A (es) 1998-09-18

Family

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Also Published As

Publication number Publication date
CA2158763C (en) 2002-10-29
GR3024164T3 (en) 1997-10-31
US5684156A (en) 1997-11-04
FI113649B (fi) 2004-05-31
DE69500313D1 (de) 1997-06-26
NZ281460A (en) 1996-10-28
DK0693055T3 (da) 1997-12-15
CN1123026A (zh) 1996-05-22
ATE153330T1 (de) 1997-06-15
CN1220261A (zh) 1999-06-23
KR100218978B1 (ko) 1999-09-01
EP0693055A1 (en) 1996-01-24
NO953988L (no) 1995-12-07
JPH08509005A (ja) 1996-09-24
AU1840895A (en) 1995-08-29
AU677513B2 (en) 1997-04-24
DE69500313T2 (de) 1997-11-06
JP2686367B2 (ja) 1997-12-08
CA2158763A1 (en) 1995-08-17
FI954749A0 (fi) 1995-10-05
CN1046501C (zh) 1999-11-17
NO305432B1 (no) 1999-05-31
NO953988D0 (no) 1995-10-06
EP0693055B1 (en) 1997-05-21
KR960701836A (ko) 1996-03-28
HK1019742A1 (en) 2000-02-25
ES2103151T3 (es) 1997-08-16
CN1107056C (zh) 2003-04-30
WO1995021818A1 (en) 1995-08-17
FI954749L (fi) 1995-10-05

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