ATE216427T1 - Verfahren zur herstellung von polypeptidabkömmlingen - Google Patents

Verfahren zur herstellung von polypeptidabkömmlingen

Info

Publication number
ATE216427T1
ATE216427T1 AT96926325T AT96926325T ATE216427T1 AT E216427 T1 ATE216427 T1 AT E216427T1 AT 96926325 T AT96926325 T AT 96926325T AT 96926325 T AT96926325 T AT 96926325T AT E216427 T1 ATE216427 T1 AT E216427T1
Authority
AT
Austria
Prior art keywords
polypeptide
dna
homologous
encoding
circular plasmid
Prior art date
Application number
AT96926325T
Other languages
English (en)
Inventor
Jens Sigurd Okkels
Original Assignee
Novozymes As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes As filed Critical Novozymes As
Application granted granted Critical
Publication of ATE216427T1 publication Critical patent/ATE216427T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C12N15/1027—Mutagenizing nucleic acids by DNA shuffling, e.g. RSR, STEP, RPR

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
AT96926325T 1995-08-11 1996-08-12 Verfahren zur herstellung von polypeptidabkömmlingen ATE216427T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK90795 1995-08-11
DK104795 1995-09-20
PCT/DK1996/000343 WO1997007205A1 (en) 1995-08-11 1996-08-12 Method for preparing polypeptide variants

Publications (1)

Publication Number Publication Date
ATE216427T1 true ATE216427T1 (de) 2002-05-15

Family

ID=26064882

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96926325T ATE216427T1 (de) 1995-08-11 1996-08-12 Verfahren zur herstellung von polypeptidabkömmlingen

Country Status (9)

Country Link
US (2) US20030148441A1 (de)
EP (2) EP1213350A3 (de)
JP (1) JP4156666B2 (de)
CN (1) CN1128875C (de)
AT (1) ATE216427T1 (de)
AU (2) AU6655396A (de)
DE (1) DE69620766T2 (de)
DK (1) DK0843725T3 (de)
WO (2) WO1997007205A1 (de)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605793A (en) * 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US20060257890A1 (en) 1996-05-20 2006-11-16 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6995017B1 (en) 1994-02-17 2006-02-07 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6309883B1 (en) 1994-02-17 2001-10-30 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6165793A (en) * 1996-03-25 2000-12-26 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
JPH08228778A (ja) * 1995-02-27 1996-09-10 Showa Denko Kk 新規なリパーゼ遺伝子及びそれを用いたリパーゼの製造方法
US6936289B2 (en) 1995-06-07 2005-08-30 Danisco A/S Method of improving the properties of a flour dough, a flour dough improving composition and improved food products
US6537776B1 (en) 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
US6489145B1 (en) * 1996-07-09 2002-12-03 Diversa Corporation Method of DNA shuffling
US6764835B2 (en) 1995-12-07 2004-07-20 Diversa Corporation Saturation mutageneis in directed evolution
US6326204B1 (en) 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
KR100568008B1 (ko) 1997-01-17 2006-04-07 맥시겐, 인크. 반복적 서열 재조합에 의한 전세포 및 유기체의 개량 방법
US7148054B2 (en) 1997-01-17 2006-12-12 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
US6159688A (en) 1997-03-18 2000-12-12 Novo Nordisk A/S Methods of producing polynucleotide variants
US6159687A (en) 1997-03-18 2000-12-12 Novo Nordisk A/S Methods for generating recombined polynucleotides
IL131966A0 (en) 1997-03-18 2001-03-19 Novo Industri As An in vitro method for construction of a dna library
US6153410A (en) * 1997-03-25 2000-11-28 California Institute Of Technology Recombination of polynucleotide sequences using random or defined primers
ES2350891T3 (es) 1997-04-09 2011-01-28 Danisco A/S Lipasa y utilización de la misma para mejorar las masas y los productos horneados.
US6207442B1 (en) 1997-10-16 2001-03-27 Zymogenetics, Inc. Plasmid construction by homologous recombination
EP1036198B1 (de) 1997-12-08 2012-09-26 California Institute Of Technology Verfahren zur Herstellung von Polynukleotid- und Polypeptidsequenzen
EP1036201A2 (de) * 1997-12-12 2000-09-20 Intergen Company Methode zum nachweis von apoptose unter verwendung von "fret" markierten oligonukleotiden
US7390619B1 (en) 1998-02-11 2008-06-24 Maxygen, Inc. Optimization of immunomodulatory properties of genetic vaccines
EP0943678A3 (de) * 1998-02-18 2000-05-10 Novo Nordisk A/S Lipase Varianten
BR9910174A (pt) 1998-05-01 2001-03-06 Maxygen Inc Processo para se obter um gene recombinante otimizado de resistência à praga, biblioteca, e, processo para se obter um organismo que seja patogênico a uma praga de vegetal
US7153655B2 (en) 1998-06-16 2006-12-26 Alligator Bioscience Ab Method for in vitro molecular evolution of protein function involving the use of exonuclease enzyme and two populations of parent polynucleotide sequence
EP1104459A1 (de) 1998-08-12 2001-06-06 Maxygen, Inc. Dna-shuffling von monooxygenase genen für die herstellung von industriellen chemikalien
JP4283351B2 (ja) * 1998-08-27 2009-06-24 サントリー酒類株式会社 新規な油脂組成物の製造方法および用途
US6500639B2 (en) 1998-10-07 2002-12-31 Maxygen, Inc. DNA shuffling to produce nucleic acids for mycotoxin detoxification
JP5043254B2 (ja) 1998-10-26 2012-10-10 ノボザイムス アクティーゼルスカブ 糸状面細胞内の問題のｄｎａライブラリーの作製及びスクリーニング
US6767701B1 (en) 1998-10-26 2004-07-27 Novozymes A/S Methods of constructing and screening a DNA library of interest in filamentous fungal cells
WO2000028018A1 (en) 1998-11-10 2000-05-18 Maxygen, Inc. Modified adp-glucose pyrophosphorylase for improvement and optimization of plant phenotypes
US7312062B2 (en) 1998-11-27 2007-12-25 Novozymes A/S Lipolytic enzyme variants
JP4723087B2 (ja) 1998-11-27 2011-07-13 ノボザイムス アクティーゼルスカブ 脂質分解酵素変異体
US6917882B2 (en) 1999-01-19 2005-07-12 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US6436675B1 (en) 1999-09-28 2002-08-20 Maxygen, Inc. Use of codon-varied oligonucleotide synthesis for synthetic shuffling
US6376246B1 (en) 1999-02-05 2002-04-23 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
JP2002534966A (ja) 1999-01-19 2002-10-22 マキシジェン， インコーポレイテッド オリゴヌクレオチド媒介核酸組換え
US7024312B1 (en) 1999-01-19 2006-04-04 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US6961664B2 (en) 1999-01-19 2005-11-01 Maxygen Methods of populating data structures for use in evolutionary simulations
US7384387B1 (en) 1999-02-11 2008-06-10 Maxygen, Inc. High throughput mass spectrometry
US6531316B1 (en) 1999-03-05 2003-03-11 Maxyag, Inc. Encryption of traits using split gene sequences and engineered genetic elements
AU3719500A (en) 1999-03-05 2000-09-21 Maxygen, Inc. Recombination of insertion modified nucleic acids
US6569685B1 (en) 1999-10-05 2003-05-27 The Molecular Sciences Institute, Inc. Protein fingerprint system and related methods
US7430477B2 (en) 1999-10-12 2008-09-30 Maxygen, Inc. Methods of populating data structures for use in evolutionary simulations
ES2335385T3 (es) * 1999-10-13 2010-03-26 The Board Of Trustees Of The Leland Stanford Junior University Biosintesis de sustratos de policetido sintasa.
US6686515B1 (en) 1999-11-23 2004-02-03 Maxygen, Inc. Homologous recombination in plants
US7115712B1 (en) 1999-12-02 2006-10-03 Maxygen, Inc. Cytokine polypeptides
SK11672002A3 (sk) 2000-01-10 2002-12-03 Maxygen Holdings Ltd. Polypeptidový konjugát, spôsob jeho výroby, farmaceutický prostriedok s jeho obsahom a jeho použitie
CA2396320A1 (en) 2000-01-11 2001-07-19 Maxygen, Inc. Integrated systems and methods for diversity generation and screening
PL204285B1 (pl) 2000-02-11 2009-12-31 Bayer Healthcare Llc Koniugat polipeptydowy, polipeptyd, sekwencja nukleotydowa, wektor ekspresyjny, komórka gospodarz, sposób wytwarzania koniugatu polipeptydowego, środek farmaceutyczny i zastosowanie koniugatu polipeptydowego
US6248541B1 (en) 2000-04-21 2001-06-19 Genencor International, Inc. Screening under nutrient limited conditions
US6534292B1 (en) 2000-05-08 2003-03-18 Genencor International, Inc. Methods for forming recombined nucleic acids
US7094875B2 (en) 2000-06-23 2006-08-22 Maxygen, Inc. Co-stimulatory polypeptides
US7074590B2 (en) 2000-06-23 2006-07-11 Maxygen, Inc. Chimeric promoters
EP2281878A1 (de) 2000-06-26 2011-02-09 Novozymes A/S Lipolytisches Enzym
US6858422B2 (en) 2000-07-13 2005-02-22 Codexis, Inc. Lipase genes
AU2001280968A1 (en) 2000-07-31 2002-02-13 Menzel, Rolf Compositions and methods for directed gene assembly
US6582914B1 (en) 2000-10-26 2003-06-24 Genencor International, Inc. Method for generating a library of oligonucleotides comprising a controlled distribution of mutations
US6958213B2 (en) 2000-12-12 2005-10-25 Alligator Bioscience Ab Method for in vitro molecular evolution of protein function
WO2002066622A2 (en) * 2001-02-23 2002-08-29 Novozymes A/S Method of generating diversity into lipolytic enzymes and lipolytic enzyme genes
EP1387616B1 (de) 2001-05-18 2007-05-16 Danisco A/S Verfahren zur herstellung von teig mit einem enzym
WO2003000941A2 (en) 2001-06-26 2003-01-03 Novozymes A/S Polypeptides having cellobiohydrolase i activity and polynucleotides encoding same
EP1409667B2 (de) 2001-07-23 2009-06-10 DSM IP Assets B.V. Verfahren zur herstellung von polynukleotidvarianten
WO2003089617A2 (en) 2002-04-22 2003-10-30 Novozymes Biotech, Inc. Methods for increasing homologous recombination of a nucleic acid sequence
DE60331644D1 (de) * 2002-04-22 2010-04-22 Novozymes Inc Verfahren zur herstellung von varianten einer dna-sequenz in filamentösen pilzen
EP1504098B2 (de) 2002-05-17 2011-02-09 Alligator Bioscience AB Eine methode zur in vitro molekularen evolution der proteinfunktion
US7560260B2 (en) 2002-07-25 2009-07-14 Bio-Rad Laboratories, Inc. Compositions with polymerase activity
ATE494368T1 (de) 2002-10-01 2011-01-15 Novozymes As Polypeptide der gh-61-familie
DE60328715D1 (de) 2002-12-20 2009-09-17 Novozymes As Polypeptide mit cellobiohydrolase ii-aktivität und dafür kodierende polynucleotide
ES2534903T3 (es) 2002-12-20 2015-04-30 Novozymes A/S Variantes de galactanasas
DE602004030000D1 (de) 2003-01-17 2010-12-23 Danisco Verfahren zur in-situ-herstellung eines emulgators in einem nahrungsmittel
WO2004099228A2 (en) 2003-05-02 2004-11-18 Novozymes Inc. Variants of beta-glucosidases
WO2005030926A2 (en) 2003-08-25 2005-04-07 Novozymes Inc. Variants of glycoside hydrolases
ES2358092T3 (es) 2003-10-10 2011-05-05 Novozymes A/S Variantes de proteasa.
WO2005066339A2 (en) 2004-01-06 2005-07-21 Novozymes A/S Polypeptides of alicyclobacillus sp.
NZ549198A (en) 2004-02-25 2009-05-31 Novozymes As Fungal cell wall degrading lysozyme for use as an inhibitor of dental biofilms
GB0405637D0 (en) 2004-03-12 2004-04-21 Danisco Protein
EP1766040B1 (de) 2004-05-27 2017-08-09 Novozymes, Inc. Verfahren für transformation und expressionsscreening von fadenpilzzellen mit einer dna-bibliothek
EP1776455B1 (de) 2004-07-16 2015-03-18 DuPont Nutrition Biosciences ApS Lipolytisches enzym, dessen anwendung in der lebensmittelindustrie
US8119387B2 (en) 2005-08-16 2012-02-21 Novozymes A/S Polypeptides of strain Bacillus sp. P203
EP1777292A1 (de) * 2005-10-19 2007-04-25 Signalomics GmbH Verfahren zum Erzeugen von genetischer Diversität in vivo
WO2008008950A2 (en) 2006-07-14 2008-01-17 Novozymes, Inc. Methods for producing secreted polypeptides having biological activity
BRPI0820500A2 (pt) 2007-11-05 2015-06-16 Danisco Us Inc Variantes de alfa-amilase de bacillus sp. Ts-23 com propriedades alteradas
KR20100085964A (ko) 2007-11-05 2010-07-29 다니스코 유에스 인크. 변경된 특성을 가진 알파-아밀라아제 변이체
US8236545B2 (en) 2008-02-04 2012-08-07 Danisco Us Inc., Genencor Division TS23 alpha-amylase variants with altered properties
DK2337837T4 (en) 2008-09-25 2017-02-06 Danisco Us Inc ALPHA-AMYLASE MIXTURES AND PROCEDURES FOR USING IT
BRPI1013388A2 (pt) 2009-04-01 2019-04-09 Danisco Us Inc composição de limpeza que compreende uma alfa-amilase e uma protease e método de limpeza de um tecido ou superficie dura
BRPI0905122A2 (pt) * 2009-12-17 2011-08-09 Petroleo Brasileiro Sa processo de produção de lipases por meio de modificação genética de levedura
FI123942B (fi) 2010-10-29 2013-12-31 Ab Enzymes Oy Sieniperäisen seriiniproteaasin variantteja
AU2012302636B2 (en) * 2011-09-04 2016-09-15 Glytech, Inc. Glycosylated polypeptide and drug composition containing said polypeptide
EP2880159A1 (de) 2012-07-30 2015-06-10 Allylix, Inc. Für nukleinsäuremoleküle codierende sclareol- und labdendioldiphosphatsynthasepolypeptide und ihre verwendung
BR112015009774A2 (pt) 2012-11-01 2017-12-05 Univ British Columbia polipeptídeos citocromo p450 e citocromo p450 redutase, codificando moléculas de ácido nucléicos e usos das mesmas
ES2891377T3 (es) 2013-03-14 2022-01-27 Evolva Inc Polipéptidos de valenceno sintasa, moléculas de ácido nucleico codificantes y usos de los mismos
CN107667177A (zh) 2015-04-07 2018-02-06 诺维信公司 用于选择具有增强活性的酶的方法
WO2016164596A2 (en) 2015-04-07 2016-10-13 Novozymes A/S Methods for selecting enzymes having lipase activity
US20190161786A1 (en) 2016-04-07 2019-05-30 Novozymes A/S Methods for selecting enzymes having protease activity
RU2018141488A (ru) * 2016-04-29 2020-05-29 Пуратос Нв Композиции для печеных продуктов, содержащих липолитические ферменты, и их применения
CN108004151B (zh) * 2018-01-15 2019-07-19 青岛农业大学 一种从海带中分离的翅孢壳真菌及其应用
CN109666661A (zh) * 2018-12-31 2019-04-23 苏州埃斯腾特生物科技有限公司 去除纸浆中胶粘物的生物酶制剂
US20230287383A1 (en) 2020-07-03 2023-09-14 Engenes Biotech Gmbh PYRROLYSYL-tRNA SYNTHETASE VARIANTS AND USES THEREOF
CA3257053A1 (en) 2022-05-14 2023-11-23 Novozymes A/S COMPOSITIONS AND METHODS FOR THE PREVENTION, TREATMENT, SUPPRESSION AND/OR ELIMINATION OF PHYTOPATHOGENIC INFESTATIONS AND INFECTIONS

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8315980D0 (en) * 1983-06-10 1983-07-13 Biogen Nv Producing hybrid dna sequences
ATE93541T1 (de) * 1985-07-03 1993-09-15 Genencor Int Hybride polypeptide und verfahren zu deren herstellung.
US5605793A (en) * 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination

Also Published As

Publication number Publication date
DK0843725T3 (da) 2002-08-12
US20050048649A1 (en) 2005-03-03
EP1213350A3 (de) 2002-12-04
DE69620766T2 (de) 2004-11-18
EP1213350A2 (de) 2002-06-12
EP0843725A1 (de) 1998-05-27
JP4156666B2 (ja) 2008-09-24
JPH11510700A (ja) 1999-09-21
WO1997007205A1 (en) 1997-02-27
AU6655396A (en) 1997-03-12
EP0843725B1 (de) 2002-04-17
US20030148441A1 (en) 2003-08-07
CN1192782A (zh) 1998-09-09
WO1997007206A1 (en) 1997-02-27
CN1128875C (zh) 2003-11-26
AU6655496A (en) 1997-03-12
US20050124066A9 (en) 2005-06-09
DE69620766D1 (de) 2002-05-23

Similar Documents

Publication Publication Date Title
ATE216427T1 (de) Verfahren zur herstellung von polypeptidabkömmlingen
ATE283917T1 (de) Agouti verwandtes gen
ATE253633T1 (de) Cystic fibrosis gen
DE59608743D1 (de) Verfahren zur herstellung von rekombinanten proteinen in e. coli mittels hochzelldichte-fermentation
DE69018920D1 (de) Verwendung von dns-fragmenten, die ein signalpeptid kodieren zur sekretion von reifen proteinen in rekombinanten hefen, expressions-kassetten, transformierte hefen und verfahren zur herstellung dieser proteine.
DE68927073D1 (de) Modifiziertes Baculovirus,Herstellung und Verwendung als Expressionsvektor
ATE258189T1 (de) Verfahren zur herstellung von erythropoietin frei von tierischen proteinen
NO179253C (no) Rekombinant DNA-sekvens som koder for humant proapolipoprotein A-I, ekspresjonsvektorer, cellekulturer samt fremgangsmåte for fremstilling av proteinet
GB9701425D0 (en) A method for in vitro molecular evolution of protein function
DE3585953D1 (de) Dna-fragmente, expressionsvektoren, proteine, wirte und verfahren zur herstellung der proteine.
SG108208A1 (en) Connective tissue growth factor
ATE118821T1 (de) Nukleotidesequenzen, die ein protein mit ureareaktivität kodieren.
DE69412597D1 (de) Methode zur herstellung von gelatine
DE69637648D1 (de) Verfahren zur herstellung rekombinanter adenovirus-genome
MX9602977A (es) Proteinas que reparan la mala union de adn humano.
PT83968A (de) Verfahren zur verbesserung des expression von eukaryontenprotein
DE69319012D1 (de) Protein mit Knochenbildungs-Eigenschaften und Verfahren zu seiner Herstellung
DE3683447D1 (de) Verfahren zur herstellung von humanlysozym.
DE3789678D1 (de) Herstellung von erythropoietinproduzierenden Zellen und Verfahren zur Herstellung von Erythropoietin mit Verwendung dieser Zellen.
ATE127478T1 (de) Onkogen kodierendes polypeptid, das wachstumsfaktoraktivität besitzt, verfahren zu seiner herstellung und verwendung.
ATE100495T1 (de) Rekombinantes marek-krankheitsvirus, verfahren zu seiner herstellung, und vakzine.
ATE125298T1 (de) Verfahren zur herstellung von motilinähnlichen polypeptiden und seine expression.
PL309882A1 (en) Dna sequence encoding novel biosynthetic insulin precursors and insulin obtaining method
WO1998027200A3 (en) Human and mammalian dna replication origin consensus sequences
WO1994026897A3 (en) Dna encoding two fish neuropeptides

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties