ATE194595T1 - Benzonitrile als 5-ht agonisten und antagonisten - Google Patents

Benzonitrile als 5-ht agonisten und antagonisten

Info

Publication number
ATE194595T1
ATE194595T1 AT96104955T AT96104955T ATE194595T1 AT E194595 T1 ATE194595 T1 AT E194595T1 AT 96104955 T AT96104955 T AT 96104955T AT 96104955 T AT96104955 T AT 96104955T AT E194595 T1 ATE194595 T1 AT E194595T1
Authority
AT
Austria
Prior art keywords
benzonitriles
agonists
antagonists
Prior art date
Application number
AT96104955T
Other languages
German (de)
English (en)
Inventor
Henning Dr Boettcher
Karl Ulrich Dr Buehring
Hartmut Dr Greiner
Gerd Bartoszyk
Christoph Dr Seyfried
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of ATE194595T1 publication Critical patent/ATE194595T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
AT96104955T 1995-04-05 1996-03-28 Benzonitrile als 5-ht agonisten und antagonisten ATE194595T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19512639A DE19512639A1 (de) 1995-04-05 1995-04-05 Benzonitrile und -fluoride

Publications (1)

Publication Number Publication Date
ATE194595T1 true ATE194595T1 (de) 2000-07-15

Family

ID=7758788

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96104955T ATE194595T1 (de) 1995-04-05 1996-03-28 Benzonitrile als 5-ht agonisten und antagonisten

Country Status (28)

Country Link
US (1) US6310068B1 (ref)
EP (1) EP0736525B1 (ref)
JP (1) JP3834098B2 (ref)
KR (1) KR100437751B1 (ref)
CN (1) CN1072209C (ref)
AR (1) AR002982A1 (ref)
AT (1) ATE194595T1 (ref)
AU (1) AU709708B2 (ref)
BR (1) BR9601275A (ref)
CA (1) CA2173418C (ref)
CO (1) CO4700469A1 (ref)
CY (1) CY2242B1 (ref)
CZ (1) CZ289449B6 (ref)
DE (2) DE19512639A1 (ref)
DK (1) DK0736525T3 (ref)
ES (1) ES2150039T3 (ref)
GR (1) GR3034514T3 (ref)
HU (1) HUP9600876A3 (ref)
NO (1) NO305903B1 (ref)
PL (1) PL183147B1 (ref)
PT (1) PT736525E (ref)
RU (1) RU2168508C2 (ref)
SI (1) SI0736525T1 (ref)
SK (1) SK281457B6 (ref)
TR (1) TR199600286A2 (ref)
TW (1) TW323279B (ref)
UA (1) UA45325C2 (ref)
ZA (1) ZA962768B (ref)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR004229A1 (es) * 1995-11-06 1998-11-04 Wyeth Corp Derivados indolalquilo de benzodioxanmetilamina y su uso para preparar medicamentos
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US7517880B2 (en) 1997-12-22 2009-04-14 Bayer Pharmaceuticals Corporation Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
ES2219302T3 (es) * 1999-01-07 2004-12-01 Wyeth Derivados de arilpiperazinil-ciclohexilindol para el tratamiento de la depresion.
US7351834B1 (en) 1999-01-13 2008-04-01 Bayer Pharmaceuticals Corporation ω-Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
WO2000042012A1 (en) * 1999-01-13 2000-07-20 Bayer Corporation φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
WO2000041698A1 (en) 1999-01-13 2000-07-20 Bayer Corporation φ-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS
AU1502702A (en) * 2000-11-14 2002-05-27 Merck Patent Gmbh Novel uses of combined 5-HT<sub>1A</sub> agonists and serotonin reuptake inhibitors
UA76130C2 (en) 2000-11-20 2006-07-17 Merck Patent Gmbh Use of compounds combining properties of selective inhibitors of serotonin re-uptake and agonists of 5-ht1a receptor for treatment of irritable bowel syndrome
AR035521A1 (es) * 2000-12-22 2004-06-02 Lundbeck & Co As H Derivados de 3-indolina y composicion farmaceutica que los comprende
US7371763B2 (en) * 2001-04-20 2008-05-13 Bayer Pharmaceuticals Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
ES2393900T3 (es) * 2001-12-03 2012-12-28 Bayer Healthcare Llc Compuestos de aril-urea en combinación con otros agentes citostáticos o citotóxicos para tratamiento de cánceres humanos
US20030207872A1 (en) * 2002-01-11 2003-11-06 Bayer Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US20030216396A1 (en) 2002-02-11 2003-11-20 Bayer Corporation Pyridine, quinoline, and isoquinoline N-oxides as kinase inhibitors
EP2324825A1 (en) 2002-02-11 2011-05-25 Bayer Healthcare LLC Aryl ureas with angiogenesis inhibiting activity
UY28213A1 (es) 2003-02-28 2004-09-30 Bayer Pharmaceuticals Corp Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos.
DK1626714T3 (da) 2003-05-20 2007-10-15 Bayer Pharmaceuticals Corp Dirarylurinstoffer mod sygdomme medieret af PDGFR
CN1856469B (zh) 2003-07-23 2013-03-06 拜耳医药保健有限责任公司 用于治疗和预防疾病和疾病症状的氟代ω-羧芳基二苯基脲
TWI367098B (en) * 2004-12-23 2012-07-01 Kowa Co Treating agent for glaucoma
CN102875538A (zh) * 2012-10-16 2013-01-16 北京诚创思达医药科技有限公司 维拉唑酮或其盐酸盐的制备方法
CN104337812B (zh) 2013-07-29 2018-09-14 广东东阳光药业有限公司 取代的杂芳基化合物及其使用方法和用途
WO2015090235A1 (en) 2013-12-20 2015-06-25 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use thereof
US10316025B2 (en) 2015-06-03 2019-06-11 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use and use thereof
AU2018340376B2 (en) 2017-09-29 2022-09-01 Sunshine Lake Pharma Co., Ltd. Substituted pyrimidine piperazine compound and use thereof
CN118834152B (zh) * 2023-04-23 2025-09-23 复旦大学附属肿瘤医院 一种维拉佐酮衍生物v02及其合成方法和在制备抗肿瘤药物中的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1075156A (en) 1963-08-27 1967-07-12 Luso Farmaco Inst Substituted piperazines
US3468882A (en) 1966-10-07 1969-09-23 Sterling Drug Inc Phenylhydrazone derivatives as intermediates for preparing indoles
DE2138865A1 (de) 1970-08-15 1973-02-22 Sumitomo Chemical Co 3-indolylpiperazine, verfahren zu ihrer herstellung und arzneimittel
GB8830312D0 (en) 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
DE3923045A1 (de) * 1989-07-13 1991-01-17 Merck Patent Gmbh Indolderivate
DE4101686A1 (de) * 1991-01-22 1992-07-23 Merck Patent Gmbh Indolderivate
CA2092112A1 (en) * 1992-03-23 1993-09-24 Nobuyoshi Iwata Indole and indazole derivatives, for the treatment and prophylaxis of cerebral disorders, their preparation and their use

Also Published As

Publication number Publication date
CA2173418A1 (en) 1996-10-06
BR9601275A (pt) 1998-01-13
HU9600876D0 (en) 1996-05-28
EP0736525B1 (de) 2000-07-12
ES2150039T3 (es) 2000-11-16
UA45325C2 (uk) 2002-04-15
JPH09151174A (ja) 1997-06-10
AR002982A1 (es) 1998-05-27
US6310068B1 (en) 2001-10-30
AU709708B2 (en) 1999-09-02
CA2173418C (en) 2007-06-12
TR199600286A2 (tr) 1997-03-21
SK40396A3 (en) 1996-11-06
CZ289449B6 (cs) 2002-01-16
RU2168508C2 (ru) 2001-06-10
EP0736525A1 (de) 1996-10-09
CN1072209C (zh) 2001-10-03
KR960037675A (ko) 1996-11-19
CO4700469A1 (es) 1998-12-29
CZ96496A3 (en) 1996-10-16
DE59605568D1 (de) 2000-08-17
JP3834098B2 (ja) 2006-10-18
HUP9600876A2 (hu) 1998-09-28
CY2242B1 (en) 2003-07-04
AU5040896A (en) 1996-10-17
ZA962768B (en) 1996-11-13
NO305903B1 (no) 1999-08-16
SI0736525T1 (en) 2001-02-28
GR3034514T3 (en) 2000-12-29
TW323279B (ref) 1997-12-21
HUP9600876A3 (en) 2000-04-28
DE19512639A1 (de) 1996-10-10
PL183147B1 (pl) 2002-05-31
NO961346D0 (no) 1996-04-02
PT736525E (pt) 2000-12-29
CN1137036A (zh) 1996-12-04
PL313632A1 (en) 1996-10-14
DK0736525T3 (da) 2000-10-30
NO961346L (no) 1996-10-07
KR100437751B1 (ko) 2004-08-25
SK281457B6 (sk) 2001-03-12

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