ATE170835T1 - Asymmetrisches herstellungsverfahren für florfenicol, thiamphenicol, chloramphenicol und oxazolin-zwischenprodukte - Google Patents

Asymmetrisches herstellungsverfahren für florfenicol, thiamphenicol, chloramphenicol und oxazolin-zwischenprodukte

Info

Publication number
ATE170835T1
ATE170835T1 AT94903599T AT94903599T ATE170835T1 AT E170835 T1 ATE170835 T1 AT E170835T1 AT 94903599 T AT94903599 T AT 94903599T AT 94903599 T AT94903599 T AT 94903599T AT E170835 T1 ATE170835 T1 AT E170835T1
Authority
AT
Austria
Prior art keywords
acid
oxazoline
florfenicol
chloride
epoxide
Prior art date
Application number
AT94903599T
Other languages
English (en)
Inventor
Guang-Zhong Wu
Wanda I Tormos
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE170835T1 publication Critical patent/ATE170835T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials
AT94903599T 1992-12-18 1993-12-15 Asymmetrisches herstellungsverfahren für florfenicol, thiamphenicol, chloramphenicol und oxazolin-zwischenprodukte ATE170835T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/993,932 US5352832A (en) 1992-12-18 1992-12-18 Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates

Publications (1)

Publication Number Publication Date
ATE170835T1 true ATE170835T1 (de) 1998-09-15

Family

ID=25540089

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94903599T ATE170835T1 (de) 1992-12-18 1993-12-15 Asymmetrisches herstellungsverfahren für florfenicol, thiamphenicol, chloramphenicol und oxazolin-zwischenprodukte

Country Status (20)

Country Link
US (1) US5352832A (de)
EP (1) EP0674618B1 (de)
JP (1) JP3428016B2 (de)
KR (1) KR100284216B1 (de)
AT (1) ATE170835T1 (de)
AU (1) AU676003B2 (de)
CA (1) CA2152089C (de)
CZ (1) CZ287461B6 (de)
DE (1) DE69320986T2 (de)
DK (1) DK0674618T3 (de)
ES (1) ES2120605T3 (de)
FI (1) FI109295B (de)
HU (1) HU225110B1 (de)
NO (1) NO303575B1 (de)
NZ (1) NZ259239A (de)
PL (1) PL177891B1 (de)
RU (1) RU2126383C1 (de)
SK (1) SK281701B6 (de)
UA (1) UA43331C2 (de)
WO (1) WO1994014764A1 (de)

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US7361689B2 (en) * 2003-12-31 2008-04-22 Schering-Plough Animal Health Corporation Antibacterial 1-(4-mono- and di-halomethylsulphonylphenyl)-2-acylamino-3-fluoroproponals and preparation thereof
DE602005012107D1 (de) * 2004-08-13 2009-02-12 Schering Plough Ltd Pharmazeutische formulierungen mit einem antibioti
CN101065352A (zh) 2004-09-23 2007-10-31 先灵-普劳有限公司 使用新的三氟甲磺酰苯胺肟醚衍生物控制动物中的寄生虫
CA2587495A1 (en) * 2004-11-19 2006-05-26 Schering-Plough Ltd. Control of parasites in animals by the use of parasiticidal 2-phenyl-3-(1h-pyrrol-2-yl) acrylonitrile derivatives
JP5017122B2 (ja) * 2004-12-21 2012-09-05 インターベツト・インターナシヨナル・ベー・ベー 注射可能な獣医学組成物
MX2007015729A (es) * 2005-06-09 2008-02-21 Schering Plough Ltd Control de parasitos en animales con derivados de n-[(feniloxi)fenil]-1,1,1-trifluorometansulfonamida y de n[(fenilsulfanil)fenil]-1,1,1-trifluorometansulfonamida.
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
US7518017B2 (en) 2006-02-17 2009-04-14 Idexx Laboratories Fenicol compounds and methods synthesizing 2-trifluoroacetamido-3-substituted propiophenone compounds
US20070238700A1 (en) * 2006-04-10 2007-10-11 Winzenberg Kevin N N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
US8044230B2 (en) * 2006-12-13 2011-10-25 Intervet Inc. Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof
WO2008076259A1 (en) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Water-soluble prodrugs of florfenicol and its analogs
MX2009011642A (es) * 2007-04-27 2010-01-29 Schering Plough Ltd Compuestos y metodos para potenciar la solubilidad de florfenicol y antibioticos estructuralmente relacionados utilizando ciclodextrinas.
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
NO2957284T3 (de) 2007-06-27 2018-06-16
US7550625B2 (en) * 2007-10-19 2009-06-23 Idexx Laboratories Esters of florfenicol
EP2217207B1 (de) 2007-11-09 2019-01-09 Intervet International B.V. Feste formulierung mit schneller freisetzung, zubereitung und verwendung
TWI468407B (zh) 2008-02-06 2015-01-11 Du Pont 中離子農藥
US8314252B2 (en) 2008-07-30 2012-11-20 Intervet Inc. Process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol
CN101337916B (zh) * 2008-08-12 2011-02-16 张家港市恒盛药用化学有限公司 氟苯尼考磺酸酯及其盐以及它们的制备方法
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
EP2462125A2 (de) 2009-08-05 2012-06-13 E. I. du Pont de Nemours and Company Mesoionische pestizide
US20120122679A1 (en) 2009-08-05 2012-05-17 E. I. Du Pont De Nemours And Company Mesoionic pesticides
UA107804C2 (en) 2009-08-05 2015-02-25 Du Pont Mixtures of pesticides mezoionnyh
BRPI1002023A2 (pt) 2010-03-01 2011-10-25 Nanocore Biotecnologia S A forma farmacêutica sólida de dissolução rápida para tratamento de infecções bacterianas
MA34247B1 (fr) 2010-05-27 2013-05-02 Du Pont Forme cristalline du 4-[5-[3-chloro-5-(trifluorométhyl) phényl] -4,5-dihydro-5-(trifluorométhyl)-3-isoxazolyl]-n-[2-oxo-2-[(2, 2,2-trifluoroéthyl) amino] éthyl]-1-naphtalènecarboxamide
CN101921214B (zh) * 2010-08-03 2013-04-10 复旦大学 反式对甲砜基肉桂醇的合成方法
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
JPWO2012105574A1 (ja) * 2011-01-31 2014-07-03 国立大学法人 長崎大学 光学活性化合物又はその塩の製造方法
CN102417472B (zh) * 2011-12-12 2013-11-13 齐鲁动物保健品有限公司 一种氟苯尼考的制备方法
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
CN102827042B (zh) * 2012-09-17 2013-11-06 湖北美天生物科技有限公司 氟苯尼考的手性合成方法
CN102863361B (zh) * 2012-10-17 2014-03-12 湖北美天生物科技有限公司 甲砜霉素的手性催化合成方法
CN102911133B (zh) * 2012-10-31 2014-07-02 绍兴民生医药有限公司 (4r,5r)-2-二氯甲基-4,5-二氢-5-(4-甲砜基苯基)-4-恶唑甲醇的纯化方法
CN103336072A (zh) * 2013-06-19 2013-10-02 湖北龙翔药业有限公司 一种测定氟苯尼考中手性活性成分含量的方法
CN103880719A (zh) * 2014-03-27 2014-06-25 张家港威胜生物医药有限公司 一种制备氟苯尼考琥珀酸酯的方法
MX371184B (es) * 2014-04-16 2020-01-21 Masteam Bio Tech Co Ltd Método para sintetizar florfenicol.
CN103980167B (zh) * 2014-04-17 2016-06-08 天津大学 一种无定形氟苯尼考及其制备方法
CN106349130B (zh) * 2016-08-25 2018-01-23 潍坊大有生物化工有限公司 一种新的氟苯尼考的合成方法
CN111153838B (zh) * 2020-01-19 2021-08-24 浙江大学宁波理工学院 一种氟苯尼考的合成方法
CN113185473B (zh) * 2021-06-30 2021-10-08 山东国邦药业有限公司 一种氟苯尼考中间体氟甲砜噁唑的制备方法

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US4361557A (en) * 1980-01-28 1982-11-30 Schering Corporation 1-Aryl-2-acylamido-3-fluoro-1-propanol acylates, methods for their use as anti-bacterial agents and compositions useful therefor
IT1173213B (it) * 1984-02-03 1987-06-18 Zambon Spa Procedimento per fluorurare alcuni derivati dall'1l-fenil-2-ammino-1,3-propandiolo e loro intermedi
US4900847A (en) * 1985-04-04 1990-02-13 Massachusetts Institute Of Technology Catalytic asymmetric epoxidation
US4876352A (en) * 1988-09-14 1989-10-24 Schering Corporation Pressurized fluorination of hydroxy alkyl groups
IT1237798B (it) * 1989-10-20 1993-06-17 Zambon Spa Processo per l'inversione stereochimica di (2s,3s)-2-ammino-3-fenil-1 ,3-propandioli nei corrispondenti enantiomeri (2r,3r).
CA2023600A1 (en) * 1990-08-29 1992-02-23 Wilfred P. Shum Asymmetric epoxidation using a chiral hydroperoxide
DK0555340T3 (da) * 1990-10-25 1995-03-06 Schering Corp Fremgangsmåde til fremstilling af florfenicol, analoger heraf og oxazolinmellemprodukter dertil
JPH06502563A (ja) * 1990-10-31 1994-03-24 バクスター　インターナショナル　インコーポレーテッド オーバー・ザ・ワイヤ・カテーテル
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Also Published As

Publication number Publication date
DE69320986T2 (de) 1999-03-04
KR950704244A (ko) 1995-11-17
UA43331C2 (uk) 2001-12-17
EP0674618A1 (de) 1995-10-04
HU225110B1 (en) 2006-06-28
NO952425L (no) 1995-06-16
RU2126383C1 (ru) 1999-02-20
WO1994014764A1 (en) 1994-07-07
PL309393A1 (en) 1995-10-02
FI109295B (fi) 2002-06-28
AU676003B2 (en) 1997-02-27
HUT72669A (en) 1996-05-28
JP3428016B2 (ja) 2003-07-22
EP0674618B1 (de) 1998-09-09
SK281701B6 (sk) 2001-07-10
AU5748494A (en) 1994-07-19
FI952872A0 (fi) 1995-06-12
NO303575B1 (no) 1998-08-03
CA2152089A1 (en) 1994-07-07
HU9501776D0 (en) 1995-08-28
NO952425D0 (no) 1995-06-16
CZ287461B6 (en) 2000-11-15
NZ259239A (en) 1996-04-26
DK0674618T3 (da) 1999-02-22
CA2152089C (en) 2006-10-24
DE69320986D1 (de) 1998-10-15
PL177891B1 (pl) 2000-01-31
JPH08504819A (ja) 1996-05-28
CZ159895A3 (en) 1996-01-17
US5352832A (en) 1994-10-04
ES2120605T3 (es) 1998-11-01
KR100284216B1 (ko) 2001-04-02
SK77795A3 (en) 1995-12-06
FI952872A (fi) 1995-06-12

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