NO952425L - Asymmetrisk fremgangsmåte for fremstilling av florfeikol, tiamfenikol, kloramfenikol og oksazolinmellomprodukter - Google Patents

Asymmetrisk fremgangsmåte for fremstilling av florfeikol, tiamfenikol, kloramfenikol og oksazolinmellomprodukter

Info

Publication number
NO952425L
NO952425L NO952425A NO952425A NO952425L NO 952425 L NO952425 L NO 952425L NO 952425 A NO952425 A NO 952425A NO 952425 A NO952425 A NO 952425A NO 952425 L NO952425 L NO 952425L
Authority
NO
Norway
Prior art keywords
acid
oxazoline
chloride
epoxide
florfenicol
Prior art date
Application number
NO952425A
Other languages
English (en)
Other versions
NO303575B1 (no
NO952425D0 (no
Inventor
Guang-Zhong Wu
Wanda I Tormos
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of NO952425L publication Critical patent/NO952425L/no
Publication of NO952425D0 publication Critical patent/NO952425D0/no
Publication of NO303575B1 publication Critical patent/NO303575B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Epoxy Compounds (AREA)
NO19952425A 1992-12-18 1995-06-16 Asymmetrisk fremgangsmate for fremstilling av florfenikol, tiamfenikol, kloramfenikol og oksazolinmellomprodukter NO303575B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/993,932 US5352832A (en) 1992-12-18 1992-12-18 Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates
PCT/US1993/012071 WO1994014764A1 (en) 1992-12-18 1993-12-15 Asymmetric process for preparing florfenicol, thiamphenicol, chloramphenicol and oxazoline intermediates

Publications (3)

Publication Number Publication Date
NO952425L true NO952425L (no) 1995-06-16
NO952425D0 NO952425D0 (no) 1995-06-16
NO303575B1 NO303575B1 (no) 1998-08-03

Family

ID=25540089

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19952425A NO303575B1 (no) 1992-12-18 1995-06-16 Asymmetrisk fremgangsmate for fremstilling av florfenikol, tiamfenikol, kloramfenikol og oksazolinmellomprodukter

Country Status (20)

Country Link
US (1) US5352832A (no)
EP (1) EP0674618B1 (no)
JP (1) JP3428016B2 (no)
KR (1) KR100284216B1 (no)
AT (1) ATE170835T1 (no)
AU (1) AU676003B2 (no)
CA (1) CA2152089C (no)
CZ (1) CZ287461B6 (no)
DE (1) DE69320986T2 (no)
DK (1) DK0674618T3 (no)
ES (1) ES2120605T3 (no)
FI (1) FI109295B (no)
HU (1) HU225110B1 (no)
NO (1) NO303575B1 (no)
NZ (1) NZ259239A (no)
PL (1) PL177891B1 (no)
RU (1) RU2126383C1 (no)
SK (1) SK281701B6 (no)
UA (1) UA43331C2 (no)
WO (1) WO1994014764A1 (no)

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US20050049210A1 (en) * 2003-08-27 2005-03-03 Idexx Laboratories, Inc. Methods for the controlled delivery of pharmacologically active compounds
US7126005B2 (en) * 2003-10-06 2006-10-24 Aurobindo Pharma Limited Process for preparing florfenicol
EP1696934B1 (en) * 2003-12-23 2013-05-29 Schering-Plough Ltd. Florfenicol prodrug having improved water solubility
WO2005066119A2 (en) * 2003-12-31 2005-07-21 Schering-Plough Ltd. Antibacterial 1-(4-mono-and di-halomethylsulphonylphenyl)-2-acylamino-3-fluoropropanols and preparation thereof
CA2576589C (en) * 2004-08-13 2013-11-12 Schering-Plough Ltd. Pharmaceutical formulation comprising an antibiotic, a triazole and a corticosteroid
DE602005009381D1 (de) 2004-09-23 2008-10-09 Schering Plough Ltd Bekämpfung von parasiten in tieren durch verwendung neuer trifluormethansulfonanilidoximetherderivate
JP4750126B2 (ja) * 2004-11-19 2011-08-17 シェーリング−プラウ・リミテッド 殺寄生虫薬２−フェニル−３−（１ｈ−ピロール−２−イル）アクリロニトリル誘導体の使用による動物における寄生虫の制御
US8680154B2 (en) * 2004-12-21 2014-03-25 Intervet International B.V. Injectable veterinary composition
EP1890547A2 (en) * 2005-06-09 2008-02-27 Schering-Plough Ltd. Control of parasites in animals by n-[(phenyloxy)phenyl]-1,1,1-trifluoromethanesulfonamide and n-[(phenylsulfanyl)phenyl]-1,1,1-trifluoromethanesulfonamide derivatives
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
US7518017B2 (en) 2006-02-17 2009-04-14 Idexx Laboratories Fenicol compounds and methods synthesizing 2-trifluoroacetamido-3-substituted propiophenone compounds
US20070238700A1 (en) * 2006-04-10 2007-10-11 Winzenberg Kevin N N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
CN101605756A (zh) * 2006-12-13 2009-12-16 先灵-普劳有限公司 氟苯尼考及其类似物的水溶性前药
WO2008076256A1 (en) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof
WO2008133901A1 (en) * 2007-04-27 2008-11-06 Schering-Plough Ltd. Compounds and methods for enhancing solubility of florfenicol and structurally-related antibiotics using cyclodextrins
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
DK2182945T3 (en) 2007-06-27 2015-11-16 Du Pont PROCEDURE TO COMBAT PESTS WITH ANIMALS
US7550625B2 (en) * 2007-10-19 2009-06-23 Idexx Laboratories Esters of florfenicol
PL2217207T3 (pl) 2007-11-09 2019-05-31 Intervet Int Bv Preparat o szybkim uwalnianiu w postaci stałej, jego przygotowanie i zastosowanie
TWI401023B (zh) 2008-02-06 2013-07-11 Du Pont 中離子農藥
WO2010014566A2 (en) 2008-07-30 2010-02-04 Intervet International B.V. Process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol
CN101337916B (zh) * 2008-08-12 2011-02-16 张家港市恒盛药用化学有限公司 氟苯尼考磺酸酯及其盐以及它们的制备方法
AU2010279587A1 (en) 2009-08-05 2012-02-09 E. I. Du Pont De Nemours And Company Mesoionic pesticides
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
UA107804C2 (xx) 2009-08-05 2015-02-25 Du Pont Суміші мезоіонних пестицидів
EP2461684A2 (en) 2009-08-05 2012-06-13 E. I. du Pont de Nemours and Company Mesoionic pesticides
BRPI1002023A2 (pt) 2010-03-01 2011-10-25 Nanocore Biotecnologia S A forma farmacêutica sólida de dissolução rápida para tratamento de infecções bacterianas
EP2576523B1 (en) 2010-05-27 2016-01-13 E. I. du Pont de Nemours and Company Crystalline form of 4-[5 - [3 -chloro-5 -(trifluoromethyl)phenyl] -4,5 -dihydro-5 -(trifluoromethyl)-3 - isoxazolyl]-n-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1- naphthalenecarboxamide
CN101921214B (zh) * 2010-08-03 2013-04-10 复旦大学 反式对甲砜基肉桂醇的合成方法
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
CN103415511B (zh) * 2011-01-31 2016-01-20 国立大学法人长崎大学 光学活性化合物或其盐的制造方法
CN102417472B (zh) * 2011-12-12 2013-11-13 齐鲁动物保健品有限公司 一种氟苯尼考的制备方法
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
CN102827042B (zh) * 2012-09-17 2013-11-06 湖北美天生物科技有限公司 氟苯尼考的手性合成方法
CN102863361B (zh) * 2012-10-17 2014-03-12 湖北美天生物科技有限公司 甲砜霉素的手性催化合成方法
CN102911133B (zh) * 2012-10-31 2014-07-02 绍兴民生医药有限公司 (4r,5r)-2-二氯甲基-4,5-二氢-5-(4-甲砜基苯基)-4-恶唑甲醇的纯化方法
CN103336072A (zh) * 2013-06-19 2013-10-02 湖北龙翔药业有限公司 一种测定氟苯尼考中手性活性成分含量的方法
CN103880719A (zh) * 2014-03-27 2014-06-25 张家港威胜生物医药有限公司 一种制备氟苯尼考琥珀酸酯的方法
MX371184B (es) * 2014-04-16 2020-01-21 Masteam Bio Tech Co Ltd Método para sintetizar florfenicol.
CN103980167B (zh) * 2014-04-17 2016-06-08 天津大学 一种无定形氟苯尼考及其制备方法
CN106349130B (zh) * 2016-08-25 2018-01-23 潍坊大有生物化工有限公司 一种新的氟苯尼考的合成方法
CN111153838B (zh) * 2020-01-19 2021-08-24 浙江大学宁波理工学院 一种氟苯尼考的合成方法
CN113185473B (zh) * 2021-06-30 2021-10-08 山东国邦药业有限公司 一种氟苯尼考中间体氟甲砜噁唑的制备方法

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Also Published As

Publication number Publication date
AU676003B2 (en) 1997-02-27
SK77795A3 (en) 1995-12-06
CZ159895A3 (en) 1996-01-17
PL177891B1 (pl) 2000-01-31
HU9501776D0 (en) 1995-08-28
JP3428016B2 (ja) 2003-07-22
CZ287461B6 (en) 2000-11-15
ATE170835T1 (de) 1998-09-15
JPH08504819A (ja) 1996-05-28
EP0674618A1 (en) 1995-10-04
DE69320986T2 (de) 1999-03-04
ES2120605T3 (es) 1998-11-01
CA2152089A1 (en) 1994-07-07
FI109295B (fi) 2002-06-28
NO303575B1 (no) 1998-08-03
DE69320986D1 (de) 1998-10-15
NO952425D0 (no) 1995-06-16
SK281701B6 (sk) 2001-07-10
PL309393A1 (en) 1995-10-02
UA43331C2 (uk) 2001-12-17
KR950704244A (ko) 1995-11-17
FI952872A0 (fi) 1995-06-12
WO1994014764A1 (en) 1994-07-07
CA2152089C (en) 2006-10-24
FI952872L (fi) 1995-06-12
DK0674618T3 (da) 1999-02-22
RU2126383C1 (ru) 1999-02-20
NZ259239A (en) 1996-04-26
KR100284216B1 (ko) 2001-04-02
HUT72669A (en) 1996-05-28
AU5748494A (en) 1994-07-19
US5352832A (en) 1994-10-04
EP0674618B1 (en) 1998-09-09
HU225110B1 (en) 2006-06-28

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Owner name: MERCK SHARP AND DOHME CORP

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