UA43331C2 - Спосіб асиметричного одержання флорфеніколу, спосіб регіовибіркового розкриття хірального епоксиду та спосіб одержання r, s- ізомеру флорфеніколу - Google Patents

Спосіб асиметричного одержання флорфеніколу, спосіб регіовибіркового розкриття хірального епоксиду та спосіб одержання r, s- ізомеру флорфеніколу

Info

Publication number
UA43331C2
UA43331C2 UA95073385A UA95073385A UA43331C2 UA 43331 C2 UA43331 C2 UA 43331C2 UA 95073385 A UA95073385 A UA 95073385A UA 95073385 A UA95073385 A UA 95073385A UA 43331 C2 UA43331 C2 UA 43331C2
Authority
UA
Ukraine
Prior art keywords
obtaining
florfenicol
florfenikola
assimetric
isomer
Prior art date
Application number
UA95073385A
Other languages
English (en)
Russian (ru)
Inventor
Ву Гуанг-Зонг
Тормос I Ванда
Тормос И. Ванда
Original Assignee
Шерінг Корпорейшн
Шеринг Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Шерінг Корпорейшн, Шеринг Корпорейшн filed Critical Шерінг Корпорейшн
Publication of UA43331C2 publication Critical patent/UA43331C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Спосіб асиметричного отримання флорфеніколу формули (I) включає стадію регіовибіркового розкриття хірального епоксиду формули (II) шляхом послідовної обробки сильною основою, кислотою Л’юіса й діхлорацетонітрилом.
UA95073385A 1992-12-18 1993-12-15 Спосіб асиметричного одержання флорфеніколу, спосіб регіовибіркового розкриття хірального епоксиду та спосіб одержання r, s- ізомеру флорфеніколу UA43331C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/993,932 US5352832A (en) 1992-12-18 1992-12-18 Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates
PCT/US1993/012071 WO1994014764A1 (en) 1992-12-18 1993-12-15 Asymmetric process for preparing florfenicol, thiamphenicol, chloramphenicol and oxazoline intermediates

Publications (1)

Publication Number Publication Date
UA43331C2 true UA43331C2 (uk) 2001-12-17

Family

ID=25540089

Family Applications (1)

Application Number Title Priority Date Filing Date
UA95073385A UA43331C2 (uk) 1992-12-18 1993-12-15 Спосіб асиметричного одержання флорфеніколу, спосіб регіовибіркового розкриття хірального епоксиду та спосіб одержання r, s- ізомеру флорфеніколу

Country Status (20)

Country Link
US (1) US5352832A (uk)
EP (1) EP0674618B1 (uk)
JP (1) JP3428016B2 (uk)
KR (1) KR100284216B1 (uk)
AT (1) ATE170835T1 (uk)
AU (1) AU676003B2 (uk)
CA (1) CA2152089C (uk)
CZ (1) CZ287461B6 (uk)
DE (1) DE69320986T2 (uk)
DK (1) DK0674618T3 (uk)
ES (1) ES2120605T3 (uk)
FI (1) FI109295B (uk)
HU (1) HU225110B1 (uk)
NO (1) NO303575B1 (uk)
NZ (1) NZ259239A (uk)
PL (1) PL177891B1 (uk)
RU (1) RU2126383C1 (uk)
SK (1) SK281701B6 (uk)
UA (1) UA43331C2 (uk)
WO (1) WO1994014764A1 (uk)

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US7126005B2 (en) * 2003-10-06 2006-10-24 Aurobindo Pharma Limited Process for preparing florfenicol
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US20090062397A1 (en) * 2007-04-27 2009-03-05 Schering-Plough Animal Health Corporation Compounds and methods for enhancing solubility of florfenicol and structurally-related antibiotics using cyclodextrins
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ES2666187T3 (es) 2007-06-27 2018-05-03 E. I. Du Pont De Nemours And Company Procedimiento de control de plagas en animales
US7550625B2 (en) * 2007-10-19 2009-06-23 Idexx Laboratories Esters of florfenicol
CN101909600A (zh) 2007-11-09 2010-12-08 英特维特国际股份有限公司 速释固体制剂、其制备及其应用
TWI468407B (zh) 2008-02-06 2015-01-11 Du Pont 中離子農藥
EP2321269B1 (en) 2008-07-30 2018-09-19 Intervet International B.V. Process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol
CN101337916B (zh) * 2008-08-12 2011-02-16 张家港市恒盛药用化学有限公司 氟苯尼考磺酸酯及其盐以及它们的制备方法
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
EP2461684A2 (en) 2009-08-05 2012-06-13 E. I. du Pont de Nemours and Company Mesoionic pesticides
UA107804C2 (en) 2009-08-05 2015-02-25 Du Pont Mixtures of pesticides mezoionnyh
AU2010279587A1 (en) 2009-08-05 2012-02-09 E. I. Du Pont De Nemours And Company Mesoionic pesticides
BRPI1002023A2 (pt) 2010-03-01 2011-10-25 Nanocore Biotecnologia S A forma farmacêutica sólida de dissolução rápida para tratamento de infecções bacterianas
MY156670A (en) 2010-05-27 2016-03-15 Du Pont Crystalline form of 4-[5-[3-chloro-5-(trifluoromethly)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-n-[2-oxo-2-[(2,2,2-trifluoroethyl) amino]ethyl]-1-naphthalenecarboxamide
CN101921214B (zh) * 2010-08-03 2013-04-10 复旦大学 反式对甲砜基肉桂醇的合成方法
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
US8969585B2 (en) * 2011-01-31 2015-03-03 Nagasaki University Method for producing optically active compound or salt thereof
CN102417472B (zh) * 2011-12-12 2013-11-13 齐鲁动物保健品有限公司 一种氟苯尼考的制备方法
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
CN102827042B (zh) * 2012-09-17 2013-11-06 湖北美天生物科技有限公司 氟苯尼考的手性合成方法
CN102863361B (zh) * 2012-10-17 2014-03-12 湖北美天生物科技有限公司 甲砜霉素的手性催化合成方法
CN102911133B (zh) * 2012-10-31 2014-07-02 绍兴民生医药有限公司 (4r,5r)-2-二氯甲基-4,5-二氢-5-(4-甲砜基苯基)-4-恶唑甲醇的纯化方法
CN103336072A (zh) * 2013-06-19 2013-10-02 湖北龙翔药业有限公司 一种测定氟苯尼考中手性活性成分含量的方法
CN103880719A (zh) * 2014-03-27 2014-06-25 张家港威胜生物医药有限公司 一种制备氟苯尼考琥珀酸酯的方法
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CN103980167B (zh) * 2014-04-17 2016-06-08 天津大学 一种无定形氟苯尼考及其制备方法
CN106349130B (zh) * 2016-08-25 2018-01-23 潍坊大有生物化工有限公司 一种新的氟苯尼考的合成方法
CN111153838B (zh) * 2020-01-19 2021-08-24 浙江大学宁波理工学院 一种氟苯尼考的合成方法
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Also Published As

Publication number Publication date
AU676003B2 (en) 1997-02-27
SK281701B6 (sk) 2001-07-10
AU5748494A (en) 1994-07-19
DE69320986D1 (de) 1998-10-15
US5352832A (en) 1994-10-04
NO952425D0 (no) 1995-06-16
KR100284216B1 (ko) 2001-04-02
FI109295B (fi) 2002-06-28
JPH08504819A (ja) 1996-05-28
CZ287461B6 (en) 2000-11-15
NZ259239A (en) 1996-04-26
ATE170835T1 (de) 1998-09-15
RU2126383C1 (ru) 1999-02-20
KR950704244A (ko) 1995-11-17
ES2120605T3 (es) 1998-11-01
JP3428016B2 (ja) 2003-07-22
NO952425L (no) 1995-06-16
PL177891B1 (pl) 2000-01-31
FI952872A0 (fi) 1995-06-12
CA2152089C (en) 2006-10-24
DE69320986T2 (de) 1999-03-04
EP0674618A1 (en) 1995-10-04
EP0674618B1 (en) 1998-09-09
HU9501776D0 (en) 1995-08-28
CA2152089A1 (en) 1994-07-07
FI952872A (fi) 1995-06-12
NO303575B1 (no) 1998-08-03
SK77795A3 (en) 1995-12-06
WO1994014764A1 (en) 1994-07-07
DK0674618T3 (da) 1999-02-22
HU225110B1 (en) 2006-06-28
PL309393A1 (en) 1995-10-02
HUT72669A (en) 1996-05-28
CZ159895A3 (en) 1996-01-17

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