ATE163937T1 - Verfahren zur herstellung von chlorsulfat und sulfamatderivate von 2,3:4,5-bis-0-(1- methylethylidene)-beta-d-fructopyranose und (1- methylcyclohexyl)methanol - Google Patents

Verfahren zur herstellung von chlorsulfat und sulfamatderivate von 2,3:4,5-bis-0-(1- methylethylidene)-beta-d-fructopyranose und (1- methylcyclohexyl)methanol

Info

Publication number
ATE163937T1
ATE163937T1 AT92308509T AT92308509T ATE163937T1 AT E163937 T1 ATE163937 T1 AT E163937T1 AT 92308509 T AT92308509 T AT 92308509T AT 92308509 T AT92308509 T AT 92308509T AT E163937 T1 ATE163937 T1 AT E163937T1
Authority
AT
Austria
Prior art keywords
fructopyranose
methylethylidene
methylcyclohexyl
beta
bis
Prior art date
Application number
AT92308509T
Other languages
English (en)
Inventor
Cynthia A Maryanoff
Kirk L Sorgi
Lorraine Scott
Original Assignee
Mcneilab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mcneilab Inc filed Critical Mcneilab Inc
Application granted granted Critical
Publication of ATE163937T1 publication Critical patent/ATE163937T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/34—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfuric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D309/06—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT92308509T 1991-09-19 1992-09-18 Verfahren zur herstellung von chlorsulfat und sulfamatderivate von 2,3:4,5-bis-0-(1- methylethylidene)-beta-d-fructopyranose und (1- methylcyclohexyl)methanol ATE163937T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76272091A 1991-09-19 1991-09-19
US92626992A 1992-08-05 1992-08-05

Publications (1)

Publication Number Publication Date
ATE163937T1 true ATE163937T1 (de) 1998-03-15

Family

ID=27117178

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92308509T ATE163937T1 (de) 1991-09-19 1992-09-18 Verfahren zur herstellung von chlorsulfat und sulfamatderivate von 2,3:4,5-bis-0-(1- methylethylidene)-beta-d-fructopyranose und (1- methylcyclohexyl)methanol

Country Status (23)

Country Link
US (1) US5387700A (de)
EP (1) EP0533483B1 (de)
JP (1) JP3174410B2 (de)
KR (1) KR100229180B1 (de)
CN (1) CN1035820C (de)
AT (1) ATE163937T1 (de)
AU (1) AU651244B2 (de)
CA (1) CA2078519C (de)
DE (1) DE69224691T2 (de)
DK (1) DK0533483T3 (de)
EG (1) EG20164A (de)
ES (1) ES2114917T3 (de)
FI (1) FI107731B (de)
GR (1) GR3026618T3 (de)
HU (1) HU212634B (de)
IL (1) IL103172A (de)
MX (1) MX9205305A (de)
MY (1) MY113564A (de)
NO (1) NO179284C (de)
NZ (1) NZ244409A (de)
PH (1) PH31291A (de)
TW (1) TW217413B (de)
ZW (1) ZW14792A1 (de)

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US7196209B2 (en) * 2002-10-31 2007-03-27 Ortho-Mcneil Pharmaceutical, Inc. Continuous process for the preparation of fructopyranose sulfamate derivatives
UA81657C2 (ru) * 2003-03-04 2008-01-25 Орто-Макнейл Фармасьютикел, Инк. Способ получения противосудорожных производных топирамата
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MXPA06005462A (es) * 2003-11-14 2006-12-15 Johnson & Johnson Liberacion controlada de topiramato en formas de dosificacion liquida.
KR20050062976A (ko) * 2003-12-19 2005-06-28 일동제약주식회사 2,3:4,5-비스-오-(1-메틸에틸리덴)-베타-디-프럭토피라노즈설파메이트의 새로운 개량된 제조방법
JP2007517063A (ja) * 2003-12-29 2007-06-28 アルザ・コーポレーシヨン トピラメートの新規な薬剤組成物および剤形
US20050175696A1 (en) * 2003-12-29 2005-08-11 David Edgren Drug granule coatings that impart smear resistance during mechanical compression
MXPA06007509A (es) * 2003-12-29 2007-10-18 Johnson & Johnson Composiciones de farmaco y formas de dosis novedosas.
US20050203287A1 (en) * 2004-03-11 2005-09-15 Chandrasekhar Batchu Process for the preparation of sulfamate derivatives
TW200612905A (en) * 2004-06-16 2006-05-01 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
MY147767A (en) * 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
KR20070057848A (ko) * 2004-08-24 2007-06-07 얀센 파마슈티카 엔.브이. 항경련제로 유용한 신규 벤조-융합된 헤테로아릴 설파미드유도체
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RU2007148444A (ru) * 2005-05-25 2009-06-27 Янссен Фармацевтика Н.В. (Be) Педиатрическая композиция топирамата
US20070155827A1 (en) * 2005-12-19 2007-07-05 Smith-Swintosky Virginia L Use of benzo-fused heterocycle sulfamide derivatives for the treatment of depression
US8497298B2 (en) * 2005-12-19 2013-07-30 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels
US8691867B2 (en) * 2005-12-19 2014-04-08 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction
US8492431B2 (en) * 2005-12-19 2013-07-23 Janssen Pharmaceutica, N.V. Use of benzo-fused heterocycle sulfamide derivatives for the treatment of obesity
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US20070191449A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of Benzo-Heteroaryl Sulfamide Derivatives for the Treatment of Depression
US20070191474A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of benzo-fused heterocyle sulfamide derivatives for the treatment of migraine
US20070191461A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of benzo-heteroaryl sulfamide derivatives for the treatment of migraine
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JP5424571B2 (ja) * 2007-04-12 2014-02-26 協和発酵キリン株式会社 トピラマート含有固形製剤
CN101720397B (zh) * 2007-04-24 2013-01-02 福博科技术公司 电力牵引传动装置
CN101450951B (zh) * 2007-11-30 2012-10-10 重庆凯林制药有限公司 托吡酯的制备方法
US20090247616A1 (en) * 2008-03-26 2009-10-01 Smith-Swintosky Virginia L Use of benzo-fused heterocyle sulfamide derivatives for the treatment of anxiety
US20090247617A1 (en) * 2008-03-26 2009-10-01 Abdel-Magid Ahmed F Process for the preparation of benzo-fused heteroaryl sulfamates
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JP5643844B2 (ja) * 2010-02-05 2014-12-17 サイノファーム タイワン リミテッド トピラマート（ｔｏｐｉｒａｍａｔｅ）の製造方法
CN102936268A (zh) * 2012-11-13 2013-02-20 江苏吉贝尔药业有限公司 一种托吡酯中间体丙酮叉的制备方法
CN106397502A (zh) * 2016-08-31 2017-02-15 安徽省润生医药股份有限公司 一种托吡酯的合成工艺
CN108341844A (zh) * 2018-04-25 2018-07-31 广州小桔生物科技有限公司 一种高纯度托吡酯的制备方法
CN110655542A (zh) * 2018-06-29 2020-01-07 鲁南制药集团股份有限公司 一种2,3:4,5-双-O-(1-甲基亚乙基)-β-D-吡喃果糖氯磺酸酯的晶型
CN110655541A (zh) * 2018-06-29 2020-01-07 鲁南制药集团股份有限公司 一种2,3:4,5-双-O-(1-甲基亚乙基)-β-D-吡喃果糖氯磺酸酯晶型
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Also Published As

Publication number Publication date
TW217413B (de) 1993-12-11
NO923637D0 (no) 1992-09-18
CN1035820C (zh) 1997-09-10
HU212634B (en) 1996-09-30
EP0533483B1 (de) 1998-03-11
NO179284B (no) 1996-06-03
IL103172A (en) 1997-01-10
AU2451892A (en) 1993-03-25
ES2114917T3 (es) 1998-06-16
US5387700A (en) 1995-02-07
NO179284C (no) 1996-09-11
MY113564A (en) 2002-04-30
NZ244409A (en) 1995-02-24
KR930006029A (ko) 1993-04-20
FI924189A0 (fi) 1992-09-18
GR3026618T3 (en) 1998-07-31
DE69224691T2 (de) 1998-08-20
EG20164A (en) 1997-08-31
PH31291A (en) 1998-07-06
KR100229180B1 (ko) 1999-11-01
FI924189A (fi) 1993-03-20
DK0533483T3 (da) 1998-09-28
DE69224691D1 (de) 1998-04-16
CA2078519A1 (en) 1993-03-20
ZW14792A1 (en) 1994-04-20
NO923637L (no) 1993-03-22
CN1075317A (zh) 1993-08-18
EP0533483A2 (de) 1993-03-24
FI107731B (fi) 2001-09-28
HU9202974D0 (en) 1992-11-30
JPH05230011A (ja) 1993-09-07
EP0533483A3 (en) 1994-11-02
JP3174410B2 (ja) 2001-06-11
CA2078519C (en) 2003-09-16
MX9205305A (es) 1993-07-01
IL103172A0 (en) 1993-02-21
AU651244B2 (en) 1994-07-14
HUT63612A (en) 1993-09-28

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