EG20164A - Process for the preparation of chlorosulfate and sulfamate derivatives of 2,3,4,5- bis-0-(1-methylethylidene) -8-D-fructopyranose and cyclohexylmethanol - Google Patents

Process for the preparation of chlorosulfate and sulfamate derivatives of 2,3,4,5- bis-0-(1-methylethylidene) -8-D-fructopyranose and cyclohexylmethanol

Info

Publication number
EG20164A
EG20164A EG54692A EG54692A EG20164A EG 20164 A EG20164 A EG 20164A EG 54692 A EG54692 A EG 54692A EG 54692 A EG54692 A EG 54692A EG 20164 A EG20164 A EG 20164A
Authority
EG
Egypt
Prior art keywords
chlorosulfate
fructopyranose
methylethylidene
bis
cyclohexylmethanol
Prior art date
Application number
EG54692A
Other languages
English (en)
Inventor
Cynthia A Maryanoff
Lorraine Scott
Original Assignee
Mc Neiab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mc Neiab Inc filed Critical Mc Neiab Inc
Application granted granted Critical
Publication of EG20164A publication Critical patent/EG20164A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/34—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfuric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D309/06—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EG54692A 1991-09-19 1992-09-17 Process for the preparation of chlorosulfate and sulfamate derivatives of 2,3,4,5- bis-0-(1-methylethylidene) -8-D-fructopyranose and cyclohexylmethanol EG20164A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76272091A 1991-09-19 1991-09-19
US92626992A 1992-08-05 1992-08-05

Publications (1)

Publication Number Publication Date
EG20164A true EG20164A (en) 1997-08-31

Family

ID=27117178

Family Applications (1)

Application Number Title Priority Date Filing Date
EG54692A EG20164A (en) 1991-09-19 1992-09-17 Process for the preparation of chlorosulfate and sulfamate derivatives of 2,3,4,5- bis-0-(1-methylethylidene) -8-D-fructopyranose and cyclohexylmethanol

Country Status (23)

Country Link
US (1) US5387700A (xx)
EP (1) EP0533483B1 (xx)
JP (1) JP3174410B2 (xx)
KR (1) KR100229180B1 (xx)
CN (1) CN1035820C (xx)
AT (1) ATE163937T1 (xx)
AU (1) AU651244B2 (xx)
CA (1) CA2078519C (xx)
DE (1) DE69224691T2 (xx)
DK (1) DK0533483T3 (xx)
EG (1) EG20164A (xx)
ES (1) ES2114917T3 (xx)
FI (1) FI107731B (xx)
GR (1) GR3026618T3 (xx)
HU (1) HU212634B (xx)
IL (1) IL103172A (xx)
MX (1) MX9205305A (xx)
MY (1) MY113564A (xx)
NO (1) NO179284C (xx)
NZ (1) NZ244409A (xx)
PH (1) PH31291A (xx)
TW (1) TW217413B (xx)
ZW (1) ZW14792A1 (xx)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3250777B2 (ja) * 1995-02-13 2002-01-28 セントラル硝子株式会社 イミド類、その塩類およびそれらの製造法
UA65607C2 (uk) * 1998-03-04 2004-04-15 Орто-Макнейл Фармацевтикал, Інк. Фармацевтична композиція (варіанти) та спосіб її приготування
BR0008791A (pt) * 1999-02-17 2005-04-05 Ortho Mcneil Pharm Inc Derivados anticonvulsivos, úteis no tratamento de tremor essencial
US6420369B1 (en) 1999-05-24 2002-07-16 Ortho-Mcneil Pharmaceutical, Inc. Anticonvulsant derivatives useful in treating dementia
EP1309324B1 (en) * 2000-07-07 2006-03-22 Ortho-McNeil Pharmaceutical, Inc. Anticonvulsant derivatives useful for treating and preventing the development of type ii diabetes mellitus and syndrome x
US6627653B2 (en) 2000-08-02 2003-09-30 Ortho-Mcneil Pharmaceutical, Inc. Anticonvulsant derivatives useful for the treatment of depression
RU2003112618A (ru) * 2000-10-30 2004-09-27 Орто-Макнейл Фармасьютикал, Инк. (Us) Комбинированная терапия, включающая антидиабетические и противосудорожные средства
UA78211C2 (en) * 2001-07-09 2007-03-15 Ortho Mcneil Pharm Inc Salts of fructopyranose derivatives as anticonvulsant
US7041650B2 (en) * 2001-07-09 2006-05-09 Ortho-Mcneil Pharmaceutical, Inc. Anticonvulsant derivative salts
US20030092636A1 (en) * 2001-11-06 2003-05-15 Silberstein Stephen D. Treatment and prevention of paresthesia comprising co-therapy with anticonvulsant derivatives and potassium
US20030224006A1 (en) 2002-03-01 2003-12-04 Zaworotko Michael J. Multiple-component solid phases containing at least one active pharmaceutical ingredient
CN100352506C (zh) * 2002-02-26 2007-12-05 奥索-麦克尼尔药品公司 抗惊厥剂衍生物和抗偏头痛药物联合的制药用途
US7060725B2 (en) * 2002-05-13 2006-06-13 Janssen Pharmaceutica N.V. Substituted sulfamate anticonvulsant derivatives
AR039744A1 (es) * 2002-06-26 2005-03-09 Alza Corp Metodos y formas de dosificacion para aumentar la solubilidad de las composiciones de farmacos para la administracion controlada
CA2494233A1 (en) * 2002-07-29 2004-02-05 Alza Corporation Formulations and dosage forms for controlled delivery of topiramate
CN100430408C (zh) * 2002-10-31 2008-11-05 奥索-麦克尼尔药品公司 制备吡喃果糖氨基磺酸酯衍生物的连续法
US7196209B2 (en) * 2002-10-31 2007-03-27 Ortho-Mcneil Pharmaceutical, Inc. Continuous process for the preparation of fructopyranose sulfamate derivatives
UA81657C2 (ru) * 2003-03-04 2008-01-25 Орто-Макнейл Фармасьютикел, Инк. Способ получения противосудорожных производных топирамата
WO2004108732A1 (en) * 2003-05-12 2004-12-16 Sun Pharmaceutical Industries Limited PROCESS FOR THE PREPARATION OF 2,3:4,5-BIS-O(1-METHYLETHYLIDENE)-ß-D-FRUCTOPYRANOSE SULFAMATE
EP1653922A2 (en) * 2003-08-06 2006-05-10 Alza Corporation Uniform delivery of topiramate over prolonged period of time with enhanced dispersion formulation
US20050136108A1 (en) * 2003-08-22 2005-06-23 Yam Noymi V. Stepwise delivery of topiramate over prolonged period of time
CA2564227A1 (en) * 2003-09-02 2005-03-10 Alza Corporation Novel drug compositions and dosage forms of topiramate
CA2545834A1 (en) * 2003-11-14 2005-06-02 Alza Corporation Controlled release of topiramate in liquid dosage forms
KR20050062976A (ko) * 2003-12-19 2005-06-28 일동제약주식회사 2,3:4,5-비스-오-(1-메틸에틸리덴)-베타-디-프럭토피라노즈설파메이트의 새로운 개량된 제조방법
AU2004312084A1 (en) * 2003-12-29 2005-07-21 Alza Corporation, Inc. Novel drug compositions and dosage forms of topiramate
MXPA06007509A (es) * 2003-12-29 2007-10-18 Johnson & Johnson Composiciones de farmaco y formas de dosis novedosas.
US20050175696A1 (en) * 2003-12-29 2005-08-11 David Edgren Drug granule coatings that impart smear resistance during mechanical compression
US20050203287A1 (en) * 2004-03-11 2005-09-15 Chandrasekhar Batchu Process for the preparation of sulfamate derivatives
TW200612905A (en) * 2004-06-16 2006-05-01 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
MY147767A (en) * 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
AU2005277134A1 (en) * 2004-08-24 2006-03-02 Janssen Pharmaceutica N.V. Novel benzo-fused heteroaryl sulfamide derivatives useful as anticonvulsant agents
DK1815165T3 (da) * 2004-10-05 2012-06-18 Fallbrook Technologies Inc Trinløst variabel transmission
JP2008545650A (ja) * 2005-05-20 2008-12-18 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ スルファミド誘導体の製造方法
RU2007148444A (ru) * 2005-05-25 2009-06-27 Янссен Фармацевтика Н.В. (Be) Педиатрическая композиция топирамата
US8937096B2 (en) * 2005-12-19 2015-01-20 Janssen Pharmaceutica Nv Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder
US8497298B2 (en) * 2005-12-19 2013-07-30 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels
US8691867B2 (en) * 2005-12-19 2014-04-08 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction
US20070155827A1 (en) * 2005-12-19 2007-07-05 Smith-Swintosky Virginia L Use of benzo-fused heterocycle sulfamide derivatives for the treatment of depression
US8716231B2 (en) * 2005-12-19 2014-05-06 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain
US20070155823A1 (en) * 2005-12-19 2007-07-05 Smith-Swintosky Virginia L Use of benzo-fused heterocycle sulfamide derivatives as neuroprotective agents
US8492431B2 (en) * 2005-12-19 2013-07-23 Janssen Pharmaceutica, N.V. Use of benzo-fused heterocycle sulfamide derivatives for the treatment of obesity
US20070191459A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of Benzo-Heteroaryl Sulfamide Derivatives for Lowering Lipids and Lowering Blood Glucose Levels
US20070191474A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of benzo-fused heterocyle sulfamide derivatives for the treatment of migraine
US20070191449A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of Benzo-Heteroaryl Sulfamide Derivatives for the Treatment of Depression
US20070191461A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of benzo-heteroaryl sulfamide derivatives for the treatment of migraine
US20070191453A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of benzo-heteroaryl sulfamide derivatives for the treatment of substance abuse and addiction
WO2007099388A1 (en) * 2006-03-01 2007-09-07 Glade Organics Private Limited An improved process for the manufacture of topiramate
WO2007108009A1 (en) * 2006-03-17 2007-09-27 Alembic Limited A process for purification of topiramate
EA200870556A1 (ru) * 2006-05-19 2009-06-30 Янссен Фармацевтика Н.В. Комбинированная терапия в лечении эпилепсии и родственных расстройств
JP5424571B2 (ja) * 2007-04-12 2014-02-26 協和発酵キリン株式会社 トピラマート含有固形製剤
CN101720397B (zh) * 2007-04-24 2013-01-02 福博科技术公司 电力牵引传动装置
CN101450951B (zh) * 2007-11-30 2012-10-10 重庆凯林制药有限公司 托吡酯的制备方法
US20090247617A1 (en) * 2008-03-26 2009-10-01 Abdel-Magid Ahmed F Process for the preparation of benzo-fused heteroaryl sulfamates
US20090247616A1 (en) * 2008-03-26 2009-10-01 Smith-Swintosky Virginia L Use of benzo-fused heterocyle sulfamide derivatives for the treatment of anxiety
NZ590682A (en) 2008-06-23 2012-09-28 Janssen Pharmaceutica Nv Crystalline form of (2S)-(-)-N-(6-chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-sulfamide
US8815939B2 (en) * 2008-07-22 2014-08-26 Janssen Pharmaceutica Nv Substituted sulfamide derivatives
JP5643844B2 (ja) * 2010-02-05 2014-12-17 サイノファーム タイワン リミテッド トピラマート（ｔｏｐｉｒａｍａｔｅ）の製造方法
CN102936268A (zh) * 2012-11-13 2013-02-20 江苏吉贝尔药业有限公司 一种托吡酯中间体丙酮叉的制备方法
CN106397502A (zh) * 2016-08-31 2017-02-15 安徽省润生医药股份有限公司 一种托吡酯的合成工艺
CN108341844A (zh) * 2018-04-25 2018-07-31 广州小桔生物科技有限公司 一种高纯度托吡酯的制备方法
CN110655541A (zh) * 2018-06-29 2020-01-07 鲁南制药集团股份有限公司 一种2,3:4,5-双-O-(1-甲基亚乙基)-β-D-吡喃果糖氯磺酸酯晶型
CN110655542A (zh) * 2018-06-29 2020-01-07 鲁南制药集团股份有限公司 一种2,3:4,5-双-O-(1-甲基亚乙基)-β-D-吡喃果糖氯磺酸酯的晶型
US20220016074A1 (en) 2018-11-21 2022-01-20 Rosemont Pharmaceuticals Limited Oral topiramate suspension formulations with extended shelf stability and enhanced bioavailability
CN114350340B (zh) * 2022-01-13 2023-01-17 陕西科技大学 一种压裂用增渗剂及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4513006A (en) * 1983-09-26 1985-04-23 Mcneil Lab., Inc. Anticonvulsant sulfamate derivatives
US4582916A (en) * 1983-09-26 1986-04-15 Mcneilab, Inc. Chlorosulfate and azidosulfate esters of tetrahydro-2H-pyran-2-yl-methanol

Also Published As

Publication number Publication date
JPH05230011A (ja) 1993-09-07
HU212634B (en) 1996-09-30
CA2078519C (en) 2003-09-16
KR100229180B1 (ko) 1999-11-01
HUT63612A (en) 1993-09-28
ATE163937T1 (de) 1998-03-15
PH31291A (en) 1998-07-06
FI924189A (fi) 1993-03-20
ES2114917T3 (es) 1998-06-16
FI924189A0 (fi) 1992-09-18
NZ244409A (en) 1995-02-24
NO179284C (no) 1996-09-11
CN1075317A (zh) 1993-08-18
ZW14792A1 (en) 1994-04-20
EP0533483A2 (en) 1993-03-24
EP0533483B1 (en) 1998-03-11
AU2451892A (en) 1993-03-25
FI107731B (fi) 2001-09-28
JP3174410B2 (ja) 2001-06-11
EP0533483A3 (en) 1994-11-02
KR930006029A (ko) 1993-04-20
DK0533483T3 (da) 1998-09-28
AU651244B2 (en) 1994-07-14
DE69224691T2 (de) 1998-08-20
NO923637D0 (no) 1992-09-18
CN1035820C (zh) 1997-09-10
GR3026618T3 (en) 1998-07-31
US5387700A (en) 1995-02-07
DE69224691D1 (de) 1998-04-16
MX9205305A (es) 1993-07-01
MY113564A (en) 2002-04-30
IL103172A0 (en) 1993-02-21
CA2078519A1 (en) 1993-03-20
NO923637L (no) 1993-03-22
HU9202974D0 (en) 1992-11-30
TW217413B (xx) 1993-12-11
NO179284B (no) 1996-06-03
IL103172A (en) 1997-01-10

Similar Documents

Publication Publication Date Title
EG20164A (en) Process for the preparation of chlorosulfate and sulfamate derivatives of 2,3,4,5- bis-0-(1-methylethylidene) -8-D-fructopyranose and cyclohexylmethanol
HUT61754A (en) Process for producing 2-thienylglycide derivatives
AU6781690A (en) Process for producing foams
EP0616994A3 (en) Process for the preparation of ether alcohols by hydrogenolysis of cyclic ketals.
CA2055483A1 (en) Polyester chain-extended vinyl ether urethane oligomers
EP0380750A3 (en) Glycidyl azide polymer and method of preparation
AU9002291A (en) A process for producing alkoxysilane-terminated polyethers
AU7614787A (en) Process for producing alpha-l-aspartyl-l-phenylalanine methyl ester having an improved solubility
AU8127891A (en) Method for the production of an internal slide surface on a guide sleeve consisting of plastic material for a length-adjustable chair column
HU904906D0 (en) Process for producing alpha-1-aspartil-1-phenylalanine-methyl-esther-hydrochloride utilizing separated n-formyl-1-aspartil-anhydride
AU4504085A (en) Synthesis of trifluoroethanol and hexafluroisopropanol
AU590439B2 (en) Process for producing alpha-L-aspartyl-L-phenylalanine methyl ester having an improved solubility
IT7829321A0 (it) Processo pert la preparazione di un copolimero di esteri vinilici.
DE69409800T2 (de) Verfahren zur herstellung von halogenierten alkoholen
AU8404291A (en) Device for producing hollow glass mouldings
ATE128113T1 (de) Calicheamicinon, dessen abkömmlinge und analogen und verfahren zu deren herstellung.
ES461175A1 (es) Un procedimiento de preparar nuevas 2,3-alcohilen-bis-(oxi)-benzamidas sustituidas.
HUT60324A (en) Process for producing compositions of yeast biomass base
AU628251B2 (en) Method for culturing a chlorella
AU7971891A (en) Process for producing enantiomer-pure alpha-hydroxylproponioaldehyde derivatives
AU8121591A (en) Novel process for producing 6-acyl-7-deacetylforskolin derivatives
EP1602727A3 (en) Novel erythromycins and process for their preparation