ATE128113T1 - Calicheamicinon, dessen abkömmlinge und analogen und verfahren zu deren herstellung. - Google Patents

Calicheamicinon, dessen abkömmlinge und analogen und verfahren zu deren herstellung.

Info

Publication number
ATE128113T1
ATE128113T1 AT91303818T AT91303818T ATE128113T1 AT E128113 T1 ATE128113 T1 AT E128113T1 AT 91303818 T AT91303818 T AT 91303818T AT 91303818 T AT91303818 T AT 91303818T AT E128113 T1 ATE128113 T1 AT E128113T1
Authority
AT
Austria
Prior art keywords
derivatives
calichamicinone
analogues
production
calicheamicinone
Prior art date
Application number
AT91303818T
Other languages
English (en)
Inventor
Samuel J Danishefsky
John School Of Chemi Haseltine
Maria Paz Cabal
Nobuharu Iwasawa
Robert S Coleman
Original Assignee
Univ Yale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Yale filed Critical Univ Yale
Application granted granted Critical
Publication of ATE128113T1 publication Critical patent/ATE128113T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
AT91303818T 1990-04-27 1991-04-26 Calicheamicinon, dessen abkömmlinge und analogen und verfahren zu deren herstellung. ATE128113T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51520990A 1990-04-27 1990-04-27

Publications (1)

Publication Number Publication Date
ATE128113T1 true ATE128113T1 (de) 1995-10-15

Family

ID=24050400

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91303818T ATE128113T1 (de) 1990-04-27 1991-04-26 Calicheamicinon, dessen abkömmlinge und analogen und verfahren zu deren herstellung.

Country Status (8)

Country Link
EP (1) EP0454494B1 (de)
JP (1) JPH04279544A (de)
AT (1) ATE128113T1 (de)
CA (1) CA2039789A1 (de)
DE (1) DE69113102T2 (de)
DK (1) DK0454494T3 (de)
ES (1) ES2079569T3 (de)
GR (1) GR3017912T3 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997041109A1 (en) * 1996-04-26 1997-11-06 University Of Alberta Synthesis of (±) - calicheamicinone, precursors, intermediates and derivatives
BRPI0316018B8 (pt) 2002-11-12 2021-05-25 Brigham & Womens Hospital Inc vacina polissacarídica para infecções estafilocócicas
EP3312158A1 (de) 2008-07-21 2018-04-25 The Brigham and Women's Hospital, Inc. Verfahren und zusammensetzungen in verbindung mit synthetischen beta-1,6 glucosamin-oligosacchariden

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL79519A0 (en) * 1985-08-27 1986-10-31 Bristol Myers Co Bbm-1675c and d antitumor antibiotics
US4837206A (en) * 1987-04-29 1989-06-06 Bristol-Myers Company Esperamicin derivatives

Also Published As

Publication number Publication date
GR3017912T3 (en) 1996-01-31
EP0454494A2 (de) 1991-10-30
CA2039789A1 (en) 1991-10-28
DE69113102T2 (de) 1996-03-28
EP0454494A3 (en) 1993-05-26
EP0454494B1 (de) 1995-09-20
DK0454494T3 (da) 1995-12-04
DE69113102D1 (de) 1995-10-26
JPH04279544A (ja) 1992-10-05
ES2079569T3 (es) 1996-01-16

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee