FI107731B - Menetelmä 2,3:4,5-bis-O-(1-metyylietylideeni)-beta-D-fruktopyranoosin ja (1-metyylisykloheksyyli)metanolin kloorisulfaatti- ja sulfamaattijohdannaisten valmistamiseksi - Google Patents

Menetelmä 2,3:4,5-bis-O-(1-metyylietylideeni)-beta-D-fruktopyranoosin ja (1-metyylisykloheksyyli)metanolin kloorisulfaatti- ja sulfamaattijohdannaisten valmistamiseksi Download PDF

Info

Publication number
FI107731B
FI107731B FI924189A FI924189A FI107731B FI 107731 B FI107731 B FI 107731B FI 924189 A FI924189 A FI 924189A FI 924189 A FI924189 A FI 924189A FI 107731 B FI107731 B FI 107731B
Authority
FI
Finland
Prior art keywords
formula
compound
amine
process according
reaction
Prior art date
Application number
FI924189A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI924189A0 (fi
FI924189A (fi
Inventor
Cynthia A Maryanoff
Lorraine Scott
Kirk L Sorgi
Original Assignee
Mcneilab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mcneilab Inc filed Critical Mcneilab Inc
Publication of FI924189A0 publication Critical patent/FI924189A0/fi
Publication of FI924189A publication Critical patent/FI924189A/fi
Application granted granted Critical
Publication of FI107731B publication Critical patent/FI107731B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/34—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfuric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D309/06—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI924189A 1991-09-19 1992-09-18 Menetelmä 2,3:4,5-bis-O-(1-metyylietylideeni)-beta-D-fruktopyranoosin ja (1-metyylisykloheksyyli)metanolin kloorisulfaatti- ja sulfamaattijohdannaisten valmistamiseksi FI107731B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US76272091A 1991-09-19 1991-09-19
US76272091 1991-09-19
US92626992A 1992-08-05 1992-08-05
US92626992 1992-08-05

Publications (3)

Publication Number Publication Date
FI924189A0 FI924189A0 (fi) 1992-09-18
FI924189A FI924189A (fi) 1993-03-20
FI107731B true FI107731B (fi) 2001-09-28

Family

ID=27117178

Family Applications (1)

Application Number Title Priority Date Filing Date
FI924189A FI107731B (fi) 1991-09-19 1992-09-18 Menetelmä 2,3:4,5-bis-O-(1-metyylietylideeni)-beta-D-fruktopyranoosin ja (1-metyylisykloheksyyli)metanolin kloorisulfaatti- ja sulfamaattijohdannaisten valmistamiseksi

Country Status (23)

Country Link
US (1) US5387700A (de)
EP (1) EP0533483B1 (de)
JP (1) JP3174410B2 (de)
KR (1) KR100229180B1 (de)
CN (1) CN1035820C (de)
AT (1) ATE163937T1 (de)
AU (1) AU651244B2 (de)
CA (1) CA2078519C (de)
DE (1) DE69224691T2 (de)
DK (1) DK0533483T3 (de)
EG (1) EG20164A (de)
ES (1) ES2114917T3 (de)
FI (1) FI107731B (de)
GR (1) GR3026618T3 (de)
HU (1) HU212634B (de)
IL (1) IL103172A (de)
MX (1) MX9205305A (de)
MY (1) MY113564A (de)
NO (1) NO179284C (de)
NZ (1) NZ244409A (de)
PH (1) PH31291A (de)
TW (1) TW217413B (de)
ZW (1) ZW14792A1 (de)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3250777B2 (ja) * 1995-02-13 2002-01-28 セントラル硝子株式会社 イミド類、その塩類およびそれらの製造法
UA65607C2 (uk) * 1998-03-04 2004-04-15 Орто-Макнейл Фармацевтикал, Інк. Фармацевтична композиція (варіанти) та спосіб її приготування
NZ513724A (en) * 1999-02-17 2004-01-30 Ortho Mcneil Pharm Inc Anticonvulsant derivatives useful in treating essential tremor
US6420369B1 (en) 1999-05-24 2002-07-16 Ortho-Mcneil Pharmaceutical, Inc. Anticonvulsant derivatives useful in treating dementia
DE60118206T2 (de) * 2000-07-07 2006-12-14 Ortho-Mcneil Pharmaceutical, Inc. Antikonvulsive derivate zur behandlung und vorbeugung der entwicklung von typ ii diabetes und syndrom x
AU2001280865A1 (en) 2000-08-02 2002-02-13 Ortho-Mcneil Pharmaceutical, Inc. Anticonvulsant derivatives useful for the treatment of depression
WO2002064210A2 (en) * 2000-10-30 2002-08-22 Ortho-Mcneil Pharmaceutical, Inc. Combination therapy comprising anti-diabetic and anticonvulsant agents
US7041650B2 (en) * 2001-07-09 2006-05-09 Ortho-Mcneil Pharmaceutical, Inc. Anticonvulsant derivative salts
UA78211C2 (en) * 2001-07-09 2007-03-15 Ortho Mcneil Pharm Inc Salts of fructopyranose derivatives as anticonvulsant
MXPA04004380A (es) * 2001-11-06 2005-06-08 Johnson & Johnson Tratamiento y prevencion de parestesia que comprende co-terapia con derivados anticonvulsivos y potasio.
RU2004126093A (ru) * 2002-02-26 2005-04-10 Орто-Макнейл Фармасьютикал, Инк. (Us) Комбинированная терапия для лечения мигрени, включающая применение производных противосудорожных средств и средств от мигрени
EP1494998A2 (de) 2002-03-01 2005-01-12 University Of South Florida Mehrkomponenten festphasen enthaltend wenigstens einen pharmazeutischen wirkstoff
US7060725B2 (en) * 2002-05-13 2006-06-13 Janssen Pharmaceutica N.V. Substituted sulfamate anticonvulsant derivatives
AR039744A1 (es) * 2002-06-26 2005-03-09 Alza Corp Metodos y formas de dosificacion para aumentar la solubilidad de las composiciones de farmacos para la administracion controlada
EP1534238A1 (de) * 2002-07-29 2005-06-01 ALZA Corporation Formulierungen und dosierformen fuer die kontrollierte abgabe von topiramat
UA80450C2 (en) * 2002-10-31 2007-09-25 Ortho Mcneil Pharm Inc Continuous process for the preparation of fructopyranose sulfamate derivatives
US7196209B2 (en) * 2002-10-31 2007-03-27 Ortho-Mcneil Pharmaceutical, Inc. Continuous process for the preparation of fructopyranose sulfamate derivatives
UA81657C2 (ru) * 2003-03-04 2008-01-25 Орто-Макнейл Фармасьютикел, Инк. Способ получения противосудорожных производных топирамата
WO2004108732A1 (en) * 2003-05-12 2004-12-16 Sun Pharmaceutical Industries Limited PROCESS FOR THE PREPARATION OF 2,3:4,5-BIS-O(1-METHYLETHYLIDENE)-ß-D-FRUCTOPYRANOSE SULFAMATE
CA2534920A1 (en) * 2003-08-06 2005-02-24 Alza Corporation Uniform delivery of topiramate over prolonged period of time with enhanced dispersion formulation
US20050136108A1 (en) * 2003-08-22 2005-06-23 Yam Noymi V. Stepwise delivery of topiramate over prolonged period of time
WO2005020959A2 (en) * 2003-09-02 2005-03-10 Alza Corporation Novel drug compositions and dosage forms of topiramate
JP2007511519A (ja) * 2003-11-14 2007-05-10 アルザ・コーポレーシヨン 液状投薬形態物におけるトピラメートの制御放出
KR20050062976A (ko) * 2003-12-19 2005-06-28 일동제약주식회사 2,3:4,5-비스-오-(1-메틸에틸리덴)-베타-디-프럭토피라노즈설파메이트의 새로운 개량된 제조방법
US20050175696A1 (en) * 2003-12-29 2005-08-11 David Edgren Drug granule coatings that impart smear resistance during mechanical compression
EP1701708A2 (de) * 2003-12-29 2006-09-20 Alza Corporation Neue arzneimittelzusammensetzungen und dosierformen von topiramat
JP2007517061A (ja) * 2003-12-29 2007-06-28 アルザ・コーポレーシヨン 新規薬剤組成物及び投与形態物
US20050203287A1 (en) * 2004-03-11 2005-09-15 Chandrasekhar Batchu Process for the preparation of sulfamate derivatives
MY147767A (en) * 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
AR049646A1 (es) * 2004-06-16 2006-08-23 Janssen Pharmaceutica Nv Derivados de sulfamato y sulfamida utiles para el tratamiento de la epilepsia y trastornos relacionados
MY142329A (en) * 2004-08-24 2010-11-15 Janssen Pharmaceutica Nv Novel benzo-fused heteroaryl sulfamide derivatives useful as anticonvulsant agents.
DK1815165T3 (da) * 2004-10-05 2012-06-18 Fallbrook Technologies Inc Trinløst variabel transmission
AU2006249577A1 (en) * 2005-05-20 2006-11-30 Janssen Pharmaceutica N.V. Process for preparation of sulfamide derivatives
AU2006251213A1 (en) * 2005-05-25 2006-11-30 Janssen Pharmaceutica N.V. Pediatric formulation of topiramate
US8937096B2 (en) * 2005-12-19 2015-01-20 Janssen Pharmaceutica Nv Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder
US8691867B2 (en) * 2005-12-19 2014-04-08 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction
US8492431B2 (en) * 2005-12-19 2013-07-23 Janssen Pharmaceutica, N.V. Use of benzo-fused heterocycle sulfamide derivatives for the treatment of obesity
US20070155823A1 (en) * 2005-12-19 2007-07-05 Smith-Swintosky Virginia L Use of benzo-fused heterocycle sulfamide derivatives as neuroprotective agents
US8497298B2 (en) * 2005-12-19 2013-07-30 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels
US8716231B2 (en) * 2005-12-19 2014-05-06 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain
US20070155827A1 (en) * 2005-12-19 2007-07-05 Smith-Swintosky Virginia L Use of benzo-fused heterocycle sulfamide derivatives for the treatment of depression
US20070191461A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of benzo-heteroaryl sulfamide derivatives for the treatment of migraine
US20070191474A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of benzo-fused heterocyle sulfamide derivatives for the treatment of migraine
US20070191453A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of benzo-heteroaryl sulfamide derivatives for the treatment of substance abuse and addiction
US20070191449A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of Benzo-Heteroaryl Sulfamide Derivatives for the Treatment of Depression
US20070191459A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of Benzo-Heteroaryl Sulfamide Derivatives for Lowering Lipids and Lowering Blood Glucose Levels
WO2007099388A1 (en) * 2006-03-01 2007-09-07 Glade Organics Private Limited An improved process for the manufacture of topiramate
WO2007108009A1 (en) * 2006-03-17 2007-09-27 Alembic Limited A process for purification of topiramate
JP2009537635A (ja) * 2006-05-19 2009-10-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 癲癇の処置のための共同−療法
JP5424571B2 (ja) * 2007-04-12 2014-02-26 協和発酵キリン株式会社 トピラマート含有固形製剤
JP5591686B2 (ja) * 2007-04-24 2014-09-17 フォールブルック インテレクチュアル プロパティー カンパニー エルエルシー 電気牽引駆動装置
CN101450951B (zh) * 2007-11-30 2012-10-10 重庆凯林制药有限公司 托吡酯的制备方法
US20090247616A1 (en) * 2008-03-26 2009-10-01 Smith-Swintosky Virginia L Use of benzo-fused heterocyle sulfamide derivatives for the treatment of anxiety
US20090247617A1 (en) * 2008-03-26 2009-10-01 Abdel-Magid Ahmed F Process for the preparation of benzo-fused heteroaryl sulfamates
CA2729056A1 (en) 2008-06-23 2010-01-21 Janssen Pharmaceutica Nv Crystalline form of (2s)-(-)-n-(6-chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-sulfamide
US8815939B2 (en) * 2008-07-22 2014-08-26 Janssen Pharmaceutica Nv Substituted sulfamide derivatives
WO2011096934A1 (en) 2010-02-05 2011-08-11 Scinopharm Taiwan, Ltd. Process for the preparation and purification of topiramate
CN102936268A (zh) * 2012-11-13 2013-02-20 江苏吉贝尔药业有限公司 一种托吡酯中间体丙酮叉的制备方法
CN106397502A (zh) * 2016-08-31 2017-02-15 安徽省润生医药股份有限公司 一种托吡酯的合成工艺
CN108341844A (zh) * 2018-04-25 2018-07-31 广州小桔生物科技有限公司 一种高纯度托吡酯的制备方法
CN110655541A (zh) * 2018-06-29 2020-01-07 鲁南制药集团股份有限公司 一种2,3:4,5-双-O-(1-甲基亚乙基)-β-D-吡喃果糖氯磺酸酯晶型
CN110655542A (zh) * 2018-06-29 2020-01-07 鲁南制药集团股份有限公司 一种2,3:4,5-双-O-(1-甲基亚乙基)-β-D-吡喃果糖氯磺酸酯的晶型
EP3883546A1 (de) 2018-11-21 2021-09-29 Rosemont Pharmaceuticals Ltd Orale topiramat-suspensionsformulierungen mit verlängerter lagerstabilität und verbesserter bioverfügbarkeit
CN114350340B (zh) * 2022-01-13 2023-01-17 陕西科技大学 一种压裂用增渗剂及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4582916A (en) * 1983-09-26 1986-04-15 Mcneilab, Inc. Chlorosulfate and azidosulfate esters of tetrahydro-2H-pyran-2-yl-methanol
US4513006A (en) * 1983-09-26 1985-04-23 Mcneil Lab., Inc. Anticonvulsant sulfamate derivatives

Also Published As

Publication number Publication date
EP0533483A3 (en) 1994-11-02
AU2451892A (en) 1993-03-25
MY113564A (en) 2002-04-30
TW217413B (de) 1993-12-11
KR100229180B1 (ko) 1999-11-01
DK0533483T3 (da) 1998-09-28
US5387700A (en) 1995-02-07
NO179284C (no) 1996-09-11
EP0533483B1 (de) 1998-03-11
CA2078519C (en) 2003-09-16
MX9205305A (es) 1993-07-01
EG20164A (en) 1997-08-31
IL103172A (en) 1997-01-10
NZ244409A (en) 1995-02-24
FI924189A0 (fi) 1992-09-18
KR930006029A (ko) 1993-04-20
NO179284B (no) 1996-06-03
DE69224691T2 (de) 1998-08-20
CN1035820C (zh) 1997-09-10
JP3174410B2 (ja) 2001-06-11
DE69224691D1 (de) 1998-04-16
EP0533483A2 (de) 1993-03-24
NO923637L (no) 1993-03-22
PH31291A (en) 1998-07-06
GR3026618T3 (en) 1998-07-31
AU651244B2 (en) 1994-07-14
ZW14792A1 (en) 1994-04-20
HU9202974D0 (en) 1992-11-30
HUT63612A (en) 1993-09-28
HU212634B (en) 1996-09-30
JPH05230011A (ja) 1993-09-07
IL103172A0 (en) 1993-02-21
ES2114917T3 (es) 1998-06-16
ATE163937T1 (de) 1998-03-15
FI924189A (fi) 1993-03-20
CN1075317A (zh) 1993-08-18
CA2078519A1 (en) 1993-03-20
NO923637D0 (no) 1992-09-18

Similar Documents

Publication Publication Date Title
FI107731B (fi) Menetelmä 2,3:4,5-bis-O-(1-metyylietylideeni)-beta-D-fruktopyranoosin ja (1-metyylisykloheksyyli)metanolin kloorisulfaatti- ja sulfamaattijohdannaisten valmistamiseksi
EP0001500A1 (de) 1-Carbocyclisch Aryl-2-mono oder -bis-(alkoxycarbonyl)-guani-dinoäthane, Verfahren zu ihrer Herstellung und Herstellung von 4.5-Dihydro-2-alkoxycarbonylamino-5-carbocyclisch Aryl-imidazolen aus diesen
US4981996A (en) Method for the production of O-substituted hydroxylamines
US20050203287A1 (en) Process for the preparation of sulfamate derivatives
US6281367B1 (en) Process for the synthesis of HIV protease inhibitors
KR100210731B1 (ko) 2-클로로-5-메틸-피리딘의 제조방법
US6320057B1 (en) Intermediates for the preparation of 2-imidazoline-5-ones
RU2710939C1 (ru) Способ получения регулятора роста растений N-(изопропоксикарбонил)этаноламина
KR100674098B1 (ko) Ｎ,ｎ-디알킬아릴아민 촉매의 존재하에서ｎ-알크(엔)옥시(또는 아릴옥시)카보닐이소티오시아네이트 및 그의 유도체를 제조하는 방법
Rigo et al. Studies on pyrrolidinones. Synthesis of N‐acylpyroglutamic acids having bactericide and fungicide properties
US6175019B1 (en) Process for the preparation of 1,3-dimethylimidazolium 4-carboxylate
EP0157661B1 (de) Diisocyanat-1-10-Dekan und Verfahren zu ihrer Herstellung
GB2170806A (en) N-(b-mercapto-iso-butyryl)proline, derivatives and a process for their preparation
US5352794A (en) Process for the preparation of N-(2-chloro-pyridin-5-yl-methyl)ethylenediamine
KR930006198B1 (ko) 신규 α-클로로케톤 유도체 및 그 제조법
EP0902000B1 (de) Verfahren zur Herstellung von 1,1-Dialkoxycycloalkanen
KR100415520B1 (ko) 1-(2-클로로페닐)-5(4h)-테트라졸리논의제조방법
Shimazu et al. Reactivity of 1, 3-di-tert-butylaziridinones with phenyl substituents. A new fragmentation of α-lactams
JPH0528708B2 (de)
US4892956A (en) 5-cyano-4,5-dihydro-3,4-dicarboxypyrazole derivatives
US4234514A (en) Method of preparing ketoxime carbamates
EP2938595B1 (de) Verfahren zur synthese eines hydrazin zur behandlung des papillomavirus
FR3037952A1 (fr) Procede de synthese d'oximes aromatiques
US4924001A (en) Process for preparing 5-cyano-4, 5-dihydro-3,4-dicarboxypyrazole derivatives
RU2325380C2 (ru) Способ получения 1-(пиримидин-2-ил)пропан-2-онов

Legal Events

Date Code Title Description
MA Patent expired