AT393386B - Verfahren zur herstellung eines monoklonalen antikoerpers - Google Patents

Verfahren zur herstellung eines monoklonalen antikoerpers Download PDF

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Publication number
AT393386B
AT393386B AT9019/83A AT901983A AT393386B AT 393386 B AT393386 B AT 393386B AT 9019/83 A AT9019/83 A AT 9019/83A AT 901983 A AT901983 A AT 901983A AT 393386 B AT393386 B AT 393386B
Authority
AT
Austria
Prior art keywords
antigen
antibody
medium
environment
antibodies
Prior art date
Application number
AT9019/83A
Other languages
German (de)
English (en)
Other versions
ATA901983A (de
Original Assignee
Hybritech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hybritech Inc filed Critical Hybritech Inc
Publication of ATA901983A publication Critical patent/ATA901983A/de
Application granted granted Critical
Publication of AT393386B publication Critical patent/AT393386B/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT9019/83A 1982-04-12 1983-04-12 Verfahren zur herstellung eines monoklonalen antikoerpers AT393386B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36778182A 1982-04-12 1982-04-12

Publications (2)

Publication Number Publication Date
ATA901983A ATA901983A (de) 1991-03-15
AT393386B true AT393386B (de) 1991-10-10

Family

ID=23448565

Family Applications (1)

Application Number Title Priority Date Filing Date
AT9019/83A AT393386B (de) 1982-04-12 1983-04-12 Verfahren zur herstellung eines monoklonalen antikoerpers

Country Status (11)

Country Link
EP (1) EP0105359A4 (enExample)
AT (1) AT393386B (enExample)
AU (1) AU622099B2 (enExample)
CA (1) CA1209907A (enExample)
CH (1) CH672028A5 (enExample)
DK (1) DK192191A (enExample)
ES (3) ES8404858A1 (enExample)
FI (1) FI88403C (enExample)
GB (1) GB2128630B (enExample)
IT (1) IT1219779B (enExample)
WO (1) WO1983003678A1 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8328918D0 (en) * 1983-10-28 1983-11-30 Unilever Plc Alkaline phosphatase
GB8331071D0 (en) * 1983-11-22 1983-12-29 Karayiannis P Assay for dna/rna
US4666865A (en) * 1984-01-13 1987-05-19 Centocor, Inc. Immunoassay for biologically active human interferon-gamma employing unique monoclonal antibodies
US4789631A (en) * 1984-02-17 1988-12-06 Synbiotics Corporation Immunoassay for anti-dirofilaria immitis antibody
GB8426468D0 (en) * 1984-10-19 1984-11-28 Technology Licence Co Ltd Monoclonal antibodies
AU5259786A (en) * 1985-01-30 1986-08-07 United States Of America, The Monoclonal antibodies against chlamydial genes specific lipopolysaccharide
US4859611A (en) * 1985-02-28 1989-08-22 Massachusetts Institute Of Technology Affinity column and process for detection of low molecular weight toxic substances
US4818687A (en) * 1985-02-28 1989-04-04 Massachusetts Institute Of Technology Affinity column and process for detection of low molecular weight toxic substances
IL75828A (en) * 1985-07-17 1991-06-10 Univ Ramot Immobilization by biologically active proteins
NZ218336A (en) * 1985-12-09 1991-08-27 Kirin Amgen Inc Monoclonal antibodies to human pluripotent granulocyte colony stimulating factor (hpg-csf)
US5175255A (en) * 1987-03-23 1992-12-29 Amgen Inc. Methods for purification of platelet-derived growth factor
US5190859A (en) * 1987-02-26 1993-03-02 Dana-Farber Cancer Institute, Inc. Purification of LFA-3
SE468653B (sv) * 1987-03-06 1993-02-22 Perstorp Biolytica Adsorbent foer isokratisk affinitetskromatografi
JPS6463599A (en) * 1987-05-01 1989-03-09 Xoma Corp Purification of immunoglobulin by selective anti-idiotype bond
JPH03500682A (ja) * 1987-07-14 1991-02-14 ザ　ビクトリア　ユニヴアーシテイ　オブ　マンチエスター 診断方法
CA1323567C (en) * 1987-10-05 1993-10-26 Gene R. Nathans Method for purification of antibodies
US5582862A (en) * 1988-04-04 1996-12-10 General Hospital Corporation Antibodies that bind to α2-antiplasmin crosslinked to fibrin which do not inhibit plasma α2-antiplasmin
US5372812A (en) * 1988-04-04 1994-12-13 The General Hospital Corporation Composition and method for acceleration of clot lysis
US20030017147A1 (en) * 1996-09-20 2003-01-23 Guy L Reed Composition and method for enhancing fibrinolysis
TW201920257A (zh) * 2008-04-11 2019-06-01 日商中外製藥股份有限公司 重複結合複數個抗原的抗原結合分子
TWI654203B (zh) 2010-11-30 2019-03-21 Chugai Seiyaku Kabushiki Kaisha 具有鈣依存性的抗原結合能力之抗體
SG10201609665PA (en) 2011-02-25 2017-01-27 Chugai Pharmaceutical Co Ltd FcɣRIIb-SPECIFIC Fc ANTIBODY
JP6322411B2 (ja) 2011-09-30 2018-05-09 中外製薬株式会社 複数の生理活性を有する抗原の消失を促進する抗原結合分子
KR20210074395A (ko) 2011-11-30 2021-06-21 추가이 세이야쿠 가부시키가이샤 면역 복합체를 형성하는 세포내로의 운반체（캐리어）를 포함하는 의약
CA2865158C (en) 2012-02-24 2022-11-01 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule for promoting disappearance of antigen via fc.gamma.riib
EA201791366A1 (ru) 2014-12-19 2018-02-28 Чугаи Сейяку Кабусики Кайся Антитела к c5 и способы их применения
MX2017005774A (es) 2014-12-19 2017-07-28 Chugai Pharmaceutical Co Ltd Anticuerpos antimiostatina, polipeptidos que contienen regiones fc variantes, y metodos de uso.
CN114773469B (zh) 2015-02-05 2025-12-19 中外制药株式会社 包含离子浓度依赖性的抗原结合结构域的抗体，fc区变体，il-8-结合抗体及其应用
EP3394098A4 (en) 2015-12-25 2019-11-13 Chugai Seiyaku Kabushiki Kaisha ANTI-MYOSTATIN ANTIBODIES AND METHOD OF USE
CN116271014A (zh) 2016-08-05 2023-06-23 中外制药株式会社 用于预防或治疗il-8相关疾病的组合物
WO2018139623A1 (en) 2017-01-30 2018-08-02 Chugai Seiyaku Kabushiki Kaisha Anti-sclerostin antibodies and methods of use
CN110724204B (zh) * 2019-11-18 2021-10-22 广东菲鹏制药股份有限公司 Fc融合蛋白的纯化方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4172124A (en) * 1978-04-28 1979-10-23 The Wistar Institute Method of producing tumor antibodies

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3264713D1 (en) * 1981-02-26 1985-08-22 Unilever Plc A process and apparatus for the recovery of immunoglobulines
US4474893A (en) * 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies
US4361509A (en) * 1981-12-14 1982-11-30 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4172124A (en) * 1978-04-28 1979-10-23 The Wistar Institute Method of producing tumor antibodies

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BIOCHEMICAL JOURNAL, VOL. 200, 1981; S. 1-10 *
JOURNAL OF BIOLOGICAL CHEMISTRY, VOL. 256, NO. 8, 1981; S. 3833-3839 *
JOURNAL OF IMMUNOLOGICAL METHODS, VOL. 46, NO. 2, 1981; S. 337-345 *
JOURNAL OF IMMUNOLOGY, VOL. 127, NO. 3, 1981; S. 923-930 *
MONOCLONAL ANTIBODIES IN ENDOCRINE RESEARCH, 1981, S. 157-166 *
PRINCIPALS OF IMMUNOLOGY, 2. AUFL., 1979; S. 499-501 *
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, VOL. 78, NO. 1, 1981; 1981; S. 1797-1806 *
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, VOL. 78, NO. 3, 1981; S. 1848-1852 *

Also Published As

Publication number Publication date
WO1983003678A1 (en) 1983-10-27
ES8506902A1 (es) 1985-08-01
AU622099B2 (en) 1992-04-02
DK192191D0 (da) 1991-11-26
ES521371A0 (es) 1984-05-16
FI834530A0 (fi) 1983-12-09
GB8332644D0 (en) 1984-01-11
EP0105359A4 (en) 1984-08-20
ATA901983A (de) 1991-03-15
CA1209907A (en) 1986-08-19
DK192191A (da) 1991-11-26
FI88403B (fi) 1993-01-29
AU7256987A (en) 1987-09-03
ES8404858A1 (es) 1984-05-16
FI88403C (fi) 1993-05-10
GB2128630B (en) 1986-08-28
ES528001A0 (es) 1987-07-01
IT1219779B (it) 1990-05-24
ES8706964A1 (es) 1987-07-01
CH672028A5 (enExample) 1989-10-13
GB2128630A (en) 1984-05-02
ES528000A0 (es) 1985-08-01
FI834530L (fi) 1983-12-09
EP0105359A1 (en) 1984-04-18
IT8320550A0 (it) 1983-04-12

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