CH672028A5 - - Google Patents

Download PDF

Info

Publication number
CH672028A5
CH672028A5 CH6699/83A CH669983A CH672028A5 CH 672028 A5 CH672028 A5 CH 672028A5 CH 6699/83 A CH6699/83 A CH 6699/83A CH 669983 A CH669983 A CH 669983A CH 672028 A5 CH672028 A5 CH 672028A5
Authority
CH
Switzerland
Prior art keywords
environment
antigen
antibody
affinity
antibodies
Prior art date
Application number
CH6699/83A
Other languages
German (de)
English (en)
Inventor
Richard M Bartholomew
Daniel E Beidler
Gary S David
Original Assignee
Hybritech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hybritech Inc filed Critical Hybritech Inc
Publication of CH672028A5 publication Critical patent/CH672028A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CH6699/83A 1982-04-12 1983-04-12 CH672028A5 (enExample)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36778182A 1982-04-12 1982-04-12

Publications (1)

Publication Number Publication Date
CH672028A5 true CH672028A5 (enExample) 1989-10-13

Family

ID=23448565

Family Applications (1)

Application Number Title Priority Date Filing Date
CH6699/83A CH672028A5 (enExample) 1982-04-12 1983-04-12

Country Status (11)

Country Link
EP (1) EP0105359A4 (enExample)
AT (1) AT393386B (enExample)
AU (1) AU622099B2 (enExample)
CA (1) CA1209907A (enExample)
CH (1) CH672028A5 (enExample)
DK (1) DK192191A (enExample)
ES (3) ES8404858A1 (enExample)
FI (1) FI88403C (enExample)
GB (1) GB2128630B (enExample)
IT (1) IT1219779B (enExample)
WO (1) WO1983003678A1 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8328918D0 (en) * 1983-10-28 1983-11-30 Unilever Plc Alkaline phosphatase
GB8331071D0 (en) * 1983-11-22 1983-12-29 Karayiannis P Assay for dna/rna
US4666865A (en) * 1984-01-13 1987-05-19 Centocor, Inc. Immunoassay for biologically active human interferon-gamma employing unique monoclonal antibodies
US4789631A (en) * 1984-02-17 1988-12-06 Synbiotics Corporation Immunoassay for anti-dirofilaria immitis antibody
GB8426468D0 (en) * 1984-10-19 1984-11-28 Technology Licence Co Ltd Monoclonal antibodies
AU5259786A (en) * 1985-01-30 1986-08-07 United States Of America, The Monoclonal antibodies against chlamydial genes specific lipopolysaccharide
US4859611A (en) * 1985-02-28 1989-08-22 Massachusetts Institute Of Technology Affinity column and process for detection of low molecular weight toxic substances
US4818687A (en) * 1985-02-28 1989-04-04 Massachusetts Institute Of Technology Affinity column and process for detection of low molecular weight toxic substances
IL75828A (en) * 1985-07-17 1991-06-10 Univ Ramot Immobilization by biologically active proteins
NZ218336A (en) * 1985-12-09 1991-08-27 Kirin Amgen Inc Monoclonal antibodies to human pluripotent granulocyte colony stimulating factor (hpg-csf)
US5175255A (en) * 1987-03-23 1992-12-29 Amgen Inc. Methods for purification of platelet-derived growth factor
US5190859A (en) * 1987-02-26 1993-03-02 Dana-Farber Cancer Institute, Inc. Purification of LFA-3
SE468653B (sv) * 1987-03-06 1993-02-22 Perstorp Biolytica Adsorbent foer isokratisk affinitetskromatografi
JPS6463599A (en) * 1987-05-01 1989-03-09 Xoma Corp Purification of immunoglobulin by selective anti-idiotype bond
JPH03500682A (ja) * 1987-07-14 1991-02-14 ザ　ビクトリア　ユニヴアーシテイ　オブ　マンチエスター 診断方法
CA1323567C (en) * 1987-10-05 1993-10-26 Gene R. Nathans Method for purification of antibodies
US5582862A (en) * 1988-04-04 1996-12-10 General Hospital Corporation Antibodies that bind to α2-antiplasmin crosslinked to fibrin which do not inhibit plasma α2-antiplasmin
US5372812A (en) * 1988-04-04 1994-12-13 The General Hospital Corporation Composition and method for acceleration of clot lysis
US20030017147A1 (en) * 1996-09-20 2003-01-23 Guy L Reed Composition and method for enhancing fibrinolysis
TW201920257A (zh) * 2008-04-11 2019-06-01 日商中外製藥股份有限公司 重複結合複數個抗原的抗原結合分子
TWI654203B (zh) 2010-11-30 2019-03-21 Chugai Seiyaku Kabushiki Kaisha 具有鈣依存性的抗原結合能力之抗體
SG10201609665PA (en) 2011-02-25 2017-01-27 Chugai Pharmaceutical Co Ltd FcɣRIIb-SPECIFIC Fc ANTIBODY
JP6322411B2 (ja) 2011-09-30 2018-05-09 中外製薬株式会社 複数の生理活性を有する抗原の消失を促進する抗原結合分子
KR20210074395A (ko) 2011-11-30 2021-06-21 추가이 세이야쿠 가부시키가이샤 면역 복합체를 형성하는 세포내로의 운반체（캐리어）를 포함하는 의약
CA2865158C (en) 2012-02-24 2022-11-01 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule for promoting disappearance of antigen via fc.gamma.riib
EA201791366A1 (ru) 2014-12-19 2018-02-28 Чугаи Сейяку Кабусики Кайся Антитела к c5 и способы их применения
MX2017005774A (es) 2014-12-19 2017-07-28 Chugai Pharmaceutical Co Ltd Anticuerpos antimiostatina, polipeptidos que contienen regiones fc variantes, y metodos de uso.
CN114773469B (zh) 2015-02-05 2025-12-19 中外制药株式会社 包含离子浓度依赖性的抗原结合结构域的抗体，fc区变体，il-8-结合抗体及其应用
EP3394098A4 (en) 2015-12-25 2019-11-13 Chugai Seiyaku Kabushiki Kaisha ANTI-MYOSTATIN ANTIBODIES AND METHOD OF USE
CN116271014A (zh) 2016-08-05 2023-06-23 中外制药株式会社 用于预防或治疗il-8相关疾病的组合物
WO2018139623A1 (en) 2017-01-30 2018-08-02 Chugai Seiyaku Kabushiki Kaisha Anti-sclerostin antibodies and methods of use
CN110724204B (zh) * 2019-11-18 2021-10-22 广东菲鹏制药股份有限公司 Fc融合蛋白的纯化方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4172124A (en) * 1978-04-28 1979-10-23 The Wistar Institute Method of producing tumor antibodies
DE3264713D1 (en) * 1981-02-26 1985-08-22 Unilever Plc A process and apparatus for the recovery of immunoglobulines
US4474893A (en) * 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies
US4361509A (en) * 1981-12-14 1982-11-30 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies

Also Published As

Publication number Publication date
WO1983003678A1 (en) 1983-10-27
ES8506902A1 (es) 1985-08-01
AU622099B2 (en) 1992-04-02
DK192191D0 (da) 1991-11-26
ES521371A0 (es) 1984-05-16
FI834530A0 (fi) 1983-12-09
GB8332644D0 (en) 1984-01-11
EP0105359A4 (en) 1984-08-20
ATA901983A (de) 1991-03-15
CA1209907A (en) 1986-08-19
DK192191A (da) 1991-11-26
FI88403B (fi) 1993-01-29
AU7256987A (en) 1987-09-03
ES8404858A1 (es) 1984-05-16
FI88403C (fi) 1993-05-10
AT393386B (de) 1991-10-10
GB2128630B (en) 1986-08-28
ES528001A0 (es) 1987-07-01
IT1219779B (it) 1990-05-24
ES8706964A1 (es) 1987-07-01
GB2128630A (en) 1984-05-02
ES528000A0 (es) 1985-08-01
FI834530L (fi) 1983-12-09
EP0105359A1 (en) 1984-04-18
IT8320550A0 (it) 1983-04-12

Similar Documents

Publication Publication Date Title
AT393386B (de) Verfahren zur herstellung eines monoklonalen antikoerpers
DE69014147T2 (de) Reinigungsverfahren für Antikörper.
DE69936916T2 (de) Liganden-bindetest und kit mit einer abtrennzone für störende probenkomponenten
DE69530315T2 (de) Rückgewinnung und verwendungen von spezifischen bindungsreagenzen
DE3751432T2 (de) Rezeptoren für Immunkomplexe, Verfahren zur ihrer Herstellung und Verfahren zur Prüfung diese benutzend.
DE3750354T2 (de) Monoklonale Antikörper und Verfahren zum Nachweis von Dioxinen und Dibenzofuranen.
DE69420413T2 (de) Mca prüfung/kit zum nachweis von metallkationen
EP0782585B1 (de) RHEUMAFAKTOR-ENTSTÖRUNG MIT ANTI-Fd-ANTIKÖRPERN
EP0174652B1 (de) Immunchemisches Messverfahren für Haptene und Proteine
DE19649389A1 (de) Antigenspezifischer IgM-Nachweis
EP0185372B1 (de) Verfahren zur Herstellung eines immunreaktiven porösen Trägermaterials
DE69226148T2 (de) Radioimmunologisches Untersuchungsverfahren zum PTHrP nachweis
DE3873877T2 (de) Bestimmung von monokinen.
EP0943098B1 (de) Rezeptorbindungsassay zum nachweis von tsh-rezeptor-autoantikörpern
EP1015885B1 (de) Aufreinigung von substanzen aus einer biologischen probe
DE69304528T3 (de) Verfahren zur bestimmung der menge eines schilddrüsenhormon-liganden in einer biologischen flüssigkeit und satz zur durchführung dieses verfahrens
DE3623846A1 (de) Zusammensetzung zur selektiven bestimmung einer biologisch aktiven substanz
DE2755008A1 (de) Verfahren zur immunologischen bestimmung mit hilfe von enzym-markierungen
EP0547059B1 (de) Pankreas-elastase-1-spezifischer antikörper, ein verfahren zu seiner gewinnung und ein testkit der solche antikörper enthält
DE3854834T2 (de) Immuntest unter Verwendung von Antigenen, produziert in heterologen Organismen
DE3855007T2 (de) METHODE ZUR REINIGUNG REKOMBINANTER t-PA VON DEN IHREN ENTSPRECHENDEN WIRTSZELLPROTEINEN
EP0249877A2 (de) Verfahren zur Herstellung eines immunreaktiven Trägermaterials für die heterogene immunologische Analyse
EP0021050B1 (de) Verfahren zur Gewinnung von immunologisch aktiven enzymmarkierten Konjugaten
DE69628878T2 (de) Methode zur Bestimmung von Cholinesterase und Methode zur Unterscheidung zwischen Leberzirrhose und Hepatitis
EP0444561A2 (de) Verfahren zur immunologischen Bestimmung von Liganden

Legal Events

Date Code Title Description
PL Patent ceased
PL Patent ceased