AT354462B - Verfahren zur herstellung von neuen 9- substituierten purinen und deren salzen - Google Patents

Verfahren zur herstellung von neuen 9- substituierten purinen und deren salzen

Info

Publication number
AT354462B
AT354462B AT676375A AT676375A AT354462B AT 354462 B AT354462 B AT 354462B AT 676375 A AT676375 A AT 676375A AT 676375 A AT676375 A AT 676375A AT 354462 B AT354462 B AT 354462B
Authority
AT
Austria
Prior art keywords
salts
producing new
substituted purines
purines
substituted
Prior art date
Application number
AT676375A
Other languages
English (en)
Other versions
ATA676375A (de
Inventor
Howard John Schaeffer
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10402412&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AT354462(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wellcome Found filed Critical Wellcome Found
Priority to AT610277A priority Critical patent/AT357565B/de
Application granted granted Critical
Publication of AT354462B publication Critical patent/AT354462B/de
Priority to AT104079A priority patent/AT361941B/de
Publication of ATA676375A publication Critical patent/ATA676375A/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
AT676375A 1974-09-02 1975-09-02 Verfahren zur herstellung von neuen 9- substituierten purinen und deren salzen AT354462B (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AT610277A AT357565B (de) 1974-09-02 1977-08-23 Verfahren zur herstellung von neuen substi- tuierten purinen und deren salzen
AT104079A AT361941B (de) 1974-09-02 1979-02-12 Verfahren zur herstellung von neuen 9-substi- tuierten purinen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB38278/74A GB1523865A (en) 1974-09-02 1974-09-02 Purine compunds and salts thereof

Publications (2)

Publication Number Publication Date
AT354462B true AT354462B (de) 1979-01-10
ATA676375A ATA676375A (de) 1979-06-15

Family

ID=10402412

Family Applications (1)

Application Number Title Priority Date Filing Date
AT676375A AT354462B (de) 1974-09-02 1975-09-02 Verfahren zur herstellung von neuen 9- substituierten purinen und deren salzen

Country Status (35)

Country Link
US (3) US4360522A (de)
JP (1) JPS5154589A (de)
AR (4) AR220299A1 (de)
AT (1) AT354462B (de)
AU (1) AU503160B2 (de)
BE (1) BE833006A (de)
BG (4) BG24815A3 (de)
CA (1) CA1062257A (de)
CH (7) CH626363A5 (de)
CS (2) CS203093B2 (de)
CY (1) CY1033A (de)
DD (1) DD122092A5 (de)
DE (1) DE2539963A1 (de)
DK (1) DK146595C (de)
ES (3) ES440631A1 (de)
FI (1) FI60709C (de)
FR (1) FR2282892A1 (de)
GB (1) GB1523865A (de)
HK (1) HK84379A (de)
HU (1) HU176730B (de)
IE (1) IE42282B1 (de)
IL (1) IL48035A (de)
KE (1) KE3002A (de)
LU (1) LU73304A1 (de)
MC (1) MC1068A1 (de)
MY (1) MY8200191A (de)
NL (1) NL175061C (de)
NO (1) NO144216C (de)
NZ (1) NZ178556A (de)
RO (4) RO74274A (de)
SE (1) SE428562C (de)
SU (7) SU904523A3 (de)
YU (4) YU39947B (de)
ZA (1) ZA755574B (de)
ZM (1) ZM12875A1 (de)

Families Citing this family (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4146715A (en) 1975-08-27 1979-03-27 Burroughs Wellcome Co. 2-amido-9-(2-acyloxyethoxymethyl)hypoxanthines
US4060616A (en) * 1976-03-01 1977-11-29 Burroughs Wellcome Co. Purine derivatives with repeating unit
AU521577B2 (en) * 1977-02-24 1982-04-22 Wellcome Foundation Limited, The 9-hydroxyethoxymethyl guanine phosphates
US4287188A (en) 1977-02-24 1981-09-01 Burroughs Wellcome Co. Purine derivatives
KR830005852A (ko) * 1980-07-18 1983-09-14 미첼 페터 잭슨 피부와 점막의 비루스 감염치료에 적합한 국소치료제의 제조방법
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
US5157120A (en) * 1980-09-16 1992-10-20 Syntex (U.S.A.) Inc. Guanine derivatives
AU547311B2 (en) * 1980-10-15 1985-10-17 Wellcome Foundation Limited, The Treating viral infections in fish
US4355032B2 (en) * 1981-05-21 1990-10-30 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
US4603219A (en) * 1981-05-21 1986-07-29 Syntex (U.S.A.) Inc. 1,3-dibenzyloxy-2-acetoxymethoxypropane, intermediate for 9-(1,3-dihydroxy-2-propoxymethyl)guanine
US4423050A (en) * 1981-05-21 1983-12-27 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
DE3278501D1 (en) * 1981-08-11 1988-06-23 Wellcome Found Antiviral compounds
AU564576B2 (en) * 1981-09-24 1987-08-20 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Purine derivatives
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
EP0101441B1 (de) * 1982-02-12 1987-01-14 Syntex (U.S.A.) Inc. Antivirale zusammensetzungen
SE8203856D0 (sv) * 1982-06-21 1982-06-21 Astra Laekemedel Ab Novel derivatives of guanine ii
SE8203855D0 (sv) * 1982-06-21 1982-06-21 Astra Laekemedel Ab Novel derivatives of guanine i
NL8202626A (nl) * 1982-06-29 1984-01-16 Stichting Rega V Z W Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
ATE33654T1 (de) * 1982-10-14 1988-05-15 Wellcome Found Antivirale purinderivate.
US4745119A (en) * 1982-10-14 1988-05-17 Burroughs Wellcome Co. Method for using purine derivatives
US4649140A (en) * 1982-10-14 1987-03-10 Burroughs Wellcome Co. Purine derivatives
US4609662A (en) * 1982-10-14 1986-09-02 Burroughs Wellcome Co. Method for using purine derivatives
US5059604A (en) * 1982-10-14 1991-10-22 Burroughs Wellcome Co. 2-amino purine derivatives
US4612314A (en) * 1982-12-22 1986-09-16 Syntex (U.S.A.) Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
US4461757A (en) * 1983-02-23 1984-07-24 Ens Bio Logicals Inc. Dimethylaminomethylenated anti-herpes compounds
ES520140A0 (es) * 1983-02-25 1984-04-01 Ind Farma Especial Un procedimiento para la preparacion de acicloguanosina.
US5047533A (en) * 1983-05-24 1991-09-10 Sri International Acyclic purine phosphonate nucleotide analogs
US4557934A (en) 1983-06-21 1985-12-10 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one
JPS6023380A (ja) * 1983-06-24 1985-02-05 メルク・エンド・カムパニー・インコーポレーテッド 抗ウイルス剤
US4880820A (en) * 1983-06-24 1989-11-14 Merck & Co., Inc. Guanine derivatives
US5684153A (en) 1984-08-16 1997-11-04 Beecham Group Plc Process for the preparation of purine derivatives
US4897479A (en) * 1983-09-30 1990-01-30 Merck & Co., Inc. Arylsulfonyloxy purine intermediates
JPS6094992A (ja) * 1983-10-28 1985-05-28 Sankyo Co Ltd グリゼオ−ル酸誘導体
ZA848080B (en) * 1983-10-31 1985-06-26 Warner Lambert Co Purine derivatives
US4918219A (en) * 1983-10-31 1990-04-17 Warner-Lambert Company Glycerine derivatives
US4806642A (en) * 1984-10-05 1989-02-21 Warner-Lambert Company Purine derivatives
IE842642L (en) * 1983-10-31 1985-04-30 Harvard College Purine Derivatives
US4579849A (en) * 1984-04-06 1986-04-01 Merck & Co., Inc. N-alkylguanine acyclonucleosides as antiviral agents
US4617304A (en) * 1984-04-10 1986-10-14 Merck & Co., Inc. Purine derivatives
DK163985A (da) * 1984-04-13 1985-10-14 Wellcome Found Antivirale purinderivater, fremgangsmaade til deres fremstilling og farmaceutiske kompositioner indeholdende forbindelserne
US4636507A (en) * 1984-04-30 1987-01-13 Hoechst-Roussel Pharmaceuticals Inc. Host defense mechanism enhancement
JPH0625061B2 (ja) 1984-07-03 1994-04-06 ザ ウエルカム フアウンデ−シヨン リミテツド 抗ウイルス性化合物
WO1986000901A1 (en) * 1984-07-20 1986-02-13 Gauntt Charles O Immunoregulatory and anti-viral compound
SE8406538D0 (sv) * 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
US5683990A (en) * 1985-03-16 1997-11-04 Glaxo Wellcome Inc. Treatment of human viral infections
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
CS263952B1 (en) * 1985-04-25 1989-05-12 Holy Antonin Remedy with antiviral effect
CS263951B1 (en) * 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
EP0203736B1 (de) 1985-05-02 1989-11-23 The Wellcome Foundation Limited Antivirale Verbindungen
IL78643A0 (en) * 1985-05-02 1986-08-31 Wellcome Found Purine derivatives,their preparation and pharmaceutical compositions containing them
DE3529497A1 (de) * 1985-08-17 1987-02-26 Boehringer Mannheim Gmbh N(pfeil hoch)6(pfeil hoch)-disubstituierte purinderivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
DE3627024A1 (de) * 1985-09-24 1987-04-02 Hoechst Ag In 6- und 9-stellung substituierte 2-aminopurine, ihre verwendung, diese purine enthaltende arzneimittel und verfahren zur herstellung der purine
IT1207507B (it) * 1985-10-21 1989-05-25 Baldacci Lab Spa Coniugato della 9-(2-idrossietossimetil)guanina con albumina umana lattosaminata, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono.
WO1988002258A1 (en) * 1986-10-06 1988-04-07 The University Of Virginia Alumni Patents Foundati Use of an adenosine, hypoxanthine and ribose-containing solution for improved protection of the heart during surgery
WO1988003923A1 (en) * 1986-11-25 1988-06-02 Institut Organicheskogo Sinteza Akademii Nauk Latv 9-substituted guanines
US4978655A (en) * 1986-12-17 1990-12-18 Yale University Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses
US4829055A (en) * 1987-01-23 1989-05-09 Naficy Sadeque S Method of treatment for herpes infections of external tissues
US5565566A (en) * 1987-04-24 1996-10-15 Discovery Therapeutics, Inc. N6 -substituted 9-methyladenines: a new class of adenosine receptor antagonists
US4835104A (en) * 1987-06-16 1989-05-30 Ajinomoto Co., Inc., Patent & Licensing Department Process for producing and purifying 2',3'-dideoxynucleosides, and process for producing 2',3'-dideoxy-2',3'-didehydronucleosides
US6306647B1 (en) 1987-06-16 2001-10-23 Ajinomoto Co., Inc. Process for producing and purifying 2′,3′-dideoxynucleosides, and process for producing 2′,3′-dideoxy-2′,3′-didehydronucleosides
GB8719367D0 (en) * 1987-08-15 1987-09-23 Wellcome Found Therapeutic compounds
GB8725939D0 (en) * 1987-11-05 1987-12-09 Wellcome Found Therapeutic compounds
CA1302887C (en) * 1987-11-24 1992-06-09 Yves Langelier Combination of acyclovir or a derivative thereof and bacitracin
JPH01121424U (de) * 1988-02-10 1989-08-17
US5164395A (en) * 1988-06-27 1992-11-17 Burroughs Wellcome Co. Antiviral acetyl pyridine derivative or said acetyl pyridine derivative in combination with acyclovir
GB8815241D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Antiviral combinations & compounds therefor
GB8816760D0 (en) * 1988-07-14 1988-08-17 Wellcome Found Therapeutic compounds
JPH02164881A (ja) * 1988-10-24 1990-06-25 Wellcome Found Ltd:The 治療用ヌクレオシド化合物
KR910700253A (ko) * 1989-01-31 1991-03-14 로버트 제이, 바란 N_6-치환-9-메틸아데닌: 신규한 부류의 아데노신 수용체 길항질
US4966895A (en) * 1989-02-02 1990-10-30 Merck & Co. Inc. Cyclic monophosphates of purine and pyrimidine acyclonucleosides as anti-retroviral agents
GB8907173D0 (en) * 1989-03-30 1989-05-10 Beecham Group Plc Novel compounds
GB8912043D0 (en) * 1989-05-25 1989-07-12 Beecham Group Plc Novel compounds
GB9001886D0 (en) * 1990-01-26 1990-03-28 Beecham Group Plc Pharmaceutical formulation
DE4008858A1 (de) * 1990-03-20 1991-09-26 Hoechst Ag Substituierte purine, verfahren zu ihrer hertellung sowie ihre verwendung als antivirale mittel
CA2033447C (en) * 1990-12-31 1999-08-31 Robert Deziel Synergistic combination for treating herpes infections
US5580571A (en) * 1991-10-15 1996-12-03 Hostetler; Karl Y. Nucleoside analogues
US5879700A (en) * 1991-10-15 1999-03-09 Hostetler; Karl Y. Nucleoside analogue phosphates for topical use
CA2091732C (en) * 1992-07-08 1998-07-21 Anica Markovac A process for the preparation of 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine
DK169121B1 (da) 1992-09-09 1994-08-22 Gea Farmaceutisk Fabrik As Antiviralt virksom farmaceutisk olie-i-vand-emulsion indeholdende 9-[(2-hydroxyethoxy)methyl]guanin (acyclovir) eller et salt eller en ester deraf
DE59310344D1 (de) * 1992-09-24 2003-07-24 Hoechst Ag N1-Substituierte 1H-1,2,3-Triazolo[4,5-d]pyrimidine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als antivirale Mittel
US5654286A (en) * 1993-05-12 1997-08-05 Hostetler; Karl Y. Nucleotides for topical treatment of psoriasis, and methods for using same
US6015573A (en) * 1993-05-12 2000-01-18 Hostetler; Karl Y. Nucleoside phosphate therapy for viral infection
IT1264599B1 (it) * 1993-06-14 1996-10-04 Solar Chem Sa Processo per la sintesi della 9-(2-idrossietossimetil)- guanina
US5567816A (en) * 1994-07-26 1996-10-22 Syntex (U.S.A.) Inc. Preparation of acyclovir using 1,3 dioxolane
US5840891A (en) * 1994-07-28 1998-11-24 Syntex (U.S.A.) Inc. 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
US5565565A (en) * 1994-08-04 1996-10-15 Syntex (U.S.A.) Inc. Preparation of N-9 substituted guanine compounds
US5627185A (en) * 1994-11-23 1997-05-06 Gosselin; Gilles Acyclovir derivatives as antiviral agents
US5840890A (en) * 1996-01-26 1998-11-24 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5700936A (en) * 1996-01-26 1997-12-23 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
US6040446A (en) * 1996-01-26 2000-03-21 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US5756736A (en) * 1996-01-26 1998-05-26 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
IN179493B (de) * 1996-02-22 1997-10-11 Lupin Laboraties Ltd
US5789589A (en) * 1996-04-22 1998-08-04 Drug Innovation & Design, Inc. Guanine analog phosphates
US6440980B1 (en) * 1996-09-17 2002-08-27 Avanir Pharmaceuticals Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs
US6180790B1 (en) 1997-05-15 2001-01-30 Drug Innovation And Design, Inc. Methods of preparing acyclovir prodrugs
US6031096A (en) * 1997-05-15 2000-02-29 Drug Innovation & Design, Inc. Acyclovir diester derivatives
RU2004115001A (ru) * 2001-10-16 2005-04-10 Аванир Фармасьютикалс (Us) Подавление вирусом n-докосанолом
EP1440072A4 (de) * 2001-10-30 2005-02-02 Conforma Therapeutic Corp Purinanaloga mit hsp90-inhibierender wirkung
US20070129334A1 (en) * 2001-10-30 2007-06-07 Conforma Therapeutics Corporation Orally Active Purine-Based Inhibitors of Heat Shock Protein 90
WO2004048380A1 (en) 2002-11-22 2004-06-10 Ranbaxy Laboratories Limited Process for the synthesis of ganciclovir
KR20090053867A (ko) 2003-01-14 2009-05-27 길리애드 사이언시즈, 인코포레이티드 복합 항바이러스 치료를 위한 조성물 및 방법
US20040200730A1 (en) * 2003-04-14 2004-10-14 Kyo Jibiki Hydrometallurgical copper recovery process
NZ551455A (en) 2004-05-19 2012-03-30 Emisphere Tech Inc Acyclovir formulations
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
EP2001488A4 (de) * 2006-03-14 2009-11-25 Alt Solutions Inc Prävention und behandlung von krebs und anderen erkrankungen
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
CN102753563A (zh) 2008-12-23 2012-10-24 吉利德制药有限责任公司 核苷类似物
AR074977A1 (es) 2008-12-23 2011-03-02 Pharmasset Inc Sintesis de nucleosidos de purina
PT2376088T (pt) 2008-12-23 2017-05-02 Gilead Pharmasset Llc Fosforamidatos de nucleósidos de 2-amino-purina 6-osubstituída
CN102858790A (zh) 2010-03-31 2013-01-02 吉利德制药有限责任公司 核苷氨基磷酸酯
GB201819418D0 (en) 2018-11-29 2019-01-16 Daniel Calladine Ltd Anti-viral compositions
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4199574A (en) * 1974-09-02 1980-04-22 Burroughs Wellcome Co. Methods and compositions for treating viral infections and guanine acyclic nucleosides
US4146715A (en) * 1975-08-27 1979-03-27 Burroughs Wellcome Co. 2-amido-9-(2-acyloxyethoxymethyl)hypoxanthines

Also Published As

Publication number Publication date
CY1033A (en) 1980-08-01
SU904523A3 (ru) 1982-02-07
FR2282892B1 (de) 1980-04-25
CH626364A5 (de) 1981-11-13
CS203093B2 (en) 1981-02-27
AU503160B2 (en) 1979-08-23
FR2282892A1 (fr) 1976-03-26
YU40079B (en) 1985-06-30
SE7509675L (sv) 1976-03-03
AU8445975A (en) 1977-03-10
NO753009L (de) 1976-03-03
NL175061B (nl) 1984-04-16
DE2539963A1 (de) 1976-03-18
BE833006A (fr) 1976-03-02
IE42282B1 (en) 1980-07-16
RO76939A (ro) 1981-06-22
US4323573A (en) 1982-04-06
SE428562B (sv) 1983-07-11
YU120082A (en) 1982-08-31
LU73304A1 (de) 1976-08-13
SU686618A3 (ru) 1979-09-15
US4360522A (en) 1982-11-23
CA1062257A (en) 1979-09-11
DK146595C (da) 1984-04-24
SE428562C (sv) 1985-08-20
CH628897A5 (de) 1982-03-31
ES455979A1 (es) 1978-01-16
FI60709C (fi) 1982-03-10
AR212914A1 (es) 1978-11-15
RO74276A (ro) 1981-06-26
IL48035A0 (en) 1975-11-25
DK146595B (da) 1983-11-14
NL175061C (nl) 1984-09-17
YU39947B (en) 1985-06-30
AR220885A1 (es) 1980-12-15
BG25094A3 (en) 1978-07-12
AR220299A1 (es) 1980-10-31
YU119982A (en) 1982-08-31
ZM12875A1 (en) 1977-09-21
HU176730B (en) 1981-04-28
CH623586A5 (de) 1981-06-15
DK392675A (da) 1976-03-03
BG26389A3 (de) 1979-03-15
CS203092B2 (en) 1981-02-27
US4294831A (en) 1981-10-13
JPS6147839B2 (de) 1986-10-21
RO74275A (ro) 1981-09-24
SU858569A3 (ru) 1981-08-23
AR220508A1 (es) 1980-11-14
ES455978A1 (es) 1978-01-16
DE2539963C2 (de) 1987-01-22
BG26536A4 (de) 1979-04-12
NL7510342A (nl) 1976-03-04
SU799664A3 (ru) 1981-01-23
NO144216C (no) 1981-07-15
YU40080B (en) 1985-06-30
JPS5154589A (en) 1976-05-13
GB1523865A (en) 1978-09-06
KE3002A (en) 1979-12-14
YU222075A (en) 1982-08-31
FI752465A (de) 1976-03-03
ATA676375A (de) 1979-06-15
RO74274A (ro) 1981-09-24
BG24815A3 (en) 1978-05-12
ES440631A1 (es) 1977-06-16
NO144216B (no) 1981-04-06
FI60709B (fi) 1981-11-30
CH629805A5 (de) 1982-05-14
CH626363A5 (de) 1981-11-13
MC1068A1 (fr) 1976-05-21
SU700064A3 (ru) 1979-11-25
YU120182A (en) 1982-08-31
CH629206A5 (de) 1982-04-15
CH623587A5 (de) 1981-06-15
IL48035A (en) 1981-07-31
SU751325A3 (ru) 1980-07-23
DD122092A5 (de) 1976-09-12
NZ178556A (en) 1978-09-25
MY8200191A (en) 1982-12-31
SU784777A3 (ru) 1980-11-30
IE42282L (en) 1976-03-02
HK84379A (en) 1979-12-14
ZA755574B (en) 1977-04-27

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