ES8403904A1 - Un procedimiento para la preparacion de acicloguanosina. - Google Patents
Un procedimiento para la preparacion de acicloguanosina.Info
- Publication number
- ES8403904A1 ES8403904A1 ES520140A ES520140A ES8403904A1 ES 8403904 A1 ES8403904 A1 ES 8403904A1 ES 520140 A ES520140 A ES 520140A ES 520140 A ES520140 A ES 520140A ES 8403904 A1 ES8403904 A1 ES 8403904A1
- Authority
- ES
- Spain
- Prior art keywords
- acycloguanosine
- preparation
- protecting
- chloromethyloxy
- acetoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE ACICLOGUANOSINA, DE FORMULA ESTRUCTURAL (I).COMPRENDE LAS SIGUIENTES FASES: PRIMERA, SE HACE REACCIONAR GUANINA DE FORMULA (II) CON BENZALDEHIDO EN DIMETILFORMAMIDA Y EN PRESENCIA DE UNA BASE, PARA OBTENER LA CORRESPONDIENTE BASE SCHIFF; SEGUNDA, EL PRODUCTO OBTENIDO EN LA PRIMERA FASE SE HACE REACCIONAR CON UN DERIVADO DEL ACIDO ACETICO, PARA OBTENER EL ACETIL DERIVADO DE FORMULA (III); Y POR ULTIMO, EL PRODUCTO OBTENIDO EN LA SEGUNDA FASE SE HACE REACCIONAR CON 1-ACETOXI-2-CLOROMETILOXIETANO, EN PRESENCIA DE UNA AMINA TERCIARIA,Y A CONTINUACION EL PRODUCTO OBTENIDO SE HIDROLIZA PARA OBTENER LA ACICLOGUANOSINA.DE APLICACION EN LA PREPARACION DE PRODUCTOS FARMACEUTICOS.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES520140A ES520140A0 (es) | 1983-02-25 | 1983-02-25 | Un procedimiento para la preparacion de acicloguanosina. |
FR8402884A FR2541681B1 (fr) | 1983-02-25 | 1984-02-24 | Procede de preparation d'acycloguanosine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES520140A ES520140A0 (es) | 1983-02-25 | 1983-02-25 | Un procedimiento para la preparacion de acicloguanosina. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8403904A1 true ES8403904A1 (es) | 1984-04-01 |
ES520140A0 ES520140A0 (es) | 1984-04-01 |
Family
ID=8485386
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES520140A Granted ES520140A0 (es) | 1983-02-25 | 1983-02-25 | Un procedimiento para la preparacion de acicloguanosina. |
Country Status (2)
Country | Link |
---|---|
ES (1) | ES520140A0 (es) |
FR (1) | FR2541681B1 (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2047457A1 (es) * | 1992-08-03 | 1994-02-16 | Union Quimico Farma | Procedimiento para obtener aciclovir. |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0184473A1 (en) * | 1984-10-26 | 1986-06-11 | Merck & Co. Inc. | Regioselective synthesis of 9-substituted purine acyclonucleoside derivatives |
DE4020481A1 (de) * | 1990-06-27 | 1992-01-02 | Hoechst Ag | Verfahren zur herstellung von substituierten acyclischen nukleosiden und dabei auftretende zwischenprodukte |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1523865A (en) * | 1974-09-02 | 1978-09-06 | Wellcome Found | Purine compunds and salts thereof |
AU515553B2 (en) * | 1976-03-01 | 1981-04-09 | The Wellcome Foundation Limited | Purine derivatives |
-
1983
- 1983-02-25 ES ES520140A patent/ES520140A0/es active Granted
-
1984
- 1984-02-24 FR FR8402884A patent/FR2541681B1/fr not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2047457A1 (es) * | 1992-08-03 | 1994-02-16 | Union Quimico Farma | Procedimiento para obtener aciclovir. |
Also Published As
Publication number | Publication date |
---|---|
FR2541681A1 (fr) | 1984-08-31 |
FR2541681B1 (fr) | 1986-10-10 |
ES520140A0 (es) | 1984-04-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19980302 |