IL48035A - Pharmaceutical compositions containing 9(1-alkoxy(or alkylthio)alkyl)purine derivatives,some new compounds of this type and their preparation - Google Patents

Pharmaceutical compositions containing 9(1-alkoxy(or alkylthio)alkyl)purine derivatives,some new compounds of this type and their preparation

Info

Publication number
IL48035A
IL48035A IL48035A IL4803575A IL48035A IL 48035 A IL48035 A IL 48035A IL 48035 A IL48035 A IL 48035A IL 4803575 A IL4803575 A IL 4803575A IL 48035 A IL48035 A IL 48035A
Authority
IL
Israel
Prior art keywords
alkylthio
alkoxy
alkyl
preparation
pharmaceutical compositions
Prior art date
Application number
IL48035A
Other languages
English (en)
Other versions
IL48035A0 (en
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10402412&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL48035(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of IL48035A0 publication Critical patent/IL48035A0/xx
Priority to IL51571A priority Critical patent/IL51571A/xx
Publication of IL48035A publication Critical patent/IL48035A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IL48035A 1974-09-02 1975-09-02 Pharmaceutical compositions containing 9(1-alkoxy(or alkylthio)alkyl)purine derivatives,some new compounds of this type and their preparation IL48035A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL51571A IL51571A (en) 1974-09-02 1977-03-01 Esters of 9-(2-hydroxyethoxymethyl)guanine and 2-amino-9-(2-hydroxyethoxymethyl)adenine and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB38278/74A GB1523865A (en) 1974-09-02 1974-09-02 Purine compunds and salts thereof

Publications (2)

Publication Number Publication Date
IL48035A0 IL48035A0 (en) 1975-11-25
IL48035A true IL48035A (en) 1981-07-31

Family

ID=10402412

Family Applications (1)

Application Number Title Priority Date Filing Date
IL48035A IL48035A (en) 1974-09-02 1975-09-02 Pharmaceutical compositions containing 9(1-alkoxy(or alkylthio)alkyl)purine derivatives,some new compounds of this type and their preparation

Country Status (35)

Country Link
US (3) US4360522A (xx)
JP (1) JPS5154589A (xx)
AR (4) AR220299A1 (xx)
AT (1) AT354462B (xx)
AU (1) AU503160B2 (xx)
BE (1) BE833006A (xx)
BG (4) BG26536A4 (xx)
CA (1) CA1062257A (xx)
CH (7) CH626363A5 (xx)
CS (2) CS203093B2 (xx)
CY (1) CY1033A (xx)
DD (1) DD122092A5 (xx)
DE (1) DE2539963C2 (xx)
DK (1) DK146595C (xx)
ES (3) ES440631A1 (xx)
FI (1) FI60709C (xx)
FR (1) FR2282892A1 (xx)
GB (1) GB1523865A (xx)
HK (1) HK84379A (xx)
HU (1) HU176730B (xx)
IE (1) IE42282B1 (xx)
IL (1) IL48035A (xx)
KE (1) KE3002A (xx)
LU (1) LU73304A1 (xx)
MC (1) MC1068A1 (xx)
MY (1) MY8200191A (xx)
NL (1) NL175061C (xx)
NO (1) NO144216C (xx)
NZ (1) NZ178556A (xx)
RO (4) RO76939A (xx)
SE (1) SE428562C (xx)
SU (7) SU904523A3 (xx)
YU (4) YU39947B (xx)
ZA (1) ZA755574B (xx)
ZM (1) ZM12875A1 (xx)

Families Citing this family (114)

* Cited by examiner, † Cited by third party
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US4146715A (en) 1975-08-27 1979-03-27 Burroughs Wellcome Co. 2-amido-9-(2-acyloxyethoxymethyl)hypoxanthines
US4060616A (en) * 1976-03-01 1977-11-29 Burroughs Wellcome Co. Purine derivatives with repeating unit
AU521577B2 (en) * 1977-02-24 1982-04-22 Wellcome Foundation Limited, The 9-hydroxyethoxymethyl guanine phosphates
US4287188A (en) 1977-02-24 1981-09-01 Burroughs Wellcome Co. Purine derivatives
KR830005852A (ko) * 1980-07-18 1983-09-14 미첼 페터 잭슨 피부와 점막의 비루스 감염치료에 적합한 국소치료제의 제조방법
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
US5157120A (en) * 1980-09-16 1992-10-20 Syntex (U.S.A.) Inc. Guanine derivatives
JPS57102818A (en) * 1980-10-15 1982-06-26 Wellcome Found Treatment for fish virus diseases
US4603219A (en) * 1981-05-21 1986-07-29 Syntex (U.S.A.) Inc. 1,3-dibenzyloxy-2-acetoxymethoxypropane, intermediate for 9-(1,3-dihydroxy-2-propoxymethyl)guanine
US4423050A (en) * 1981-05-21 1983-12-27 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
US4355032B2 (en) * 1981-05-21 1990-10-30 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
CS594082A2 (en) * 1981-08-11 1989-08-14 Wellcome Found Method of antiviral effective 2-amino-9-/(2-hydroxy-1-hydroxymethyl-ethoxy)methyl/purines production
AU564576B2 (en) * 1981-09-24 1987-08-20 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Purine derivatives
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
MC1585A1 (fr) * 1982-02-12 1985-02-22 Ens Bio Logicals Inc Procede de fabrication de compositions antivirales
SE8203855D0 (sv) * 1982-06-21 1982-06-21 Astra Laekemedel Ab Novel derivatives of guanine i
SE8203856D0 (sv) * 1982-06-21 1982-06-21 Astra Laekemedel Ab Novel derivatives of guanine ii
NL8202626A (nl) * 1982-06-29 1984-01-16 Stichting Rega V Z W Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
US4609662A (en) * 1982-10-14 1986-09-02 Burroughs Wellcome Co. Method for using purine derivatives
US4745119A (en) * 1982-10-14 1988-05-17 Burroughs Wellcome Co. Method for using purine derivatives
US5059604A (en) * 1982-10-14 1991-10-22 Burroughs Wellcome Co. 2-amino purine derivatives
US4649140A (en) * 1982-10-14 1987-03-10 Burroughs Wellcome Co. Purine derivatives
ZW22283A1 (en) * 1982-10-14 1985-05-22 Wellcome Found Antiviral compounds
US4612314A (en) * 1982-12-22 1986-09-16 Syntex (U.S.A.) Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
US4461757A (en) * 1983-02-23 1984-07-24 Ens Bio Logicals Inc. Dimethylaminomethylenated anti-herpes compounds
ES520140A0 (es) * 1983-02-25 1984-04-01 Ind Farma Especial Un procedimiento para la preparacion de acicloguanosina.
US5047533A (en) * 1983-05-24 1991-09-10 Sri International Acyclic purine phosphonate nucleotide analogs
US4557934A (en) 1983-06-21 1985-12-10 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one
ZA844744B (en) * 1983-06-24 1986-02-26 Merck & Co Inc Antiviral agents
US4880820A (en) * 1983-06-24 1989-11-14 Merck & Co., Inc. Guanine derivatives
US5684153A (en) 1984-08-16 1997-11-04 Beecham Group Plc Process for the preparation of purine derivatives
US4897479A (en) * 1983-09-30 1990-01-30 Merck & Co., Inc. Arylsulfonyloxy purine intermediates
JPS6094992A (ja) * 1983-10-28 1985-05-28 Sankyo Co Ltd グリゼオ−ル酸誘導体
US4918219A (en) * 1983-10-31 1990-04-17 Warner-Lambert Company Glycerine derivatives
ZA848080B (en) * 1983-10-31 1985-06-26 Warner Lambert Co Purine derivatives
IE842642L (en) * 1983-10-31 1985-04-30 Harvard College Purine Derivatives
US4806642A (en) * 1984-10-05 1989-02-21 Warner-Lambert Company Purine derivatives
US4579849A (en) * 1984-04-06 1986-04-01 Merck & Co., Inc. N-alkylguanine acyclonucleosides as antiviral agents
US4617304A (en) * 1984-04-10 1986-10-14 Merck & Co., Inc. Purine derivatives
IL74881A0 (en) * 1984-04-13 1985-07-31 Wellcome Found Purine derivatives,their preparation and pharmaceutical compositions containing them
US4636507A (en) * 1984-04-30 1987-01-13 Hoechst-Roussel Pharmaceuticals Inc. Host defense mechanism enhancement
EP0167385B1 (en) 1984-07-03 1992-03-18 The Wellcome Foundation Limited Antiviral compounds, treatment and formulations
WO1986000901A1 (en) * 1984-07-20 1986-02-13 Gauntt Charles O Immunoregulatory and anti-viral compound
SE8406538D0 (sv) * 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
US5683990A (en) * 1985-03-16 1997-11-04 Glaxo Wellcome Inc. Treatment of human viral infections
CS263952B1 (en) * 1985-04-25 1989-05-12 Holy Antonin Remedy with antiviral effect
CS263951B1 (en) * 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
DE3667058D1 (en) 1985-05-02 1989-12-28 Wellcome Found Antiviral compounds
IL78643A0 (en) * 1985-05-02 1986-08-31 Wellcome Found Purine derivatives,their preparation and pharmaceutical compositions containing them
DE3529497A1 (de) * 1985-08-17 1987-02-26 Boehringer Mannheim Gmbh N(pfeil hoch)6(pfeil hoch)-disubstituierte purinderivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
DE3627024A1 (de) * 1985-09-24 1987-04-02 Hoechst Ag In 6- und 9-stellung substituierte 2-aminopurine, ihre verwendung, diese purine enthaltende arzneimittel und verfahren zur herstellung der purine
IT1207507B (it) * 1985-10-21 1989-05-25 Baldacci Lab Spa Coniugato della 9-(2-idrossietossimetil)guanina con albumina umana lattosaminata, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono.
NZ222051A (en) * 1986-10-06 1990-07-26 Univ Virginia Solution containing adenosine or hypoxanthine and optionally ribose for heart protection during surgery
US4916225A (en) * 1986-11-25 1990-04-10 Institut Organicheskogo Sinteza Akademii Nauk Latviiskoi Ssr 9-substituted guanines
US4978655A (en) * 1986-12-17 1990-12-18 Yale University Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses
US4829055A (en) * 1987-01-23 1989-05-09 Naficy Sadeque S Method of treatment for herpes infections of external tissues
US5565566A (en) * 1987-04-24 1996-10-15 Discovery Therapeutics, Inc. N6 -substituted 9-methyladenines: a new class of adenosine receptor antagonists
US4835104A (en) * 1987-06-16 1989-05-30 Ajinomoto Co., Inc., Patent & Licensing Department Process for producing and purifying 2',3'-dideoxynucleosides, and process for producing 2',3'-dideoxy-2',3'-didehydronucleosides
US6306647B1 (en) 1987-06-16 2001-10-23 Ajinomoto Co., Inc. Process for producing and purifying 2′,3′-dideoxynucleosides, and process for producing 2′,3′-dideoxy-2′,3′-didehydronucleosides
GB8719367D0 (en) * 1987-08-15 1987-09-23 Wellcome Found Therapeutic compounds
GB8725939D0 (en) * 1987-11-05 1987-12-09 Wellcome Found Therapeutic compounds
CA1302887C (en) * 1987-11-24 1992-06-09 Yves Langelier Combination of acyclovir or a derivative thereof and bacitracin
JPH01121424U (xx) * 1988-02-10 1989-08-17
US5164395A (en) * 1988-06-27 1992-11-17 Burroughs Wellcome Co. Antiviral acetyl pyridine derivative or said acetyl pyridine derivative in combination with acyclovir
GB8815241D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Antiviral combinations & compounds therefor
GB8816760D0 (en) * 1988-07-14 1988-08-17 Wellcome Found Therapeutic compounds
JPH02164881A (ja) * 1988-10-24 1990-06-25 Wellcome Found Ltd:The 治療用ヌクレオシド化合物
WO1990009178A1 (en) * 1989-01-31 1990-08-23 Whitby Research, Inc. N6-substituted 9-methyladenines: a new class of adenosine receptor antagonists
US4966895A (en) * 1989-02-02 1990-10-30 Merck & Co. Inc. Cyclic monophosphates of purine and pyrimidine acyclonucleosides as anti-retroviral agents
GB8907173D0 (en) * 1989-03-30 1989-05-10 Beecham Group Plc Novel compounds
GB8912043D0 (en) * 1989-05-25 1989-07-12 Beecham Group Plc Novel compounds
GB9001886D0 (en) * 1990-01-26 1990-03-28 Beecham Group Plc Pharmaceutical formulation
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CA2033447C (en) * 1990-12-31 1999-08-31 Robert Deziel Synergistic combination for treating herpes infections
US5580571A (en) * 1991-10-15 1996-12-03 Hostetler; Karl Y. Nucleoside analogues
US5879700A (en) * 1991-10-15 1999-03-09 Hostetler; Karl Y. Nucleoside analogue phosphates for topical use
CA2091732C (en) * 1992-07-08 1998-07-21 Anica Markovac A process for the preparation of 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine
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EP0589335B1 (de) * 1992-09-24 2003-06-18 Hoechst Aktiengesellschaft N1-Substituierte 1H-1,2,3-Triazolo[4,5-d]pyrimidine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als antivirale Mittel
US5654286A (en) * 1993-05-12 1997-08-05 Hostetler; Karl Y. Nucleotides for topical treatment of psoriasis, and methods for using same
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US5567816A (en) * 1994-07-26 1996-10-22 Syntex (U.S.A.) Inc. Preparation of acyclovir using 1,3 dioxolane
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US5565565A (en) * 1994-08-04 1996-10-15 Syntex (U.S.A.) Inc. Preparation of N-9 substituted guanine compounds
US5627185A (en) * 1994-11-23 1997-05-06 Gosselin; Gilles Acyclovir derivatives as antiviral agents
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US6040446A (en) * 1996-01-26 2000-03-21 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US5756736A (en) * 1996-01-26 1998-05-26 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5700936A (en) * 1996-01-26 1997-12-23 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
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US5789589A (en) * 1996-04-22 1998-08-04 Drug Innovation & Design, Inc. Guanine analog phosphates
US6440980B1 (en) * 1996-09-17 2002-08-27 Avanir Pharmaceuticals Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs
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ATE222914T1 (de) * 1997-05-15 2002-09-15 Drug Innovation & Design Inc Diester-derivate von acyclovir
NZ532944A (en) * 2001-10-16 2005-10-28 Avanir Pharmaceuticals Stable, topical formulation for treating viral and inflammatory conditions comprising 10% n-docosanol, 5% of a stearate, 8% mineral oil, 5% propylene glycol, 2.7% benzyl alcohol and water
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TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
JP5571947B2 (ja) * 2006-03-14 2014-08-13 アルト ソリューションズ インコーポレーテッド 癌およびその他の疾患の予防および治療
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KR101715981B1 (ko) 2010-03-31 2017-03-13 길리애드 파마셋 엘엘씨 뉴클레오사이드 포스포르아미데이트
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Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4199574A (en) * 1974-09-02 1980-04-22 Burroughs Wellcome Co. Methods and compositions for treating viral infections and guanine acyclic nucleosides
US4146715A (en) * 1975-08-27 1979-03-27 Burroughs Wellcome Co. 2-amido-9-(2-acyloxyethoxymethyl)hypoxanthines

Also Published As

Publication number Publication date
NL175061B (nl) 1984-04-16
DE2539963C2 (de) 1987-01-22
SE428562C (sv) 1985-11-18
SU799664A3 (ru) 1981-01-23
AT354462B (de) 1979-01-10
KE3002A (en) 1979-12-14
IE42282L (en) 1976-03-02
SU686618A3 (ru) 1979-09-15
YU222075A (en) 1982-08-31
ATA676375A (de) 1979-06-15
HK84379A (en) 1979-12-14
CH626363A5 (xx) 1981-11-13
NO753009L (xx) 1976-03-03
BG25094A3 (en) 1978-07-12
CS203093B2 (en) 1981-02-27
YU40079B (en) 1985-06-30
US4360522A (en) 1982-11-23
CH629206A5 (de) 1982-04-15
FI60709B (fi) 1981-11-30
DD122092A5 (xx) 1976-09-12
DE2539963A1 (de) 1976-03-18
ES440631A1 (es) 1977-06-16
CH623586A5 (xx) 1981-06-15
NO144216B (no) 1981-04-06
CH629805A5 (de) 1982-05-14
SU700064A3 (ru) 1979-11-25
YU120182A (en) 1982-08-31
DK392675A (da) 1976-03-03
CA1062257A (en) 1979-09-11
SU784777A3 (ru) 1980-11-30
HU176730B (en) 1981-04-28
US4294831A (en) 1981-10-13
CH623587A5 (xx) 1981-06-15
BE833006A (fr) 1976-03-02
NZ178556A (en) 1978-09-25
AR220299A1 (es) 1980-10-31
SU858569A3 (ru) 1981-08-23
NL7510342A (nl) 1976-03-04
AR220508A1 (es) 1980-11-14
SU751325A3 (ru) 1980-07-23
AR220885A1 (es) 1980-12-15
YU120082A (en) 1982-08-31
GB1523865A (en) 1978-09-06
AR212914A1 (es) 1978-11-15
YU39947B (en) 1985-06-30
DK146595C (da) 1984-04-24
FR2282892A1 (fr) 1976-03-26
JPS6147839B2 (xx) 1986-10-21
RO74275A (ro) 1981-09-24
CH628897A5 (de) 1982-03-31
ES455979A1 (es) 1978-01-16
AU8445975A (en) 1977-03-10
MC1068A1 (fr) 1976-05-21
NO144216C (no) 1981-07-15
BG26389A3 (bg) 1979-03-15
FR2282892B1 (xx) 1980-04-25
BG26536A4 (bg) 1979-04-12
FI752465A (xx) 1976-03-03
JPS5154589A (en) 1976-05-13
SE428562B (sv) 1983-07-11
RO74276A (ro) 1981-06-26
IE42282B1 (en) 1980-07-16
RO74274A (ro) 1981-09-24
DK146595B (da) 1983-11-14
ZA755574B (en) 1977-04-27
CH626364A5 (xx) 1981-11-13
AU503160B2 (en) 1979-08-23
CY1033A (en) 1980-08-01
NL175061C (nl) 1984-09-17
FI60709C (fi) 1982-03-10
LU73304A1 (xx) 1976-08-13
RO76939A (ro) 1981-06-22
YU40080B (en) 1985-06-30
ZM12875A1 (en) 1977-09-21
US4323573A (en) 1982-04-06
MY8200191A (en) 1982-12-31
BG24815A3 (en) 1978-05-12
YU119982A (en) 1982-08-31
ES455978A1 (es) 1978-01-16
IL48035A0 (en) 1975-11-25
SU904523A3 (ru) 1982-02-07
SE7509675L (sv) 1976-03-03
CS203092B2 (en) 1981-02-27

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