AR222359A1 - Procedimiento para la purificacion de proteinas de elevado peso molecular - Google Patents

Procedimiento para la purificacion de proteinas de elevado peso molecular

Info

Publication number
AR222359A1
AR222359A1 AR278993A AR27899379A AR222359A1 AR 222359 A1 AR222359 A1 AR 222359A1 AR 278993 A AR278993 A AR 278993A AR 27899379 A AR27899379 A AR 27899379A AR 222359 A1 AR222359 A1 AR 222359A1
Authority
AR
Argentina
Prior art keywords
purification
procedure
molecular weight
high molecular
weight proteins
Prior art date
Application number
AR278993A
Other languages
English (en)
Spanish (es)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of AR222359A1 publication Critical patent/AR222359A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/811—Interferon
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/828—Cancer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/142—Interferon

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AR278993A 1978-11-24 1979-11-22 Procedimiento para la purificacion de proteinas de elevado peso molecular AR222359A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96325778A 1978-11-24 1978-11-24
US6237479A 1979-07-31 1979-07-31
US7771079A 1979-09-21 1979-09-21

Publications (1)

Publication Number Publication Date
AR222359A1 true AR222359A1 (es) 1981-05-15

Family

ID=27370266

Family Applications (1)

Application Number Title Priority Date Filing Date
AR278993A AR222359A1 (es) 1978-11-24 1979-11-22 Procedimiento para la purificacion de proteinas de elevado peso molecular

Country Status (34)

Country Link
US (1) US4289690A (instruction)
JP (1) JPH07224098A (instruction)
KR (1) KR830002616B1 (instruction)
AR (1) AR222359A1 (instruction)
AU (2) AU535936B2 (instruction)
BE (1) BE880201A (instruction)
CA (1) CA1129409A (instruction)
CH (3) CH654843A5 (instruction)
DE (1) DE2947134A1 (instruction)
DK (1) DK161048C (instruction)
DO (1) DOP1979002953A (instruction)
ES (1) ES486263A0 (instruction)
FI (1) FI69476C (instruction)
FR (1) FR2442054A1 (instruction)
GB (1) GB2037296B (instruction)
GR (1) GR72828B (instruction)
HK (1) HK26684A (instruction)
IE (1) IE48882B1 (instruction)
IL (1) IL58759A (instruction)
IN (1) IN150740B (instruction)
IT (1) IT1127253B (instruction)
KE (1) KE3347A (instruction)
LU (2) LU81918A1 (instruction)
MC (1) MC1300A1 (instruction)
MY (1) MY8500222A (instruction)
NL (1) NL193085C (instruction)
NO (1) NO151157C (instruction)
NZ (1) NZ192201A (instruction)
PH (1) PH20763A (instruction)
PT (1) PT70495A (instruction)
RO (1) RO79132B (instruction)
SE (1) SE454276B (instruction)
SG (1) SG71183G (instruction)
YU (1) YU286179A (instruction)

Families Citing this family (120)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI77877C (fi) * 1979-04-20 1989-05-10 Technobiotic Ltd Foerfarande foer framstaellning och rening av human le-formig interferonprotein.
US6410697B1 (en) * 1979-04-20 2002-06-25 Schering Corporation Process for purifying human leukocyte interferon
US4530901A (en) * 1980-01-08 1985-07-23 Biogen N.V. Recombinant DNA molecules and their use in producing human interferon-like polypeptides
US6835557B1 (en) 1980-01-08 2004-12-28 Biogen, Inc. DNA sequences, recombinant DNA molecules and processes for producing human interferon-like polypeptides
YU45104B (en) 1980-04-03 1992-03-10 Biogen Nv Process for producing recombinant dnk molecule, capable of inducting polypeptide expression in an one-cell host
CH651308A5 (de) * 1980-07-01 1985-09-13 Hoffmann La Roche Interferone und deren herstellung.
US6610830B1 (en) 1980-07-01 2003-08-26 Hoffman-La Roche Inc. Microbial production of mature human leukocyte interferons
IL63916A0 (en) * 1980-09-25 1981-12-31 Genentech Inc Microbial production of human fibroblast interferon
US4315852A (en) 1980-11-26 1982-02-16 Schering Corporation Extraction of interferon from bacteria
US4364863A (en) 1980-12-29 1982-12-21 Schering Corporation Extraction of interferon from bacteria
EP0062971B1 (en) * 1981-03-27 1990-03-07 Imperial Chemical Industries Plc Genetically modified microorganisms
IL65475A0 (en) * 1981-04-17 1982-07-30 Meloy Lab Production of immune interferon and its mrna
WO1983000693A1 (en) * 1981-08-14 1983-03-03 Berg, Kurt, Frimann SUBJECTS RELATING TO HUMAN INTEFERON-'alpha' SUBTYPE PROTEINS AND CORRESPONDING ANTIBODIES
US4810645A (en) * 1981-08-14 1989-03-07 Hoffmann-La Roche Inc. Microbial production of mature human leukocyte interferon K and L
US4801685A (en) * 1981-08-14 1989-01-31 Hoffmann-La Roche Inc. Microbial production of mature human leukocyte interferon K and L
US4672108A (en) * 1981-12-07 1987-06-09 Hoffmann-La Roche Inc. Crystalline human leukocyte interferon
EP0082481B2 (en) * 1981-12-23 1990-09-12 Schering Corporation Stabilised alpha-interferon formulations and their preparation
US5098703A (en) * 1982-01-15 1992-03-24 Cetus Corporation Interferon-alpha 76
US4973479A (en) * 1982-01-15 1990-11-27 Cetus Corporation Interferon-α61
US4975276A (en) * 1982-01-15 1990-12-04 Cetus Corporation Interferon-alpha 54
ZA83768B (en) * 1982-03-01 1983-10-26 Hoffmann La Roche Homogeneous human immune interferon and process therefor
US6432677B1 (en) 1982-03-08 2002-08-13 Genentech, Inc. Non-human animal interferons
US5827694A (en) * 1982-03-08 1998-10-27 Genentech, Inc. DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
US5831023A (en) * 1982-11-01 1998-11-03 Genentech, Inc. Recombinant animal interferon polypeptides
US4534906A (en) * 1982-11-01 1985-08-13 Genentech, Inc. Removal of impurities from human leukocyte interferon preparations
US4432895A (en) * 1982-11-24 1984-02-21 Hoffmann-La Roche Inc. Monomeric interferons
US4820515A (en) * 1982-12-13 1989-04-11 Texas A&M University System Method of using interferon in low dosage to regulate appetite and efficiency of food utilization
JPS59137417A (ja) * 1983-01-28 1984-08-07 Morinaga Milk Ind Co Ltd 人尿由来コロニ−形成刺激因子及びカリクレインの製造法
IL67896A (en) * 1983-02-13 1987-03-31 Yeda Res & Dev Two biologically active human gama interferon subtypes,purification thereof and pharmaceutical compositions containing them
US4599306A (en) * 1983-04-15 1986-07-08 Amgen Monoclonal antibodies which specifically bind to human immune interferon
US4723000A (en) * 1983-07-05 1988-02-02 Biospectrum, Inc. Human interferon gamma and interleukin-2
US4710377A (en) * 1983-08-19 1987-12-01 American Cyanamid Company Antigens and monoclonal antibodies reactive against sporozoites of Eimeria spp.
US4675383A (en) * 1983-11-15 1987-06-23 The Salk Institute For Biological Studies Purification of T-cell growth factor
US4568488A (en) * 1984-01-11 1986-02-04 Lee Huang Sylvia Reverse immunoaffinity chromatography purification method
US4499014A (en) * 1984-02-07 1985-02-12 Interferon Sciences, Inc. Method for purifying gamma-interferon
AU594014B2 (en) * 1984-03-21 1990-03-01 Research Corporation Technologies, Inc. Recombinant DNA molecules
US4569790A (en) * 1984-03-28 1986-02-11 Cetus Corporation Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions
IL71555A (en) * 1984-04-15 1992-06-21 State Of Israel Israel Inst Fo Bovine interferon
US6133433A (en) * 1984-07-27 2000-10-17 City Of Hope Method for detection and prevention of human cytomegalovirus infection
US6242567B1 (en) 1984-07-27 2001-06-05 City Of Hope Method for detection and prevention of human cytomegalovirus infection
UA29377C2 (uk) * 1984-09-19 2000-11-15 Новартіс Аг Спосіб отримання білка з активністю колонієстимулювального фактора гранулоцитів та макрофагів(gm-csf) приматів
US5322837A (en) * 1985-01-11 1994-06-21 Genetics Institute, Inc. Homogeneous erythropoietin compositions and methods of using same
US4677195A (en) * 1985-01-11 1987-06-30 Genetics Institute, Inc. Method for the purification of erythropoietin and erythropoietin compositions
US5792450A (en) * 1985-02-05 1998-08-11 Chiron Corporation Purified human CSF-1
US5532341A (en) * 1985-03-28 1996-07-02 Sloan-Kettering Institute For Cancer Research Human pluripotent hematopoietic colony stimulating factor
US4667016A (en) * 1985-06-20 1987-05-19 Kirin-Amgen, Inc. Erythropoietin purification
IL79176A (en) * 1985-06-20 1992-06-21 Kirin Amgen Inc Process for the recovery of erythropoietin from a fluid
NZ212523A (en) * 1985-06-24 1989-01-06 Univ Massey Mobile phase for purification of proteins by high performance liquid chromatography
GB8522336D0 (en) * 1985-09-09 1985-10-16 Biogen Nv Composition for treatment of allergies
US4894439A (en) * 1986-05-22 1990-01-16 Cetus Corporation N-terminal derivatives of tumor necrosis factor purified by microporous PTFE membranes
US5427780A (en) * 1985-10-30 1995-06-27 Biogen, Inc. Composition comprising Mullerian inhibiting substance-like polypeptides
US4677197A (en) * 1985-10-30 1987-06-30 Cetus Corporation Purification method for tumor necrosis factor
US4770781A (en) * 1986-03-03 1988-09-13 Merck & Co., Inc. Purification of human interleukin-1 species
US5030559A (en) * 1986-04-01 1991-07-09 Board Of Regents, The University Of Texas System Methods and compositions for the identification of metastatic human tumors
US4935372A (en) * 1986-05-20 1990-06-19 Dana Farber Cancer Institute Art nucleotide segments, vectors, cell lines methods of preparation and use
US5028422A (en) * 1986-05-27 1991-07-02 Schering Corporation Treatment of basal cell carcinoma intralesionally with recombinant human alpha interferon
US4894440A (en) * 1986-09-17 1990-01-16 Massachusetts Institute Of Technology Method of isolating megakaryocyte stimulatory factor
IL84170A0 (en) * 1986-10-17 1988-03-31 Interferon Sciences Inc Method for detecting interferon
US4851220A (en) * 1986-11-26 1989-07-25 Schering Corporation Stable oleaginous gel
US4894330A (en) * 1986-12-23 1990-01-16 Cetus Corporation Purification of recombinant beta-interferon incorporating RP-HPLC
US5190751A (en) * 1987-01-20 1993-03-02 Schering Corporation Treatment of certain leukemias with a combination of gamma interferon and alpha interferon
US4853218A (en) * 1987-02-24 1989-08-01 Schering Corporation Zinc-protamine-alpha interferon complex
US5034513A (en) * 1987-05-27 1991-07-23 The United States Of America As Represented By The Secretary Of Agriculture Avian interleukin-2
US4871538A (en) * 1987-07-13 1989-10-03 Schering Corporation Insoluble copper-alpha interferon complex
DE3879085T2 (de) * 1987-10-21 1993-06-24 Akzo Nv Snrnp-a-antigen und fragmente davon.
US5559212A (en) * 1988-04-06 1996-09-24 Alfacell Corporation Frog embryo and egg-derived tumor cell anti-proliferation protein
US5179198A (en) * 1988-07-11 1993-01-12 Hidechika Okada Glycoprotein and gene coding therefor
US5256410A (en) * 1988-12-01 1993-10-26 Schering Corporation Treatment of squamous cell carcinoma intralesionally with recombinant human alpha interferon
US5661126A (en) * 1989-01-19 1997-08-26 The General Hospital Corporation Use of mullerian inhibiting substance for treating certain tumors and for modulating class I major histocompatibility antigen expression
WO1990009442A1 (en) * 1989-02-08 1990-08-23 Uab Research Foundation Antiproliferation factor
US7264944B1 (en) * 1989-04-21 2007-09-04 Amgen Inc. TNF receptors, TNF binding proteins and DNAs coding for them
ES2238070T3 (es) 1989-04-21 2005-08-16 Amgen Inc. Receptor del tnf, proteina ligante del tnf y adn codante para estos.
US6221675B1 (en) 1989-04-21 2001-04-24 Amgen, Inc. TNF receptors, TNF binding proteins and DNAs coding for them
US5766939A (en) * 1989-05-05 1998-06-16 Baylor College Of Medicine Production of recombinant lactoferrin and lactoferrin polypeptides using CDNA sequences in various organisms
US6100054A (en) * 1989-05-05 2000-08-08 Baylor College Of Medicine Production for recombinant lactoferrin and lactoferrin polypeptides using DNA sequences in various organisms
US5571691A (en) * 1989-05-05 1996-11-05 Baylor College Of Medicine Production of recombinant lactoferrin and lactoferrin polypeptides using CDNA sequences in various organisms
IL94183A (en) 1989-05-05 2003-09-17 Baylor College Medicine cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE
US5849881A (en) * 1989-05-05 1998-12-15 Baylor College Medicine Production of recombinant lactoferrin and lactoferrin polypeptides using cDNA sequences in various organisms
US5216128A (en) * 1989-06-01 1993-06-01 Yeda Research And Development Co., Ltd. IFN-β2/IL-6 receptor its preparation and pharmaceutical compositions containing it
IL95031A (en) 1989-07-18 2007-03-08 Amgen Inc Method for the production of a human recombinant tumor necrosis factor inhibitor
US6143866A (en) * 1989-07-18 2000-11-07 Amgen, Inc. Tumor necrosis factor (TNF) inhibitor and method for obtaining the same
US6552170B1 (en) * 1990-04-06 2003-04-22 Amgen Inc. PEGylation reagents and compounds formed therewith
GB9013016D0 (en) * 1990-06-11 1990-08-01 Mars Uk Ltd Compounds
JP3230091B2 (ja) * 1990-06-25 2001-11-19 ウェルファイド株式会社 ヒト血清アルブミンの着色抑制方法
EP0537280B1 (en) * 1990-07-02 1997-09-17 National Jewish Center For Immunology And Respiratory Medicine Preparation and use of transfer factor
FI930058A0 (fi) * 1990-07-10 1993-01-08 Boehringer Ingelheim Int O-glykolyserad alfa-ifn
JP3015969B2 (ja) * 1990-11-30 2000-03-06 ダイナボット株式会社 扁平上皮癌関連抗原蛋白質及び該蛋白質をコードするｄｎａ
DE4113949A1 (de) * 1991-04-29 1992-11-05 Behringwerke Ag Schizosaccharomyces spezifische polypeptide
DE69324671D1 (de) * 1992-02-10 1999-06-02 Interferon Sciences Inc Verbesserte alpha-interferon-zusammensetzung und verfahren zu ihrer herstellung aus leukocyten des menschlichen peripheren blute
US5676942A (en) * 1992-02-10 1997-10-14 Interferon Sciences, Inc. Composition containing human alpha interferon species proteins and method for use thereof
US5440018A (en) * 1992-05-20 1995-08-08 The Green Cross Corporation Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same
US5521287A (en) * 1992-05-20 1996-05-28 The Green Cross Corporation Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same
US5434249A (en) * 1992-05-27 1995-07-18 Viragen Inc. Method for modulating specific activity of inteferon alpha
WO1994000154A1 (en) * 1992-06-24 1994-01-06 Merck & Co., Inc. DNA ENCODING PRECURSOR INTERLEUKIN 1β CONVERTING ENZYME
US5728553A (en) 1992-09-23 1998-03-17 Delta Biotechnology Limited High purity albumin and method of producing
EP0673440A4 (en) * 1992-11-30 1997-10-01 Us Health ENZYME NAD: ARGININE ADP-RIBOSYLTRANSFERASE OF MAMMALIAN MUSCLES.
FR2701263B1 (fr) * 1993-02-09 1995-04-21 Elie Stefas Procédé d'obtention d'une composition aqueuse protéinique, composition correspondante, glycoprotéine contenue et son utilisation pour la stabilisation de l'albumine et la détection ou le dosage d'anticorps.
US5550114A (en) * 1993-04-02 1996-08-27 Thomas Jefferson University Epidermal growth factor inhibitor
CA2160127A1 (en) * 1993-04-07 1994-10-13 David C. Fritzinger Dna encoding cobra c3, cvf1, and cvf2
US5714344A (en) * 1993-04-07 1998-02-03 Georgetown University Protease-derivatized CVF
ES2370937T3 (es) 1993-09-13 2011-12-23 Protein Sciences Corporation Un método para producir vacunas antigripales polivalentes a base de hemaglutinina.
US5762939A (en) * 1993-09-13 1998-06-09 Mg-Pmc, Llc Method for producing influenza hemagglutinin multivalent vaccines using baculovirus
DE69423361T2 (de) * 1993-10-05 2000-12-07 Miller Brewing Co., Milwaukee Geklonte pullulanase
US5885567A (en) * 1993-10-22 1999-03-23 University Of Connecticut Treatment of infection in fowl by oral administration of avian interferon proteins
US6020465A (en) * 1993-10-22 2000-02-01 University Of Connecticut Recombinant avian type i interferon
US5681931A (en) * 1995-03-15 1997-10-28 Becton, Dickinson And Company Human restrictin
US5883224A (en) * 1996-04-19 1999-03-16 Cytokine Sciences, Inc. Characterization of transfer factors and methods of use
US6111081A (en) * 1996-05-31 2000-08-29 Baylor College Of Medicine Lactoferrin variants and uses thereof
US5922320A (en) * 1996-06-14 1999-07-13 Georgetown University Recombinant proCVF
TW555765B (en) 1996-07-09 2003-10-01 Amgen Inc Low molecular weight soluble tumor necrosis factor type-I and type-II proteins
ATE247974T1 (de) 1996-12-06 2003-09-15 Amgen Inc Kombinationtherapie mit einem tnf-bindendem protein zür behandlung von durch tnf verursachten erkrangungen
FR2774988B1 (fr) * 1998-02-16 2000-05-05 Commissariat Energie Atomique Procede de purification de la prpres a partir d'un echantillon biologique et ses applications
US6660843B1 (en) * 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
US6433144B1 (en) * 1999-01-12 2002-08-13 Viragen, Inc. Compositions of highly-purified natural mixtures of type I Interferon derived from leukocytes and methods
GB9902000D0 (en) 1999-01-30 1999-03-17 Delta Biotechnology Ltd Process
US7087726B2 (en) 2001-02-22 2006-08-08 Genentech, Inc. Anti-interferon-α antibodies
EP1740608B1 (en) 2004-02-02 2012-02-22 Ambrx, Inc. Modified human growth hormone polypeptides and their uses
EP1966232A1 (en) * 2005-12-23 2008-09-10 Novo Nordisk A/S Purification of proteins using preparative reverse phase chromatography (rpc)
EP2132217A2 (en) * 2007-02-26 2009-12-16 Alltech Associates Inc. Ultra-fast chromatography
RU2452491C1 (ru) * 2010-11-10 2012-06-10 Александр Иванович Сотниченко Детоксикант пищеварительного тракта позвоночных

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3699222A (en) * 1958-03-11 1972-10-17 Nat Res Dev Production of viral interfering substances
US3144390A (en) * 1960-06-28 1964-08-11 Nat Res Dev Process for the purification of interferon
GB980227A (en) * 1962-08-16 1965-01-13 Glaxo Lab Ltd Purification and/or concentration of material containing interferon
GB1026726A (en) * 1962-11-23 1966-04-20 Ici Ltd New assay technique
GB1055896A (en) * 1963-12-10 1967-01-18 Glaxo Lab Ltd Silica adsorbents in interferon purification and/or concentration
US3256152A (en) * 1965-06-14 1966-06-14 Merck & Co Inc Concentration and purification of interferons, viral inhibiting substances (vis), viral inhibiting factors (vif), or viral inhibitory material
US3548053A (en) * 1965-09-07 1970-12-15 Horner Frank W Ltd Interferon production
DE1617401A1 (de) * 1966-05-02 1972-02-17 Centre Nat Rech Scient Verfahren zur Herstellung von Interferon-Praeparaten
US3652538A (en) * 1969-08-08 1972-03-28 Pfizer Formulation process for polynucleotide homopolymers
DE2041735A1 (de) * 1970-08-22 1972-02-24 Merck Patent Gmbh Thio-pyrimidin-derivate
US3773924A (en) * 1970-12-24 1973-11-20 M Ho Interferon production
BE790953A (fr) * 1971-11-05 1973-05-03 Beecham Group Ltd Matiere biologiquement active
US3800035A (en) * 1971-12-07 1974-03-26 Smithkline Corp Production of interferon from human leukocytes in the absence of serum
US3948886A (en) * 1972-03-13 1976-04-06 Icn Pharmaceuticals, Inc. 6-Substituted purine 3',5'-cyclic nucleotides
US3819482A (en) * 1972-05-08 1974-06-25 J Semancik Method of preparing high yields of double-stranded ribonucleic acid
US3970749A (en) * 1973-04-03 1976-07-20 Baugh Clarence L Interferon production
US4061538A (en) * 1973-04-04 1977-12-06 Sandoz Ltd. Enzymatically oxidizing interferon
FR2244543B1 (instruction) * 1973-07-27 1977-07-01 Inst Nl Sante Rech Medica
US3910824A (en) * 1973-10-18 1975-10-07 Searle & Co Interferon assay
US4024222A (en) * 1973-10-30 1977-05-17 The Johns Hopkins University Nucleic acid complexes
NL7404590A (nl) * 1974-04-03 1975-10-07 Stichting Rega V Z W Werkwijze voor het reactiveren van interferon.
NL7404589A (nl) * 1974-04-03 1975-10-07 Stichting Rega V Z W Werkwijze voor het stabiliseren van interferon.
US3975344A (en) * 1974-10-02 1976-08-17 G. D. Searle & Co. Interferon purification
JPS5322156B2 (instruction) * 1975-01-07 1978-07-06
US4144126A (en) * 1975-05-21 1979-03-13 Beecham Group Limited Cell culture method
US4100150A (en) * 1975-11-04 1978-07-11 G. D. Searle & Co. Stabilization of interferon against mechanical stress using thioctic acid
NL7605805A (nl) * 1976-05-28 1977-11-30 Stichting Rega V Z W Werkwijze voor het zuiveren van interferon.
US4038139A (en) * 1976-07-16 1977-07-26 G. D. Searle & Co., Limited Cell culture medium
FR2389380B1 (instruction) * 1977-05-02 1980-02-29 Anvar
JPH031320A (ja) * 1989-05-29 1991-01-08 Hitachi Maxell Ltd 磁性紛末とこれを用いた磁気記録媒体

Also Published As

Publication number Publication date
IE48882B1 (en) 1985-06-12
KE3347A (en) 1983-12-16
LU88314I2 (fr) 1994-05-04
US4289690A (en) 1981-09-15
FR2442054B1 (instruction) 1983-09-09
GB2037296A (en) 1980-07-09
SE454276B (sv) 1988-04-18
MC1300A1 (fr) 1980-10-03
NO151157B (no) 1984-11-12
YU286179A (en) 1983-10-31
DK161048B (da) 1991-05-27
DE2947134C2 (instruction) 1988-04-21
KR830000910A (ko) 1983-04-28
NO793819L (no) 1980-05-28
FR2442054A1 (fr) 1980-06-20
DOP1979002953A (es) 1992-11-10
PT70495A (en) 1979-12-01
MY8500222A (en) 1985-12-31
CH654843A5 (de) 1986-03-14
RO79132A (ro) 1982-07-06
IT1127253B (it) 1986-05-21
IL58759A (en) 1983-02-23
PH20763A (en) 1987-04-10
AU1586683A (en) 1983-12-08
AU561672B2 (en) 1987-05-14
CH658459A5 (de) 1986-11-14
ES8100502A1 (es) 1980-11-01
GR72828B (instruction) 1983-12-06
CH653347A5 (de) 1985-12-31
IE792247L (en) 1980-05-24
NZ192201A (en) 1985-07-31
FI69476C (fi) 1986-02-10
GB2037296B (en) 1983-07-27
NL193085B (nl) 1998-06-02
DK161048C (da) 1991-11-04
KR830002616B1 (ko) 1983-12-06
HK26684A (en) 1984-03-30
RO79132B (ro) 1983-05-30
AU535936B2 (en) 1984-04-12
SG71183G (en) 1984-08-03
NO151157C (no) 1985-02-20
DE2947134A1 (de) 1980-06-12
IN150740B (instruction) 1982-12-04
DK496779A (da) 1980-05-25
CA1129409A (en) 1982-08-10
FI69476B (fi) 1985-10-31
AU5313679A (en) 1980-05-29
JPH07224098A (ja) 1995-08-22
IT7927524A0 (it) 1979-11-23
ES486263A0 (es) 1980-11-01
IL58759A0 (en) 1980-02-29
NL193085C (nl) 1998-10-05
BE880201A (fr) 1980-05-22
SE7909721L (sv) 1980-06-16
NL7908516A (nl) 1980-05-28
LU81918A1 (de) 1981-06-04
FI793649A7 (fi) 1980-05-25

Similar Documents

Publication Publication Date Title
AR222359A1 (es) Procedimiento para la purificacion de proteinas de elevado peso molecular
MX6387E (es) Procedimiento para la preparacion de n-(heterocicloaminocarbonil)arilsulfonamidas
MX5631E (es) Procedimiento para la preparacion de acil-anilinas
MX5793E (es) Procedimiento para la preparacion de 4-amino-5-alquilsulfonil-orto-anisamidas
ES484821A0 (es) Procedimiento para la conformacion de colagenos
MX6749E (es) Procedimiento para la preparacion de derivados de tetrazolilalcoxicarboestirilo
ES482498A0 (es) Procedimiento para la preparacion de 2-cloro-6-nitroanilinas
MX6181E (es) Procedimiento para la preparacion de derivados n-protegidos de antibioticos aminoglucosidicos
MX156069A (es) Proceso mejorado para la preparacion de poliesteres de peso molecular elevado
MX5375E (es) Procedimiento para la preparacion de n-(diaminofosfinil)-arilcarboxamidas
AR223833A1 (es) Procedimiento para la preparacion de nuevos derivados antigenos
AR221428A1 (es) Procedimiento para la preparacion de derivados de pirrolidinil-y de pirrolidinilmetil-benzamidas
AR227379A1 (es) Procedimiento para la preparacion de 1-aril-2-imidazolil vinileteres
MX6305E (es) Procedimiento para la preparacion de 3-0(beta-d-glucouronopiranosil)-soyasapogenol b
ES485567A0 (es) Procedimiento para la preparacion de azolilcetales
MX5594E (es) Procedimiento mejorado para la preparacion de derivados de n-trifluoroacetil-n-fosfonometilglicinatos
MX5909E (es) Procedimiento mejorado para la preparacion de ciclohexanona
ES484342A0 (es) Procedimiento para la preparacion de propenilensulfona
MX149694A (es) Procedimiento para la preparacion de trialcoxisilanos de fenoxialquilo
MX5955E (es) Procedimiento para la preparacion de derivados de piridoxina
AR224768A1 (es) Procedimiento para la purificacion de gases no reactivos
MX5605E (es) Procedimiento mejorado para la preparacion de 2-isopropilaminopirimidina
MX5674E (es) Procedimiento para la preparacion de derivados de la butenofenona
MX5445E (es) Procedimiento para la preparacion de derivados de isotiocianobenzotiazol
MX6158E (es) Procedimiento para la preparacion de derivados piperazinilbenzoheterociclicos