AR106100A1 - Compuestos bicíclicos como inhibidores duales atx / ca - Google Patents

Compuestos bicíclicos como inhibidores duales atx / ca

Info

Publication number
AR106100A1
AR106100A1 ARP160102880A ARP160102880A AR106100A1 AR 106100 A1 AR106100 A1 AR 106100A1 AR P160102880 A ARP160102880 A AR P160102880A AR P160102880 A ARP160102880 A AR P160102880A AR 106100 A1 AR106100 A1 AR 106100A1
Authority
AR
Argentina
Prior art keywords
alkyl
substituted
alkoxy
cycloalkyl
thiophenyl
Prior art date
Application number
ARP160102880A
Other languages
English (en)
Spanish (es)
Inventor
Ullmer Christoph
Schmitz Petra
Rudolph Markus
Mattei Patrizio
Hunziker Daniel
Hert Jrme
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR106100A1 publication Critical patent/AR106100A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
ARP160102880A 2015-09-24 2016-09-22 Compuestos bicíclicos como inhibidores duales atx / ca AR106100A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15186642 2015-09-24

Publications (1)

Publication Number Publication Date
AR106100A1 true AR106100A1 (es) 2017-12-13

Family

ID=54199040

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160102880A AR106100A1 (es) 2015-09-24 2016-09-22 Compuestos bicíclicos como inhibidores duales atx / ca

Country Status (19)

Country Link
US (2) US10738053B2 (enExample)
EP (1) EP3353181B1 (enExample)
JP (1) JP6845230B2 (enExample)
KR (1) KR20180053408A (enExample)
CN (1) CN107614505B (enExample)
AR (1) AR106100A1 (enExample)
AU (1) AU2016328365B2 (enExample)
BR (1) BR112017026682A2 (enExample)
CA (1) CA2984585A1 (enExample)
CL (1) CL2018000649A1 (enExample)
CO (1) CO2017011152A2 (enExample)
CR (1) CR20180143A (enExample)
IL (1) IL255511B (enExample)
MX (1) MX2017015034A (enExample)
PE (1) PE20180233A1 (enExample)
PH (1) PH12018500409A1 (enExample)
RU (1) RU2725138C2 (enExample)
TW (1) TW201725206A (enExample)
WO (1) WO2017050747A1 (enExample)

Families Citing this family (16)

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SI2861566T1 (sl) 2012-06-13 2017-03-31 F. Hoffmann-La Roche Ag Novi diazaspirocikloalkan in azaspirocikloalkan
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AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
AU2014356583B2 (en) 2013-11-26 2019-02-28 F. Hoffmann-La Roche Ag New octahydro-cyclobuta (1,2-c;3,4-c')dipyrrol-2-yl
CR20160418A (es) 2014-03-26 2016-11-07 Hoffmann La Roche Nuevos compuestos biciclicos de 7 eslabones
MA50635A (fr) 2014-03-26 2020-08-12 Hoffmann La Roche Nouveaux composés bicycliques comme inhibiteurs de la production d'autotaxin (atx) et de l'acide lysophosphatidique
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
EP3344619B1 (en) 2015-09-04 2020-10-28 H. Hoffnabb-La Roche Ag Phenoxymethyl derivatives
WO2017050747A1 (en) 2015-09-24 2017-03-30 F. Hoffmann-La Roche Ag New bicyclic compounds as dual atx/ca inhibitors
MA42918A (fr) * 2015-09-24 2018-08-01 Hoffmann La Roche Composés bicycliques utilisés en tant qu'inhibiteurs d'atx
BR112018006080A2 (pt) 2015-09-24 2018-10-09 F. Hoffmann-La Roche Ag novos compostos bicíclicos como inibidores de dupla ação de atx/ca
AU2016328437A1 (en) 2015-09-24 2018-01-25 F. Hoffmann-La Roche Ag Bicyclic compounds as ATX inhibitors
RU2019132254A (ru) * 2017-03-16 2021-04-16 Ф. Хоффманн-Ля Рош Аг Гетероциклические соединения, пригодные в качестве дуальных ингибиторов atx/ca
EP3596060B1 (en) 2017-03-16 2023-09-20 F. Hoffmann-La Roche AG New bicyclic compounds as atx inhibitors
US12391667B2 (en) 2019-07-22 2025-08-19 Boehringer Ingelheim International Gmbh N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as Autotaxin (ATX) modulators for the treatment of inflammatory airway or fibrotic diseases
FI4274572T3 (fi) 2021-01-05 2026-03-27 Zydus Lifesciences Ltd Uusia autotaksiinin inhibiittoreita

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