JP6845230B2 - デュアルａｔｘ／ｃａ阻害剤としての新規な二環式化合物 - Google Patents

デュアルａｔｘ／ｃａ阻害剤としての新規な二環式化合物 Download PDF

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JP6845230B2
JP6845230B2 JP2018515621A JP2018515621A JP6845230B2 JP 6845230 B2 JP6845230 B2 JP 6845230B2 JP 2018515621 A JP2018515621 A JP 2018515621A JP 2018515621 A JP2018515621 A JP 2018515621A JP 6845230 B2 JP6845230 B2 JP 6845230B2
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substituted
alkyl
alkoxy
pyrrole
trans
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JP2018528244A (ja
JP2018528244A5 (enExample
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ヘルト，イェロム
フンツィカー，ダニエル
マタイ，パトリツィオ
ルドルフ，マルクス
シュミッツ，ペトラ
ウルマー，クリストフ
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2018515621A 2015-09-24 2016-09-20 デュアルａｔｘ／ｃａ阻害剤としての新規な二環式化合物 Active JP6845230B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15186642 2015-09-24
EP15186642.3 2015-09-24
PCT/EP2016/072277 WO2017050747A1 (en) 2015-09-24 2016-09-20 New bicyclic compounds as dual atx/ca inhibitors

Publications (3)

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JP2018528244A JP2018528244A (ja) 2018-09-27
JP2018528244A5 JP2018528244A5 (enExample) 2019-10-24
JP6845230B2 true JP6845230B2 (ja) 2021-03-17

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JP2018515621A Active JP6845230B2 (ja) 2015-09-24 2016-09-20 デュアルａｔｘ／ｃａ阻害剤としての新規な二環式化合物

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US (2) US10738053B2 (enExample)
EP (1) EP3353181B1 (enExample)
JP (1) JP6845230B2 (enExample)
KR (1) KR20180053408A (enExample)
CN (1) CN107614505B (enExample)
AR (1) AR106100A1 (enExample)
AU (1) AU2016328365B2 (enExample)
BR (1) BR112017026682A2 (enExample)
CA (1) CA2984585A1 (enExample)
CL (1) CL2018000649A1 (enExample)
CO (1) CO2017011152A2 (enExample)
CR (1) CR20180143A (enExample)
IL (1) IL255511B (enExample)
MX (1) MX2017015034A (enExample)
PE (1) PE20180233A1 (enExample)
PH (1) PH12018500409A1 (enExample)
RU (1) RU2725138C2 (enExample)
TW (1) TW201725206A (enExample)
WO (1) WO2017050747A1 (enExample)

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CN106103446B (zh) 2014-03-26 2019-07-30 豪夫迈·罗氏有限公司 作为自分泌运动因子(atx)和溶血磷脂酸(lpa)生产抑制剂的二环化合物
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CN108026077B (zh) 2015-09-04 2021-11-05 豪夫迈·罗氏有限公司 苯氧基甲基衍生物
EP3353178B1 (en) * 2015-09-24 2021-07-14 F. Hoffmann-La Roche AG Bicyclic compounds as dual atx/ca inhibitors
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CR20180143A (es) 2015-09-24 2018-05-03 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores duales de atx/ca
RU2019132254A (ru) * 2017-03-16 2021-04-16 Ф. Хоффманн-Ля Рош Аг Гетероциклические соединения, пригодные в качестве дуальных ингибиторов atx/ca
CN110382484B (zh) 2017-03-16 2022-12-06 豪夫迈·罗氏有限公司 新的作为atx抑制剂的二环化合物
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