JP6845230B2 - デュアルａｔｘ／ｃａ阻害剤としての新規な二環式化合物 - Google Patents

デュアルａｔｘ／ｃａ阻害剤としての新規な二環式化合物 Download PDF

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JP6845230B2
JP6845230B2 JP2018515621A JP2018515621A JP6845230B2 JP 6845230 B2 JP6845230 B2 JP 6845230B2 JP 2018515621 A JP2018515621 A JP 2018515621A JP 2018515621 A JP2018515621 A JP 2018515621A JP 6845230 B2 JP6845230 B2 JP 6845230B2
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substituted
alkyl
alkoxy
pyrrole
trans
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JP2018528244A5 (enExample
JP2018528244A (ja
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ヘルト，イェロム
フンツィカー，ダニエル
マタイ，パトリツィオ
ルドルフ，マルクス
シュミッツ，ペトラ
ウルマー，クリストフ
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2018515621A 2015-09-24 2016-09-20 デュアルａｔｘ／ｃａ阻害剤としての新規な二環式化合物 Active JP6845230B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15186642 2015-09-24
EP15186642.3 2015-09-24
PCT/EP2016/072277 WO2017050747A1 (en) 2015-09-24 2016-09-20 New bicyclic compounds as dual atx/ca inhibitors

Publications (3)

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JP2018528244A JP2018528244A (ja) 2018-09-27
JP2018528244A5 JP2018528244A5 (enExample) 2019-10-24
JP6845230B2 true JP6845230B2 (ja) 2021-03-17

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JP2018515621A Active JP6845230B2 (ja) 2015-09-24 2016-09-20 デュアルａｔｘ／ｃａ阻害剤としての新規な二環式化合物

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US (2) US10738053B2 (enExample)
EP (1) EP3353181B1 (enExample)
JP (1) JP6845230B2 (enExample)
KR (1) KR20180053408A (enExample)
CN (1) CN107614505B (enExample)
AR (1) AR106100A1 (enExample)
AU (1) AU2016328365B2 (enExample)
BR (1) BR112017026682A2 (enExample)
CA (1) CA2984585A1 (enExample)
CL (1) CL2018000649A1 (enExample)
CO (1) CO2017011152A2 (enExample)
CR (1) CR20180143A (enExample)
IL (1) IL255511B (enExample)
MX (1) MX2017015034A (enExample)
PE (1) PE20180233A1 (enExample)
PH (1) PH12018500409A1 (enExample)
RU (1) RU2725138C2 (enExample)
TW (1) TW201725206A (enExample)
WO (1) WO2017050747A1 (enExample)

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EA032357B1 (ru) 2014-03-26 2019-05-31 Ф. Хоффманн-Ля Рош Аг Конденсированные [1,4]диазепиновые соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa)
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JP6876685B2 (ja) 2015-09-24 2021-05-26 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ａｔｘ阻害剤としての二環式化合物
WO2017050732A1 (en) 2015-09-24 2017-03-30 F. Hoffmann-La Roche Ag Bicyclic compounds as atx inhibitors
AU2016328436B2 (en) * 2015-09-24 2020-05-14 F. Hoffmann-La Roche Ag New bicyclic compounds as dual ATX/CA inhibitors
RU2019132254A (ru) * 2017-03-16 2021-04-16 Ф. Хоффманн-Ля Рош Аг Гетероциклические соединения, пригодные в качестве дуальных ингибиторов atx/ca
JP7090099B2 (ja) 2017-03-16 2022-06-23 エフ．ホフマン－ラ ロシュ アーゲー Ａｔｘインヒビターとしての新規二環式化合物
CN114127054B (zh) 2019-07-22 2024-04-09 勃林格殷格翰国际有限公司 作为用于治疗炎性气道或纤维化疾病的自分泌运动因子(atx)调节剂的n-甲基、n-(6-(甲氧基)哒嗪-3-基)胺衍生物
JP2024502337A (ja) 2021-01-05 2024-01-18 ザイダス ライフサイエンシズ リミティド オートタキシンの新規阻害剤

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